List of works - Philippe Marambaud

A CBP binding transcriptional repressor produced by the PS1/epsilon-cleavage of N-cadherin is inhibited by PS1 FAD mutations

scientific article (publication date: 5 September 2003)

A polymorphism in CALHM1 influences Ca2+ homeostasis, Abeta levels, and Alzheimer's disease risk

scientific article

A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions

scientific article

AMP-activated protein kinase signaling activation by resveratrol modulates amyloid-beta peptide metabolism.

scientific article

AMPK is abnormally activated in tangle- and pre-tangle-bearing neurons in Alzheimer’s disease and other tauopathies ⬇️

scientific article published on October 19, 2010

Alpha-secretase-derived product of beta-amyloid precursor protein is decreased by presenilin 1 mutations linked to familial Alzheimer's disease.

scientific article

Alzheimer's disease-linked mutation of presenilin 2 (N141I-PS2) drastically lowers APPalpha secretion: control by the proteasome.

scientific article published on November 1998

Amyloid-beta peptide degradation in cell cultures by mycoplasma contaminants

scientific article

Anti-tau conformational scFv MC1 antibody efficiently reduces pathological tau species in adult JNPL3 mice

scientific article published on 22 August 2018

CALHM1 P86L polymorphism modulates CSF Aβ levels in cognitively healthy individuals at risk for Alzheimer's disease.

scientific article

CALHM1 controls the Ca²⁺-dependent MEK, ERK, RSK and MSK signaling cascade in neurons

scientific article

CALHM1 ion channel mediates purinergic neurotransmission of sweet, bitter and umami tastes

scientific journal article

CB2 receptor deficiency increases amyloid pathology and alters tau processing in a transgenic mouse model of Alzheimer's disease.

scientific article published on 14 March 2014

CB₂ receptor deficiency increases amyloid pathology and alters tau processing in a transgenic mouse model of Alzheimer's disease.

scientific article

CNI-1493 inhibits Abeta production, plaque formation, and cognitive deterioration in an animal model of Alzheimer's disease.

scientific article published on 23 June 2008

Calcium homeostasis modulator 1 (CALHM1) is the pore-forming subunit of an ion channel that mediates extracellular Ca2+ regulation of neuronal excitability

scientific article

Calcium signaling in neurodegeneration

scientific article published on 6 May 2009

Cathepsin D displays in vitro beta-secretase-like specificity.

scientific article published on March 1997

Characterization of new polyclonal antibodies specific for 40 and 42 amino acid-long amyloid beta peptides: their use to examine the cell biology of presenilins and the immunohistochemistry of sporadic Alzheimer's disease and cerebral amyloid angiop

scientific article

Chemical synapses without synaptic vesicles: Purinergic neurotransmission through a CALHM1 channel-mitochondrial signaling complex.

scientific article

Constitutive and protein kinase C-regulated secretory cleavage of Alzheimer's beta-amyloid precursor protein: different control of early and late events by the proteasome.

scientific article

Correcting Smad1/5/8, mTOR, and VEGFR2 treats pathology in hereditary hemorrhagic telangiectasia models

scientific article published on 01 February 2020

Effect of protein kinase A inhibitors on the production of Abeta40 and Abeta42 by human cells expressing normal and Alzheimer's disease-linked mutated betaAPP and presenilin 1.

scientific article

Endocannabinoids in Alzheimer's disease and their impact on normative cognitive performance: a case-control and cohort study

scientific article published on 14 January 2009

Gas1 interferes with AβPP trafficking by facilitating the accumulation of immature AβPP in endoplasmic reticulum-associated raft subdomains

scientific article published on January 2012

Genetic and molecular aspects of Alzheimer's disease shed light on new mechanisms of transcriptional regulation.

scientific article

Growth arrest-specific 1 binds to and controls the maturation and processing of the amyloid-beta precursor protein

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

How do taste cells lacking synapses mediate neurotransmission? CALHM1, a voltage-gated ATP channel.

scientific article published on 17 September 2013

Identification and biology of α-secretase.

scientific article

Inhibition of AMP-activated protein kinase signaling alleviates impairments in hippocampal synaptic plasticity induced by amyloid β.

scientific article

Intracellular pH regulates amyloid precursor protein intracellular domain accumulation.

scientific article published on 3 January 2007

JLK inhibitors: isocoumarin compounds as putative probes to selectively target the gamma-secretase pathway

scientific article

JLK isocoumarin inhibitors: selective gamma-secretase inhibitors that do not interfere with notch pathway in vitro or in vivo

scientific article published on November 2003

Letter to the Editor on "Involvement of AMP-activated-protein-kinase (AMPK) in neuronal amyloidogenesis"

scientific article published on 16 September 2010

Molecular and Pharmacological Modulation of CALHM1 Promote Neuroprotection against Oxygen and Glucose Deprivation in a Model of Hippocampal Slices

scientific article published on 09 March 2020

Novel resveratrol analogues attenuate renal ischemic injury in rats.

scientific article

Novel synthetic small-molecule activators of AMPK as enhancers of autophagy and amyloid-β peptide degradation.

scientific article

Overexpression of extracellular superoxide dismutase has a protective role against hyperoxia-induced brain injury in neonatal mice.

scientific article published on 10 February 2012

Overexpression of extracellular superoxide dismutase protects against brain injury induced by chronic hypoxia

scientific article

Presenilin-1: a component of synaptic and endothelial adherens junctions.

scientific article

Proteasome contributes to the alpha-secretase pathway of amyloid precursor protein in human cells

scientific article published on 01 February 1997

Resveratrol mitigates lipopolysaccharide- and Aβ-mediated microglial inflammation by inhibiting the TLR4/NF-κB/STAT signaling cascade

scientific article published on 16 December 2011

Role of peroxisome proliferator-activated receptor gamma in amyloid precursor protein processing and amyloid beta-mediated cell death.

scientific article

Role of the proteasome in Alzheimer’s disease

Salty taste deficits in CALHM1 knockout mice

scientific article

Sucrose-conditioned flavor preferences in sweet ageusic T1r3 and Calhm1 knockout mice.

scientific article published on 31 December 2013

TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity

scientific article

Tacrolimus rescues the signaling and gene expression signature of endothelial ALK1 loss-of-function and improves HHT vascular pathology.

scientific article published on 14 September 2017

The CALHM1 P86L polymorphism is a genetic modifier of age at onset in Alzheimer's disease: a meta-analysis study

scientific article

The cytoplasmic sequence of E-cadherin promotes non-amyloidogenic degradation of A beta precursors.

scientific article published on 26 January 2006

Therapeutic potential of resveratrol in Alzheimer's disease

scientific article

[CALHM1, a novel gene to blame in Alzheimer disease].

scientific article published in November 2008

[Strategies for identification of secretases implicated in Alzheimer's disease]

scientific article published on 01 May 1998

List of works by Philippe Marambaud

A CBP binding transcriptional repressor produced by the PS1/epsilon-cleavage of N-cadherin is inhibited by PS1 FAD mutations

A polymorphism in CALHM1 influences Ca2+ homeostasis, Abeta levels, and Alzheimer's disease risk

A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions

AMP-activated protein kinase signaling activation by resveratrol modulates amyloid-beta peptide metabolism.

AMPK is abnormally activated in tangle- and pre-tangle-bearing neurons in Alzheimer’s disease and other tauopathies ⬇️

Alpha-secretase-derived product of beta-amyloid precursor protein is decreased by presenilin 1 mutations linked to familial Alzheimer's disease.

Alzheimer's disease-linked mutation of presenilin 2 (N141I-PS2) drastically lowers APPalpha secretion: control by the proteasome.

Amyloid-beta peptide degradation in cell cultures by mycoplasma contaminants

Anti-tau conformational scFv MC1 antibody efficiently reduces pathological tau species in adult JNPL3 mice

CALHM1 P86L polymorphism modulates CSF Aβ levels in cognitively healthy individuals at risk for Alzheimer's disease.

CALHM1 controls the Ca²⁺-dependent MEK, ERK, RSK and MSK signaling cascade in neurons

CALHM1 ion channel mediates purinergic neurotransmission of sweet, bitter and umami tastes

CB2 receptor deficiency increases amyloid pathology and alters tau processing in a transgenic mouse model of Alzheimer's disease.

CB₂ receptor deficiency increases amyloid pathology and alters tau processing in a transgenic mouse model of Alzheimer's disease.

CNI-1493 inhibits Abeta production, plaque formation, and cognitive deterioration in an animal model of Alzheimer's disease.

Calcium homeostasis modulator 1 (CALHM1) is the pore-forming subunit of an ion channel that mediates extracellular Ca2+ regulation of neuronal excitability

Calcium signaling in neurodegeneration

Cathepsin D displays in vitro beta-secretase-like specificity.

Characterization of new polyclonal antibodies specific for 40 and 42 amino acid-long amyloid beta peptides: their use to examine the cell biology of presenilins and the immunohistochemistry of sporadic Alzheimer's disease and cerebral amyloid angiop

Chemical synapses without synaptic vesicles: Purinergic neurotransmission through a CALHM1 channel-mitochondrial signaling complex.

Constitutive and protein kinase C-regulated secretory cleavage of Alzheimer's beta-amyloid precursor protein: different control of early and late events by the proteasome.

Correcting Smad1/5/8, mTOR, and VEGFR2 treats pathology in hereditary hemorrhagic telangiectasia models

Effect of protein kinase A inhibitors on the production of Abeta40 and Abeta42 by human cells expressing normal and Alzheimer's disease-linked mutated betaAPP and presenilin 1.

Endocannabinoids in Alzheimer's disease and their impact on normative cognitive performance: a case-control and cohort study

Gas1 interferes with AβPP trafficking by facilitating the accumulation of immature AβPP in endoplasmic reticulum-associated raft subdomains

Genetic and molecular aspects of Alzheimer's disease shed light on new mechanisms of transcriptional regulation.

Growth arrest-specific 1 binds to and controls the maturation and processing of the amyloid-beta precursor protein

Guidelines for the use and interpretation of assays for monitoring autophagy

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

How do taste cells lacking synapses mediate neurotransmission? CALHM1, a voltage-gated ATP channel.

Identification and biology of α-secretase.

Inhibition of AMP-activated protein kinase signaling alleviates impairments in hippocampal synaptic plasticity induced by amyloid β.

Intracellular pH regulates amyloid precursor protein intracellular domain accumulation.

JLK inhibitors: isocoumarin compounds as putative probes to selectively target the gamma-secretase pathway

JLK isocoumarin inhibitors: selective gamma-secretase inhibitors that do not interfere with notch pathway in vitro or in vivo

Letter to the Editor on "Involvement of AMP-activated-protein-kinase (AMPK) in neuronal amyloidogenesis"

Molecular and Pharmacological Modulation of CALHM1 Promote Neuroprotection against Oxygen and Glucose Deprivation in a Model of Hippocampal Slices

Novel resveratrol analogues attenuate renal ischemic injury in rats.

Novel synthetic small-molecule activators of AMPK as enhancers of autophagy and amyloid-β peptide degradation.

Overexpression of extracellular superoxide dismutase has a protective role against hyperoxia-induced brain injury in neonatal mice.

Overexpression of extracellular superoxide dismutase protects against brain injury induced by chronic hypoxia

Presenilin-1: a component of synaptic and endothelial adherens junctions.

Proteasome contributes to the alpha-secretase pathway of amyloid precursor protein in human cells

Resveratrol mitigates lipopolysaccharide- and Aβ-mediated microglial inflammation by inhibiting the TLR4/NF-κB/STAT signaling cascade

Role of peroxisome proliferator-activated receptor gamma in amyloid precursor protein processing and amyloid beta-mediated cell death.

Role of the proteasome in Alzheimer’s disease

Salty taste deficits in CALHM1 knockout mice

Sucrose-conditioned flavor preferences in sweet ageusic T1r3 and Calhm1 knockout mice.

TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity

Tacrolimus rescues the signaling and gene expression signature of endothelial ALK1 loss-of-function and improves HHT vascular pathology.

The CALHM1 P86L polymorphism is a genetic modifier of age at onset in Alzheimer's disease: a meta-analysis study

The cytoplasmic sequence of E-cadherin promotes non-amyloidogenic degradation of A beta precursors.

Therapeutic potential of resveratrol in Alzheimer's disease

[CALHM1, a novel gene to blame in Alzheimer disease].

[Strategies for identification of secretases implicated in Alzheimer's disease]