List of works - Alexander Schleiffer

A Caenorhabditis elegans cohesion protein with functions in meiotic chromosome pairing and disjunction

scientific article

A REC8-dependent plant Shugoshin is required for maintenance of centromeric cohesion during meiosis and has no mitotic functions

scientific article published in May 2005

A cooperative mechanism drives budding yeast kinetochore assembly downstream of CENP-A.

scientific article

A high-throughput method to identify trans-activation domains within transcription factor sequences

scholarly article by Cosmas D Arnold published in August 2018

A screen for genes required for meiosis and spore formation based on whole-genome expression.

scientific article

A structural basis for kinetochore recruitment of the Ndc80 complex via two distinct centromere receptors

scientific article

ANGEL2 is a member of the CCR4 family of deadenylases with 2',3'-cyclic phosphatase activity

scientific article published on 01 July 2020

ANNIE: integrated de novo protein sequence annotation

scientific article published on 23 April 2009

Analysis of orthologous groups reveals archease and DDX1 as tRNA splicing factors

scientific article

Arabidopsis SMG7 protein is required for exit from meiosis.

scientific article

Augmenting β-augmentation: structural basis of how BamB binds BamA and may support folding of outer membrane proteins

scientific article

CENP-T proteins are conserved centromere receptors of the Ndc80 complex

scientific article

Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complex

scientific article

Combinatorial activation and repression by seven transcription factors specify Drosophila odorant receptor expression

scientific article

DOUTfinder--identification of distant domain outliers using subsignificant sequence similarity

scientific article

Dbl2 Regulates Rad51 and DNA Joint Molecule Metabolism to Ensure Proper Meiotic Chromosome Segregation

scientific article

Deep and precise quantification of the mouse synaptosomal proteome reveals substantial remodeling during postnatal maturation

scientific article published on 22 September 2014

Diversity and roles of (t)RNA ligases

scientific article published on 17 March 2012

Eco1 is a novel acetyltransferase that can acetylate proteins involved in cohesion

scientific article

Endosome and Golgi-associated degradation (EGAD) of membrane proteins regulates sphingolipid metabolism

scientific article published on 27 May 2019

Family matters: structural and functional conservation of centromere-associated proteins from yeast to humans

scientific article published on 05 March 2013

Forkhead-like transcription factors recruit Ndd1 to the chromatin of G2/M-specific promoters

scientific article

From a single double helix to paired double helices and back

scientific article

Functional genomics identifies monopolin: a kinetochore protein required for segregation of homologs during meiosis i.

scientific article

GMI1, a structural-maintenance-of-chromosomes-hinge domain-containing protein, is involved in somatic homologous recombination in Arabidopsis

scientific article

HSPC117 is the essential subunit of a human tRNA splicing ligase complex

scientific article

HUWE1 employs a giant substrate-binding ring to feed and regulate its HECT E3 domain

scientific article published on 22 July 2021

High-throughput knockout screen in fission yeast

scientific article published on January 2006

Human Scc4 is required for cohesin binding to chromatin, sister-chromatid cohesion, and mitotic progression

scientific article

Inhibitory effect of TIS7 on Sp1-C/EBPalpha transcription factor module activity

scientific article published in February 2004

Kinetochore recruitment of two nucleolar proteins is required for homolog segregation in meiosis I.

scientific article

Kleisins: a superfamily of bacterial and eukaryotic SMC protein partners

scientific article

LSD1 inhibition induces differentiation and cell death in Merkel cell carcinoma

scientific article published on 07 October 2020

Laser microsurgery provides evidence for merotelic kinetochore attachments in fission yeast cells lacking Pcs1 or Clr4.

scientific article

Linear ubiquitination by LUBEL has a role in Drosophila heat stress response.

scientific article published on 04 October 2016

MYRbase: analysis of genome-wide glycine myristoylation enlarges the functional spectrum of eukaryotic myristoylated proteins

scientific article

Mammalian inscuteable regulates spindle orientation and cell fate in the developing retina

scientific article published on November 2005

Mitotic activation of the kinase Aurora-A requires its binding partner Bora

scientific article published on August 2006

Molecular processes during fat cell development revealed by gene expression profiling and functional annotation

scientific article

Mouse ANKRD31 Regulates Spatiotemporal Patterning of Meiotic Recombination Initiation and Ensures Recombination between X and Y Sex Chromosomes

scientific article published on 15 April 2019

Multilayered VBC score predicts sgRNAs that efficiently generate loss-of-function alleles

scientific article published on 08 June 2020

Proline-rich protein PRR19 functions with cyclin-like CNTD1 to promote meiotic crossing over in mouse

scientific article published on 18 June 2020

RNA degradation in fission yeast mitochondria is stimulated by a member of a new family of proteins that are conserved in lower eukaryotes

scientific article

Role of the RNA/DNA kinase Grc3 in transcription termination by RNA polymerase I

scientific article

Sister chromatid separation and chromosome re-duplication are regulated by different mechanisms in response to spindle damage

scientific article published on May 1999

Site-specific ubiquitination of the E3 ligase HOIP regulates apoptosis and immune signaling

scientific article published on 20 November 2020

Sororin mediates sister chromatid cohesion by antagonizing Wapl

scientific article

Structural basis for the disaggregase activity and regulation of Hsp104.

scientific article published on 30 November 2016

Switching transcription on and off during the yeast cell cycle: Cln/Cdc28 kinases activate bound transcription factor SBF (Swi4/Swi6) at start, whereas Clb/Cdc28 kinases displace it from the promoter in G2.

scientific article

Systematic analysis of human protein complexes identifies chromosome segregation proteins

scientific article

Taxonomy workbench

scientific article

The Drosophila meiotic kleisin C(2)M functions before the meiotic divisions

scientific article published on 30 July 2004

The Ly6/uPAR protein Bouncer is necessary and sufficient for species-specific fertilization

scientific article

The kinetochore proteins Pcs1 and Mde4 and heterochromatin are required to prevent merotelic orientation

scientific article published on July 2007

The transmembrane protein Golden goal regulates R8 photoreceptor axon-axon and axon-target interactions

scientific article

Topology and structure of an engineered human cohesin complex bound to Pds5B.

scientific article

Two fission yeast homologs of Drosophila Mei-S332 are required for chromosome segregation during meiosis I and II.

scientific article published in February 2004

Wapl controls the dynamic association of cohesin with chromatin

scientific article

Yeast cohesin complex requires a conserved protein, Eco1p(Ctf7), to establish cohesion between sister chromatids during DNA replication

scientific article

Zebrafish Ski7 tunes RNA levels during the oocyte-to-embryo transition

scientific article published on 18 February 2021

List of works by Alexander Schleiffer

A Caenorhabditis elegans cohesion protein with functions in meiotic chromosome pairing and disjunction

A REC8-dependent plant Shugoshin is required for maintenance of centromeric cohesion during meiosis and has no mitotic functions

A cooperative mechanism drives budding yeast kinetochore assembly downstream of CENP-A.

A high-throughput method to identify trans-activation domains within transcription factor sequences

A screen for genes required for meiosis and spore formation based on whole-genome expression.

A structural basis for kinetochore recruitment of the Ndc80 complex via two distinct centromere receptors

ANGEL2 is a member of the CCR4 family of deadenylases with 2',3'-cyclic phosphatase activity

ANNIE: integrated de novo protein sequence annotation

Analysis of orthologous groups reveals archease and DDX1 as tRNA splicing factors

Arabidopsis SMG7 protein is required for exit from meiosis.

Augmenting β-augmentation: structural basis of how BamB binds BamA and may support folding of outer membrane proteins

CENP-T proteins are conserved centromere receptors of the Ndc80 complex

Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complex

Combinatorial activation and repression by seven transcription factors specify Drosophila odorant receptor expression

DOUTfinder--identification of distant domain outliers using subsignificant sequence similarity

Dbl2 Regulates Rad51 and DNA Joint Molecule Metabolism to Ensure Proper Meiotic Chromosome Segregation

Deep and precise quantification of the mouse synaptosomal proteome reveals substantial remodeling during postnatal maturation

Diversity and roles of (t)RNA ligases

Eco1 is a novel acetyltransferase that can acetylate proteins involved in cohesion

Endosome and Golgi-associated degradation (EGAD) of membrane proteins regulates sphingolipid metabolism

Family matters: structural and functional conservation of centromere-associated proteins from yeast to humans

Forkhead-like transcription factors recruit Ndd1 to the chromatin of G2/M-specific promoters

From a single double helix to paired double helices and back

Functional genomics identifies monopolin: a kinetochore protein required for segregation of homologs during meiosis i.

GMI1, a structural-maintenance-of-chromosomes-hinge domain-containing protein, is involved in somatic homologous recombination in Arabidopsis

HSPC117 is the essential subunit of a human tRNA splicing ligase complex

HUWE1 employs a giant substrate-binding ring to feed and regulate its HECT E3 domain

High-throughput knockout screen in fission yeast

Human Scc4 is required for cohesin binding to chromatin, sister-chromatid cohesion, and mitotic progression

Inhibitory effect of TIS7 on Sp1-C/EBPalpha transcription factor module activity

Kinetochore recruitment of two nucleolar proteins is required for homolog segregation in meiosis I.

Kleisins: a superfamily of bacterial and eukaryotic SMC protein partners

LSD1 inhibition induces differentiation and cell death in Merkel cell carcinoma

Laser microsurgery provides evidence for merotelic kinetochore attachments in fission yeast cells lacking Pcs1 or Clr4.

Linear ubiquitination by LUBEL has a role in Drosophila heat stress response.

MYRbase: analysis of genome-wide glycine myristoylation enlarges the functional spectrum of eukaryotic myristoylated proteins

Mammalian inscuteable regulates spindle orientation and cell fate in the developing retina

Mitotic activation of the kinase Aurora-A requires its binding partner Bora

Molecular processes during fat cell development revealed by gene expression profiling and functional annotation

Mouse ANKRD31 Regulates Spatiotemporal Patterning of Meiotic Recombination Initiation and Ensures Recombination between X and Y Sex Chromosomes

Multilayered VBC score predicts sgRNAs that efficiently generate loss-of-function alleles

Proline-rich protein PRR19 functions with cyclin-like CNTD1 to promote meiotic crossing over in mouse

RNA degradation in fission yeast mitochondria is stimulated by a member of a new family of proteins that are conserved in lower eukaryotes

Role of the RNA/DNA kinase Grc3 in transcription termination by RNA polymerase I

Sister chromatid separation and chromosome re-duplication are regulated by different mechanisms in response to spindle damage

Site-specific ubiquitination of the E3 ligase HOIP regulates apoptosis and immune signaling

Sororin mediates sister chromatid cohesion by antagonizing Wapl

Structural basis for the disaggregase activity and regulation of Hsp104.

Switching transcription on and off during the yeast cell cycle: Cln/Cdc28 kinases activate bound transcription factor SBF (Swi4/Swi6) at start, whereas Clb/Cdc28 kinases displace it from the promoter in G2.

Systematic analysis of human protein complexes identifies chromosome segregation proteins

Taxonomy workbench

The Drosophila meiotic kleisin C(2)M functions before the meiotic divisions

The Ly6/uPAR protein Bouncer is necessary and sufficient for species-specific fertilization

The kinetochore proteins Pcs1 and Mde4 and heterochromatin are required to prevent merotelic orientation

The transmembrane protein Golden goal regulates R8 photoreceptor axon-axon and axon-target interactions

Topology and structure of an engineered human cohesin complex bound to Pds5B.

Two fission yeast homologs of Drosophila Mei-S332 are required for chromosome segregation during meiosis I and II.

Wapl controls the dynamic association of cohesin with chromatin

Yeast cohesin complex requires a conserved protein, Eco1p(Ctf7), to establish cohesion between sister chromatids during DNA replication

Zebrafish Ski7 tunes RNA levels during the oocyte-to-embryo transition