List of works by Pipsa Saharinen

Angiopoietin signaling in the vasculature

scientific article

Angiopoietin-2 inhibition prevents transplant ischemia-reperfusion injury and chronic rejection in rat cardiac allografts.

scientific article published on 7 April 2014

Angiopoietins assemble distinct Tie2 signalling complexes in endothelial cell-cell and cell-matrix contacts

scientific article

Association of Angiopoietin-2 and Ki-67 Expression with Vascular Density and Sunitinib Response in Metastatic Renal Cell Carcinoma

scientific article

Autoinhibition of Jak2 tyrosine kinase is dependent on specific regions in its pseudokinase domain

scientific article

Binding of SH2-B family members within a potential negative regulatory region maintains JAK2 in an active state

scientific article published on September 2006

Blocking integrin inactivation as an anti-angiogenic therapy

scientific article published on 31 March 2015

Characterization of ANGPT2 mutations associated with primary lymphedema

scientific article published on 01 September 2020

Claudin-like protein 24 interacts with the VEGFR-2 and VEGFR-3 pathways and regulates lymphatic vessel development

scientific journal article

Donor simvastatin treatment prevents ischemia-reperfusion and acute kidney injury by preserving microvascular barrier function

scientific article

Double target for tumor mass destruction.

scientific article

Effects of angiopoietin-2-blocking antibody on endothelial cell-cell junctions and lung metastasis

scientific article published on 17 February 2012

Endothelial destabilization by angiopoietin-2 via integrin β1 activation.

scientific article

How do angiopoietins Tie in with vascular endothelial growth factors?

scientific article published on May 2010

Interferon gamma activation of Raf-1 is Jak1-dependent and p21ras-independent

scientific article

Ligand oligomerization state controls Tie2 receptor trafficking and angiopoietin-2-specific responses.

scientific article published on 22 February 2012

Liprin (beta)1 is highly expressed in lymphatic vasculature and is important for lymphatic vessel integrity

scientific article

Loss of endothelial Tie1 receptor impairs lymphatic vessel development-brief report

scientific article published on 12 November 2009

Lymphangiogenesis requires Ang2/Tie/PI3K signaling for VEGFR3 cell-surface expression

scientific article published in 2022

Lymphatic vasculature: development, molecular regulation and role in tumor metastasis and inflammation.

scientific article published on July 2004

Molecular regulation of lymphangiogenesis

scientific article published on April 2004

Multiple angiopoietin recombinant proteins activate the Tie1 receptor tyrosine kinase and promote its interaction with Tie2

scientific article

Platelet-derived growth factor (PDGF)-induced activation of signal transducer and activator of transcription (Stat) 5 is mediated by PDGF beta-receptor and is not dependent on c-src, fyn, jak1 or jak2 kinases

scientific article published on February 2000

Receptor tyrosine kinase-mediated angiogenesis

scientific article

Recessive primary congenital lymphoedema caused by a VEGFR3 mutation.

scientific article published on 15 March 2009

Regulation of Jak2 through the ubiquitin-proteasome pathway involves phosphorylation of Jak2 on Y1007 and interaction with SOCS-1.

scientific article

Regulation of the Jak2 tyrosine kinase by its pseudokinase domain

scientific article

Signaling and functions of angiopoietin-1 in vascular protection.

scientific article

Simvastatin pretreatment reduces caspase-9 and RIPK1 protein activity in rat cardiac allograft ischemia-reperfusion

scientific article

The Bmx tyrosine kinase is activated by IL-3 and G-CSF in a PI-3K dependent manner

scientific article (publication date: 24 August 2000)

The Janus kinases (Jaks)

scientific article

The Schlemm's canal is a VEGF-C/VEGFR-3-responsive lymphatic-like vessel

scientific article (publication date: September 2014)

The pseudokinase domain is required for suppression of basal activity of Jak2 and Jak3 tyrosine kinases and for cytokine-inducible activation of signal transduction

scientific article

The sinus venosus contributes to coronary vasculature through VEGFC-stimulated angiogenesis

scientific article

The yin, the yang, and the angiopoietin-1.

scientific article published on 23 May 2011

Tie1 deletion inhibits tumor growth and improves angiopoietin antagonist therapy

scientific article published on 16 January 2014

Transcriptomal comparison of human dermal lymphatic endothelial cells ex vivo and in vitro

scientific article published on January 2007

VEGF and angiopoietin signaling in tumor angiogenesis and metastasis

scientific article published on 12 April 2011

VEGF-C and aortic cardiomyocytes guide coronary artery stem development

scientific article

VEGF-C is required for intestinal lymphatic vessel maintenance and lipid absorption

scientific article

Vascular endothelial growth factor-angiopoietin chimera with improved properties for therapeutic angiogenesis

scientific article published on January 2013

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