List of works - Víctor Quesada

A comprehensive assessment of somatic mutation detection in cancer using whole-genome sequencing.

scientific article

A functional ubiquitin-specific protease embedded in the large tegument protein (ORF64) of murine gammaherpesvirus 68 is active during the course of infection

scientific article

A spotlight on cancer researchers in Spain: new paradigms and disruptive ideas

scientific article published on 09 August 2019

Adaptive Evolution Favoring KLK4 Downregulation in East Asians.

scientific article

Altered patterns of global protein synthesis and translational fidelity in RPS15-mutated chronic lymphocytic leukemia

scientific article published on 04 September 2018

Apicomplexan UCHL3 retains dual specificity for ubiquitin and Nedd8 throughout evolution

Association of the POT1 Germline Missense Variant p.I78T With Familial Melanoma

Birth-and-death of KLK3 and KLK2 in primates: evolution driven by reproductive biology

scientific article published on January 2012

CANCERTOOL: A Visualization and Representation Interface to Exploit Cancer Datasets

scientific article published on 19 September 2018

Cell-cell adhesion genes CTNNA2 and CTNNA3 are tumour suppressors frequently mutated in laryngeal carcinomas.

scientific article published in January 2013

Chronic Lymphocytic Leukemia withSF3B1Mutation

scientific article published on 01 June 2012

Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases

scientific article

Cloning, expression analysis, and structural characterization of seven novel human ADAMTSs, a family of metalloproteinases with disintegrin and thrombospondin-1 domains

scientific article

Comparative genomic analysis of the zebra finch degradome provides new insights into evolution of proteases in birds and mammals

scientific article (publication date: April 2010)

Cystatin D is a candidate tumor suppressor gene induced by vitamin D in human colon cancer cells

scientific article published on August 2009

Deubiquitinases in cancer: new functions and therapeutic options.

scientific article published on 26 September 2011

Development of a CRISPR/Cas9-based therapy for Hutchinson-Gilford progeria syndrome

scientific article published on 18 February 2019

Differential mechanisms of tolerance to extreme environmental conditions in tardigrades

scientific article published on 17 October 2019

Epigenomic analysis detects widespread gene-body DNA hypomethylation in chronic lymphocytic leukemia.

scientific article published on 14 October 2012

Exome sequencing identifies a novel mutation in PIK3R1 as the cause of SHORT syndrome

scientific article

Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia

scientific article

Extreme genomic erosion after recurrent demographic bottlenecks in the highly endangered Iberian lynx

scientific article

Frequent birth-and-death events throughout perforin-1 evolution

scientific article published on 19 October 2020

Frequent somatic mutations in components of the RNA processing machinery in chronic lymphocytic leukemia

scientific article

Functional analysis of sucrase-isomaltase mutations from chronic lymphocytic leukemia patients

scientific article

Genome Sequencing and Analysis Methods in Chronic Lymphocytic Leukemia

scientific article published on 01 January 2019

Giant tortoise genomes provide insights into longevity and age-related disease

scientific article published on 03 December 2018

Human autophagins, a family of cysteine proteinases potentially implicated in cell degradation by autophagy

scientific article

Human polyserase-2, a novel enzyme with three tandem serine protease domains in a single polypeptide chain

scientific article

Identification and characterization of ADAMTS-20 defines a novel subfamily of metalloproteinases-disintegrins with multiple thrombospondin-1 repeats and a unique GON domain

scientific journal article

Identification and characterization of human and mouse ovastacin: a novel metalloproteinase similar to hatching enzymes from arthropods, birds, amphibians, and fish

scientific article

Identification and characterization of human polyserase-3, a novel protein with tandem serine-protease domains in the same polypeptide chain

scientific article

Identification and enzymatic characterization of two diverging murine counterparts of human interstitial collagenase (MMP-1) expressed at sites of embryo implantation

scientific journal article

Identification of human aminopeptidase O, a novel metalloprotease with structural similarity to aminopeptidase B and leukotriene A4 hydrolase

scientific article

Insights into the evolution of longevity from the bowhead whale genome ⬇️

scientific article

Matriptase-2 mutations in iron-refractory iron deficiency anemia patients provide new insights into protease activation mechanisms.

scientific article published on 10 July 2009

Molecular pathogenesis of CLL and its evolution

scientific article

Mutations in CHD2 cause defective association with active chromatin in chronic lymphocytic leukemia

scientific article

Mutations in TLR/MYD88 pathway identify a subset of young chronic lymphocytic leukemia patients with favorable outcome

scientific article published on 29 April 2014

NOTCH1 mutations identify a genetic subgroup of chronic lymphocytic leukemia patients with high risk of transformation and poor outcome.

scientific article published on 6 December 2012

Next-generation sequencing reveals the secrets of the chronic lymphocytic leukemia genome.

scientific article published on 22 August 2012

Non-coding recurrent mutations in chronic lymphocytic leukaemia

scientific article published in Nature

Nonsense mutations in the shelterin complex genes ACD and TERF2IP in familial melanoma

scientific article

Novel LMNA mutations cause an aggressive atypical neonatal progeria without progerin accumulation

scientific article published on 22 June 2016

POT1 loss-of-function variants predispose to familial melanoma

scientific article

POT1 mutations cause telomere dysfunction in chronic lymphocytic leukemia

scientific article

Polyserase-I, a human polyprotease with the ability to generate independent serine protease domains from a single translation product

scientific article

Progerin accelerates atherosclerosis by inducing endoplasmic reticulum stress in vascular smooth muscle cells

scientific article published on 01 April 2019

Proteolytic systems: constructing degradomes

scientific article published on January 2009

Recurrent gene mutations in CLL.

scientific article published on January 2013

Sequence variation at KLK and WFDC clusters and its association to semen hyperviscosity and other male infertility phenotypes

scientific article published on 7 November 2016

Sexual and Apogamous Species of Woodferns Show Different Protein and Phytohormone Profiles

scientific article published on 12 November 2021

Structural and enzymatic characterization of Drosophila Dm2-MMP, a membrane-bound matrix metalloproteinase with tissue-specific expression.

scientific article published on 19 April 2002

The Degradome database: expanding roles of mammalian proteases in life and disease

scientific article published on 8 November 2015

The Degradome database: mammalian proteases and diseases of proteolysis

scientific article published on 06 September 2008

The Novel Evolution of the Sperm Whale Genome

scientific article

The genomic landscape of chronic lymphocytic leukemia: clinical implications

scientific article

Transcriptome characterization by RNA sequencing identifies a major molecular and clinical subdivision in chronic lymphocytic leukemia

scientific article

USP39 Deubiquitinase Is Essential for KRAS Oncogene-driven Cancer.

scientific article

Virtual laboratory lessons in enzymology

scientific article published on 30 June 2020

Visualization of gene expression by fluorescent multiplex reverse transcriptase-PCR amplification.

scientific article published in January 2007

nVenn: generalized, quasi-proportional Venn and Euler diagrams

scholarly article by José G Pérez-Silva published in February 2018

List of works by Víctor Quesada

A comprehensive assessment of somatic mutation detection in cancer using whole-genome sequencing.

A functional ubiquitin-specific protease embedded in the large tegument protein (ORF64) of murine gammaherpesvirus 68 is active during the course of infection

A spotlight on cancer researchers in Spain: new paradigms and disruptive ideas

Adaptive Evolution Favoring KLK4 Downregulation in East Asians.

Altered patterns of global protein synthesis and translational fidelity in RPS15-mutated chronic lymphocytic leukemia

Apicomplexan UCHL3 retains dual specificity for ubiquitin and Nedd8 throughout evolution

Association of the POT1 Germline Missense Variant p.I78T With Familial Melanoma

Birth-and-death of KLK3 and KLK2 in primates: evolution driven by reproductive biology

CANCERTOOL: A Visualization and Representation Interface to Exploit Cancer Datasets

Cell-cell adhesion genes CTNNA2 and CTNNA3 are tumour suppressors frequently mutated in laryngeal carcinomas.

Chronic Lymphocytic Leukemia withSF3B1Mutation

Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases

Cloning, expression analysis, and structural characterization of seven novel human ADAMTSs, a family of metalloproteinases with disintegrin and thrombospondin-1 domains

Comparative genomic analysis of the zebra finch degradome provides new insights into evolution of proteases in birds and mammals

Cystatin D is a candidate tumor suppressor gene induced by vitamin D in human colon cancer cells

Deubiquitinases in cancer: new functions and therapeutic options.

Development of a CRISPR/Cas9-based therapy for Hutchinson-Gilford progeria syndrome

Differential mechanisms of tolerance to extreme environmental conditions in tardigrades

Epigenomic analysis detects widespread gene-body DNA hypomethylation in chronic lymphocytic leukemia.

Exome sequencing identifies a novel mutation in PIK3R1 as the cause of SHORT syndrome

Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia

Extreme genomic erosion after recurrent demographic bottlenecks in the highly endangered Iberian lynx

Frequent birth-and-death events throughout perforin-1 evolution

Frequent somatic mutations in components of the RNA processing machinery in chronic lymphocytic leukemia

Functional analysis of sucrase-isomaltase mutations from chronic lymphocytic leukemia patients

Genome Sequencing and Analysis Methods in Chronic Lymphocytic Leukemia

Giant tortoise genomes provide insights into longevity and age-related disease

Human autophagins, a family of cysteine proteinases potentially implicated in cell degradation by autophagy

Human polyserase-2, a novel enzyme with three tandem serine protease domains in a single polypeptide chain

Identification and characterization of ADAMTS-20 defines a novel subfamily of metalloproteinases-disintegrins with multiple thrombospondin-1 repeats and a unique GON domain

Identification and characterization of human and mouse ovastacin: a novel metalloproteinase similar to hatching enzymes from arthropods, birds, amphibians, and fish

Identification and characterization of human polyserase-3, a novel protein with tandem serine-protease domains in the same polypeptide chain

Identification and enzymatic characterization of two diverging murine counterparts of human interstitial collagenase (MMP-1) expressed at sites of embryo implantation

Identification of human aminopeptidase O, a novel metalloprotease with structural similarity to aminopeptidase B and leukotriene A4 hydrolase

Insights into the evolution of longevity from the bowhead whale genome ⬇️

Matriptase-2 mutations in iron-refractory iron deficiency anemia patients provide new insights into protease activation mechanisms.

Molecular pathogenesis of CLL and its evolution

Mutations in CHD2 cause defective association with active chromatin in chronic lymphocytic leukemia

Mutations in TLR/MYD88 pathway identify a subset of young chronic lymphocytic leukemia patients with favorable outcome

NOTCH1 mutations identify a genetic subgroup of chronic lymphocytic leukemia patients with high risk of transformation and poor outcome.

Next-generation sequencing reveals the secrets of the chronic lymphocytic leukemia genome.

Non-coding recurrent mutations in chronic lymphocytic leukaemia

Nonsense mutations in the shelterin complex genes ACD and TERF2IP in familial melanoma

Novel LMNA mutations cause an aggressive atypical neonatal progeria without progerin accumulation

POT1 loss-of-function variants predispose to familial melanoma

POT1 mutations cause telomere dysfunction in chronic lymphocytic leukemia

Polyserase-I, a human polyprotease with the ability to generate independent serine protease domains from a single translation product

Progerin accelerates atherosclerosis by inducing endoplasmic reticulum stress in vascular smooth muscle cells

Proteolytic systems: constructing degradomes

Recurrent gene mutations in CLL.

Sequence variation at KLK and WFDC clusters and its association to semen hyperviscosity and other male infertility phenotypes

Sexual and Apogamous Species of Woodferns Show Different Protein and Phytohormone Profiles

Structural and enzymatic characterization of Drosophila Dm2-MMP, a membrane-bound matrix metalloproteinase with tissue-specific expression.

The Degradome database: expanding roles of mammalian proteases in life and disease

The Degradome database: mammalian proteases and diseases of proteolysis

The Novel Evolution of the Sperm Whale Genome

The genomic landscape of chronic lymphocytic leukemia: clinical implications

Transcriptome characterization by RNA sequencing identifies a major molecular and clinical subdivision in chronic lymphocytic leukemia

USP39 Deubiquitinase Is Essential for KRAS Oncogene-driven Cancer.

Virtual laboratory lessons in enzymology

Visualization of gene expression by fluorescent multiplex reverse transcriptase-PCR amplification.

nVenn: generalized, quasi-proportional Venn and Euler diagrams