List of works - Nicholas J. Timpson

A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity

scientific article

Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes

scientific article (publication date: June 2007)

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

scientific article

Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes

scientific article

Six new loci associated with body mass index highlight a neuronal influence on body weight regulation

scientific article

Newly identified loci that influence lipid concentrations and risk of coronary artery disease

scientific article

Mendelian randomization: Using genes as instruments for making causal inferences in epidemiology

article

Common variants near MC4R are associated with fat mass, weight and risk of obesity

scientific article

A reference panel of 64,976 haplotypes for genotype imputation

scientific article

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

scientific article

Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways

scientific article

The UK10K project identifies rare variants in health and disease

scientific article

Genome-wide association study identifies 74 loci associated with educational attainment

scientific article published on 11 May 2016

GWAS of 126,559 individuals identifies genetic variants associated with educational attainment

scientific article published on 21 June 2013

The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis

scientific article published on 14 March 2012

Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution

scientific article published in June 2009

Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses

scientific article published on 18 April 2016

Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals

scientific article

Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children

scientific article

The MR-Base platform supports systematic causal inference across the human phenome

scientific article published on 30 May 2018

A common variant of HMGA2 is associated with adult and childhood height in the general population

scientific article

A genome-wide association meta-analysis identifies new childhood obesity loci

scientific article

Common variants in the GDF5-UQCC region are associated with variation in human height

scientific article

HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials

scientific article published on 24 September 2014

Clustered environments and randomized genes: a fundamental distinction between conventional and genetic epidemiology

scientific article (publication date: December 2007)

Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche

scientific article

Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia

scientific article

Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected given its effect on BMI

scientific article

Using published data in Mendelian randomization: a blueprint for efficient identification of causal risk factors

scientific article

Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture

scientific article

Using multiple genetic variants as instrumental variables for modifiable risk factors

scientific article published on January 7, 2011

Prenatal exposure to maternal smoking and offspring DNA methylation across the lifecourse: findings from the Avon Longitudinal Study of Parents and Children (ALSPAC).

scientific article

Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight

scientific article

New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism

scientific article published on 2 December 2012

Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis

scientific article

C-reactive protein and its role in metabolic syndrome: mendelian randomisation study

scientific article published in December 2005

Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders

scientific article published on 14 April 2013

Association of plasma uric acid with ischaemic heart disease and blood pressure: mendelian randomisation analysis of two large cohorts

scientific article published on 18 July 2013

The effect of elevated body mass index on ischemic heart disease risk: causal estimates from a Mendelian randomisation approach

scientific article (publication date: 2012)

Genome-wide associations for birth weight and correlations with adult disease

scientific article

Does greater adiposity increase blood pressure and hypertension risk?: Mendelian randomization using the FTO/MC4R genotype

scientific article published on 26 May 2009

WNT16 influences bone mineral density, cortical bone thickness, bone strength, and osteoporotic fracture risk

scientific article published in July 2012

A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci

scientific article

Common genetic variants associated with cognitive performance identified using the proxy-phenotype method

scientific article

Genetic markers of adult obesity risk are associated with greater early infancy weight gain and growth

scientific article (publication date: 25 May 2010)

Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases: A Mendelian Randomization Study

scientific article published on 23 February 2017

Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization

scientific article

Improved imputation of low-frequency and rare variants using the UK10K haplotype reference panel

scientific article

Association between genetic variants on chromosome 15q25 locus and objective measures of tobacco exposure

scientific article

Childhood intelligence is heritable, highly polygenic and associated with FNBP1L

scientific article

List of works by Nicholas J. Timpson

A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity

Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes

Six new loci associated with body mass index highlight a neuronal influence on body weight regulation

Newly identified loci that influence lipid concentrations and risk of coronary artery disease

Mendelian randomization: Using genes as instruments for making causal inferences in epidemiology

Common variants near MC4R are associated with fat mass, weight and risk of obesity

A reference panel of 64,976 haplotypes for genotype imputation

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways

The UK10K project identifies rare variants in health and disease

Genome-wide association study identifies 74 loci associated with educational attainment

GWAS of 126,559 individuals identifies genetic variants associated with educational attainment

The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis

Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution

Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses

Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals

Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children

The MR-Base platform supports systematic causal inference across the human phenome

A common variant of HMGA2 is associated with adult and childhood height in the general population

A genome-wide association meta-analysis identifies new childhood obesity loci

Common variants in the GDF5-UQCC region are associated with variation in human height

HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials

Clustered environments and randomized genes: a fundamental distinction between conventional and genetic epidemiology

Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche

Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia

Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected given its effect on BMI

Using published data in Mendelian randomization: a blueprint for efficient identification of causal risk factors

Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture

Using multiple genetic variants as instrumental variables for modifiable risk factors

Prenatal exposure to maternal smoking and offspring DNA methylation across the lifecourse: findings from the Avon Longitudinal Study of Parents and Children (ALSPAC).

Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight

New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism

Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis

C-reactive protein and its role in metabolic syndrome: mendelian randomisation study

Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders

Association of plasma uric acid with ischaemic heart disease and blood pressure: mendelian randomisation analysis of two large cohorts

The effect of elevated body mass index on ischemic heart disease risk: causal estimates from a Mendelian randomisation approach

Genome-wide associations for birth weight and correlations with adult disease

Does greater adiposity increase blood pressure and hypertension risk?: Mendelian randomization using the FTO/MC4R genotype

WNT16 influences bone mineral density, cortical bone thickness, bone strength, and osteoporotic fracture risk

A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci

Common genetic variants associated with cognitive performance identified using the proxy-phenotype method

Genetic markers of adult obesity risk are associated with greater early infancy weight gain and growth

Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases: A Mendelian Randomization Study

Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization

Improved imputation of low-frequency and rare variants using the UK10K haplotype reference panel

Association between genetic variants on chromosome 15q25 locus and objective measures of tobacco exposure

Childhood intelligence is heritable, highly polygenic and associated with FNBP1L