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List of works by Danish Saleheen

A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease

scientific article

A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease

scientific article published on June 2016

A novel MMP12 locus is associated with large artery atherosclerotic stroke using a genome-wide age-at-onset informed approach

scientific article

A novel haplotype in ABCA1 gene effects plasma HDL-C concentration

scientific article published on 23 June 2006

A novel interaction between the FLJ33534 locus and smoking in obesity: a genome-wide study of 14 131 Pakistani adults

scientific article published on 17 August 2015

A novel mutation in a patient with pantothenate kinase-associated neurodegeneration

scientific article published on September 2005

ANGPTL3 Deficiency and Protection Against Coronary Artery Disease

scientific article published on 29 March 2017

Analysis of predicted loss-of-function variants in UK Biobank identifies variants protective for disease

scientific article published on 24 April 2018

Analysis of protein-coding genetic variation in 60,706 humans

scientific article (publication date: 17 August 2016)

Apolipoprotein(a) isoform size, lipoprotein(a) concentration, and coronary artery disease: a mendelian randomisation analysis

scientific article

Apolipoprotein(a) isoforms and the risk of vascular disease: systematic review of 40 studies involving 58,000 participants

scientific article published on May 2010

Are myocardial infarction--associated single-nucleotide polymorphisms associated with ischemic stroke?

scientific article published on 23 February 2012

Association between C reactive protein and coronary heart disease: mendelian randomisation analysis based on individual participant data

scientific article (publication date: 15 February 2011)

Association of HDL cholesterol efflux capacity with incident coronary heart disease events: a prospective case-control study

scientific article

Association of Rare and Common Variation in the Lipoprotein Lipase Gene With Coronary Artery Disease

scientific article

Association of cholesteryl ester transfer protein genotypes with CETP mass and activity, lipid levels, and coronary risk

scientific article published on June 2008

Association of phosphodiesterase 4D gene with ischemic stroke in a Pakistani population

scientific article published on 15 September 2005

Association of the 9p21.3 locus with risk of first-ever myocardial infarction in Pakistanis: case-control study in South Asia and updated meta-analysis of Europeans

scientific article published on 15 April 2010

B-type natriuretic peptides and cardiovascular risk: systematic review and meta-analysis of 40 prospective studies

scientific article

BRCA2 variants and cardiovascular disease in a multi-ethnic study

scientific article

Bayesian methods for meta-analysis of causal relationships estimated using genetic instrumental variables

scientific article published on May 2010

CAD risk factors and acute myocardial infarction in Pakistan

scientific article published in August 2004

Candidate gene association study of coronary artery calcification in chronic kidney disease: findings from the CRIC study (Chronic Renal Insufficiency Cohort).

scientific article published on 30 May 2013

Cardiovascular diseases and hyperhomocysteinemia.

scientific article published in January 2005

Causal Assessment of Serum Urate Levels in Cardiometabolic Diseases Through a Mendelian Randomization Study

scientific article

Cholesterol ester transfer protein inhibition by TA-8995 in patients with mild dyslipidaemia (TULIP): a randomised, double-blind, placebo-controlled phase 2 trial

scientific article (publication date: August 2015)

Cilostazol versus aspirin for secondary prevention of vascular events after stroke

scientific article

Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease

scientific article published on 2 March 2016

Common and Rare Genetic Variation in CCR2, CCR5, or CX3CR1 and Risk of Atherosclerotic Coronary Heart Disease and Glucometabolic Traits

scientific article published on 24 March 2016

Common coding variant in SERPINA1 increases the risk for large artery stroke

scientific article

Common variants associated with plasma triglycerides and risk for coronary artery disease

scientific article

Corrigendum: Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk

scientific article published in September 2017

DNA Sequence Variation in Encoding the Activin-Receptor Like Kinase 7 Influences Body Fat Distribution and Protects Against Type 2 Diabetes

Defining the role of common variation in the genomic and biological architecture of adult human height

scientific article

Diagnostic Yield and Clinical Utility of Sequencing Familial Hypercholesterolemia Genes in Patients With Severe Hypercholesterolemia

scientific article

Discovery and refinement of loci associated with lipid levels

scientific article

Disentangling the Causal Association of Plasma Lipid Traits and Type 2 Diabetes Using Human Genetics

scientific article published on 3 August 2016

ERRATUM: Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height

article by Matthew B. Lanktree et al published June 2012 in American Journal of Human Genetics

Epidemiology and public health policy of tobacco use and cardiovascular disorders in low- and middle-income countries

scientific article published on 17 July 2014

Epigenome-wide association of DNA methylation markers in peripheral blood from Indian Asians and Europeans with incident type 2 diabetes: a nested case-control study

scientific article

Erratum: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls

scientific article published on 23 January 2018

Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction

scientific article

Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls

article by Jason Flannick et al published 22 May 2019 in Nature

Exome-wide association study of plasma lipids in >300,000 individuals

scientific article published on 30 October 2017

Factors associated with adherence to anti-hypertensive treatment in Pakistan

scientific article

Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms

scientific article published on 22 May 2017

Fine Mapping and Functional Analysis Reveal a Role of SLC22A1 in Acylcarnitine Transport

scientific article

Frequency and determinants of intracranial atherosclerotic stroke in urban Pakistan

scientific article published on August 2014

From Loci to Biology: Functional Genomics of Genome-Wide Association for Coronary Disease

scientific article published on February 2016

Genetic association of long-chain acyl-CoA synthetase 1 variants with fasting glucose, diabetes, and subclinical atherosclerosis

scientific article

Genetic determinants of major blood lipids in Pakistanis compared with Europeans

scientific article published on 22 June 2010

Genetic invalidation of Lp-PLA2 as a therapeutic target: Large-scale study of five functional Lp-PLA2-lowering alleles

scientific article

Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies

scientific article published on 5 October 2012

Genetic studies of body mass index yield new insights for obesity biology

scientific article

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

scientific article published on 6 October 2011

Genetic variation at 16q24.2 is associated with small vessel stroke

scientific article

Genetically determined height and coronary artery disease

scientific article

Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes

scientific article

Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes

scientific article published on 28 January 2016

Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India

scientific article

Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci

scientific article

Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption

scientific article

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility

scientific article

Homocysteine and Coronary Heart Disease: Meta-analysis of MTHFR Case-Control Studies, Avoiding Publication Bias ⬇️

scientific article (publication date: February 2012)

Human knockouts and phenotypic analysis in a cohort with a high rate of consanguinity

scientific article published on April 2017

Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease

scientific article published on 4 September 2017

Identification of seven loci affecting mean telomere length and their association with disease

scientific article published on April 2013

Inactivating mutations in NPC1L1 and protection from coronary heart disease

scientific article

Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies

scientific article published on 14 March 2012

Large-Scale Gene-Centric Meta-Analysis across 39 Studies Identifies Type 2 Diabetes Loci.

scientific article

Large-scale association analysis identifies new risk loci for coronary artery disease

scientific article published on 02 December 2012

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

scientific article

Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci

scientific article

Lipid-Related Markers and Cardiovascular Disease Prediction ⬇️

scientific article published on June 20, 2012

Lipoprotein(a) and Risk of Myocardial Infarction and Death in Chronic Kidney Disease: Findings From the CRIC Study (Chronic Renal Insufficiency Cohort).

scientific article published on 24 August 2017

Loss of Cardioprotective Effects at the ADAMTS7 Locus as a Result of Gene-Smoking Interactions

scientific article published on May 2017

Low-frequency and common genetic variation in ischemic stroke: The METASTROKE collaboration.

scientific article

Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height

scientific article

Molecular analysis of the XLRS1 gene in 4 females affected with X-linked juvenile retinoschisis

scientific article

Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes

scientific article published on 12 March 2018

Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease

scientific article (publication date: 17 September 2013)

New genetic loci link adipose and insulin biology to body fat distribution

scientific article

Novel mutation in the PANK2 gene leads to pantothenate kinase-associated neurodegeneration in a Pakistani family

scientific article published in October 2007

PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

article

Phenotypic Characterization of Genetically Lowered Human Lipoprotein(a) Levels

scientific article published on December 2016

Phenotypic Consequences of a Genetic Predisposition to Enhanced Nitric Oxide Signaling

scientific article published on 5 October 2017

Physical activity, smoking, and genetic predisposition to obesity in people from Pakistan: the PROMIS study

scientific article published on 18 December 2015

Protein-Truncating Variants at the Cholesteryl Ester Transfer Protein Gene and Risk for Coronary Heart Disease

scientific article published on 15 May 2017

Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

scientific article published on 22 December 2017

Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution

article

Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

scientific article published on 16 March 2018

Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

scientific article

R1615P: a novel mutation in ABCA1 associated with low levels of HDL and type II diabetes mellitus

scientific article published in August 2005

Rare and low-frequency coding variants alter human adult height

scientific article (publication date: February 2017)

Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease

scientific journal article

Refining The Accuracy Of Validated Target Identification Through Coding Variant Fine-Mapping In Type 2 Diabetes

article

Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes

scientific article published on 9 April 2018

Sequence data and association statistics from 12,940 type 2 diabetes cases and controls

scientific article published on 19 December 2017

Strong association of a renin intronic dimorphism with essential hypertension.

scientific article

Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease ⬇️

scientific article published on February 2017

Systolic Blood Pressure and Risk of Type 2 Diabetes: A Mendelian Randomization Study

scientific article published on 4 October 2016

The "eye of the tiger" sign

scientific article

The Bangladesh Risk of Acute Vascular Events (BRAVE) Study: objectives and design

scientific article published in May 2015

The Karachi intracranial stenosis study (KISS) Protocol: an urban multicenter case-control investigation reporting the clinical, radiologic and biochemical associations of intracranial stenosis in Pakistan

scientific article published on 15 July 2009

The Pakistan Risk of Myocardial Infarction Study: a resource for the study of genetic, lifestyle and other determinants of myocardial infarction in South Asia

scientific article published on 30 April 2009

The burden of stroke and transient ischemic attack in Pakistan: a community-based prevalence study

scientific article

The genetic architecture of type 2 diabetes

scientific article (publication date: 11 July 2016)

The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals

scientific article published on 12 September 2016

Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation

scientific article

Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension

scientific article published on 12 September 2016

Transancestral fine-mapping of four type 2 diabetes susceptibility loci highlights potential causal regulatory mechanisms

scientific article published on 23 February 2016

Triglyceride-mediated pathways and coronary disease: collaborative analysis of 101 studies

scientific article

Using Mendelian Randomization studies to Assess Causality and Identify New Therapeutic Targets in Cardiovascular Medicine

scientific article published on 10 September 2016

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