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List of works by Nicholas McGranahan

A breast cancer meta-analysis of two expression measures of chromosomal instability reveals a relationship with younger age at diagnosis and high risk histopathological variables

scientific article published on July 2011

A clonal expression biomarker associates with lung cancer mortality

scientific article published on 07 October 2019

APC/C Dysfunction Limits Excessive Cancer Chromosomal Instability

scientific article published on 9 January 2017

APOBEC Enzymes: Mutagenic Fuel for Cancer Evolution and Heterogeneity

scientific article published on 19 June 2015

APOBEC mutagenesis in drug resistance and immune escape in HIV and cancer evolution

scientific article published on 8 January 2018

Abstract 983: Intratumor heterogeneity in non-small cell lung cancer inferred by multi-region exome sequencing

Allele-Specific HLA Loss and Immune Escape in Lung Cancer Evolution

scientific article published on 21 October 2017

BCL9L Dysfunction Impairs Caspase-2 Expression Permitting Aneuploidy Tolerance in Colorectal Cancer

scientific article

Biological and Therapeutic Impact of Intratumor Heterogeneity in Cancer Evolution

article published in 2015

Biological and therapeutic impact of intratumor heterogeneity in cancer evolution

scientific article

Cancer Evolution Constrained by the Immune Microenvironment

scientific article published in August 2017

Cancer Genome Evolutionary Trajectories in Metastasis

scientific article published on 01 January 2020

Cancer chromosomal instability: therapeutic and diagnostic challenges

scientific article

Cancer: evolution within a lifetime

scientific article published on October 2014

Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes

scientific article published on 15 April 2021

Chromosomal instability drives metastasis through a cytosolic DNA response

scientific article published on 17 January 2018

Chromosomal instability selects gene copy-number variants encoding core regulators of proliferation in ER+ breast cancer.

scientific article

Clonal Heterogeneity and Tumor Evolution: Past, Present, and the Future

scientific article published on February 2017

Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade

scientific article published on 03 March 2016

Clonal status of actionable driver events and the timing of mutational processes in cancer evolution

scientific article

Computational Methods for Analysis of Tumor Clonality and Evolutionary History

scientific article published on 01 January 2019

Computational optimisation of targeted DNA sequencing for cancer detection.

scientific article published on 3 December 2013

Consensus on precision medicine for metastatic cancers: a report from the MAP conference.

scientific article published on 3 May 2016

Corrigendum: Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution

scientific article published in Nature

Cyclin D mediates tolerance of genome-doubling in cancers with functional p53.

scientific article

DNA replication stress mediates APOBEC3 family mutagenesis in breast cancer

scientific article

Deciphering intratumor heterogeneity and temporal acquisition of driver events to refine precision medicine

scientific article

DeconstructSigs: delineating mutational processes in single tumors distinguishes DNA repair deficiencies and patterns of carcinoma evolution

scientific article published on 22 February 2016

Deterministic Evolutionary Trajectories Influence Primary Tumor Growth: TRACERx Renal

scientific article published on 11 April 2018

Development of synchronous VHL syndrome tumors reveals contingencies and constraints to tumor evolution

scientific article

Differential binding affinity of mutated peptides for MHC class I is a predictor of survival in advanced lung cancer and melanoma

scientific article

Evolution and clinical impact of co-occurring genetic alterations in advanced-stage EGFR-mutant lung cancers.

scientific article published on 6 November 2017

Evolution of DNA methylome from precancerous lesions to invasive lung adenocarcinomas

scientific article published on 29 January 2021

Genomic Features of Response to Combination Immunotherapy in Patients with Advanced Non-Small-Cell Lung Cancer

scientific article published on 12 April 2018

Genomic architecture and evolution of clear cell renal cell carcinomas defined by multiregion sequencing

scientific article

Geospatial immune variability illuminates differential evolution of lung adenocarcinoma

scientific article published on 27 May 2020

Germline ancestry influences the evolutionary disease course in lung adenocarcinomas

scientific article published on 17 April 2020

Glioblastoma adaptation traced through decline of an IDH1 clonal driver and macro-evolution of a double-minute chromosome

scientific article published on 2 March 2015

Inferring mutational timing and reconstructing tumour evolutionary histories

scientific article

Insertion-and-deletion-derived tumour-specific neoantigens and the immunogenic phenotype: a pan-cancer analysis

scientific article published on 07 July 2017

Interplay between whole-genome doubling and the accumulation of deleterious alterations in cancer evolution

scientific article published on 05 March 2020

Intratumoural evolutionary landscape of high-risk prostate cancer: the PROGENY study of genomic and immune parameters

scientific article published in October 2017

Large-scale detection of antigen-specific T cells using peptide-MHC-I multimers labeled with DNA barcodes.

scientific article published on 29 August 2016

MCL-1 gains occur with high frequency in lung adenocarcinoma and can be targeted therapeutically

scientific article published on 10 September 2020

Meta-analysis of tumor- and T cell-intrinsic mechanisms of sensitization to checkpoint inhibition

scientific article published on 27 January 2021

Neoantigen quality, not quantity

scientific article published on 01 August 2019

Neoantigen-directed immune escape in lung cancer evolution

scientific article published on 20 March 2019

Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling.

scientific article

Parallel evolution of tumour subclones mimics diversity between tumours

scientific article published in August 2013

Pervasive chromosomal instability and karyotype order in tumour evolution

scientific article published on 02 September 2020

Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution

scientific article

Publisher Correction: A clonal expression biomarker associates with lung cancer mortality

scientific article published on 03 June 2020

Publisher Correction: Spatial heterogeneity of the T cell receptor repertoire reflects the mutational landscape in lung cancer

scientific article published on 03 June 2020

SETD2 loss-of-function promotes renal cancer branched evolution through replication stress and impaired DNA repair

scientific article

Spatial and temporal diversity in genomic instability processes defines lung cancer evolution

scientific article

Spatial heterogeneity of the T cell receptor repertoire reflects the mutational landscape in lung cancer

scientific article published on 07 October 2019

The causes and consequences of genetic heterogeneity in cancer evolution

scientific article (publication date: 19 September 2013)

Timing the Landmark Events in the Evolution of Clear Cell Renal Cell Cancer: TRACERx Renal

scientific article published on 4 April 2018

Tolerance of whole-genome doubling propagates chromosomal instability and accelerates cancer genome evolution.

scientific article

Tracking genomic cancer evolution for precision medicine: the lung TRACERx study

scientific article

Tracking the Evolution of Non-Small-Cell Lung Cancer

scientific article published on 26 April 2017

Tracking the genomic evolution of esophageal adenocarcinoma through neoadjuvant chemotherapy

scientific article published on 23 May 2015

Ultra-deep T cell receptor sequencing reveals the complexity and intratumour heterogeneity of T cell clones in renal cell carcinomas

scientific article

Whole Genome Doubling mitigates Muller's Ratchet in Cancer Evolution: Supplementary figures

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