List of works by Cecília Rodrigues

(3'R)-hydroxytabernaelegantine C: A bisindole alkaloid with potent apoptosis inducing activity in colon (HCT116, SW620) and liver (HepG2) cancer cells.

scientific article

.DELTA.22-Ursodeoxycholic Acid, a Unique Metabolite of Administered Ursodeoxycholic Acid in Rats, Indicating Partial .beta.-Oxidation as a Major Pathway for Bile Acid Metabolism

scientific article published on 01 April 1995

6-Acetonyldihydrochelerythrine Is a Potent Inducer of Apoptosis in HCT116 and SW620 Colon Cancer Cells.

scientific article

A Novel Small Molecule p53 Stabilizer for Brain Cell Differentiation

scientific article published on 31 January 2019

A bile acid protects against motor and cognitive deficits and reduces striatal degeneration in the 3-nitropropionic acid model of Huntington's disease.

scientific article published in October 2001

A distinct microarray gene expression profile in primary rat hepatocytes incubated with ursodeoxycholic acid.

scientific article published on 7 April 2005

Aberrant MEK5/ERK5 signalling contributes to human colon cancer progression via NF-κB activation

scientific article

Ablation of RIP3 protects from dopaminergic neurodegeneration in experimental Parkinson's disease

scientific article published on 05 November 2019

Acquired resistance to aromatase inhibitors: where we stand!

scientific article published on 12 March 2018

Administration of tauroursodeoxycholic acid (TUDCA) reduces apoptosis following myocardial infarction in rat.

scientific article

Aging confers different sensitivity to the neurotoxic properties of unconjugated bilirubin.

scientific article

Amyloid β Peptide Compromises Neural Stem Cell Fate by Irreversibly Disturbing Mitochondrial Oxidative State and Blocking Mitochondrial Biogenesis and Dynamics

scientific article published on 18 September 2018

Amyloid β peptides promote autophagy-dependent differentiation of mouse neural stem cells: Aβ-mediated neural differentiation.

scientific article published on 2 June 2013

Amyloid-β pathology is attenuated by tauroursodeoxycholic acid treatment in APP/PS1 mice after disease onset.

scientific article published on 28 September 2014

Amyloid-β peptide-induced secretion of endoplasmic reticulum chaperone glycoprotein GRP94.

scientific article published in January 2011

Antitumour Potential of Gigartina pistillata Carrageenans against Colorectal Cancer Stem Cell-Enriched Tumourspheres

scientific article published on 12 January 2020

Apoptosis and Bcl-2 expression in the livers of patients with steatohepatitis

scientific article published on 01 January 2006

Apoptosis and insulin resistance in liver and peripheral tissues of morbidly obese patients is associated with different stages of non-alcoholic fatty liver disease.

scientific article

Apoptosis in transgenic mice expressing the P301L mutated form of human tau.

scientific article published in May 2008

Apoptosis inducing activity of benzophenanthridine-type alkaloids and 2-arylbenzofuran neolignans in HCT116 colon carcinoma cells.

scientific article

Apoptosis-associated microRNAs are modulated in mouse, rat and human neural differentiation ⬇️

scientific article published on September 24, 2010

Apoptotic cell death does not parallel other indicators of liver damage in chronic hepatitis C patients.

scientific article published in May 2000

Application of Tauroursodeoxycholic Acid for Treatment of Neurological and Non-neurological Diseases: Is There a Potential for Treating Traumatic Brain Injury?

scientific article

Association of Plasmodium berghei With the Apical Domain of Hepatocytes Is Necessary for the Parasite's Liver Stage Development

scientific article published on 01 January 2019

Bile acid concentrations in human and rat liver tissue and in hepatocyte nuclei

scientific article published on 01 January 1997

Bile acid patterns in meconium are influenced by cholestasis of pregnancy and not altered by ursodeoxycholic acid treatment

scientific article

Bile acids and apoptosis modulation: an emerging role in experimental Alzheimer's disease.

scientific article published on 22 January 2008

Bile acids and hepatocyte apoptosis: Living/leaving life in the Fas lane

scientific article published on 01 September 1999

Bile acids: regulation of apoptosis by ursodeoxycholic acid

scientific article

Bilirubin directly disrupts membrane lipid polarity and fluidity, protein order, and redox status in rat mitochondria.

scientific article published in March 2002

Bilirubin induces apoptosis via the mitochondrial pathway in developing rat brain neurons.

scientific article

Bilirubin-induced apoptosis in cultured rat neural cells is aggravated by chenodeoxycholic acid but prevented by ursodeoxycholic acid.

scientific article published in March 2001

Binding Studies of Bile Acids using the Native Fluorescence of the Tryptophan Residue Of Bax Protein

scientific article published on 01 June 2006

Blue light potentiates neurogenesis induced by retinoic acid-loaded responsive nanoparticles

scientific article published on 30 June 2017

Bovine oocyte membrane permeability and cryosurvival: Effects of different cryoprotectants and calcium in the vitrification media.

scientific article published on 7 March 2018

Caspases and p53 modulate FOXO3A/Id1 signaling during mouse neural stem cell differentiation.

scientific article published in July 2009

Chemical Variations on the p53 Reactivation Theme

scientific article

Circulating Inflammatory miRNAs Associated with Parkinson's Disease Pathophysiology

scientific article published on 23 June 2020

Clinical pharmacokinetics of therapeutic bile acids.

scientific article

Cobalt complexes bearing scorpionate ligands: synthesis, characterization, cytotoxicity and DNA cleavage.

scientific article published in November 2012

Colorectal cancer: can nutrients modulate NF-kappaB and apoptosis?

scientific article published in July 2009

Combining 1,3-Ditriazolylbenzene and Quinoline to Discover a New G-Quadruplex-Interactive Small Molecule Active against Cancer Stem-Like Cells

scientific article published on 14 June 2019

Contrasting apoptotic responses of conjugated linoleic acid in the liver of obese Zucker rats fed palm oil or ovine fat.

scientific article

Convergence of miR-143 overexpression, oxidative stress and cell death in HCT116 human colon cancer cells.

scientific article published on 23 January 2018

Copper complex nanoformulations featuring highly promising therapeutic potential in murine melanoma models

scientific article published on 15 March 2019

Corrigendum: A Novel Small Molecule p53 Stabilizer for Brain Cell Differentiation

scientific article published on 24 April 2019

Creatine-supplemented diet extends Purkinje cell survival in spinocerebellar ataxia type 1 transgenic mice but does not prevent the ataxic phenotype.

scientific article

Cyclopentadienyl-ruthenium(II) and iron(II) organometallic compounds with carbohydrate derivative ligands as good colorectal anticancer agents

scientific article published on 15 May 2015

Cytotoxic bile acids, but not cytoprotective species, inhibit the ordering effect of cholesterol in model membranes at physiologically active concentrations.

scientific article published on 5 June 2013

Deficient Endoplasmic Reticulum-Mitochondrial Phosphatidylserine Transfer Causes Liver Disease

scientific article published on 01 May 2019

Deoxycholic acid modulates cell death signaling through changes in mitochondrial membrane properties

scientific article

Development and Mechanistic Insight into the Enhanced Cytotoxic Potential of Parvifloron D Albumin Nanoparticles in EGFR-Overexpressing Pancreatic Cancer Cells

scientific article published on 05 November 2019

Dibenzylbutane- and butyrolactone-type lignans as apoptosis inducers in human hepatoma HuH-7 cells.

scientific article

Differential regulation of cyclin D1 and cell death by bile acids in primary rat hepatocytes

scientific article published on 12 April 2007

Dinitro-o-cresol induces apoptosis-like cell death but not alternative oxidase expression in soybean cells

scientific article published on 16 January 2007

Dissection of the network of interactions that links RNA processing with glycolysis in the Bacillus subtilis degradosome

scientific article

Distinct kinetics and pathways of apoptosis in influenza A and B virus infection.

scientific article published on 19 May 2015

Endoplasmic reticulum enrollment in Alzheimer's disease.

scientific article published on 20 July 2012

Essential versus accessory aspects of cell death: recommendations of the NCCD 2015.

scientific article

Evaluation of Tissue and Circulating miR-21 as Potential Biomarker of Response to Chemoradiotherapy in Rectal Cancer

scientific article published on 14 September 2020

Exploring the Phytochemicals of <i>Acacia melanoxylon</i> R. Br

scientific article published on 08 December 2021

Farnesoid X Receptor Expression in Microscopic Colitis: A Potential Role in Disease Etiopathogenesis.

scientific article published on 11 October 2017

Fooling the Fas ligand in death

scientific article published on 01 August 2006

Function of nuclear steroid receptors in apoptosis: role of ursodeoxycholic acid

scientific article published on 01 July 2007

Functional dissection of a trigger enzyme: mutations of the bacillus subtilis glutamate dehydrogenase RocG that affect differentially its catalytic activity and regulatory properties

scientific article

Functional modulation of nuclear steroid receptors by tauroursodeoxycholic acid reduces amyloid beta-peptide-induced apoptosis.

scientific article published on 25 May 2006

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes.

scientific article published on 17 April 2009

Harnessing Protein-Ligand Interaction Fingerprints to Predict New Scaffolds of RIPK1 Inhibitors

scientific article published in 2022

Hepatocyte Apoptosis, Expression of Death Receptors, and Activation of NF-κB in the Liver of Nonalcoholic and Alcoholic Steatohepatitis Patients

scientific article published on 01 September 2004

Host miRNA-21 promotes liver dysfunction by targeting small intestinal <i>Lactobacillus</i> in mice

scientific article published on 01 November 2020

How to Treat Melanoma? The Current Status of Innovative Nanotechnological Strategies and the Role of Minimally Invasive Approaches like PTT and PDT

scientific article published in 2022

Identification of microRNAs during rat liver regeneration after partial hepatectomy and modulation by ursodeoxycholic acid

scientific article

Imidazoline Receptor Agonists for Managing Hypertension May Hold Promise for Treatment of Intracerebral Hemorrhage

scientific article published on 01 January 2018

Impaired cross-talk between the thioredoxin and glutathione systems is related to ASK-1 mediated apoptosis in neuronal cells exposed to mercury

scientific article published on June 2017

In Silico HCT116 Human Colon Cancer Cell-Based Models En Route to the Discovery of Lead-Like Anticancer Drugs

scientific article published on 17 July 2018

Induction of apoptosis in HuH-7 cancer cells by monoterpene and beta-carboline indole alkaloids isolated from the leaves of Tabernaemontana elegans.

scientific article

Inhibition of receptor-interacting protein kinase 1 improves experimental non-alcoholic fatty liver disease

scientific article published on 21 November 2019

Insights into the mechanisms underlying the antiproliferative potential of a Co(II) coordination compound bearing 1,10-phenanthroline-5,6-dione: DNA and protein interaction studies

scientific article published on 31 January 2014

In vitro targeting of colon cancer cells using spiropyrazoline oxindoles.

scientific article

Isoflavones as apoptosis inducers in human hepatoma HuH-7 cells.

scientific article

Isolation of Mitochondria from Liver and Extraction of Total RNA and Protein: Analyses of MicroRNA and Protein Expressions

scientific article published on 01 January 2015

KRAS oncogene repression in colon cancer cell lines by G-quadruplex binding indolo[3,2-c]quinolines.

scientific article published on 8 April 2015

Liquid Biopsies in Hepatocellular Carcinoma: Are We Winning?

scientific article published on 20 May 2020

Liver and muscle in morbid obesity: the interplay of fatty liver and insulin resistance.

scientific article

Loss of Microglial Parkin Inhibits Necroptosis and Contributes to Neuroinflammation

scientific article published on 03 August 2018

MEK5/ERK5 activation regulates colon cancer stem-like cell properties

scientific article published on 11 February 2019

MEK5/ERK5 signaling inhibition increases colon cancer cell sensitivity to 5-fluorouracil through a p53-dependent mechanism

scientific article published on 29 April 2016

Measuring the Impact of Bile Acids on the Membrane Order of Primary Hepatocytes and Isolated Mitochondria by Fluorescence Imaging and Spectroscopy

scientific article published on 01 January 2019

Mechanism and disease implications of necroptosis and neuronal inflammation

scientific article published on 05 September 2018

Membrane structural changes support the involvement of mitochondria in the bile salt-induced apoptosis of rat hepatocytes.

scientific article published in November 2002

Metabolism of orally administered tauroursodeoxycholic acid in patients with primary biliary cirrhosis.

scientific article published in March 1996

MicroRNA-143 reduces viability and increases sensitivity to 5-fluorouracil in HCT116 human colorectal cancer cells.

scientific article

MicroRNA-145 Regulates Neural Stem Cell Differentiation Through the Sox2-Lin28/let-7 Signaling Pathway.

scientific article published on 29 February 2016

MicroRNA-34a Modulates Neural Stem Cell Differentiation by Regulating Expression of Synaptic and Autophagic Proteins.

scientific article published on 28 June 2014

Mitochondria: Major Regulators of Neural Development

scientific article published on 06 May 2015

Mitochondrial membrane perturbations in cholestasis.

scientific article

Mitochondrial translocation of p53 modulates neuronal fate by preventing differentiation-induced mitochondrial stress

scientific article

Modulation of amyloid-β peptide-induced toxicity through inhibition of JNK nuclear localization and caspase-2 activation.

scientific article published on January 2010

Modulation of hepatocyte apoptosis: cross-talk between bile acids and nuclear steroid receptors.

scientific article published on January 2006

Modulation of nuclear steroid receptors by ursodeoxycholic acid inhibits TGF-beta1-induced E2F-1/p53-mediated apoptosis of rat hepatocytes.

scientific article

Modulation of steady-state messenger RNA levels in the regenerating rat liver with bile acid feeding.

scientific article published in April 2001

Molecular Basis of the Activity of SinR Protein, the Master Regulator of Biofilm Formation in Bacillus subtilis

scientific article

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

scientific article

Monocarbonyl Analogs of Curcumin with Potential to Treat Colorectal Cancer

scientific article published in 2023

Monoterpene bisindole alkaloids, from the African medicinal plant Tabernaemontana elegans, induce apoptosis in HCT116 human colon carcinoma cells.

scientific article

Monoterpene indole alkaloid hydrazone derivatives with apoptosis inducing activity in human HCT116 colon and HepG2 liver carcinoma cells.

scientific article published on 30 June 2015

N-acetylcysteine treatment attenuates the cognitive impairment and synaptic plasticity loss induced by streptozotocin.

scientific article published on 9 May 2017

NF-?B and apoptosis in colorectal tumourigenesis

scientific article published on 01 May 2007

Nanoformulations of a potent copper-based aquaporin inhibitor with cytotoxic effect against cancer cells.

scientific article published on 7 July 2016

Naphtho[2,3-d]isoxazole-4,9-dione-3-carboxylates: potent, non-cytotoxic, antiapoptotic agents.

scientific article published on 24 March 2009

Necrosome Formation and Necroptosis in Experimental Cholestasis

scientific article published on 01 January 2019

Neuroprotection by a bile acid in an acute stroke model in the rat.

scientific article published in April 2002

New Lectins from Mediterranean Flora. Activity against HT29 Colon Cancer Cells

scientific article published on 22 June 2019

New [(η(5)-C5H5)Ru(N-N)(PPh3)][PF6] compounds: colon anticancer activity and GLUT-mediated cellular uptake of carbohydrate-appended complexes.

scientific article

Nuclear translocation of UDCA by the glucocorticoid receptor is required to reduce TGF-beta1-induced apoptosis in rat hepatocytes

scientific journal article

Phenotypic high-throughput screening platform identifies novel chemotypes for necroptosis inhibition

scientific article published on 11 February 2020

Plasma levels of ursodeoxycholic acid in black bears, Ursus americanus: Seasonal changes

scientific article published on 06 March 2006

Prevention of acute kidney injury by tauroursodeoxycholic acid in rat and cell culture models.

scientific article

Processes exacerbating apoptosis in non-alcoholic steatohepatitis

scientific article published on 01 November 2019

Progesterone and Caspase-3 Activation in Equine Cyclic Corpora Lutea

scientific article published on 01 August 2007

RIPK3 acts as a lipid metabolism regulator contributing to inflammation and carcinogenesis in non-alcoholic fatty liver disease

scientific article published on 24 December 2020

RNase Y in Bacillus subtilis: a Natively disordered protein that is the functional equivalent of RNase E from Escherichia coli

scientific journal article

Relevance of serum bile acid profile in the diagnosis of intrahepatic cholestasis of pregnancy in an high incidence area: Portugal.

scientific article published in September 1998

Revisiting the metabolic syndrome and paving the way for microRNAs in non-alcoholic fatty liver disease.

scientific article published on 28 April 2014

Role of nuclear steroid receptors in apoptosis.

scientific article published on January 2009

Safety, tolerability, and cerebrospinal fluid penetration of ursodeoxycholic Acid in patients with amyotrophic lateral sclerosis.

scientific article published in January 2010

Signalling networks in cholangiocarcinoma: Molecular pathogenesis, targeted therapies and drug resistance

scientific article published on 01 May 2019

Spirotriazoline oxindoles: A novel chemical scaffold with in vitro anticancer properties

scientific article published on 21 September 2017

Synthesis and evaluation of spiroisoxazoline oxindoles as anticancer agents

scientific article published on 7 November 2013

Synthesis and evaluation of water-soluble prodrugs of ursodeoxycholic acid (UDCA), an anti-apoptotic bile acid.

scientific article

Synthesis, G-quadruplex stabilisation, docking studies, and effect on cancer cells of indolo[3,2-b]quinolines with one, two, or three basic side chains.

scientific article published on 19 August 2013

TUDCA, a bile acid, attenuates amyloid precursor protein processing and amyloid-β deposition in APP/PS1 mice.

scientific article published on 23 March 2012

Targeting KRAS Oncogene in Colon Cancer Cells with 7-Carboxylate Indolo[3,2-b]quinoline Tri-Alkylamine Derivatives.

scientific article published on 29 May 2015

Targeting miR-506 in primary biliary cirrhosis to support the HCO3− umbrella

scientific article published on 04 July 2012

Targeting the p53 pathway of apoptosis.

scientific article published on January 2010

Tauroursodeoxycholate increases rat liver ursodeoxycholate levels and limits lithocholate formation better than ursodeoxycholate

scientific article published on 01 August 1995

Tauroursodeoxycholic Acid Enhances Mitochondrial Biogenesis, Neural Stem Cell Pool, and Early Neurogenesis in Adult Rats

scientific article published on 22 May 2017

Tauroursodeoxycholic acid modulates p53-mediated apoptosis in Alzheimer's disease mutant neuroblastoma cells.

scientific article published on September 2006

Tauroursodeoxycholic acid prevents E22Q Alzheimer's Abeta toxicity in human cerebral endothelial cells.

scientific article published on March 2009

Tauroursodeoxycholic acid protects retinal neural cells from cell death induced by prolonged exposure to elevated glucose

scientific article published on 5 September 2013

Tauroursodeoxycholic acid reduces apoptosis and protects against neurological injury after acute hemorrhagic stroke in rats

scientific article

Tauroursodeoxycholic acid suppresses amyloid β-induced synaptic toxicity in vitro and in APP/PS1 mice.

scientific article published on 22 May 2012

Tauroursodeoxycholic acid, a bile acid, is neuroprotective in a transgenic animal model of Huntington's disease.

scientific article

The Emerging Role of microRNAs in Aquaporin Regulation.

scientific article

The MEK5/ERK5 signalling pathway in cancer: a promising novel therapeutic target

scientific article published on 16 June 2016

The YmdB Phosphodiesterase Is a Global Regulator of Late Adaptive Responses in Bacillus subtilis

scientific article

The analytical challenge in the determination of cathinones, key-players in the worldwide phenomenon of novel psychoactive substances.

scientific article published on 13 February 2018

The bile acid tauroursodeoxycholic acid modulates phosphorylation and translocation of bad via phosphatidylinositol 3-kinase in glutamate-induced apoptosis of rat cortical neurons.

scientific article

The gut microbiota, bile acids and their correlation in primary sclerosing cholangitis associated with inflammatory bowel disease

scientific article published on 5 May 2017

The histone deacetylase inhibitor panobinostat is a potent antitumor agent in canine diffuse large B-cell lymphoma.

scientific article published on 19 June 2018

The site-specific delivery of ursodeoxycholic acid to the rat colon by sulfate conjugation.

scientific article

Unusual case of severe cholestasis of pregnancy with early onset, improved by ursodeoxycholic acid administration

scientific article published on 01 February 1998

Unusual, dual endo- and exonuclease activity in the degradosome explained by crystal structure analysis of RNase J1

scientific article

Ursodeoxycholic acid modulates the ubiquitin-proteasome degradation pathway of p53.

scientific article published on 31 August 2010

Ursodeoxycholic acid prevents cytochrome c release in apoptosis by inhibiting mitochondrial membrane depolarization and channel formation

scientific article

Ursodeoxycholic acid: effects on hepatic unfolded protein response, apoptosis and oxidative stress in morbidly obese patients.

scientific article published on 29 August 2017

Vobasinyl-Iboga Alkaloids from Tabernaemontana elegans: Cell Cycle Arrest and Apoptosis-Inducing Activity in HCT116 Colon Cancer Cells.

scientific article

c-Jun Regulates the Stability of Anti-Apoptotic ΔNp63 in Amyloid-β-Induced Apoptosis

scientific article published on 01 January 2012

miR-143 or miR-145 overexpression increases cetuximab-mediated antibody-dependent cellular cytotoxicity in human colon cancer cells.

scientific article published on 25 January 2016

miR-34a/SIRT1/p53 is suppressed by ursodeoxycholic acid in the rat liver and activated by disease severity in human non-alcoholic fatty liver disease

scientific article published on 15 August 2012

miRNAs as Modulators of EGFR Therapy in Colorectal Cancer

scientific article published on 01 January 2018

microRNAs in Mitochondria: An Unexplored Niche.

scientific article published in January 2015

microRevolution in understanding primary biliary cholangitis pathophysiology

scientific article published on 15 November 2017

p53 and the regulation of hepatocyte apoptosis: implications for disease pathogenesis.

scientific article published on 12 October 2009

p53 dephosphorylation and p21(Cip1/Waf1) translocation correlate with caspase-3 activation in TGF-beta1-induced apoptosis of HuH-7 cells.

scientific article published in March 2004

p53 interaction with JMJD3 results in its nuclear distribution during mouse neural stem cell differentiation.

scientific article

p53 is a key molecular target of ursodeoxycholic acid in regulating apoptosis

scientific journal article

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