List of works by Orla Sheils

A molecular expression signature distinguishing follicular lesions in thyroid carcinoma using preamplification RT-PCR in archival samples.

scientific article

A novel role for the macrophage galactose-type lectin (MGL) receptor in mediating von Willebrand factor clearance.

scientific article published on 27 December 2017

Activated eosinophils in association with enteric nerves in inflammatory bowel disease

scientific article

Adenovirus 12 E1A gene detection by polymerase chain reaction in both the normal and coeliac duodenum

scientific article published in September 1994

All azoospermic males should be screened for cystic fibrosis mutations before intracytoplasmic sperm injection

scientific article

Altered eIF6 and Dicer expression is associated with clinicopathological features in ovarian serous carcinoma patients.

scientific article

Altered expression of mir-222 and mir-25 influences diverse gene expression changes in transformed normal and anaplastic thyroid cells, and impacts on MEK and TRAIL protein expression.

scientific article published on 22 June 2016

An Association between MicroRNA-21 Expression and Vitamin D Deficiency in Coronary Artery Disease.

scientific article published in January 2015

An integrated analysis of the SOX2 microRNA response program in human pluripotent and nullipotent stem cell lines.

scientific article

An integrative model for recurrence in ovarian cancer.

scientific article

Analysis of DNA in endometrial cancer cells treated with phyto-estrogenic compounds using comparative genomic hybridisation microarrays.

scientific article published on May 2005

Array comparative genomic hybridisation analysis of gamma-irradiated human thyrocytes

scientific article published on 17 July 2004

Aspirin and P2Y12 inhibition attenuate platelet-induced ovarian cancer cell invasion.

scientific article published on 9 September 2015

Assessment of ret/PTC-1 rearrangements in neoplastic thyroid tissue using TaqMan RT-PCR.

scientific article published on September 2000

BRAF T1799A mutation occurring in a case of malignant struma ovarii.

scientific article published in April 2007

BRAFV600E: implications for carcinogenesis and molecular therapy

scientific article published on March 2011

Cellular localisation of HHV-8 in Castleman's disease: is there a link with lymph node vascularity?

scientific article published in April 2000

Clinical utility of using C-reactive protein and procalcitonin as biomarkers for a novel neonatal sepsis diagnostic platform (ASCMicroPlat).

scientific article published on 14 November 2012

Colocalisation of human immunodeficiency virus and human cytomegalovirus infection in brain autopsy tissue from AIDS patients

scientific article published in April 1996

Comparing ion torrent with pyrosequencing and Sanger sequencing for the detection of TP53 mutations in colorectal cancer

scientific article published on 11 February 2014

Comparison of miRNA expression patterns using total RNA extracted from matched samples of formalin-fixed paraffin-embedded (FFPE) cells and snap frozen cells

scientific article

Complement activation within the coeliac small intestine is localised to Brunner's glands

scientific article published on November 1989

Detection of Epstein-Barr virus DNA in tongue tissues from AIDS autopsies without clinical evidence of oral hairy leukoplakia

scientific article

Detection of a tyrosine phosphatase LAR on intestinal epithelial cells and intraepithelial lymphocytes in the human duodenum

scientific article published on February 2005

Detection of measles virus in children with ileo-colonic lymphoid nodular hyperplasia, enterocolitis and developmental disorder

scientific article published in January 2002

Development of a semi-conductor sequencing-based panel for genotyping of colon and lung cancer by the Onconetwork consortium

scientific article

Distinct array comparative genomic hybridization profiles in oral squamous cell carcinoma occurring in young patients.

scientific article

Effect of BRAFV600E mutation on transcription and post-transcriptional regulation in a papillary thyroid carcinoma model

scientific article published on 13 March 2007

Effect of cyclosporin on immune complex deposition in murine glomerulonephritis

scientific article published in April 1991

Effect of ret/PTC 1 rearrangement on transcription and post-transcriptional regulation in a papillary thyroid carcinoma model

scientific article published on 11 December 2006

Enhanced regulation of cell cycle and suppression of osteoblast differentiation molecular signatures by prostate cancer stem-like holoclones

scientific article published on 2 June 2015

Epitope presentation is an important determinant of the utility of antigens identified from protein arrays in the development of autoantibody diagnostic assays

article

Evaluation of Zinc-α-2-Glycoprotein and Proteasome Subunit β-Type 6 Expression in Prostate Cancer Using Tissue Microarray Technology

scientific article

Expression microarray analysis of papillary thyroid carcinoma and benign thyroid tissue: emphasis on the follicular variant and potential markers of malignancy

scientific article published on 25 January 2007

Expression profile of human herpesvirus 8 (HHV-8) in pyothorax associated lymphoma and in effusion lymphoma

scientific article published on April 2001

FOXA1 is a potential oncogene in anaplastic thyroid carcinoma

scientific article

Free fetal DNA is not increased before 20 weeks in intrauterine growth restriction or pre-eclampsia

scientific article published on 01 February 2007

Gene expression analysis of diagnostic biopsies predicts pathological response to neoadjuvant chemoradiotherapy of esophageal cancer

scientific article published in November 2009

Gene expression profiling in cervical cancer: identification of novel markers for disease diagnosis and therapy.

scientific article published in January 2009

Genome-wide analysis of deoxyribonucleic acid in endometrial cancer using comparative genomic hybridization microarrays.

scientific article

Geographical mapping of a multifocal thyroid tumour using genetic alteration analysis & miRNA profiling.

scientific article published on 4 December 2008

Global mRNA analysis to determine a transcriptome profile of cancer stemness in a mouse model.

scientific article

HPV vaccine acceptability in HIV-infected and HIV negative men who have sex with men (MSM) in Ireland

scientific article published on 06 May 2016

Heterogeneous expression of ?-methylacyl-CoA racemase in prostatic cancer correlates with Gleason score

scientific article published in January 2007

Human papillomavirus (HPV) and the usefulness of the HPV vaccine for men who have sex with men.

scientific article published on 8 May 2014

Human papillomavirus DNA and mRNA prevalence and association with cervical cytological abnormalities in the Irish HIV population.

scientific article published on 25 September 2014

Identifying novel hypoxia-associated markers of chemoresistance in ovarian cancer.

scientific article published on 25 July 2015

Improved RNA quality and TaqMan Pre-amplification method (PreAmp) to enhance expression analysis from formalin fixed paraffin embedded (FFPE) materials

scientific article

Improved in situ detection method for telomeric tandem repeats in metaphase spreads and interphase nuclei.

scientific article published on February 2000

Inkjet-like printing of single-cells

scientific article

Interleukin-15 is associated with disease severity in viral bronchiolitis

scientific article published on 5 November 2015

Irish society of gastroenterology. Proceedings of meeting held

proceedings abstracts

Lack of association between measles virus vaccine and autism with enteropathy: a case-control study

scientific article

Ligation of TLR7 on CD19(+) CD1d(hi) B cells suppresses allergic lung inflammation via regulatory T cells.

scientific article published on 14 April 2015

Localisation of HHV-8 in AIDS related lymphadenopathy

scientific article published on February 2000

Low MAD2 expression levels associate with reduced progression-free survival in patients with high-grade serous epithelial ovarian cancer

scientific article published on 17 January 2012

Low-Level TOP2A Amplification in Prostate Cancer Is Associated with HER2 Duplication, Androgen Resistance, and Decreased Survival

scientific article published on 15 March 2007

Low-level genomic instability is a feature of papillary thyroid carcinoma: an array comparative genomic hybridization study of laser capture microdissected papillary thyroid carcinoma tumors and clonal cell lines

scientific article

MIR141 Expression Differentiates Hashimoto Thyroiditis from PTC and Benign Thyrocytes in Irish Archival Thyroid Tissues.

scientific article

MYBL2 (B-MYB) in cervical cancer: putative biomarker

scientific article

MicroRNA-31 modulates tumour sensitivity to radiation in oesophageal adenocarcinoma.

scientific article

Molecular classification and biomarker discovery in papillary thyroid carcinoma

scientific article

Molecular pathology of prostate cancer

scientific article

N-linked glycan truncation causes enhanced clearance of plasma-derived von Willebrand factor.

scientific article

N-linked glycans within the A2 domain of von Willebrand factor modulate macrophage-mediated clearance.

scientific article published on 23 August 2016

Oestrogen regulated gene expression in normal and malignant endometrial tissue

scientific article published in June 2005

P16INK4A positivity in benign, premalignant and malignant cervical glandular lesions: a potential diagnostic problem

scientific article published on 18 September 2004

Peripheral blood microRNA and VEGFA mRNA changes following electroconvulsive therapy: implications for psychotic depression.

scientific article

Platelet adhesion and degranulation induce pro-survival and pro-angiogenic signalling in ovarian cancer cells.

scientific article

Pluripotency markers are differentially induced by MEK inhibition in thyroid and melanoma BRAFV600E cell lines.

scientific article published on February 2016

Potential role of miR-9 and miR-223 in recurrent ovarian cancer

scientific article

Potential viral pathogenic mechanism for new variant inflammatory bowel disease

scientific article

Potentially important microRNA cluster on chromosome 17p13.1 in primary peritoneal carcinoma

scientific article

Prevalence of human papillomavirus in men who have sex with men in the era of an effective vaccine; a call to act.

scientific article published on 24 March 2014

Quantitation of CDC6 and MCM5 mRNA in cervical intraepithelial neoplasia and invasive squamous cell carcinoma of the cervix

scientific article published on 01 June 2005

RET protein expression in papillary renal cell carcinoma

scientific article published on 10 March 2011

RET/PTC rearrangement occurring in primary peritoneal carcinoma.

scientific article

RET/PTC rearrangements in Hashimoto's thyroiditis

scientific article published in April 2002

Rapid and fully automated bacterial pathogen detection on a centrifugal-microfluidic LabDisk using highly sensitive nested PCR with integrated sample preparation

scientific article

Real-time analysis of beta- and gamma-catenin mRNA expression in ret/PTC-1 activated and nonactivated thyroid tissues.

scientific article

Real-time quantitative analysis of E-cadherin expression in ret/PTC-1-activated thyroid neoplasms

scientific article

Regulation of microRNA biosynthesis and expression in 2102Ep embryonal carcinoma stem cells is mirrored in ovarian serous adenocarcinoma patients.

scientific article

Response to letter: limitations of human papillomavirus DNA testing in measuring previous exposure and vaccine protection

scientific article published on 9 February 2016

Ret/PTC chimeric transcripts in an Irish cohort of sporadic papillary thyroid carcinoma

scientific article published in February 2003

Sorting out mix-ups. The provenance of tissue sections may be confirmed by PCR using microsatellite markers

scientific article published in December 1996

Squamous cell carcinoma of the head and neck in young Irish adults

scientific article published in June 2006

Suppression of cancer stemness p21-regulating mRNA and microRNA signatures in recurrent ovarian cancer patient samples

scientific article published on 19 January 2012

TSH receptor status of thyroid neoplasms--TaqMan RT-PCR analysis of archival material

scientific article published on May 1999

The ExPeCT (Examining Exercise, Prostate Cancer and Circulating Tumour Cells) trial: study protocol for a randomised controlled trial.

scientific article published on 4 October 2017

The MyD88+ phenotype is an adverse prognostic factor in epithelial ovarian cancer

scientific article

The evidence base for circulating tumour DNA blood-based biomarkers for the early detection of cancer: a systematic mapping review ⬇️

scientific article published on 23 October 2017

The role of secreted frizzled-related protein 2 expression in prostate cancer.

scientific article

Topoisomerase II-alpha expression increases with increasing Gleason score and with hormone insensitivity in prostate carcinoma

scientific article published on 23 March 2006

Tyrosine phosphorylation in the human duodenum

scientific article published on January 1995

miR-223 potentially targets SWI/SNF complex protein SMARCD1 in atypical proliferative serous tumor and high-grade ovarian serous carcinoma

scientific article published on 24 October 2017

miR-29b expression is associated with disease-free survival in patients with ovarian serous carcinoma.

scientific article

p16(INK4A) genetic and epigenetic profiles differ in relation to age and site in head and neck squamous cell carcinomas

scientific article published in March 2008

p16INK4A as a marker for cervical dyskaryosis: CIN and cGIN in cervical biopsies and ThinPrep smears.

scientific article published on January 2003

p16INK4A, CDC6, and MCM5: predictive biomarkers in cervical preinvasive neoplasia and cervical cancer

scientific article published on May 2005

ret/PTC and BRAF act as distinct molecular, time-dependant triggers in a sporadic Irish cohort of papillary thyroid carcinoma

scientific article published in January 2005

ret/PTC-1 Activation in Hashimoto Thyroiditis

scientific article published in July 2000

ret/PTC-1 expression alters the immunoprofile of thyroid follicular cells

scientific article published on 27 May 2008

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