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List of works by Yuan-Ping Pang

A potent and selective tacrine analog--biomembrane permeation and physicochemical characterization

scientific article published on 01 January 2005

A single amino acid of the human and rat neurotensin receptors (subtype 1) determining the pharmacological profile of a species-selective neurotensin agonist

scientific article

ABCC9 mutations identified in human dilated cardiomyopathy disrupt catalytic KATP channel gating

scientific article

Accurate reproduction of 161 small-molecule complex crystal structures using the EUDOC program: expanding the use of EUDOC to supramolecular chemistry

scientific article

Acetylcholinesterase complexed with bivalent ligands related to huperzine a: experimental evidence for species-dependent protein-ligand complementarity

scientific article

Activation of transcription factor MEF2D by bis(3)-cognitin protects dopaminergic neurons and ameliorates Parkinsonian motor defects.

scientific article

Alkylene tether-length dependent gamma-aminobutyric acid type A receptor competitive antagonism by tacrine dimers

scientific article published on 20 October 2006

At least 10% shorter C-H bonds in cryogenic protein crystal structures than in current AMBER forcefields

scientific article published on 4 February 2015

Atomic levers control pyranose ring conformations.

scientific article

Bak Conformational Changes Induced by Ligand Binding: Insight into BH3 Domain Binding and Bak Homo-Oligomerization

scientific article published on 10 February 2012

Bis(7)-tacrine attenuates beta amyloid-induced neuronal apoptosis by regulating L-type calcium channels

scientific article published on 12 June 2006

Bis(7)-tacrine prevents glutamate-induced excitotoxicity more potently than memantine by selectively inhibiting NMDA receptors.

scientific article published on 6 March 2008

Bis(7)-tacrine, a novel acetylcholinesterase inhibitor, reverses AF64A-induced deficits in navigational memory in rats

scientific article published in March 2000

Bis(7)-tacrine, a promising anti-Alzheimer's agent, reduces hydrogen peroxide-induced injury in rat pheochromocytoma cells: comparison with tacrine

scientific article published on 01 September 2000

Bis(7)-tacrine, a promising anti-Alzheimer's dimer, affords dose- and time-dependent neuroprotection against transient focal cerebral ischemia

scientific article published on 8 May 2008

Bis(propyl)-cognitin protects against glutamate-induced neuro-excitotoxicity via concurrent regulation of NO, MAPK/ERK and PI3-K/Akt/GSK3β pathways

scientific article published on 26 January 2013

Bis-imidazoles as molecular probes for peripheral sites of the zinc endopeptidase of botulinum neurotoxin serotype A.

scientific article published on 2 February 2006

CFAP45 deficiency causes situs abnormalities and asthenospermia by disrupting an axonemal adenine nucleotide homeostasis module

scientific article published on 02 November 2020

Casp8p41 generated by HIV protease kills CD4 T cells through direct Bak activation

scientific article

Casp8p41 generated by HIV protease kills CD4 T cells through direct Bak activation.

scientific article

Characterization of an alternative BAK-binding site for BH3 peptides

scientific article published on 03 July 2020

Chemical structure of Retro-2, a compound that protects cells against ribosome-inactivating proteins

scientific article

Chimeric rat/human neurotensin receptors localize a region of the receptor sensitive to binding of a novel, species-specific, picomolar affinity peptide

scientific article

Cholinergic and non-cholinergic functions of two acetylcholinesterase genes revealed by gene-silencing in Tribolium castaneum.

scientific article published on 27 February 2012

Cholinesterase reactivation in vivo with a novel bis-oxime optimized by computer-aided design

scientific article published on 31 July 2003

Cocaine metabolism accelerated by a re-engineered human butyrylcholinesterase

scientific article

Common pharmacophore of structurally distinct small-molecule inhibitors of intracellular retrograde trafficking of ribosome inactivating proteins

scientific article

Complexes of Alkylene-Linked Tacrine Dimers withTorpedo californicaAcetylcholinesterase: Binding of Bis(5)-tacrine Produces a Dramatic Rearrangement in the Active-Site Gorge

scientific article published on 01 September 2006

Computer-aided lead optimization: improved small-molecule inhibitor of the zinc endopeptidase of botulinum neurotoxin serotype A

scientific article

Configurational entropy in protein-peptide binding: computational study of Tsg101 ubiquitin E2 variant domain with an HIV-derived PTAP nonapeptide

scientific article

Convenient Synthesis of a Library of Discrete Hydroxamic Acids Using the Hydroxythiophenol (Marshall) Resin

scientific article published on February 2008

Corrigendum to 'Protection against ischemic injury in primary cultured mouse astrocytes by bis(7)-tacrine, a novel acetylcholinesterase inhibitor' [Neurosci. Lett. 288 (2000) 95–98]

scientific article published on 01 August 2000

Critical role of the FERM domain in Pyk2 stimulated glioma cell migration

scientific article published on 31 August 2006

Crystal Packing Mediates Enantioselective Ligand Recognition at the Peripheral Site of Acetylcholinesterase

scientific article published on 01 August 2005

Crystal structures of acetylcholinesterase in complex with HI-6, Ortho-7 and obidoxime: structural basis for differences in the ability to reactivate tabun conjugates

scientific article published on 31 July 2006

Crystal structures of oxime-bound fenamiphos-acetylcholinesterases: reactivation involving flipping of the His447 ring to form a reactive Glu334-His447-oxime triad

scientific article

Development of a high performance liquid chromatography-tandem mass method for determination of bis(7)-tacrine, a promising anti-Alzheimer's dimer, in rat blood

article

Differential binding of Sin3 interacting repressor domains to the PAH2 domain of Sin3A

scientific article published on 01 July 2003

Dimeric bis (heptyl)-Cognitin Blocks Alzheimer's β-Amyloid Neurotoxicity Via the Inhibition of Aβ Fibrils Formation and Disaggregation of Preformed Fibrils

scientific article published on 28 October 2015

Discovery of a new inhibitor lead of adenovirus proteinase: steps toward selective, irreversible inhibitors of cysteine proteinases.

scientific article

Dual-site binding of bivalent 4-aminopyridine- and 4-aminoquinoline-based AChE inhibitors: contribution of the hydrophobic alkylene tether to monomer and dimer affinities

scientific article published on 01 November 1999

EUDOC: a computer program for identification of drug interaction sites in macromolecules and drug leads from chemical databases

scientific article published on 01 November 2001

East meets West in the search for Alzheimer's therapeutics - novel dimeric inhibitors from tacrine and huperzine A.

scientific article

Enzymatic activation of pyruvate kinase increases cytosolic oxaloacetate to inhibit the Warburg effect

scientific article published on 05 July 2021

Evaluation of short-tether bis-THA AChE inhibitors. A further test of the dual binding site hypothesis

scientific article published in February 1999

Evaluation of the BH3-only protein Puma as a direct Bak activator

scientific article

FF12MC: A revised AMBER forcefield and new protein simulation protocol

scientific article

From genome to drug lead: identification of a small-molecule inhibitor of the SARS virus

scientific article

Genome organization, phylogenies, expression patterns, and three-dimensional protein models of two acetylcholinesterase genes from the red flour beetle

scientific article

Heterodimeric Tacrine-Based Acetylcholinesterase Inhibitors: Investigating Ligand−Peripheral Site Interactions

scientific article published on 01 October 1999

Highly potent, selective, and low cost bis-tetrahydroaminacrine inhibitors of acetylcholinesterase. Steps toward novel drugs for treating Alzheimer's disease

scientific article published in September 1996

How fast fast-folding proteins fold in silico

scientific article published on 9 August 2017

Improved loading and cleavage methods for solid-phase synthesis using chlorotrityl resins: synthesis and testing of a library of 144 discrete chemicals as potential farnesyltransferase inhibitors

scientific article published in May 2004

In silico drug discovery: solving the "target-rich and lead-poor" imbalance using the genome-to-drug-lead paradigm

scientific article published on 01 January 2007

In vitro binding and CNS effects of novel neurotensin agonists that cross the blood-brain barrier

scientific article

Inhibition by bis(7)-tacrine of native delayed rectifier and KV1.2 encoded potassium channels

scientific article published on 15 December 2006

Inhibition of NMDA-gated ion channels by bis(7)-tacrine: whole-cell and single-channel studies

scientific article published on 2 March 2008

Inhibition of mitochondrial respiration as a source of adaphostin-induced reactive oxygen species and cytotoxicity.

scientific article published on 9 January 2007

Insect-specific irreversible inhibitors of acetylcholinesterase in pests including the bed bug, the eastern yellowjacket, German and American cockroaches, and the confused flour beetle

scientific article published on 28 January 2010

Kinetic analysis of interactions between alkylene-linked bis-pyridiniumaldoximes and human acetylcholinesterases inhibited by various organophosphorus compounds

scientific article published on 26 May 2010

Low-mass molecular dynamics simulation for configurational sampling enhancement: More evidence and theoretical explanation

scientific article published on 2 September 2015

Low-mass molecular dynamics simulation: a simple and generic technique to enhance configurational sampling

scientific article published on 30 August 2014

Mechanism of bis(7)-tacrine inhibition of GABA-activated current in cultured rat hippocampal neurons.

scientific article published on 22 April 2009

Mitochondrial proteomic analysis and characterization of the intracellular mechanisms of bis(7)-tacrine in protecting against glutamate-induced excitotoxicity in primary cultured neurons.

scientific article

Modulation of mitochondrial complex I activity averts cognitive decline in multiple animal models of familial Alzheimer's Disease

scientific article published on April 2015

Neuroprotection via inhibition of nitric oxide synthase by bis(7)-tacrine

scientific article published in April 2006

Nonbonded bivalence approach to cell-permeable molecules that target DNA sequences

scientific article published on 01 June 2004

Normal-mode-analysis-monitored energy minimization procedure for generating small-molecule bound conformations

scientific article

Novel acetylcholinesterase target site for malaria mosquito control

scientific article

Novel and viable acetylcholinesterase target site for developing effective and environmentally safe insecticides

scientific article

Novel anti-Alzheimer's dimer Bis(7)-cognitin: cellular and molecular mechanisms of neuroprotection through multiple targets

scientific article published on January 2009

Novel dimeric acetylcholinesterase inhibitor bis7-tacrine, but not donepezil, prevents glutamate-induced neuronal apoptosis by blocking N-methyl-D-aspartate receptors

scientific article published on 14 February 2005

Novel dimeric bis(7)-tacrine proton-dependently inhibits NMDA-activated currents

scientific article published on 20 July 2007

Novel selective and irreversible mosquito acetylcholinesterase inhibitors for controlling malaria and other mosquito-borne diseases

scientific article published on 15 January 2013

On the use of the experimentally determined enzyme inhibition constant as a measure of absolute binding affinity

scientific article published on 29 May 2017

Parkin Regulates Mitosis and Genomic Stability through Cdc20/Cdh1. ⬇️

scientific article

Pathologically activated neuroprotection via uncompetitive blockade of N-methyl-D-aspartate receptors with fast off-rate by novel multifunctional dimer bis(propyl)-cognitin

scientific article

Peptide-Binding Groove Contraction Linked to the Lack of T Cell Response: Using Complex Structure and Energy To Identify Neoantigens

scientific article published on 10 August 2018

Pharmacological and biochemical profiles of unique neurotensin 8-13 analogs exhibiting species selectivity, stereoselectivity, and superagonism

scientific article published on August 1995

Physiological roles for butyrylcholinesterase: A BChE-ghrelin axis

scientific article published on 22 February 2016

Plasma butyrylcholinesterase regulates ghrelin to control aggression

scientific article

Polysaccharide elasticity governed by chair–boat transitions of the glucopyranose ring

scientific article published in Nature

Potent new small-molecule inhibitor of botulinum neurotoxin serotype A endopeptidase developed by synthesis-based computer-aided molecular design

scientific article (publication date: 10 November 2009)

Potent, easily synthesized huperzine A-tacrine hybrid acetylcholinesterase inhibitors

scientific article published on 01 August 1999

Preclinical characterization of intestinal absorption and metabolism of promising anti-Alzheimer's dimer bis(7)-tacrine

scientific article published on 02 February 2008

Predicted Michaelis-Menten complexes of cocaine-butyrylcholinesterase. Engineering effective butyrylcholinesterase mutants for cocaine detoxication

scientific article

Prediction of the binding site of 1-benzyl-4-[(5,6-dimethoxy-1-indanon-2-yl)methyl]piperidine in acetylcholinesterase by docking studies with the SYSDOC program

scientific article

Prediction of the binding sites of huperzine A in acetylcholinesterase by docking studies

scientific article published in December 1994

Preference of small molecules for local minimum conformations when binding to proteins

scientific article

Prime, Shock, and Kill: Priming CD4 T Cells from HIV Patients with a BCL-2 Antagonist before HIV Reactivation Reduces HIV Reservoir Size

scientific article published on 3 February 2016

Promising anti-Alzheimer's dimer bis(7)-tacrine reduces beta-amyloid generation by directly inhibiting BACE-1 activity

scientific article published on 26 November 2007

Promising multifunctional anti-Alzheimer's dimer bis(7)-Cognitin acting as an activator of protein kinase C regulates activities of alpha-secretase and BACE-1 concurrently

scientific article published on 16 September 2009

Protection against β-amyloid-induced synaptic and memory impairments via altering β-amyloid assembly by bis(heptyl)-cognitin

scientific article published on 21 July 2015

Proteomics shows Hsp70 does not bind peptide sequences indiscriminately in vivo

scientific article published on July 2004

Rational design of alkylene-linked bis-pyridiniumaldoximes as improved acetylcholinesterase reactivators

scientific article published in June 2003

Rational design of novel neurotensin mimetics: discovery of a pharmacologically unprecedented agent exhibiting concentration-dependent dual effects as antagonist and full agonist

scientific article published on 01 August 1994

Re-engineering butyrylcholinesterase as a cocaine hydrolase

scientific article

Regulation of error-prone translesion synthesis by Spartan/C1orf124.

scientific article published on 18 December 2012

Robust Neuritogenesis-Promoting Activity by Bis(heptyl)-Cognitin Through the Activation of alpha7-Nicotinic Acetylcholine Receptor/ERK Pathway.

scientific article

Schisandrin B protects against tacrine- and bis(7)-tacrine-induced hepatotoxicity and enhances cognitive function in mice.

scientific article published in March 2002

Selective and Irreversible Inhibitors of Mosquito Acetylcholinesterases for Controlling Malaria and Other Mosquito-Borne Diseases

scientific article

Serotype-selective, small-molecule inhibitors of the zinc endopeptidase of botulinum neurotoxin serotype A

scientific article published on 03 October 2005

Small molecules showing significant protection of mice against botulinum neurotoxin serotype A

scientific article (publication date: 13 April 2010)

Small-Molecule Inhibitor Leads of Ribosome-Inactivating Proteins Developed Using the Doorstop Approach ⬇️

scientific article published on March 24, 2011

Species marker for developing novel and safe pesticides

scientific article published on 12 October 2006

Structure of HI-6*sarin-acetylcholinesterase determined by X-ray crystallography and molecular dynamics simulation: reactivator mechanism and design

scientific article published in 2009

Substantial Neuroprotective and Neurite Outgrowth-Promoting Activities by Bis(propyl)-cognitin via the Activation of Alpha7-nAChR, a Promising Anti-Alzheimer's Dimer

scientific article published on 16 July 2015

Substantial neuroprotection against K+ deprivation-induced apoptosis in primary cerebellar granule neurons by novel dimer bis(propyl)-cognitin via the activation of VEGFR-2 signaling pathway

scientific article

Successful Virtual Screening of a Chemical Database for Farnesyltransferase Inhibitor Leads

scientific article published on 01 February 2000

Successful molecular dynamics simulation of two zinc complexes bridged by a hydroxide in phosphotriesterase using the cationic dummy atom method

scientific article

Synergistic neuroprotection by bis(7)-tacrine via concurrent blockade of N-methyl-D-aspartate receptors and neuronal nitric-oxide synthase.

scientific article

The antiangiogenic activity of cleaved high molecular weight kininogen is mediated through binding to endothelial cell tropomyosin

scientific article

The physicochemical properties and the in vivo AChE inhibition of two potential anti-Alzheimer agents, bis(12)-hupyridone and bis(7)-tacrine

scientific article published on 4 September 2007

Theoretical 3D model of histamine N-methyltransferase: insights into the effects of a genetic polymorphism on enzymatic activity and thermal stability

scientific article

Three-dimensional model of a substrate-bound SARS chymotrypsin-like cysteine proteinase predicted by multiple molecular dynamics simulations: catalytic efficiency regulated by substrate binding

scientific article published in December 2004

Transient binding of an activator BH3 domain to the Bak BH3-binding groove initiates Bak oligomerization

scientific article published on 4 July 2011

Use of 1-4 interaction scaling factors to control the conformational equilibrium between α-helix and β-strand

scientific article published on 25 December 2014

Use of multiple picosecond high-mass molecular dynamics simulations to predict crystallographic B-factors of folded globular proteins

scientific article published on 20 September 2016

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