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List of works by Mark A. Brockman

A high burden of asymptomatic genital tract infections undermines the syndromic management approach among adolescents and young adults in South Africa: implications for HIV prevention efforts

article

A robust and scalable TCR-based reporter cell assay to measure HIV-1 Nef-mediated T cell immune evasion

scientific article published on 25 August 2015

Ability of HIV-1 Nef to downregulate CD4 and HLA class I differs among viral subtypes

scientific article

Afri-Can Forum 2 : Johannesburg, South Africa. 16-18 February 2015

African-led health research and capacity building- is it working?

scientific article published on 14 July 2020

Analysis of peripheral immune activation in schizophrenia using quantitative reverse-transcription polymerase chain reaction (RT-PCR)

scientific article

Attenuation of multiple Nef functions in HIV-1 elite controllers

scientific article published on 7 January 2013

Augmentation of HIV-specific T cell function by immediate treatment of hyperacute HIV-1 infection

scientific article published on 01 May 2019

Brockman, M.A., et al., Human Leukocyte Antigen (HLA) Class I Down-Regulation by Human Immunodeficiency Virus Type 1 Negative Factor (HIV-1 Nef): What Might We Learn From Natural Sequence Variants? Viruses 2012, 4, 1711-1730.

scientific article published on 5 October 2012

Challenges and Opportunities for T-Cell-Mediated Strategies to Eliminate HIV Reservoirs

scientific article

Consequences of HLA-B*13-Associated Escape Mutations on HIV-1 Replication and Nef Function

scientific article

Consequences of HLA-associated mutations in HIV-1 subtype C Nef on HLA-I downregulation ability

scientific article published on 16 January 2020

Construction, phenotypic analysis, and immunogenicity of a UL5/UL29 double deletion mutant of herpes simplex virus 2.

scientific article

Correction for Ojwach et al., "Pol-Driven Replicative Capacity Impacts Disease Progression in HIV-1 Subtype C Infection"

article

Correlates of protective cellular immunity revealed by analysis of population-level immune escape pathways in HIV-1.

scientific article

Croton megalobotrys Müll Arg. and Vitex doniana (Sweet): Traditional medicinal plants in a three-step treatment regimen that inhibit in vitro replication of HIV-1.

scientific article published on 24 June 2016

Diagnostic Accuracy of the HemoCue Hb 301, STAT-Site MHgb and URIT-12 Point-of-Care Hemoglobin Meters in a Central Laboratory and a Community Based Clinic in Durban, South Africa

scientific article

Differential Ability of Primary HIV-1 Nef Isolates To Downregulate HIV-1 Entry Receptors

scientific article

Differential Vpu-mediated CD4 and tetherin downregulation function among major HIV-1 group M subtypes

scientific article published on 06 May 2020

Differential neutralization of human immunodeficiency virus (HIV) replication in autologous CD4 T cells by HIV-specific cytotoxic T lymphocytes

scientific article published on 21 January 2009

Dual HLA B*42 and B*81-reactive T cell receptors recognize more diverse HIV-1 Gag escape variants

scientific article published in Nature Communications

Dynamic range of Nef functions in chronic HIV-1 infection

scientific article published on 13 March 2013

Dynamic range of Nef-mediated evasion of HLA class II-restricted immune responses in early HIV-1 infection

scientific article

Early selection in Gag by protective HLA alleles contributes to reduced HIV-1 replication capacity that may be largely compensated for in chronic infection

scientific article

Escape and compensation from early HLA-B57-mediated cytotoxic T-lymphocyte pressure on human immunodeficiency virus type 1 Gag alter capsid interactions with cyclophilin A.

scientific article

Escape from the dominant HLA-B27-restricted cytotoxic T-lymphocyte response in Gag is associated with a dramatic reduction in human immunodeficiency virus type 1 replication

scientific article

Expression of human inducible nitric oxide synthase in response to cytokines is regulated by hypoxia-inducible factor-1

scientific article published on 02 November 2018

Gag-protease-mediated replication capacity in HIV-1 subtype C chronic infection: associations with HLA type and clinical parameters

scientific article

Genetic Diversity, Compartmentalization, and Age of HIV Proviruses Persisting in CD4+ T Cell Subsets during Long-Term Combination Antiretroviral Therapy

scientific article published on 14 February 2020

Genetic characterization of human immunodeficiency virus type 1 in elite controllers: lack of gross genetic defects or common amino acid changes

scientific article published on 18 June 2008

Genotypic and Mechanistic Characterization of Subtype-specific HIV Adaptation to Host Cellular Immunity

article

Genotypic and functional impact of HIV-1 adaptation to its host population during the North American epidemic

scientific article

HERV-K-specific T cells eliminate diverse HIV-1/2 and SIV primary isolates.

scientific article

HIV Subtype and Nef-Mediated Immune Evasion Function Correlate with Viral Reservoir Size in Early-Treated Individuals

scientific article published on 05 March 2019

HIV and HCV cooperatively promote hepatic fibrogenesis via induction of reactive oxygen species and NFkappaB

scientific article

HIV increases HCV replication in a TGF-beta1-dependent manner.

scientific article

HIV infection increases HCV-induced hepatocyte apoptosis

scientific article

HIV-1 Nef and T-cell activation: a history of contradictions

scientific article

HIV-1 Vpu Mediates HLA-C Downregulation

scientific article published on May 2016

HLA-Associated Viral Mutations Are Common in Human Immunodeficiency Virus Type 1 Elite Controllers.

scientific article

HLA-B57/B*5801 Human Immunodeficiency Virus Type 1 Elite Controllers Select for Rare Gag Variants Associated with Reduced Viral Replication Capacity and Strong Cytotoxic T-Lymphocyte Recognition.

scientific article published in June 2009

HLA-B57/B*5801 human immunodeficiency virus type 1 elite controllers select for rare gag variants associated with reduced viral replication capacity and strong cytotoxic T-lymphocyte [corrected] recognition

scientific article published on 30 December 2008

HLA-C downregulation by HIV-1 adapts to host HLA genotype

article

HLA-associated alterations in replication capacity of chimeric NL4-3 viruses carrying gag-protease from elite controllers of human immunodeficiency virus type 1.

scientific article published on 29 October 2008

HLA-associated immune escape pathways in HIV-1 subtype B Gag, Pol and Nef proteins

scientific article

HLA-associated viral mutations are common in human immunodeficiency virus type 1 elite controllers

scientific article published on 19 January 2009

Herpes simplex virus

scientific article published on 01 March 2002

Herpes simplex virus as a tool to define the role of complement in the immune response to peripheral infection

scientific article published on December 2008

Herpes simplex virus vectors elicit durable immune responses in the presence of preexisting host immunity

scientific article

High Levels of Dual-Class Drug Resistance in HIV-Infected Children Failing First-Line Antiretroviral Therapy in Southern Ethiopia

scientific article published in February 2018

Human leukocyte antigen (HLA) class I down-regulation by human immunodeficiency virus type 1 negative factor (HIV-1 Nef): what might we learn from natural sequence variants?

scientific article

Humoral response to herpes simplex virus is complement-dependent

scientific article published on October 1999

IL-10 is up-regulated in multiple cell types during viremic HIV infection and reversibly inhibits virus-specific T cells

scientific article published on 13 April 2009

Identification of Novel HIV-1 Latency-Reversing Agents from a Library of Marine Natural Products

article

Immune screening identifies novel T cell targets encoded by antisense reading frames of HIV-1.

scientific article

Immune-mediated attenuation of HIV-1

scientific article published on August 2011

Impact of HLA-B*81-associated mutations in HIV-1 Gag on viral replication capacity

scientific article published on 11 January 2012

Impact of HLA-driven HIV adaptation on virulence in populations of high HIV seroprevalence

scientific article published in December 2014

Impact of pre-adapted HIV transmission.

scientific article published on 16 May 2016

Impaired Downregulation of NKG2D Ligands by Nef Proteins from Elite Controllers Sensitizes HIV-1-Infected Cells to Antibody-Dependent Cellular Cytotoxicity.

scientific article published on 14 June 2017

Impaired Nef function is associated with early control of HIV-1 viremia

scientific article published on 25 June 2014

Impaired replication capacity of acute/early viruses in persons who become HIV controllers

scientific article

Impairment of viral replication capacity by nef alleles from HIV elite controllers.

scientific article published on 3 October 2011

Implementation of couples' voluntary HIV counseling and testing services in Durban, South Africa

scientific article published on 2 July 2015

Implications of HIV-1 Nef for "Shock and Kill" Strategies to Eliminate Latent Viral Reservoirs

article

In vitro functional assessment of natural HIV-1 group M Vpu sequences using a universal priming approach

scientific article published on 16 November 2016

In vitro selection of clinically relevant bevirimat resistance mutations revealed by "deep" sequencing of serially passaged, quasispecies-containing recombinant HIV-1

scientific article

Influence of Gag-protease-mediated replication capacity on disease progression in individuals recently infected with HIV-1 subtype C.

scientific article

Inhibition of NF-κB-dependent HIV-1 replication by the marine natural product bengamide A.

scientific article published on 21 February 2018

Intersubtype differences in the effect of a rare p24 gag mutation on HIV-1 replicative fitness

scientific article

Knowledge of HIV serodiscordance, transmission, and prevention among couples in Durban, South Africa

scientific article published on 20 April 2015

Lack of association between HLA class II alleles and in vitro replication capacities of recombinant viruses encoding HIV-1 subtype C Gag-protease from chronically infected individuals

scientific article published on 16 November 2011

Longitudinal within-host evolution of HIV Nef-mediated CD4, HLA and SERINC5 downregulation activity: a case study

scientific article published on 09 January 2020

Macrophage-derived complement component C4 can restore humoral immunity in C4-deficient mice

scientific journal article

Maternal transmission of human immunodeficiency virus escape mutations subverts HLA-B57 immunodominance but facilitates viral control in the haploidentical infant

scientific article published on 10 June 2009

Measuring sexual relationship power equity among young women and young men South Africa: Implications for gender-transformative programming

scientific article published on 25 September 2019

Modulation of HIV reservoirs by host HLA: bridging the gap between vaccine and cure

scientific article published on 29 August 2012

Modulation of TCR-dependent NFAT signaling is impaired in HIV-1 Nef isolates from elite controllers

scientific article published on 11 February 2019

Myeloid C3 Determines Induction of Humoral Responses to Peripheral Herpes Simplex Virus Infection ⬇️

scientific article published on November 15, 2003

Natural HIV-1 Nef Polymorphisms Impair SERINC5 Downregulation Activity

scientific article published on 01 November 2019

Naturally-arising amino acid polymorphisms of HIV-1 Nef that differentially modulate downregulation of HLA-A and HLA-B molecules

article

Nef Proteins from HIV-1 Elite Controllers Are Inefficient at Preventing Antibody-Dependent Cellular Cytotoxicity

scientific article published on 30 December 2015

Nef-mediated down-regulation of CD4 and HLA class I in HIV-1 subtype C infection: association with disease progression and influence of immune pressure

scientific article published on 3 September 2014

Nef-mediated inhibition of NFAT following TCR stimulation differs between HIV-1 subtypes

scientific article published on 21 February 2019

No evidence for selection of HIV-1 with enhanced gag-protease or Nef function among breakthrough infections in the CAPRISA 004 tenofovir microbicide trial

scientific article

Novel Acylguanidine-Based Inhibitor of HIV-1.

scientific article published on 10 August 2016

Novel HLA class I associations with HIV-1 control in a unique genetically admixed population.

scientific article

Optimal long-term humoral responses to replication-defective herpes simplex virus require CD21/CD35 complement receptor expression on stromal cells

scientific article published on July 2006

P09-09. Impact of immune-driven sequence variation in HIV-1 subtype C Gag-Protease on viral fitness and disease progression

article

P09-10. Impact of CTL escape mutations in HIV-1 Nef on viral replication.

scientific article published on 22 October 2009

P09-11. Reduced replication capacity of NL4-3 chimeric viruses encoding RT-Integrase sequences from HIV-1 elite controllers

scientific article published on 22 October 2009

P09-19 LB. CTL escape mutations in gag epitopes restricted by protective HLA class I alleles cause substantial reductions in viral replication capacity

P16-41. Evidence for in vivo immune selection pressure exerted by HLA class I restricted CTL responses to anti-sense encoded HIV sequences.

scientific article published on 22 October 2009

P16-55 LB. The role of CD4+ CD25+ regulatory T cells in the control of IL-10 mediated T cell impairment in chronic HIV Infection.

scientific article

Partner notification and treatment outcomes among South African adolescents and young adults diagnosed with a sexually transmitted infection via laboratory-based screening

scientific article published on 13 May 2020

Phylogenetic approach to recover integration dates of latent HIV sequences within-host

article published in the Proceedings of the National Academy of Sciences of the United States of America

Pol-Driven Replicative Capacity Impacts Disease Progression in HIV-1 Subtype C Infection

scientific article published in October 2018

Progression to AIDS in South Africa is associated with both reverting and compensatory viral mutations

scientific article

Properties of a herpes simplex virus multiple immediate-early gene-deleted recombinant as a vaccine vector

scientific article published on 22 September 2006

Quantitative effect of suboptimal codon usage on translational efficiency of mRNA encoding HIV-1 gag in intact T cells

scientific article

Rapid ex vivo isolation and long-term culture of human Th17 cells

scientific article

Reduced replication capacity of NL4-3 recombinant viruses encoding reverse transcriptase-integrase sequences from HIV-1 elite controllers

scientific article published on February 2011

Relative Resistance of HLA-B to Downregulation by Naturally Occurring HIV-1 Nef Sequences

scientific article

Resistance of Major Histocompatibility Complex Class B (MHC-B) to Nef-Mediated Downregulation Relative to that of MHC-A Is Conserved among Primate Lentiviruses and Influences Antiviral T Cell Responses in HIV-1-Infected Individuals

scientific article published on 18 October 2017

Responsiveness of HIV-specific CD4 T cells to PD-1 blockade

scientific article

Screening of the Pan-African natural product library identifies ixoratannin A-2 and boldine as novel HIV-1 inhibitors

scientific article published on April 2015

Selective depletion of high-avidity human immunodeficiency virus type 1 (HIV-1)-specific CD8+ T cells after early HIV-1 infection

scientific article published on 7 February 2007

Sesterterpenoids Isolated from the Sponge Phorbas sp. Activate Latent HIV-1 Provirus Expression

scientific article

Significant reductions in Gag-protease-mediated HIV-1 replication capacity during the course of the epidemic in Japan

scientific article published on 14 November 2012

Structural and functional constraints limit options for cytotoxic T-lymphocyte escape in the immunodominant HLA-B27-restricted epitope in human immunodeficiency virus type 1 capsid

scientific article published on 2 April 2008

TCR clonotypes modulate the protective effect of HLA class I molecules in HIV-1 infection

scientific article published on 10 June 2012

The African natural product knipholone anthrone and its analogue anthralin (dithranol) enhance HIV-1 latency reversal

scientific article published on 11 August 2020

The Croton megalobotrys Müll Arg. traditional medicine in HIV/AIDS management: Documentation of patient use, in vitro activation of latent HIV-1 provirus, and isolation of active phorbol esters

scientific article published on 29 September 2017

Type 2 Bias of T cells expanded from the blood of melanoma patients switched to type 1 by IL-12p70 mRNA-transfected dendritic cells

scientific article published in November 2008

Unciaphenol, an Oxygenated Analogue of the Bergman Cyclization Product of Uncialamycin Exhibits Anti-HIV Activity

scientific article published on 14 October 2015

Uncommon pathways of immune escape attenuate HIV-1 integrase replication capacity

scientific article

Upregulation of CTLA-4 by HIV-specific CD4+ T cells correlates with disease progression and defines a reversible immune dysfunction

scientific article

Upregulation of PD-L1 on monocytes and dendritic cells by HIV-1 derived TLR ligands

scientific article published on March 2008

Use of a novel GFP reporter cell line to examine replication capacity of CXCR4- and CCR5-tropic HIV-1 by flow cytometry

scientific article

Variation in HIV-1 Nef function within and among viral subtypes reveals genetically separable antagonism of SERINC3 and SERINC5

scientific article published on 14 September 2020

Viral adaptation to immune selection pressure by HLA class I-restricted CTL responses targeting epitopes in HIV frameshift sequences

scientific article

Weaker HLA Footprints on HIV in the Unique and Highly Genetically Admixed Host Population of Mexico

scientific article published in November 2017

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