List of works by Frances M. Williams

'Omics' biomarkers associated with chronic low back pain: protocol of a retrospective longitudinal study.

scientific article published on 19 October 2016

'RA and the microbiome: do host genetic factors provide the link?

scientific article published on 05 March 2019

A GWAS meta-analysis from 5 population-based cohorts implicates ion channel genes in the pathogenesis of irritable bowel syndrome

article

A discordant monozygotic-twin approach to potential risk factors for chronic widespread pain in females

scientific article

A genome-wide association study suggests that a locus within the ataxin 2 binding protein 1 gene is associated with hand osteoarthritis: the Treat-OA consortium.

scientific article published on 08 June 2009

A meta-analysis of reflux genome-wide association studies in 6750 Northern Europeans from the general population

scientific article published on 3 August 2016

A new 5-lipoxygenase inhibitor seems to be safe and effective for the treatment of osteoarthritis

scientific article published on 03 February 2009

A response to Videman et al., “Challenging the cumulative injury model: positive effects of greater body mass on disc degeneration”

article

Age differences in genetic and environmental variations in stress-coping during adulthood: a study of female twins

scientific article published on 5 May 2012

An omics investigation into chronic widespread musculoskeletal pain reveals epiandrosterone sulfate as a potential biomarker

scientific article published on 22 April 2015

Analysis of genetically independent phenotypes identifies shared genetic factors associated with chronic musculoskeletal pain conditions

scientific article published on 25 June 2020

Are Epigenetic Factors Implicated in Chronic Widespread Pain?

scientific article

Are intra-articular injections of hylan more effective than injections of hyaluronic acid for knee osteoarthritis?

scientific article published on 01 July 2008

Assessment of age-related changes in heritability and IGF-1 gene effect on circulating IGF-1 levels

scientific article

Association between cartilage and bone biomarkers and incidence of radiographic knee osteoarthritis (RKOA) in UK females: a prospective study

scientific article

Association between serum cholesterol and bone mineral density

scientific article

Association of Raynaud's phenomenon with a polymorphism in the NOS1 gene.

scientific article

Association of interleukin-6 gene polymorphisms with hand osteoarthritis and hand osteoporosis

scientific article

Association of the resolvin precursor 17-HDHA, but not D- or E- series resolvins, with heat pain sensitivity and osteoarthritis pain in humans.

scientific article published on 7 September 2017

Attributes and predictors of Long-COVID: analysis of COVID cases and their symptoms collected by the Covid Symptoms Study App

scientific article

Attributes and predictors of long COVID

Author Correction: Attributes and predictors of long COVID

correction of a scholarly article

Biomarkers in osteoarthritis

scientific article published on 16 January 2008

Biomarkers: in combination they may do better

scientific article published on 29 October 2009

Chronic pain, depression and cardiovascular disease linked through a shared genetic predisposition: Analysis of a family-based cohort and twin study.

scientific article

Chronic widespread pain: clinical comorbidities and psychological correlates

scientific article

Collaborative meta-analysis: associations of 150 candidate genes with osteoporosis and osteoporotic fracture

scientific article

Contribution of putative genetic factors and candidate gene variants to inter-individual variation of circulating fractalkine (CX3CL1) levels in a large UK twins' sample

scientific article

Corrigendum to: “Shared genetic factors underlie the chronic pain syndromes” [PAIN® 2014;155(8):1562–68]

scholarly article published in Pain

Critical illness in systemic lupus erythematosus and the antiphospholipid syndrome

scientific article published on May 2002

Defining the genetic control of human blood plasma N-glycome using genome-wide association study

scientific article published on 01 June 2019

Dietary garlic and hip osteoarthritis: evidence of a protective effect and putative mechanism of action

scientific article

Differential methylation of the TRPA1 promoter in pain sensitivity

scientific article published on January 2014

Disentangling the genetics of lean mass

article

Effective measurement of knee alignment using AP knee radiographs

scientific article published on 14 September 2008

Elevated plasma fractalkine levels are associated with higher levels of IL-6, Apo-B, LDL-C and insulin, but not with body composition in a large female twin sample

scientific article published on 8 March 2013

Endplate Defect Is Heritable, Associated With Low Back Pain and Triggers Intervertebral Disc Degeneration

Epigenetics and methylation in the rheumatic diseases

scientific article published on 15 October 2013

Epigenome-wide DNA methylation in hearing ability: new mechanisms for an old problem

scientific article

Erratum: Large meta-analysis of genome-wide association studies identifies five loci for lean body mass

scientific article

Evidence that bone mineral density plays a role in degenerative disc disease: the UK Twin Spine study

scientific article

Exploring symptoms of somatization in chronic widespread pain: latent class analysis and the role of personality

scientific article

Female sexual pain: Epidemiology and genetic overlap with chronic widespread pain

scientific article published on 30 May 2017

GDF5 single-nucleotide polymorphism rs143383 is associated with lumbar disc degeneration in Northern European women

scientific article

GWAS Identifies 44 Independent Associated Genomic Loci for Self-Reported Adult Hearing Difficulty in UK Biobank

scientific article published on 26 September 2019

Genes contributing to pain sensitivity in the normal population: an exome sequencing study.

scientific article

Genetic Factors Explain the Association Between Pain Catastrophizing and Chronic Widespread Pain

scientific article published on 12 May 2017

Genetic Variants Associated with Circulating Parathyroid Hormone

scientific article published on 07 December 2016

Genetic and Environmental Factors in Age-Related Hearing Impairment

scientific article published on 17 June 2015

Genetic determinants of heel bone properties: genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium

scientific article

Genetic predisposition to chronic pain: from evolutionary advantage to a debilitating disease spectrum?

scientific article published on 01 January 2014

Genetics of age-related hearing loss

scientific article published on 27 January 2020

Genome-wide association meta-analysis identifies five novel loci for age-related hearing impairment

scientific article published on 23 October 2019

Genome-wide association study for circulating levels of PAI-1 provides novel insights into its regulation

scientific article

Genome-wide association study for circulating tissue plasminogen activator levels and functional follow-up implicates endothelial STXBP5 and STX2.

scientific article

Genome-wide association study meta-analysis of chronic widespread pain: evidence for involvement of the 5p15.2 region

scientific article

Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture

scientific article

Genome-wide meta-analysis identifies genetic locus on chromosome 9 associated with Modic changes

scientific article published on 26 February 2019

Genome-wide meta-analysis identifies new susceptibility loci for migraine

scientific article

Genome-wide meta-analysis of 158,000 individuals of European ancestry identifies three loci associated with chronic back pain

scientific article published on 27 September 2018

Genomewide linkage scan of hand osteoarthritis in female twin pairs showing replication of quantitative trait loci on chromosomes 2 and 19

scientific article

Genomewide search in familial Paget disease of bone shows evidence of genetic heterogeneity with candidate loci on chromosomes 2q36, 10p13, and 5q35

scientific article

Genomics and metabolomics of muscular mass in a community-based sample of UK females

scientific article

Gut microbiota associations with common diseases and prescription medications in a population-based cohort

scientific article published in Nature Communications

Hearing ability with age in northern European women: a new web-based approach to genetic studies

scientific article

Heritability of Raynaud's phenomenon and vascular responsiveness to cold: A study of adult female twins

scientific article published on 01 April 2007

Heritability of spinal curvature and its relationship to disc degeneration and bone mineral density in female adult twins

scientific article published on 29 July 2014

ISSLS Prize Winner: Vertebral Endplate (Modic) Change is an Independent Risk Factor for Episodes of Severe and Disabling Low Back Pain

scientific article published on August 2015

ISSLS Prize in Clinical Science 2020. Examining causal effects of body mass index on back pain: a Mendelian randomization study

scientific article published on 03 December 2019

Identification of PLCL1 gene for hip bone size variation in females in a genome-wide association study

scientific article

Identification of novel loci associated with hip shape: a meta-analysis of genome-wide association studies

Identification of quantitative trait loci for fibrin clot phenotypes: the EuroCLOT study

scientific article

Implementation of the simplified stochastic model of ageing for longitudinal osteoarthritis data assessment

scientific article

Increased DNA methylation variability in rheumatoid arthritis-discordant monozygotic twins

article

Interleukin-6 is a significant predictor of radiographic knee osteoarthritis: The Chingford Study

scientific article

Intervertebral Disc Biology: Genetic Basis of Disc Degeneration

scientific article published on 03 August 2018

Ischemic stroke is associated with the ABO locus: the EuroCLOT study

scientific article published on January 2013

Joint Stiffness Is Heritable and Associated with Fibrotic Conditions and Joint Replacement

scientific article published on 21 July 2015

Large meta-analysis of genome-wide association studies identifies five loci for lean body mass

scientific article

Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific Effects

scientific article published in January 2018

Loci at chromosomes 13, 19 and 20 influence age at natural menopause

scientific article

Longitudinal study of variation in body mass index in middle-aged UK females

scientific article

Low back and common widespread pain share common genetic determinants

scientific article

Lower limbs composition and radiographic knee osteoarthritis (RKOA) in Chingford sample--a longitudinal study

scientific article published on 18 October 2012

Lumbar disc degeneration and genetic factors are the main risk factors for low back pain in women: the UK Twin Spine Study

scientific article

Lumbar disc disease shows linkage to chromosome 19 overlapping with a QTL for hand OA.

scientific article published on 27 July 2007

Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations with measures of skeletal frame size

scientific article published in April 2009

Migraine and Antiphospholipid Antibodies: No Association Found in Migraine-Discordant Monozygotic Twins

scientific article published on 09 July 2008

Modifiable risk factors for chronic back pain: insights using the co-twin control design

scientific article

Multi-OMICS analyses of frailty and chronic widespread musculoskeletal pain suggest involvement of shared neurological pathways

scientific article published in December 2018

Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease

scientific article (publication date: 17 September 2013)

Neck and back pain and intervertebral disc degeneration: role of occupational factors

scientific article published on February 2011

Neuropathic pain as part of chronic widespread pain: environmental and genetic influences

scientific article published on 24 June 2015

Novel associations of multiple genetic loci with plasma levels of factor VII, factor VIII, and von Willebrand factor: The CHARGE (Cohorts for Heart and Aging Research in Genome Epidemiology) Consortium

scientific article

Novel genetic variants associated with lumbar disc degeneration in northern Europeans: a meta-analysis of 4600 subjects

scientific article published on 19 September 2012

Osteoarthritis

Pain Catastrophizing, Fear of Pain, and Depression and Their Association with Female Sexual Pain

scientific article published on 04 December 2019

Pain catastrophizing, neuroticism, fear of pain, and anxiety: Defining the genetic and environmental factors in a sample of female twins.

scientific article published on 22 March 2018

Pain reporting at different body sites is explained by a single underlying genetic factor

scientific article

Past, Present, and Future of Informed Consent in Pain and Genomics Research: Challenges Facing Global Medical Community

scientific article published on 26 August 2016

Pericyte mitogenic activity is reduced in the blood of type 1 diabetic patients with and without retinopathy

scientific article published on 01 January 1993

Phenotypic dissection of bone mineral density reveals skeletal site specificity and facilitates the identification of novel loci in the genetic regulation of bone mass attainment

scientific article

Plasma N-glycome composition associates with chronic low back pain

article

Prevalence and risk factors of sexual problems and sexual distress in a sample of women suffering from chronic widespread pain.

scientific article published on 7 August 2014

Progression of lumbar disc degeneration over a decade: a heritability study ⬇️

scientific article

Quantitative genetics of circulating Dickkopf-related protein 1 (DKK1) in community-based sample of UK twins

scientific article published on 13 January 2016

Reduced telomere length in rheumatoid arthritis is independent of disease activity and duration

scientific article published on 17 November 2006

Relationship between dry eye symptoms and pain sensitivity.

scientific article

Salt-inducible kinase 3, SIK3, is a new gene associated with hearing

scientific article

Schmorl's nodes: common, highly heritable, and related to lumbar disc disease.

scientific article

Self-Reported Symptoms of COVID-19, Including Symptoms Most Predictive of SARS-CoV-2 Infection, Are Heritable

scientific article

Self-reported symptoms of covid-19 including symptoms most predictive of SARS-CoV-2 infection, are heritable

scientific article published on 24 April 2020

Shared genetic factors underlie chronic pain syndromes

scientific article published on 29 May 2014

Shared genetic influence on frailty and chronic widespread pain: a study from TwinsUK.

scientific article published on 7 July 2017

Significant differences in UK and US female bone density reference ranges.

scientific article published on 9 January 2010

Strong association between vertebral endplate defect and Modic change in the general population

scientific article published in Scientific Reports

Structural vertebral endplate nomenclature and etiology: a study by the ISSLS Spinal Phenotype Focus Group.

scientific article published on 12 September 2017

The Association Between Low Back Pain and Composition of IgG Glycome

scientific article published on 27 May 2016

The Association between Chronic Widespread Musculoskeletal Pain, Depression and Fatigue Is Genetically Mediated

scientific article published on 24 November 2015

The Microbiome and Musculoskeletal Conditions of Aging: A Review of Evidence for Impact and Potential Therapeutics

scientific article published on 16 December 2015

The antiphospholipid syndrome and vascular surgery

scientific article published on February 1998

The effect of moderate alcohol consumption on bone mineral density: a study of female twins.

scientific article published on July 2004

The genetic influence on radiographic osteoarthritis is site specific at the hand, hip and knee

scientific article published on 19 January 2009

The heritable determinants of cartilage oligomeric matrix protein

scientific article published on 01 July 2006

The relationship between Modic changes and intervertebral disc degeneration. ⬇️

scientific article published on 26 August 2016

Twelve-year follow-up of chronic pain in twins: Changes in environmental and genetic influence over time

scientific article published on 20 April 2018

Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies

scientific article

TwinsUK: The UK Adult Twin Registry Update

scientific article published on 17 September 2019

Using omics in chronic pain conditions to delineate mechanisms and provide new therapeutic strategies

scientific article published on 14 March 2016

Validation of standard operating procedures in a multicenter retrospective study to identify -omics biomarkers for chronic low back pain

scientific article

Vertebral endplate change as a feature of intervertebral disc degeneration: a heritability study

scientific article published on 15 May 2014

What is the effect of alcohol consumption on the risk of chronic widespread pain? A Mendelian randomisation study using UK Biobank

scientific article published on 01 February 2019

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