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List of works by Nicholas J. Timpson

A Genome-Wide Association Meta-Analysis of Attention-Deficit/Hyperactivity Disorder Symptoms in Population-Based Pediatric Cohorts

scientific article published on 05 August 2016

A Protein Domain and Family Based Approach to Rare Variant Association Analysis

scientific article

A common haplotype of the glucokinase gene alters fasting glucose and birth weight: association in six studies and population-genetics analyses

scientific article published on 6 October 2006

A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity

scientific article

A common variant of HMGA2 is associated with adult and childhood height in the general population

scientific article

A genome-wide approach to children's aggressive behavior: The EAGLE consortium

scientific article published on 18 June 2015

A genome-wide association meta-analysis identifies new childhood obesity loci

scientific article

A genome-wide association meta-analysis of diarrhoeal disease in young children identifies FUT2 locus and provides plausible biological pathways.

scientific article

A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci

scientific article

A genome-wide association search for type 2 diabetes genes in African Americans

scientific article published on 4 January 2012

A genome-wide association study for corneal curvature identifies the platelet-derived growth factor receptor α gene as a quantitative trait locus for eye size in white Europeans.

scientific article published on 3 January 2013

A genome-wide association study of body mass index across early life and childhood

scientific article published on April 2015

A genome-wide association study reveals variants in ARL15 that influence adiponectin levels

scientific article

A meta-analysis of the associations between common variation in the PDE8B gene and thyroid hormone parameters, including assessment of longitudinal stability of associations over time and effect of thyroid hormone replacement

scientific article

A novel common variant in DCST2 is associated with length in early life and height in adulthood

scientific article published on 3 October 2014

A pathway-centric approach to rare variant association analysis

scientific article published on 31 August 2016

A population-based study of genetic variation and psychotic experiences in adolescents

scientific article

A powerful approach to sub-phenotype analysis in population-based genetic association studies

scientific article

A rare variant in APOC3 is associated with plasma triglyceride and VLDL levels in Europeans

scientific article

A recall-by-genotype study of CHRNA5-A3-B4 genotype, cotinine and smoking topography: study protocol

scientific article published on 22 January 2014

A reference panel of 64,976 haplotypes for genotype imputation

scientific article

A road map for efficient and reliable human genome epidemiology

scientific article published on January 2006

A trans-ancestral meta-analysis of genome-wide association studies reveals loci associated with childhood obesity

scientific article published on 01 October 2019

A variant in LIN28B is associated with 2D:4D finger-length ratio, a putative retrospective biomarker of prenatal testosterone exposure

scientific article

AHRR (cg05575921) hypomethylation marks smoking behaviour, morbidity and mortality

scientific article published on 18 January 2017

Adiponectin and its association with bone mass accrual in childhood

scientific article

Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association data

scientific article

Adult height variants affect birth length and growth rate in children

scientific article

Age 23 years + oral health questionnaire in Avon Longitudinal Study of Parents and Children.

scientific article

Age- and puberty-dependent association between IQ score in early childhood and depressive symptoms in adolescence

scientific article

Alcohol dehydrogenase type 1C (ADH1C) variants, alcohol consumption traits, HDL-cholesterol and risk of coronary heart disease in women and men: British Women's Heart and Health Study and Caerphilly cohorts

scientific article

An assessment of the portability of ancestry informative markers between human populations

scientific article

An interactive genome browser of association results from the UK10K cohorts project

scientific article published on 26 August 2015

Apparent latent structure within the UK Biobank sample has implications for epidemiological analysis

scientific article published in Nature Communications

Assessing causality in the association between child adiposity and physical activity levels: a Mendelian randomization analysis

scientific article (publication date: March 2014)

Assessing the causal association between 25-hydroxyvitamin D and the risk of oral and oropharyngeal cancer using Mendelian randomization.

scientific article

Assessing the utility of intermediate phenotypes for genetic mapping of psychiatric disease

scientific article published on 09 September 2014

Assessment and visualization of phenome-wide causal relationships using genetic data: an application to dental caries and periodontitis

scientific article published on 03 October 2020

Assessment of reproducibility and biological variability of fasting and postprandial plasma metabolite concentrations using 1H NMR spectroscopy

scientific article published on 20 June 2019

Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases: A Mendelian Randomization Study ⬇️

scientific article published on 23 February 2017

Association analysis of 31 common polymorphisms with type 2 diabetes and its related traits in Indian sib pairs

scientific article published on 4 November 2011

Association between C-reactive protein genotype, circulating levels, and aortic pulse wave velocity

scientific article published on 15 December 2008

Association between common variation at the FTO locus and changes in body mass index from infancy to late childhood: the complex nature of genetic association through growth and development

scientific article published on 17 February 2011

Association between fat mass through adolescence and arterial stiffness: a population-based study from The Avon Longitudinal Study of Parents and Children

scientific article published on 21 May 2019

Association between genetic variants on chromosome 15q25 locus and objective measures of tobacco exposure

scientific article

Association between polygenic risk scores for attention-deficit hyperactivity disorder and educational and cognitive outcomes in the general population

scientific article

Association of C-Reactive Protein With Blood Pressure and Hypertension

scientific article published on 24 February 2005

Association of a body mass index genetic risk score with growth throughout childhood and adolescence

scientific article

Association of genetic Loci with glucose levels in childhood and adolescence: a meta-analysis of over 6,000 children ⬇️

scientific article published on 22 April 2011

Association of maternal smoking with child cotinine levels

scientific article published on 23 July 2013

Association of plasma uric acid with ischaemic heart disease and blood pressure: mendelian randomisation analysis of two large cohorts

scientific article published on 18 July 2013

Association of the DRD2 gene Taq1A polymorphism and smoking behavior: a meta-analysis and new data

scientific article

Association study of 25 type 2 diabetes related Loci with measures of obesity in Indian sib pairs

scientific article

Associations of Body Mass and Fat Indexes With Cardiometabolic Traits

scientific article published on 01 December 2018

Associations of FTO and MC4R Variants with Obesity Traits in Indians and the Role of Rural/Urban Environment as a Possible Effect Modifier

scientific article published on 17 May 2011

Associations of Mitochondrial and Nuclear Mitochondrial Variants and Genes with Seven Metabolic Traits

article

Associations of autozygosity with a broad range of human phenotypes

scientific article published on 31 October 2019

Associations of device-measured physical activity across adolescence with metabolic traits: Prospective cohort study

scientific article published on 11 September 2018

Assumption-free estimation of the genetic contribution to refractive error across childhood.

scientific article published on 26 May 2015

Avoiding milk is associated with a reduced risk of insulin resistance and the metabolic syndrome: findings from the British Women's Heart and Health Study.

scientific article

BMI and Mortality in UK Biobank: Revised Estimates Using Mendelian Randomization

article

BMI as a Modifiable Risk Factor for Type 2 Diabetes: Refining and Understanding Causal Estimates Using Mendelian Randomization

scientific article published on 8 July 2016

Bias from questionnaire invitation and response in COVID-19 research: an example using ALSPAC

scientific article published on 08 July 2022

Blood pressure and mortality: using offspring blood pressure as an instrument for own blood pressure in the HUNT study

scientific article published on 22 July 2015

Body mass index: Has epidemiology started to break down causal contributions to health and disease?

scientific article

Body muscle gain and markers of cardiovascular disease susceptibility in young adulthood: A cohort study

scientific article published in 2021

C-reactive protein and its role in metabolic syndrome: mendelian randomisation study

scientific article published in December 2005

C-reactive protein levels and body mass index: elucidating direction of causation through reciprocal Mendelian randomization

scientific article published on 17 August 2010

Can lactase persistence genotype be used to reassess the relationship between renal cell carcinoma and milk drinking? Potentials and problems in the application of Mendelian randomization

scientific article

Characterising the index mothers in the Avon Longitudinal Study of Parents and Children (ALSPAC) who are also UKBioBank participants

scientific article published on 13 July 2022

Childhood gene-environment interactions and age-dependent effects of genetic variants associated with refractive error and myopia: The CREAM Consortium

scientific article published on 13 May 2016

Childhood intelligence is heritable, highly polygenic and associated with FNBP1L

scientific article

Chlamydia trachomatis in the age of the genome: application of molecular genotyping to improve our understanding of the immunopathogenesis of Chlamydia genital tract disease

scientific article published in June 2011

Cigarette smoke but not electronic cigarette aerosol activates a stress response in human coronary artery endothelial cells in culture

scientific article published on 22 April 2016

Clear detection of ADIPOQ locus as the major gene for plasma adiponectin: results of genome-wide association analyses including 4659 European individuals

scientific article

Clustered environments and randomized genes: a fundamental distinction between conventional and genetic epidemiology

scientific article (publication date: December 2007)

Collapsed methylation quantitative trait loci analysis for low frequency and rare variants

scientific article published on 24 August 2016

Commentary: One size fits all: are there standard rules for the use of genetic instruments in Mendelian randomization?

scientific article published on 4 September 2016

Comments on ‘Mendelian randomization: Using genes as instruments for making causal inference in epidemiology’: Authors' response

article

Common Genetic Variants Influence Whorls in Fingerprint Patterns

scientific article

Common Variation in the WNK1 Gene and Blood Pressure in Childhood

article

Common genetic variants associated with cognitive performance identified using the proxy-phenotype method

scientific article

Common maternal and fetal genetic variants show expected polygenic effects on risk of small- or large-for-gestational-age (SGA or LGA), except in the smallest 3% of babies

scientific article published on 07 December 2020

Common variants at 12q15 and 12q24 are associated with infant head circumference

scientific article published on 15 April 2012

Common variants at 6q22 and 17q21 are associated with intracranial volume

scientific article published on 15 April 2012

Common variants in left/right asymmetry genes and pathways are associated with relative hand skill

scientific article

Common variants in the GDF5-UQCC region are associated with variation in human height

scientific article

Common variants in the region around Osterix are associated with bone mineral density and growth in childhood

scientific article published on 30 January 2009

Common variants near MC4R are associated with fat mass, weight and risk of obesity

scientific article

Common variation at 16p11.2 is associated with glycosuria in pregnancy: Findings from a genome-wide association study in European women

scientific article published on 30 March 2020

Common variation contributes to the genetic architecture of social communication traits.

scientific article published on 18 September 2013

Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected given its effect on BMI

scientific article

Common variation near ROBO2 is associated with expressive vocabulary in infancy.

scientific article

Consortium-based genome-wide meta-analysis for childhood dental caries traits

scholarly article by Simon Haworth published in September 2018

Coordinated genetic scaling of the human eye: shared determination of axial eye length and corneal curvature

scientific article published on 7 March 2013

Copy Number Variations and Cognitive Phenotypes in Unselected Populations

Copy number variations and cognitive phenotypes in unselected populations

scientific article

Coronary artery disease, genetic risk and the metabolome in young individuals

scientific article published on 01 January 2018

Correction to: Is population structure in the genetic biobank era irrelevant, a challenge, or an opportunity?

scientific article published on 01 January 2020

Correction: Genome-Wide Association Scan Meta-Analysis Identifies Three Loci Influencing Adiposity and Fat Distribution.

scientific article published on 27 July 2009

Corrigendum: Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses

scientific article published on November 2016

Data Resource Profile: The ALSPAC birth cohort as a platform to study the relationship of environment and health and social factors

scientific article published on 01 August 2019

Determinants of Intima-Media Thickness in the Young: The ALSPAC Study

scientific article published on 11 October 2019

Dietary Intake, FTO Genetic Variants, and Adiposity: A Combined Analysis of Over 16,000 Children and Adolescents

scientific article published on 26 February 2015

Dietary energy density affects fat mass in early adolescence and is not modified by FTO variants

scientific article

Directional dominance on stature and cognition in diverse human populations

scientific article published in July 2015

Discovery and refinement of genetic loci associated with cardiometabolic risk using dense imputation maps

scientific article published on 26 September 2016

Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals

scientific article published on 23 November 2020

Diving deep-multipronged investigations into RIPK1 as a risk factor for obesity

scientific article published on 28 September 2020

Does bone resorption stimulate periosteal expansion? A cross-sectional analysis of β-C-telopeptides of type I collagen (CTX), genetic markers of the RANKL pathway, and periosteal circumference as measured by pQCT.

scientific article

Does greater adiposity increase blood pressure and hypertension risk?: Mendelian randomization using the FTO/MC4R genotype

scientific article published on 26 May 2009

Does high C-reactive protein concentration increase atherosclerosis? The Whitehall II Study

scientific article

ERRATUM: Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height

article by Matthew B. Lanktree et al published June 2012 in American Journal of Human Genetics

Early Cannabis Use, Polygenic Risk Score for Schizophrenia and Brain Maturation in Adolescence

scientific article published on 26 August 2015

Effect of bilirubin and Gilbert syndrome on health: cohort analysis of observational, genetic, and Mendelian randomisation associations

scientific article published in 2023

Emotional symptoms in children: The effect of maternal depression, life events, and COMT genotype

scientific article published on March 2009

Epigenetic Regulation of Associates With Myocardial Infarction and Platelet Function

scientific article published on 4 February 2022

Erratum to: Heritability and genome-wide analyses of problematic peer relationships during childhood and adolescence.

scientific article

Erratum: Common variants at 12q15 and 12q24 are associated with infant head circumference

scholarly article published in Nature Genetics

Erratum: Common variants at 6q22 and 17q21 are associated with intracranial volume

article

Erratum: Corrigendum: Genetic variants associated with subjective well-being, depressive symptoms and neuroticism identified through genome-wide analyses

article

Erratum: Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia

article

Erratum: Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

scientific article published in November 2011

Erratum: New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

scientific article published in May 2010

Erratum: Whole-genome sequence-based analysis of thyroid function

scientific article published on 20 May 2015

Ethnicity, heart failure, atrial fibrillation and diabetes: collider bias

article

European lactase persistence genotype shows evidence of association with increase in body mass index

scientific article

Evaluation and deployment of isotype-specific salivary antibody assays for detecting previous SARS-CoV-2 infection in children and adults

scientific article published on 15 March 2023

Evaluation of seven common lipid associated loci in a large Indian sib pair study

scientific article published on 14 November 2012

Evaluation of the causal effects between subjective wellbeing and cardiometabolic health: mendelian randomisation study

scientific article published in the British Medical Journal

Examination of the relationship between variation at 17q21 and childhood wheeze phenotypes.

scientific article published on 13 November 2012

Exploring possible epigenetic mediation of early-life environmental exposures on adiposity and obesity development

scientific article

Exploring the developmental overnutrition hypothesis using parental-offspring associations and FTO as an instrumental variable

scientific article

FUT2 secretor genotype and susceptibility to infections and chronic conditions in the ALSPAC cohort

scientific article published on 25 September 2018

Fraction of exhaled nitric oxide values in childhood are associated with 17q11.2-q12 and 17q12-q21 variants

scientific article

GARFIELD classifies disease-relevant genomic features through integration of functional annotations with association signals

scientific article published on 28 January 2019

GWAS of 126,559 individuals identifies genetic variants associated with educational attainment

scientific article published on 21 June 2013

GWAS of stool frequency provides insights into gastrointestinal motility and irritable bowel syndrome

publication published on 08 December 2021

GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI

scientific article published on 04 September 2019

Gene discovery for oral ulceration: a UK Biobank Study

scientific article published in The Lancet

Genetic and Environmental Risk Factors Associated With Trajectories of Depression Symptoms From Adolescence to Young Adulthood

scientific article published on 05 June 2019

Genetic association study of BDNF in depression: finding from two cohort studies and a meta-analysis

scientific article published on September 2008

Genetic determinants of height growth assessed longitudinally from infancy to adulthood in the northern Finland birth cohort 1966

scientific article

Genetic evidence of assortative mating in humans

article

Genetic influences on trajectories of systolic blood pressure across childhood and adolescence

scientific article published on 7 November 2013

Genetic markers of adult obesity risk are associated with greater early infancy weight gain and growth

scientific article (publication date: 25 May 2010)

Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses

scientific article published on 18 April 2016

Genetic variation associated with differential educational attainment in adults has anticipated associations with school performance in children

scientific article

Genetic variation at the SLC23A1 locus is associated with circulating concentrations of L-ascorbic acid (vitamin C): evidence from 5 independent studies with >15,000 participants

scientific article published on 2 June 2010

Genetics, sleep and memory: a recall-by-genotype study of ZNF804A variants and sleep neurophysiology

scientific article

Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders

scientific article published in November 2018

Genome sequencing elucidates Sardinian genetic architecture and augments association analyses for lipid and blood inflammatory markers

scientific article

Genome wide analysis for mouth ulcers identifies associations at immune regulatory loci

scientific article published on 05 March 2019

Genome wide association identifies common variants at the SERPINA6/SERPINA1 locus influencing plasma cortisol and corticosteroid binding globulin

scientific article (publication date: July 2014)

Genome-Wide Meta-Analysis of Cotinine Levels in Cigarette Smokers Identifies Locus at 4q13.2.

scientific article published on February 2016

Genome-wide Association Study for Vitamin D Levels Reveals 69 Independent Loci

scientific article published on 13 February 2020

Genome-wide analysis identifies 12 loci influencing human reproductive behavior

scientific article

Genome-wide analysis of dental caries and periodontitis combining clinical and self-reported data.

scientific article published on 24 June 2019

Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention ⬇️

scientific article published on 7 September 2022

Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index

scientific article published on 24 November 2015

Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity

scientific article

Genome-wide association meta-analysis of cortical bone mineral density unravels allelic heterogeneity at the RANKL locus and potential pleiotropic effects on bone

scientific article

Genome-wide association scan allowing for epistasis in type 2 diabetes

scientific article published on 6 December 2010

Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution

scientific article published in June 2009

Genome-wide association study for refractive astigmatism reveals genetic co-determination with spherical equivalent refractive error: the CREAM consortium

scientific article

Genome-wide association study identifies 48 common genetic variants associated with handedness

scientific article published on 28 September 2020

Genome-wide association study identifies 74 loci associated with educational attainment

scientific article published on 11 May 2016

Genome-wide association study identifies SNPs in the MHC class II loci that are associated with self-reported history of whooping cough

scientific article

Genome-wide association study identifies loci affecting blood copper, selenium and zinc

scientific article published on 29 May 2013

Genome-wide association study of blood lead shows multiple associations near ALAD

scientific article published in July 2015

Genome-wide association study of height-adjusted BMI in childhood identifies functional variant in ADCY3

scientific article

Genome-wide association study of primary tooth eruption identifies pleiotropic loci associated with height and craniofacial distances

scientific article published on 23 May 2013

Genome-wide association study of sexual maturation in males and females highlights a role for body mass and menarche loci in male puberty.

scientific article

Genome-wide association study reveals multiple loci associated with primary tooth development during infancy

scientific article

Genome-wide association study to identify common variants associated with brachial circumference: a meta-analysis of 14 cohorts

scientific article (publication date: 2012)

Genome-wide associations for birth weight and correlations with adult disease

scientific article

Genome-wide associations of human gut microbiome variation and implications for causal inference analyses

scientific article published on 22 June 2020

Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia

scientific article

Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels

scientific article published on February 2016

Genome-wide prediction of childhood asthma and related phenotypes in a longitudinal birth cohort

scientific article published on August 2012

Genomic analyses for age at menarche identify 389 independent signals and indicate BMI-independent effects of puberty timing on cancer susceptibility

scientific article published on 23 September 2016

Genomic analysis of male puberty timing highlights shared genetic basis with hair colour and lifespan ⬇️

scientific article published on 24 March 2020

HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials

scientific article published on 24 September 2014

Height-reducing variants and selection for short stature in Sardinia

scientific article

Heritability and Genome-Wide Association Analyses of Sleep Duration in Children: The EAGLE Consortium

scientific article published on 19 August 2016

Heritability and genome-wide analyses of problematic peer relationships during childhood and adolescence

scientific article published on 17 December 2014

Heritable contributions versus genetic architecture

scientific article published in February 2018

How does body fat influence bone mass in childhood? A Mendelian randomization approach

scientific article

Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders

scientific article published on 14 April 2013

Identifying Critical Points of Trajectories of Depressive Symptoms from Childhood to Young Adulthood

scientific article published on 22 January 2019

Improved imputation of low-frequency and rare variants using the UK10K haplotype reference panel

scientific article

Incorporating Non-Coding Annotations into Rare Variant Analysis

scientific article

Inflammation, insulin resistance, and diabetes--Mendelian randomization using CRP haplotypes points upstream

scientific article

Influence of puberty timing on adiposity and cardiometabolic traits: A Mendelian randomisation study

scientific article published in August 2018

Intelligence in offspring born to women exposed to intimate partner violence: a population-based cohort study

scientific article published on 10 July 2019

International Genome-Wide Association Study Consortium Identifies Novel Loci Associated With Blood Pressure in Children and Adolescents

scientific article published on 11 March 2016

Investigating the impact of cigarette smoking behaviours on DNA methylation patterns in adolescence

scientific article published on 01 January 2019

Is population structure in the genetic biobank era irrelevant, a challenge, or an opportunity?

scientific article published on 27 April 2019

Is the adiposity-associated FTO gene variant related to all-cause mortality independent of adiposity? Meta-analysis of data from 169,551 Caucasian adults

scientific article published on 5 March 2015

KCTD8 gene and brain growth in adverse intrauterine environment: a genome-wide association study.

scientific article

Lack of association between DRD2 and OPRM1 genotypes and adiposity

scientific article

Lactase persistence-related genetic variant: population substructure and health outcomes

scientific article

Large-scale GWAS of food liking reveals genetic determinants and genetic correlations with distinct neurophysiological traits

scientific article published on 18 May 2022

Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways

scientific article

Letter regarding article, “Associations of obesity and circulating insulin and glucose with breast cancer risk: a Mendelian randomization analysis”

scientific article published on 01 June 2019

Lifetime body mass index and later atherosclerosis risk in young adults: examining causal links using Mendelian randomization in the Cardiovascular Risk in Young Finns study

scientific article published on 10 June 2008

Limits of lockdown: characterising essential contacts during strict physical distancing

scientific article published on 14 May 2021

Low-Frequency Synonymous Coding Variation in CYP2R1 Has Large Effects on Vitamin D Levels and Risk of Multiple Sclerosis

scientific article published on 01 December 2018

Low-frequency variation in TP53 has large effects on head circumference and intracranial volume

scientific article published in Nature Communications

MR-PheWAS: hypothesis prioritization among potential causal effects of body mass index on many outcomes, using Mendelian randomization

scientific article

Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

scientific article published on 01 May 2019

Maturation in serum thyroid function parameters over childhood and puberty: results of a longitudinal study

scientific article published on May 2017

Mendelian Randomization Analysis Identifies CpG Sites as Putative Mediators for Genetic Influences on Cardiovascular Disease Risk.

scientific article published in October 2017

Mendelian randomization: Using genes as instruments for making causal inferences in epidemiology

article

Mendelian randomization: application to cardiovascular disease

scientific article published on February 2012

Mendelian randomization: where are we now and where are we going?

scientific article published in April 2015

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

scientific article

Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height

scientific article

Meta-analysis of Genome-Wide Association Studies for Extraversion: Findings from the Genetics of Personality Consortium

scientific article published on 11 September 2015

Meta-analysis of Genome-wide Association Studies for Neuroticism, and the Polygenic Association With Major Depressive Disorder

scientific article

Meta-analysis of gene-environment-wide association scans accounting for education level identifies additional loci for refractive error

scientific article published on 29 March 2016

Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes

scientific article

Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization

scientific article

Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis

scientific article

Meta-analysis of genome-wide scans for total body BMD in children and adults reveals allelic heterogeneity and age-specific effects at the WNT16 locus

scientific article

Meta-analysis of genome-wide studies identifies WNT16 and ESR1 SNPs associated with bone mineral density in premenopausal women

scientific article published on March 2013

Metabolic Characterization of a Rare Genetic Variation Within APOC3 and Its Lipoprotein Lipase-Independent Effects

scientific article published on 25 April 2016

Mining the human phenome using allelic scores that index biological intermediates

scientific article

Morning plasma cortisol as a cardiovascular risk factor: findings from prospective cohort and Mendelian randomization studies

scientific article published on 01 October 2019

Mosaic structural variation in children with developmental disorders

scientific article

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

scientific article

New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism

scientific article published on 2 December 2012

Newly identified loci that influence lipid concentrations and risk of coronary artery disease

scientific article

Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error

scientific article

Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals

scientific article

Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits

scientific article published on 12 October 2020

Obesity and Multiple Sclerosis: A Mendelian Randomization Study

scientific article

Obesity and cancer: Mendelian randomization approach utilizing the FTO genotype

scientific article published on 19 June 2009

P2-303 Development of predictive equations for DXA measures of adiposity in an Indian population

Paradoxical Relationship Between Body Mass Index and Thyroid Hormone Levels: A Study Using Mendelian Randomization

scientific article published on 23 November 2015

Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche

scientific article

Phenotypic dissection of bone mineral density reveals skeletal site specificity and facilitates the identification of novel loci in the genetic regulation of bone mass attainment

scientific article

Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children

scientific article

Polygenic Prediction of Weight and Obesity Trajectories from Birth to Adulthood

scientific article published on 01 April 2019

Polymorphisms in the

scientific article published in The Journal of the American Medical Association

Prenatal alcohol exposure and offspring mental health: A systematic review

article

Prenatal exposure to maternal smoking and offspring DNA methylation across the lifecourse: findings from the Avon Longitudinal Study of Parents and Children (ALSPAC).

scientific article

Prospective associations between problematic eating attitudes in midchildhood and the future onset of adolescent obesity and high blood pressure

scientific article published on 14 December 2016

Re-Examining the Association between Vitamin D and Childhood Caries

scientific article published on 21 December 2015

Reassessing the Association between Circulating Vitamin D and IGFBP-3: Observational and Mendelian Randomization Estimates from Independent Sources

article

Refining associations between TAS2R38 diplotypes and the 6-n-propylthiouracil (PROP) taste test: findings from the Avon Longitudinal Study of Parents and Children

scientific article

Remnant cholesterol, low-density lipoprotein cholesterol, and blood pressure as mediators from obesity to ischemic heart disease

scientific article published on 19 November 2014

Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes

scientific article (publication date: June 2007)

Screening for familial hypercholesterolaemia in childhood: Avon Longitudinal Study of Parents and Children (ALSPAC)

scientific article

Severe obesity in young women and reproductive health: the Danish National Birth Cohort

scientific article

Shared genetic influences between attention-deficit/hyperactivity disorder (ADHD) traits in children and clinical ADHD.

scientific article

Shared genetic variants suggest common pathways in allergy and autoimmune diseases

scientific article published on 7 February 2017

Six new loci associated with body mass index highlight a neuronal influence on body weight regulation

scientific article

Strengthening causal inference in cardiovascular epidemiology through Mendelian randomization

scientific article published on January 2008

Systematic Mendelian randomization framework elucidates hundreds of CpG sites which may mediate the influence of genetic variants on disease

scientific article published on 15 September 2018

TAS2R38 (phenylthiocarbamide) haplotypes, coronary heart disease traits, and eating behavior in the British Women's Heart and Health Study

article

Ten years on: Is dental general anaesthesia in childhood a risk factor for caries and anxiety?

scientific article published on February 2017

The ATXN1 and TRIM31 genes are related to intelligence in an ADHD background: evidence from a large collaborative study totaling 4,963 subjects

scientific article

The Avon Longitudinal Study of Parents and Children (ALSPAC): an update on the enrolled sample of index children in 2019

The Avon Longitudinal Study of Parents and Children - A resource for COVID-19 research: Generation 2 questionnaire data capture May-July 2020

scientific article published in 2020

The Avon Longitudinal Study of Parents and Children - A resource for COVID-19 research: Questionnaire data capture May-July 2020

scientific article published on 22 September 2020

The CHRNA5-A3-B4 Gene Cluster and Smoking: From Discovery to Therapeutics

scientific article

The CRP genotype, serum levels and lung function in men: the Caerphilly Prospective Study

scientific article published in April 2011

The Emergence of Networks in Human Genome Epidemiology

article

The Genetic Sphygmomanometer: an argument for routine genome-wide genotyping in the population and a new view on its use to inform clinical practice

scientific article published on 31 October 2018

The MR-Base platform supports systematic causal inference across the human phenome.

scientific article published on 30 May 2018

The UK10K project identifies rare variants in health and disease

scientific article

The association of C-reactive protein and CRP genotype with coronary heart disease: findings from five studies with 4,610 cases amongst 18,637 participants

scientific article published on 20 August 2008

The association of the PON1 Q192R polymorphism with complications and outcomes of pregnancy: findings from the British Women's Heart and Health cohort study

article

The association of the paraoxonase (PON1) Q192R polymorphism with depression in older women: findings from the British Women's Heart and Health Study

scientific article published on January 2007

The causal effect of vitamin D binding protein (DBP) levels on calcemic and cardiometabolic diseases: a Mendelian randomization study

scientific article (publication date: October 2014)

The effect of elevated body mass index on ischemic heart disease risk: causal estimates from a Mendelian randomisation approach

scientific article (publication date: 2012)

The emergence of networks in human genome epidemiology: challenges and opportunities

scholarly article published 18 December 2009

The ethics conundrum in Recall by Genotype (RbG) research: Perspectives from birth cohort participants

scientific article published in PLoS ONE

The influence of obesity-related factors in the etiology of renal cell carcinoma-A mendelian randomization study ⬇️

scientific article published on 03 January 2019

The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis

scientific article published on 14 March 2012

The range of peripapillary retinal nerve fibre layer and optic disc parameters in children aged up to but not including 18 years of age, as measured by optical coherence tomography: protocol for a systematic review

scientific article published on 30 April 2016

The range of peripapillary retinal nerve fibre layer and optic disc parameters, in children aged up to but not including 18 years of age who were born prematurely: protocol for a systematic review.

scientific article published on 31 August 2016

The role of common genetic variation in educational attainment and income: evidence from the National Child Development Study

scientific article published on 12 November 2015

The thermolabile variant of MTHFR is associated with depression in the British Women's Heart and Health Study and a meta-analysis

scientific article

Trans-ethnic association study of blood pressure determinants in over 750,000 individuals

scientific article published on 21 December 2018

Two British women studies replicated the association between the Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) and BMI.

scientific article

Type 2 diabetes risk alleles are associated with reduced size at birth

scientific article published on 19 February 2009

Using Genetic Variation to Explore the Causal Effect of Maternal Pregnancy Adiposity on Future Offspring Adiposity: A Mendelian Randomisation Study

scientific article

Using Y-Chromosomal Haplogroups in Genetic Association Studies and Suggested Implications

scientific article

Using genetic loci to understand the relationship between adiposity and psychological distress: a Mendelian Randomization study in the Copenhagen General Population Study of 53 221 adults

article published in 2011

Using genetic proxies for lifecourse sun exposure to assess the causal relationship of sun exposure with circulating vitamin d and prostate cancer risk

scientific article published on 25 February 2013

Using genetics to test the causal relationship of total adiposity and periodontitis: Mendelian randomization analyses in the Gene-Lifestyle Interactions and Dental Endpoints (GLIDE) Consortium

scientific article published on April 2015

Using inactivating mutations to provide insight into drug action

scientific article

Using multiple genetic variants as instrumental variables for modifiable risk factors ⬇️

scientific article published on January 7, 2011

Using published data in Mendelian randomization: a blueprint for efficient identification of causal risk factors

scientific article

Validation of dual energy X-ray absorptiometry measures of abdominal fat by comparison with magnetic resonance imaging in an Indian population

scientific article

Variability in the common genetic architecture of social-communication spectrum phenotypes during childhood and adolescence

scientific article published on 24 February 2014

Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight

scientific article

Variation in the SLC23A1 gene does not influence cardiometabolic outcomes to the extent expected given its association with L-ascorbic acid

scientific article published on 19 November 2014

Vitamin B-12 status during pregnancy and child's IQ at age 8: a Mendelian randomization study in the Avon longitudinal study of parents and children

scientific article published on 5 December 2012

WNT16 influences bone mineral density, cortical bone thickness, bone strength, and osteoporotic fracture risk

scientific article published in July 2012

Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits

scientific article published on 23 May 2017

Whole-genome sequence-based analysis of thyroid function.

scientific article

Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture

scientific article

Worldwide patterns of haplotype diversity at 9p21.3, a locus associated with type 2 diabetes and coronary heart disease

scientific article published on 12 May 2009

Worldwide population differentiation at disease-associated SNPs

scientific article

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