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List of works by Sergio Schenkman

'Click chemistry' synthesis of a library of 1,2,3-triazole-substituted galactose derivatives and their evaluation against Trypanosoma cruzi and its cell surface trans-sialidase

scientific article

A kinetic and structural study of two-step aggregation and fusion of neutral phospholipid vesicles promoted by serum albumin at low pH

scientific article published on 01 March 1981

A short proregion of trialysin, a pore-forming protein of Triatoma infestans salivary glands, controls activity by folding the N-terminal lytic motif

scientific article published on 25 January 2008

Actively transcribing RNA polymerase II concentrates on spliced leader genes in the nucleus of Trypanosoma cruzi

scientific article published on May 2005

American trypanosomiasis

Attachment of Trypanosoma cruzi trypomastigotes to receptors at restricted cell surface domains

scientific article published on January 1991

Beta-adrenergic antagonist propranolol inhibits mammalian cell lysosome spreading and invasion by Trypanosoma cruzi metacyclic forms.

scientific article published on 19 January 2017

Biochemical characterization of a protein tyrosine phosphatase from Trypanosoma cruzi involved in metacyclogenesis and cell invasion

scientific article published on 13 April 2011

Biochemical studies with DNA polymerase beta and DNA polymerase beta-PAK of Trypanosoma cruzi suggest the involvement of these proteins in mitochondrial DNA maintenance

scientific article

Catalase expression impairs oxidative stress-mediated signalling in Trypanosoma cruzi.

scientific article

Cell homeostasis in a Leishmania major mutant overexpressing the spliced leader RNA is maintained by an increased proteolytic activity

scientific article

Chagasic patients develop a type 1 immune response to Trypanosoma cruzi trans-sialidase

article

Characterization and role of the 3-methylglutaconyl coenzyme A hidratase in Trypanosoma brucei.

scientific article published on 30 March 2017

Characterization of TcCYC6 from Trypanosoma cruzi, a gene with homology to mitotic cyclins

scientific article published on 17 December 2015

Characterization of Trypanosoma cruzi Sirtuins as Possible Drug Targets for Chagas Disease

scientific article published on 26 May 2015

Characterization of anti-silencing factor 1 in Leishmania major.

scientific article published in May 2012

Characterization of the plasma glycosylphosphatidylinositol-specific phospholipase D (GPI-PLD).

scientific article published on September 1991

Characterization of two different Asf1 histone chaperones with distinct cellular localizations and functions in Trypanosoma brucei

scientific article published on 09 December 2013

Chemical Constituents of Anacardium occidentale as Inhibitors of Trypanosoma cruzi Sirtuins

scientific article published on 03 April 2019

Chemoenzymatic synthesis of GM3, Lewis x and sialyl Lewis x oligosaccharides in 13C-enriched form

Chemogenetic Characterization of Inositol Phosphate Metabolic Pathway Reveals Druggable Enzymes for Targeting Kinetoplastid Parasites.

scientific article published on 26 April 2016

Chromatin Proteomics Reveals Variable Histone Modifications during the Life Cycle of Trypanosoma cruzi.

scientific article published on 25 April 2016

Chromatin and nuclear organization in Trypanosoma cruzi.

scientific article published on October 2009

Chromatin modifications in trypanosomes due to stress

scientific article published on 16 February 2013

Chromosome localization changes in the Trypanosoma cruzi nucleus

scientific article

Click chemistry oligomerisation of azido-alkyne-functionalised galactose accesses triazole-linked linear oligomers and macrocycles that inhibit Trypanosoma cruzi macrophage invasion. ⬇️

scientific article published on September 2015

Co-ordinated expression of lymphoid and myeloid specific transcription factors during B-1b cell differentiation into mononuclear phagocytes in vitro

scientific article (publication date: 2009)

Comparative Proteomic Analysis of Lysine Acetylation in Trypanosomes

scientific article published on 23 November 2017

Comparative analysis of genomic sequences suggests that Trypanosoma cruzi CL Brener contains two sets of non-intercalated repeats of satellite DNA that correspond to T. cruzi I and T. cruzi II types

scientific article

Comparative transcriptome profiling of virulent and non-virulent Trypanosoma cruzi underlines the role of surface proteins during infection.

scientific article

Comparison of antibody and protective immune responses against Trypanosoma cruzi infection elicited by immunization with a parasite antigen delivered as naked DNA or recombinant protein

scholarly article published by Sergio Schenkman in 1999

Corrigendum to “Trypanosoma cruzi histone H1 is phosphorylated in a typical cyclin dependent kinase site accordingly to the cell cycle” [Mol. Biochem. Parasitol. 140 (2005) 75–86]

scholarly article published in Molecular and Biochemical Parasitology

Cyclooligomerisation of azido-alkyne-functionalised sugars: synthesis of 1,6-linked cyclic pseudo-galactooligosaccharides and assessment of their sialylation by Trypanosoma cruzi trans-sialidase

article

Cyclophilin 19 secreted in the host cell cytosol by Trypanosoma cruzi promotes ROS production required for parasite growth

scientific article published on 22 November 2020

DNA polymerase beta from Trypanosoma cruzi is involved in kinetoplast DNA replication and repair of oxidative lesions

scientific article published on 24 February 2012

Deregulation of Ikaros expression in B-1 cells: New insights in the malignant transformation to chronic lymphocytic leukemia

scientific article published on 12 July 2019

Design, synthesis and the effect of 1,2,3-triazole sialylmimetic neoglycoconjugates on Trypanosoma cruzi and its cell surface trans-sialidase

scientific article published on 22 November 2011

Differential effects of alpha-helical and beta-hairpin antimicrobial peptides against Acanthamoeba castellanii

scientific article

Differential expression profiles in the midgut of Triatoma infestans infected with Trypanosoma cruzi

scientific article

Distinct acetylation of Trypanosoma cruzi histone H4 during cell cycle, parasite differentiation, and after DNA damage.

scientific article published on 25 April 2009

Divalent metal requirements for catalysis and stability of the RNA triphosphatase from Trypanosoma cruzi

scientific article published on 20 July 2006

EIF2α phosphorylation is regulated in intracellular amastigotes for generation of infective Trypanosoma cruzi trypomastigote forms

scientific article published on 29 June 2020

Effect of ionizing radiation exposure on Trypanosoma cruzi Ubiquitin-Proteasome System.

scientific article

Effects of temperature and lipid composition on the serum albumin-induced aggregation and fusion of small unilamellar vesicles

article

Endosymbiosis in trypanosomatid protozoa: the bacterium division is controlled during the host cell cycle

scientific article published on 2 June 2015

Enzyme-linked immunoassay using recombinant trans-sialidase of Trypanosoma cruzi can be employed for monitoring of patients with Chagas' disease after drug treatment

scientific article

Eukaryotic initiation factor 5A dephosphorylation is required for translational arrest in stationary phase cells.

scientific article published in April 2013

Expression inEscherichia coli of a gene coding for epitopes of a diagnostic antigen ofParacoccidioides brasiliensis

article

Expression of non-acetylatable lysines 10 and 14 of histone H4 impairs transcription and replication in Trypanosoma cruzi

scientific article published on 19 November 2015

Expression of trypomastigote trans-sialidase in metacyclic forms of Trypanosoma cruzi increases parasite escape from its parasitophorous vacuole

scientific article published on 4 July 2006

Expression oftrans-Sialidase and 85-kDa Glycoprotein Genes inTrypanosoma cruziIs Differentially Regulated at the Post-transcriptional Level by Labile Protein Factors

scientific article published in Journal of Biological Chemistry

Functional characterization of TcCYC2 cyclin from Trypanosoma cruzi.

scientific article

Genome of the avirulent human-infective trypanosome--Trypanosoma rangeli

scientific article published in September 2014

Glycophosphatidylinositol-anchored proteins in metacyclic trypomastigotes of Trypanosoma cruzi.

scientific article

Highlights of the São Paulo ISEV workshop on extracellular vesicles in cross-kingdom communication.

scientific article published on 26 November 2017

Highlights of the XXI annual meeting of the Brazilian Society of Protozoology, the XXXII annual meeting on Basic Research in Chagas' disease & an international symposium on vesicle trafficking in parasitic Protozoa--7 to 9 November 2005, Caxambu, Mi

scientific article published on 17 August 2006

Histone H1 is phosphorylated in non-replicating and infective forms of Trypanosoma cruzi

scientific article published in February 2002

Histone H1 of Trypanosoma cruzi is concentrated in the nucleolus region and disperses upon phosphorylation during progression to mitosis

scientific article published on 15 February 2008

How to invade, replicate, and escape from host organisms. A challenge in defining virulence factors for parasites

scientific article published on 22 October 2012

Hydrolase and sialyltransferase activities of trypanosoma cruzi trans-sialidase towards NeuAc-alpha-2,3-gal-Gal-beta-O-PNP.

scientific article

Identification and characterization of a sialidase released by the salivary gland of the hematophagous insect Triatoma infestans.

scientific article published in September 1998

Identification of Inhibitors to Trypanosoma cruzi Sirtuins Based on Compounds Developed to Human Enzymes ⬇️

scientific article published on 22 May 2020

Identification of an acid-lipase in human serum which is capable of solubilizing glycophosphatidylinositol-anchored proteins

scientific article published on 01 January 1988

Identification of an atypical peptidyl-prolyl cis/trans isomerase from trypanosomatids

Identification of di-substituted ureas that prevent growth of trypanosomes through inhibition of translation initiation

scientific article published on 20 March 2018

Identification of the telomere in Trypanosoma cruzi reveals highly heterogeneous telomere lengths in different parasite strains

scientific article published on June 1999

Ikaros could be a key factor in the maintenance of "B-side" of B-1 cells

scientific article

Immunization with a plasmid DNA containing the gene of trans-sialidase reduces Trypanosoma cruzi infection in mice ⬇️

scientific article published on May 1, 1998

In vitro and in vivo trypanocidal effects of the cyclopalladated compound 7a, a drug candidate for treatment of Chagas' disease

scientific article

Infestin 1R, an intestinal subtilisin inhibitor from Triatoma infestans able to impair mammalian cell invasion by Trypanosoma cruzi

scientific article published on 21 September 2011

Infestin, a thrombin inhibitor presents in Triatoma infestans midgut, a Chagas' disease vector: gene cloning, expression and characterization of the inhibitor.

scientific article

Iron superoxide dismutases in eukaryotic pathogens: new insights from Apicomplexa and Trypanosoma structures.

scientific article published on 7 May 2015

Locating peptides generated by limited proteolysis in known protein sequences by means of computer search

scientific article published in December 1984

Lytic activity and structural differences of amphipathic peptides derived from trialysin

scientific article

Morphological events during the Trypanosoma cruzi cell cycle

scientific article

Mucin-like glycoproteins linked to the membrane by glycosylphosphatidylinositol anchor are the major acceptors of sialic acid in a reaction catalyzed by trans-sialidase in metacyclic forms of Trypanosoma cruzi

scientific article published on 01 June 1993

Nitroheterocyclic compounds are more efficacious than CYP51 inhibitors against Trypanosoma cruzi: implications for Chagas disease drug discovery and development

scientific article published on 16 April 2014

Novel membrane-bound eIF2alpha kinase in the flagellar pocket of Trypanosoma brucei

scientific article

Nuclear structure of Trypanosoma cruzi

scientific article

ORC1/CDC6 and MCM7 distinct associate with chromatin through Trypanosoma cruzi life cycle

scientific article published in February 2014

Observations on chemical and enzymatic approaches to α-2,3-sialylated octyl β-lactoside

article

Oral exposure to Phytomonas serpens attenuates thrombocytopenia and leukopenia during acute infection with Trypanosoma cruzi

scientific article

Organization of satellite DNA in the genome of Trypanosoma cruzi.

scientific article published in June 2003

Organization of trans-sialidase genes in Trypanosoma cruzi

article

Overexpression of eukaryotic initiation factor 5A (eIF5A) affects susceptibility to benznidazole in Trypanosoma cruzi populations

scientific article published on 26 July 2018

Oxidative stress protection of Trypanosomes requires selenophosphate synthase.

scientific article

Phosphorylation of eIF2α on Threonine 169 is not required for Trypanosoma brucei cell cycle arrest during differentiation.

scientific article published on 17 March 2016

Post-translational modifications of Trypanosoma cruzi histone H4.

scientific article published on 18 September 2006

Predicting the proteins of Angomonas deanei, Strigomonas culicis and their respective endosymbionts reveals new aspects of the trypanosomatidae family

scientific article published in 2013

Primary13C and β-Secondary2H KIEs for Trans-sialidase. A Snapshot of Nucleophilic Participation during Catalysis†

scientific article published on 01 May 2000

Probing the acceptor substrate binding site of Trypanosoma cruzi trans-sialidase with systematically modified substrates and glycoside libraries

scientific article

Protein synthesis attenuation by phosphorylation of eIF2α is required for the differentiation of Trypanosoma cruzi into infective forms

scientific article

Proteomic analysis reveals different composition of extracellular vesicles released by two Trypanosoma cruzi strains associated with their distinct interaction with host cells.

scientific article published on 17 April 2018

Reduction of Tubulin Expression in Angomonas deanei by RNAi Modifies the Ultrastructure of the Trypanosomatid Protozoan and Impairs Division of Its Endosymbiotic Bacterium

scientific article

Response to Horn: Introducing histone modifications in trypanosomes

scientific article published on 24 April 2007

Secreted trypanosome cyclophilin inactivates lytic insect defense peptides and induces parasite calcineurin activation and infectivity

scientific article published on 5 February 2013

Secretion of the 43 kDa glycoprotein antigen byParacoccidioides brasiliensis

scientific article published on 01 January 1988

Small-subunit rRNA processome proteins are translationally regulated during differentiation of Trypanosoma cruzi

scientific article published on 8 December 2006

Specialising the parasite nucleus: Pores, lamins, chromatin, and diversity.

scientific article

Stress induces changes in the phosphorylation of Trypanosoma cruzi RNA polymerase II, affecting its association with chromatin and RNA processing

scientific article published on 9 May 2014

Structural Characterization of the Cell Division Cycle in Strigomonas culicis, an Endosymbiont-Bearing Trypanosomatid

scientific article published on 03 January 2014

T rypanosoma cruzi trans-sialidase as a multifunctional enzyme in Chagas' disease

scientific article published on 22 July 2012

Target of rapamycin (TOR)-like 1 kinase is involved in the control of polyphosphate levels and acidocalcisome maintenance in Trypanosoma brucei

scientific article

Temperature differences for trans-glycosylation and hydrolysis reaction reveal an acceptor binding site in the catalytic mechanism of Trypanosoma cruzi trans-sialidase

scientific article

The Trypanosoma cruzi nucleic acid binding protein Tc38 presents changes in the intramitochondrial distribution during the cell cycle

scientific article

The bacterium endosymbiont of Crithidia deanei undergoes coordinated division with the host cell nucleus

scientific article

The in vivo and in vitro roles of Trypanosoma cruzi Rad51 in the repair of DNA double strand breaks and oxidative lesions

scientific article published on 13 November 2018

The largest subunit of the RNA polymerase II of Trypanosoma cruzi lacks the repeats in the carboxy-terminal domain and is encoded by several genes.

scientific article published in September 2003

The mucin-like glycoprotein super-family of Trypanosoma cruzi: structure and biological roles.

scientific article published in May 2001

The use of the green fluorescent protein to monitor and improve transfection in Trypanosoma cruzi

article

Three-dimensional reconstruction of Trypanosoma cruzi epimastigotes and organelle distribution along the cell division cycle

scientific article

Trans-sialidase from Trypanosoma cruzi epimastigotes is expressed at the stationary phase and is different from the enzyme expressed in trypomastigotes

scientific article published in September 1993

Transcription rate modulation through the Trypanosoma cruzi life cycle occurs in parallel with changes in nuclear organisation

scientific article

Trialysin, a novel pore-forming protein from saliva of hematophagous insects activated by limited proteolysis

scientific article published on 19 December 2001

Triapsin, an unusual activatable serine protease from the saliva of the hematophagous vector of Chagas' disease Triatoma infestans (Hemiptera: Reduviidae).

scientific article

Trypanosoma cruzi bromodomain factor 2 (BDF2) binds to acetylated histones and is accumulated after UV irradiation

scientific article

Trypanosoma cruzi histone H1 is phosphorylated in a typical cyclin dependent kinase site accordingly to the cell cycle.

scientific article published on March 2005

Trypanosoma cruzi invade a mammalian epithelial cell in a polarized manner

scientific article published in October 1988

Trypanosoma cruzi trans-sialidase gene lacking C-terminal repeats and expressed in epimastigote forms

scientific article published on March 1995

Trypanosomatid pin1-type peptidyl-prolyl isomerase is cytosolic and not essential for cell proliferation

scientific article

Trypanosome prereplication machinery contains a single functional orc1/cdc6 protein, which is typical of archaea

scientific article published on 28 August 2009

Two distinct groups of mucin-like genes are differentially expressed in the developmental stages of Trypanosoma cruzi

scientific article

Visual genome-wide RNAi screening to identify human host factors required for Trypanosoma cruzi infection

scientific article

trans-sialidase and sialic acid acceptors from insect to mammalian stages of Trypanosoma cruzi

scientific article published on September 1994

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