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List of works by Douglas A. Melton

"Stemness": transcriptional profiling of embryonic and adult stem cells

scientific article (publication date: 18 October 2002)

A 3D culture platform enables development of zinc-binding prodrugs for targeted proliferation of β cells

scientific article published on 18 November 2020

A Nutrient-Sensing Transition at Birth Triggers Glucose-Responsive Insulin Secretion

scientific article published on 01 May 2020

A Peninsular Structure Coordinates Asynchronous Differentiation with Morphogenesis to Generate Pancreatic Islets

A Single-Cell Transcriptomic Map of the Human and Mouse Pancreas Reveals Inter- and Intra-cell Population Structure

scientific article published on 21 September 2016

A Src inhibitor regulates the cell cycle of human pluripotent stem cells and improves directed differentiation.

scientific article

A Stem Cell Approach to Cure Type 1 Diabetes

scientific article published on 02 March 2020

A gene regulatory network in mouse embryonic stem cells

scientific article

A maternal mRNA localized to the animal pole of Xenopus eggs encodes a subunit of mitochondrial ATPase

scientific article

A maternal mRNA localized to the vegetal hemisphere in Xenopus eggs codes for a growth factor related to TGF-beta

scientific article published in December 1987

A method for the generation of human stem cell-derived alpha cells

scientific article published on 07 May 2020

A molecular mechanism for the effect of lithium on development

scientific article

A mouse macrophage factor induces head structures and organizes a body axis in Xenopus

scientific article published on August 1990

A multipotent progenitor domain guides pancreatic organogenesis

scientific article published in July 2007

A rapid increase in acetylcholinesterase mRNA during ascidian embryogenesis as demonstrated by microinjection into Xenopus laevis oocytes

scientific article published in November 1983

A simple tool to improve pluripotent stem cell differentiation.

scientific article published on 14 April 2013

A small molecule that directs differentiation of human ESCs into the pancreatic lineage.

scientific article

A transcriptionally active pseudogene in Xenopus laevis oocyte 5S DNA ⬇️

scientific article published on June 1, 1981

A truncated activin receptor inhibits mesoderm induction and formation of axial structures in Xenopus embryos

scientific article published on October 15, 1992

A two-step model for the localization of maternal mRNA in Xenopus oocytes: involvement of microtubules and microfilaments in the translocation and anchoring of Vg1 mRNA

scientific article published on 01 February 1990

Activin can induce the formation of axial structures and is expressed in the hypoblast of the chick

scientific article published in November 1990

Activin receptor patterning of foregut organogenesis

scientific journal article

Activins are expressed early in Xenopus embryogenesis and can induce axial mesoderm and anterior structures

scientific article published in November 1990

Adenosine kinase inhibition selectively promotes rodent and porcine islet β-cell replication

scientific journal article

Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation

scientific article (publication date: 6 May 2004)

Advancing Progress in Stem Cells and Biomedicine: 2018-2019 Year in Review.

scientific article published in June 2019

Alginate-microencapsulation of human stem cell-derived β cells with CXCL12 prolongs their survival and function in immunocompetent mice without systemic immunosuppression

scientific article published on 25 March 2019

All beta cells contribute equally to islet growth and maintenance

scientific article published on 29 May 2007

Altered nuclear transfer in stem-cell research - a flawed proposal.

scientific article

An enhancer responsible for activating transcription at the midblastula transition in Xenopus development

scientific article

Analysis of pancreatic development in living transgenic zebrafish embryos.

scientific article published in May 2001

Angptl4 links α-cell proliferation following glucagon receptor inhibition with adipose tissue triglyceride metabolism

scientific article

Apolipoprotein E is a pancreatic extracellular factor that maintains mature β-cell gene expression

scientific article published in PLoS ONE

Applied Developmental Biology: Making Human Pancreatic Beta Cells for Diabetics

scientific article published on 20 January 2016

Artifactual insulin release from differentiated embryonic stem cells

scientific article published in October 2004

Author Correction: Pancreas regeneration

scientific article published in Nature

Axial patterning and the establishment of polarity in the frog embryo

scientific article published on February 1990

Beta-catenin is essential for pancreatic acinar but not islet development

scientific journal article

Bimodal and graded expression of the Xenopus homeobox gene Xhox3 during embryonic development

scientific article published in May 1989

Blastemal progenitors modulate immune signaling during early limb regeneration

scientific article published on 02 January 2019

Brief Report: VGLL4 Is a Novel Regulator of Survival in Human Embryonic Stem Cells ⬇️

scientific article published on December 1, 2013

Chapter 20 Assays for Gene Function in Developing Xenopus Embryos

scientific article published on 01 January 1991

Charting cellular identity during human in vitro β-cell differentiation

scientific article published on 08 May 2019

Circadian Entrainment Triggers Maturation of Human In Vitro Islets

scientific article published on 12 December 2019

Cloning of nematode tRNA genes and their expression in the frog oocyte ⬇️

scientific article published on December 1, 1978

Control of developmental regulators by Polycomb in human embryonic stem cells

scientific article (publication date: 21 April 2006)

Core transcriptional regulatory circuitry in human embryonic stem cells

scientific article

Correction: All ß Cells Contribute Equally to Islet Growth and Maintenance.

scientific article published on 18 September 2007

Corrigendum: Generation of stem cell-derived β-cells from patients with type 1 diabetes

scientific article published on 4 August 2016

Corrigendum: Long-term glycemic control using polymer-encapsulated human stem cell-derived beta cells in immune-competent mice

scientific article published on 01 April 2016

Covalent adduct formation between the antihypertensive drug hydralazine and abasic sites in double- and single-stranded DNA.

scientific article

Derivation of Embryonic Stem-Cell Lines from Human Blastocysts

scientific article (publication date: 25 March 2004)

Derivation of human embryonic stem cells by immunosurgery

scientific article

Development of the pancreas in Xenopus laevis

scientific article published on 01 August 2000

Developmental regulation of a gastrula-specific gene injected into fertilized Xenopus eggs

scientific article published on December 1985

Differentiated human stem cells resemble fetal, not adult, β cells

scientific article published on 10 February 2014

Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors

scientific article (publication date: May 2002)

Direct lineage tracing reveals the ontogeny of pancreatic cell fates during mouse embryogenesis

scientific article

Direct regulation of intestinal fate by Notch

scientific article

Efficientin vitrosynthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter ⬇️

scientific article (publication date: 25 September 1984)

Embryonic expression and functional analysis of a Xenopus activin receptor

scientific article published on May 1, 1992

Embryonic expression and nuclear localization of Xenopus homeobox (Xhox) gene products.

scientific article

Endothelial signaling during development

scientific article

Establishment of human pluripotent stem cell-derived pancreatic β-like cells in the mouse pancreas

scientific article published on 29 March 2018

Exogenous GDF11, but not GDF8, reduces body weight and improves glucose homeostasis in mice

scientific article published on 12 March 2020

Expression of Xenopus N-CAM RNA in ectoderm is an early response to neural induction

scientific article

Expression of activin mRNA during early development in Xenopus laevis

scientific article

Extreme makeover: converting one cell into another

scientific article

Facultative endocrine progenitor cells in the adult pancreas

scientific article

Follistatin, an antagonist of activin, is expressed in the Spemann organizer and displays direct neuralizing activity

scientific article published in April 1994

Formation of the 3′ end of histone mRNA by post-transcriptional processing

scientific article published in Nature

Functional beta-cell maturation is marked by an increased glucose threshold and by expression of urocortin 3.

scientific article published on 26 February 2012

Functional evaluation of ES cell-derived endodermal populations reveals differences between Nodal and Activin A-guided differentiation

scientific article

Functional genomics of the endocrine pancreas: the pancreas clone set and PancChip, new resources for diabetes research

scientific article published in July 2002

Functional messenger RNAs are produced by SP6in vitrotranscription of cloned cDNAs ⬇️

scientific article (publication date: 25 September 1984)

Gene injection into amphibian oocytes

scientific article published on 01 January 1980

Gene transfer in amphibian eggs and oocytes

scientific article

Generation of functional human pancreatic β cells in vitro

scientific article

Generation of hypoimmunogenic human pluripotent stem cells

scientific article published on 30 April 2019

Generation of pluripotent stem cells from patients with type 1 diabetes

scientific article published on 31 August 2009

Generation of stem cell-derived β-cells from patients with type 1 diabetes

scientific article published on 10 May 2016

Genes, Signals, and Lineages in Pancreas Development ⬇️

scientific article published on January 1, 2003

Genetic targeting of the endoderm with claudin-6CreER.

scientific article published on February 2008

Genetics in an oocyte

scientific article published on June 1979

Genome-scale in vivo CRISPR screen identifies RNLS as a target for beta cell protection in type 1 diabetes

scientific article published on 27 July 2020

Global expression analysis of gene regulatory pathways during endocrine pancreatic development

scientific article published on 3 December 2003

Glucose Response by Stem Cell-Derived β Cells In Vitro Is Inhibited by a Bottleneck in Glycolysis

scientific article published on 01 May 2020

Growth factors in early embryogenesis

scientific article published on January 1989

Hormonal regulation of embryogenesis: the formation of mesoderm in Xenopus laevis

scientific article published on June 1994

How important are adult stem cells for tissue maintenance?

scientific article published on 19 September 2004

How to make a functional β-cell ⬇️

scientific article published on June 1, 2013

How to make beta cells?

scientific article

Human beta-globin pre-mRNA synthesized in vitro is accurately spliced in Xenopus oocyte nuclei

scientific article published on 01 March 1983

Human embryonic stem cells

scientific article published on 01 January 2006

Identification and cloning of localized maternal RNAs from Xenopus eggs

scientific article

Identification of a LIF-Responsive, Replication-Competent Subpopulation of Human β Cells

scientific article published on 09 January 2020

Identification of a novel transforming growth factor-beta (TGF-beta 5) mRNA in Xenopus laevis

scientific article

Identifying gene expression programs of cell-type identity and cellular activity with single-cell RNA-Seq

scientific article published on 08 July 2019

Impracticality of Egg Donor Recruitment in the Absence of Compensation ⬇️

scientific article published on October 4, 2011

In vitro RNA synthesis with SP6 RNA polymerase

scientific article published on January 1987

In vivo reprogramming of adult pancreatic exocrine cells to beta-cells

scientific article

In vivo reprogramming of pancreatic acinar cells to three islet endocrine subtypes

scientific article published on January 2014

Induction and patterning of the vertebrate nervous system

scientific article published on July 1995

Induction of axial mesoderm by zDVR-1, the zebrafish orthologue of Xenopus Vg1.

scientific article published on April 1996

Induction of dorsal mesoderm by soluble, mature Vg1 protein ⬇️

scientific article published on July 1, 1995

Induction of mesoderm by a viral oncogene in early Xenopus embryos

scientific article published in May 1989

Induction of mesoderm in Xenopus laevis embryos by translation initiation factor 4E

scientific article published on 01 August 1994

Induction of pancreatic differentiation by signals from blood vessels

scientific article published on 27 September 2001

Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds

scientific article (publication date: July 2008)

Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2

scientific article (publication date: November 2008)

Inhibition of activin receptor signaling promotes neuralization in Xenopus

scientific article published on 01 April 1994

Inhibition of mTOR Signaling Enhances Maturation of Cardiomyocytes Derived From Human-Induced Pluripotent Stem Cells via p53-Induced Quiescence

scientific article published on 11 November 2019

Injected Wnt RNA induces a complete body axis in Xenopus embryos ⬇️

scientific article published on November 15, 1991

Insulin staining of ES cell progeny from insulin uptake.

scientific article published on January 2003

Interaction between peptide growth factors and homoeobox genes in the establishment of antero-posterior polarity in frog embryos

scientific article published in Nature

Interaction of Wnt and activin in dorsal mesoderm induction in Xenopus

scientific article published on 01 December 1992

Involvement of p21ras in Xenopus mesoderm induction

scientific article published on May 1992

Involvement of the Xenopus homeobox gene Xhox3 in pattern formation along the anterior-posterior axis

scientific article published in April 1989

Key events of pancreas formation are triggered in gut endoderm by ectopic expression of pancreatic regulatory genes

scientific article

Live Cell Monitoring and Enrichment of Stem Cell-Derived β Cells Using Intracellular Zinc Content as a Population Marker

scientific article published on 01 December 2019

Localization of mRNA and axis formation during Xenopus embryogenesis.

scientific article

Localized maternal mRNAs in Xenopus laevis eggs.

scientific article published in January 1985

Localized synthesis of the Vg1 protein during early Xenopus development

article

Long-term glycemic control using polymer-encapsulated human stem cell-derived beta cells in immune-competent mice

scientific article

MARIS: method for analyzing RNA following intracellular sorting

scientific article

Marked differences in differentiation propensity among human embryonic stem cell lines

scientific article published on 17 February 2008

Microinjection of synthetic Xhox-1A homeobox mRNA disrupts somite formation in developing Xenopus embryos

scientific article

Mixer , a Homeobox Gene Required for Endoderm Development ⬇️

scientific article published on July 3, 1998

Modeling Type 1 Diabetes In Vitro Using Human Pluripotent Stem Cells

scientific article published on 01 July 2020

Modeling human nutrition using human embryonic stem cells

scientific article published on 01 March 2015

Mothers against dpp encodes a conserved cytoplasmic protein required in DPP/TGF-beta responsive cells

scientific article published in July 1996

Mutant Vg1 ligands disrupt endoderm and mesoderm formation in Xenopus embryos ⬇️

scientific article published on July 1, 1998

New Approaches, New Opportunities at the 2019 ISSCR Annual Meeting

New findings in pancreatic and intestinal endocrine development to advance regenerative medicine ⬇️

scientific article published on February 1, 2013

Nomenclature: vertebrate mediators of TGFbeta family signals

scientific article published in October 1996

Notch gene expression during pancreatic organogenesis

scientific article

Notch signaling controls multiple steps of pancreatic differentiation

scientific article

Notch signaling promotes airway mucous metaplasia and inhibits alveolar development.

scientific article published on 15 April 2009

Notch signaling reveals developmental plasticity of Pax4(+) pancreatic endocrine progenitors and shunts them to a duct fate

scientific article published on 17 November 2006

Notochord repression of endodermal Sonic hedgehog permits pancreas development ⬇️

scientific article published on June 1, 1998

Notochord to endoderm signaling is required for pancreas development ⬇️

scientific article published on November 1, 1997

Nuclear reprogramming in cells

scientific article

Nuclear reprogramming of somatic cells after fusion with human embryonic stem cells

scientific article

Optimal timing of inner cell mass isolation increases the efficiency of human embryonic stem cell derivation and allows generation of sibling cell lines

scientific article published in February 2009

Order and intracellular location of the events involved in the maturation of a spliced tRNA

scientific article published in Nature

Organ size is limited by the number of embryonic progenitor cells in the pancreas but not the liver

scientific article

Organoid Maturation by Circadian Entrainment

Pancreas development in the chick embryo

scientific article published on 01 January 1997

Pancreas development is promoted by cyclopamine, a Hedgehog signaling inhibitor ⬇️

scientific article published on October 27, 1998

Pancreas regeneration

scientific article published in Nature

Pancreas specification: a budding question

scientific article

Pancreatic lineage analysis using a retroviral vector in embryonic mice demonstrates a common progenitor for endocrine and exocrine cells

scientific article

Perspectives on the activities of ANGPTL8/betatrophin

scientific article published on 01 October 2014

Platelet-Derived Growth Factor A Chain Is Maternally Encoded in Xenopus Embryos ⬇️

scientific article published on September 2, 1988

Pre-existent pattern in Xenopus animal pole cells revealed by induction with activin

scientific article published in May 1991

Processed Vg1 protein is an axial mesoderm inducer in Xenopus

scientific article

Promoter of a eukaryotic tRNAPro gene is composed of three noncontiguous regions.

scientific article

Prospective isolation and global gene expression analysis of definitive and visceral endoderm

article

Pten constrains centroacinar cell expansion and malignant transformation in the pancreas

scientific article published in September 2005

Purification of Live Stem-Cell-Derived Islet Lineage Intermediates

scientific article published on 01 June 2020

RETRACTED: Betatrophin: A Hormone that Controls Pancreatic β Cell Proliferation ⬇️

scientific article published on April 25, 2013

Recovery from diabetes in mice by beta cell regeneration

scientific article published on September 2007

Regenerating the field of cardiovascular cell therapy

scientific article published on 18 February 2019

Regulation of pancreas development by hedgehog signaling

scientific journal article

Report of the Key Opinion Leaders Meeting on Stem Cell-derived Beta Cells

scientific article published on 01 August 2018

Reprogrammed Stomach Tissue as a Renewable Source of Functional β Cells for Blood Glucose Regulation

scientific article published on 16 February 2016

Reprogramming within hours following nuclear transfer into mouse but not human zygotes ⬇️

scientific article published on October 4, 2011

Resolving Discrepant Findings on ANGPTL8 in β-Cell Proliferation: A Collaborative Approach to Resolving the Betatrophin Controversy

scientific article

Retraction Notice to: Betatrophin: A Hormone that Controls Pancreatic β Cell Proliferation

scientific article published on 27 December 2016

Reversal of type 1 diabetes in mice

scientific article published on 01 July 2006

Reversal of β cell de-differentiation by a small molecule inhibitor of the TGFβ pathway.

scientific article

Role of VEGF-A in vascularization of pancreatic islets

scientific article

Role of endothelial cells in early pancreas and liver development

scientific article

Screening for novel pancreatic genes expressed during embryogenesis

scientific article published on 01 August 1999

Self-renewal of embryonic-stem-cell-derived progenitors by organ-matched mesenchyme

scientific article

Sequences of four tRNA genes from Caenorhabditis elegans and the expression of C. elegans tRNALeu (anticodon IAG) in Xenopus oocytes

scientific article published on December 1982

Signal transduction during mesoderm induction in Xenopus

scientific article published on January 1990

Signals from lateral plate mesoderm instruct endoderm toward a pancreatic fate

scientific article

Single-cell transcript analysis of pancreas development

scientific article published in March 2003

Site-directed mutagenesis of a tRNA gene: base alterations in the coding region affect transcription

scientific article

Slow and steady is the key to beta-cell replication

scientific article

Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells

scientific article published on April 2009

Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal

scientific journal article

Specificity of antisense oligonucleotides in vivo ⬇️

scientific article published on August 15, 1992

Stem cells. Setting standards for human embryonic stem cells

scientific article

Studies with a Xenopus BMP receptor suggest that ventral mesoderm-inducing signals override dorsal signals in vivo ⬇️

scientific article published on October 7, 1994

Synchronized stimulation and continuous insulin sensing in a microfluidic human Islet on a Chip designed for scalable manufacturing

scientific article published on 01 September 2019

TGF-beta signals and a pattern in Xenopus laevis endodermal development

scientific article

Testing pancreatic islet function at the single cell level by calcium influx with associated marker expression

scientific article

The Src family of tyrosine kinases is important for embryonic stem cell self-renewal

scientific article published on 17 May 2004

The Xenopus localized messenger RNA An3 may encode an ATP-dependent RNA helicase.

scientific article

The mRNA encoding elongation factor 1-alpha (EF-1 alpha) is a major transcript at the midblastula transition in Xenopus

scientific article

The material mRNA Vg1 is correctly localized following injection into Xenopus oocytes

scientific article published in December 1988

The molecular biography of the cell

scientific article

The process of localizing a maternal messenger RNA in Xenopus oocytes

scientific article published on 01 January 1989

The stability, toxicity and effectiveness of unmodified and phosphorothioate antisense oligodeoxynucleotides in Xenopus oocytes and embryos ⬇️

scientific article published on April 11, 1990

The vascular basement membrane: a niche for insulin gene expression and Beta cell proliferation

scientific article published on March 2006

Transcription of cloned tRNA genes and the nuclear partitioning of a tRNA precursor ⬇️

scientific article published on December 1, 1979

Transcription of tRNA genes in vivo: single-stranded compared to double-stranded templates

scientific article

Transcriptional dynamics of endodermal organ formation

scientific article published on January 2009

Translational control of activin in Xenopus laevis embryos

scientific article published on 01 January 1995

Translocation of a localized maternal mRNA to the vegetal pole of Xenopus oocytes

scientific article

Turning straw into gold: directing cell fate for regenerative medicine ⬇️

scientific article published on March 9, 2011

Vegetal messenger RNA localization directed by a 340-nt RNA sequence element in Xenopus oocytes

scientific article published on February 21, 1992

Vertebrate embryonic cells will become nerve cells unless told otherwise

scientific article

Vertebrate embryonic induction: mesodermal and neural patterning

scientific article

Vertebrate neural induction

scientific article published on January 1997

Wnt Signaling Separates the Progenitor and Endocrine Compartments during Pancreas Development

scientific article published on 01 May 2019

Wnt signaling specifies and patterns intestinal endoderm.

scientific article published on 10 August 2011

Wnt7b stimulates embryonic lung growth by coordinately increasing the replication of epithelium and mesenchyme

scientific article

Xenopus Mad proteins transduce distinct subsets of signals for the TGF beta superfamily

scientific article published in May 1996

Xenopus axis formation: induction of goosecoid by injected Xwnt-8 and activin mRNAs.

scientific article published in June 1993

Xfin: an embryonic gene encoding a multifingered protein in Xenopus

scientific article

Xnr4: a Xenopus nodal-related gene expressed in the Spemann organizer

scientific article published in April 1997

Xwnt-11: a maternally expressed Xenopus wnt gene

scientific article published in December 1993

YAP inhibition enhances the differentiation of functional stem cell-derived insulin-producing β cells

scientific article published on 01 April 2019

is a dual regulator of wound epidermis development and inflammation during the initiation of limb regeneration

scientific article published on 14 January 2020

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