List of works - Zachary A Knight

A Spotlight on Appetite

A chemical screen in diverse breast cancer cell lines reveals genetic enhancers and suppressors of sensitivity to PI3K isoform-selective inhibition.

scientific article

A critical role for mTORC1 in erythropoiesis and anemia

scientific article

A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma

scientific article published on May 2006

A dual phosphoinositide-3-kinase alpha/mTOR inhibitor cooperates with blockade of epidermal growth factor receptor in PTEN-mutant glioma

scientific article published on September 2007

A membrane capture assay for lipid kinase activity

scientific article

A novel pseudoknot element is essential for the action of a yeast telomerase

scientific article

A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling

scientific article

A remodelled protease that cleaves phosphotyrosine substrates

scientific article published on 6 September 2007

Ablation of AgRP neurons impairs adaption to restricted feeding

scientific article

Ablation of PI3K blocks BCR-ABL leukemogenesis in mice, and a dual PI3K/mTOR inhibitor prevents expansion of human BCR-ABL+ leukemia cells

scientific article published on September 2008

Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2

scientific article

Activity of the p110-alpha subunit of phosphatidylinositol-3-kinase is required for activation of epithelial sodium transport

scientific article published on 23 July 2008

Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibition

scientific article published on January 2009

Characterization of structurally distinct, isoform-selective phosphoinositide 3'-kinase inhibitors in combination with radiation in the treatment of glioblastoma

scientific article published in April 2008

Chemical genetics: where genetics and pharmacology meet

scientific article

Design of drug-resistant alleles of type-III phosphatidylinositol 4-kinases using mutagenesis and molecular modeling

scientific article

Discovery of drug-resistant and drug-sensitizing mutations in the oncogenic PI3K isoform p110 alpha

scientific article

Discovery of dual inhibitors of the immune cell PI3Ks p110delta and p110gamma: a prototype for new anti-inflammatory drugs

scientific article published on February 2010

Downregulation of MYCN through PI3K Inhibition in Mouse Models of Pediatric Neural Cancer

scientific article published on 12 May 2015

Dual inhibition of PI3Kalpha and mTOR as an alternative treatment for Kaposi's sarcoma

scientific article published on October 2008

Dynamics of Gut-Brain Communication Underlying Hunger

scientific article published in October 2017

EGFR signals to mTOR through PKC and independently of Akt in glioma

scientific article published on 27 January 2009

Effect of combined DNA repair inhibition and G2 checkpoint inhibition on cell cycle progression after DNA damage

scientific article published on April 2006

Features of selective kinase inhibitors

scientific article

For a PDK1 inhibitor, the substrate matters ⬇️

scientific article published on January 15, 2011

Genetic or pharmaceutical blockade of p110delta phosphoinositide 3-kinase enhances IgE production

scientific article published in October 2008

HIV-1 Nef assembles a Src family kinase-ZAP-70/Syk-PI3K cascade to downregulate cell-surface MHC-I.

scientific article published on April 2007

Hunger neurons drive feeding through a sustained, positive reinforcement signal

scientific article published on 24 August 2016

Hyperleptinemia is required for the development of leptin resistance

scientific article

Identification of preoptic sleep neurons using retrograde labelling and gene profiling

scientific article

Isoform-selective phosphoinositide 3'-kinase inhibitors inhibit CXCR4 signaling and overcome stromal cell-mediated drug resistance in chronic lymphocytic leukemia: a novel therapeutic approach

scientific article

Isoform-specific phosphoinositide 3-kinase inhibitors from an arylmorpholine scaffold

scientific article

Linking smell to metabolism and aging

scientific article published in November 2017

Maintenance of hormone-sensitive phosphoinositide pools in the plasma membrane requires phosphatidylinositol 4-kinase IIIalpha

scientific article

Making sense of the sensory regulation of hunger neurons

scientific article published on 22 February 2016

Molecular profiling of activated neurons by phosphorylated ribosome capture

scientific article

Molecular profiling of neurons based on connectivity

scientific article published on May 2014

Neural circuits underlying thirst and fluid homeostasis

scientific article

Obesity causes selective and long-lasting desensitization of AgRP neurons to dietary fat

scientific article published on 28 July 2020

PI-103, a dual inhibitor of Class IA phosphatidylinositide 3-kinase and mTOR, has antileukemic activity in AML.

scientific article published on 12 June 2008

PIK3CA cooperates with other phosphatidylinositol 3'-kinase pathway mutations to effect oncogenic transformation

scientific article published on October 2008

Phosphospecific proteolysis for mapping sites of protein phosphorylation

scientific article published on 17 August 2003

Rapid Sensing of Dietary Amino Acid Deficiency Does Not Require GCN2

scientific article published on August 2016

Re-examination of Dietary Amino Acid Sensing Reveals a GCN2-Independent Mechanism

scientific article published on 27 October 2015

Regulation of Body Temperature by the Nervous System

scientific article published in April 2018

Sensory detection of food rapidly modulates arcuate feeding circuits

scientific article

Small molecule inhibitors of the PI3-kinase family

scientific article published on January 2010

Sustained NPY signaling enables AgRP neurons to drive feeding

scientific article published on 29 April 2019

T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR.

scholarly article

Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases

scientific article

Targeting the cancer kinome through polypharmacology

scientific article

Targeting the gatekeeper residue in phosphoinositide 3-kinases

scientific article

The Forebrain Thirst Circuit Drives Drinking through Negative Reinforcement

scientific article published in December 2017

Thirst

Thirst neurons anticipate the homeostatic consequences of eating and drinking

scientific article published on 03 August 2016

To stabilize neutrophil polarity, PIP3 and Cdc42 augment RhoA activity at the back as well as signals at the front

scientific article

Warm-Sensitive Neurons that Control Body Temperature

scientific article published on 7 September 2016

List of works by Zachary A Knight

A Spotlight on Appetite

A chemical screen in diverse breast cancer cell lines reveals genetic enhancers and suppressors of sensitivity to PI3K isoform-selective inhibition.

A critical role for mTORC1 in erythropoiesis and anemia

A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma

A dual phosphoinositide-3-kinase alpha/mTOR inhibitor cooperates with blockade of epidermal growth factor receptor in PTEN-mutant glioma

A membrane capture assay for lipid kinase activity

A novel pseudoknot element is essential for the action of a yeast telomerase

A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling

A remodelled protease that cleaves phosphotyrosine substrates

Ablation of AgRP neurons impairs adaption to restricted feeding

Ablation of PI3K blocks BCR-ABL leukemogenesis in mice, and a dual PI3K/mTOR inhibitor prevents expansion of human BCR-ABL+ leukemia cells

Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2

Activity of the p110-alpha subunit of phosphatidylinositol-3-kinase is required for activation of epithelial sodium transport

Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibition

Characterization of structurally distinct, isoform-selective phosphoinositide 3'-kinase inhibitors in combination with radiation in the treatment of glioblastoma

Chemical genetics: where genetics and pharmacology meet

Design of drug-resistant alleles of type-III phosphatidylinositol 4-kinases using mutagenesis and molecular modeling

Discovery of drug-resistant and drug-sensitizing mutations in the oncogenic PI3K isoform p110 alpha

Discovery of dual inhibitors of the immune cell PI3Ks p110delta and p110gamma: a prototype for new anti-inflammatory drugs

Downregulation of MYCN through PI3K Inhibition in Mouse Models of Pediatric Neural Cancer

Dual inhibition of PI3Kalpha and mTOR as an alternative treatment for Kaposi's sarcoma

Dynamics of Gut-Brain Communication Underlying Hunger

EGFR signals to mTOR through PKC and independently of Akt in glioma

Effect of combined DNA repair inhibition and G2 checkpoint inhibition on cell cycle progression after DNA damage

Features of selective kinase inhibitors

For a PDK1 inhibitor, the substrate matters ⬇️

Genetic or pharmaceutical blockade of p110delta phosphoinositide 3-kinase enhances IgE production

HIV-1 Nef assembles a Src family kinase-ZAP-70/Syk-PI3K cascade to downregulate cell-surface MHC-I.

Hunger neurons drive feeding through a sustained, positive reinforcement signal

Hyperleptinemia is required for the development of leptin resistance

Identification of preoptic sleep neurons using retrograde labelling and gene profiling

Isoform-selective phosphoinositide 3'-kinase inhibitors inhibit CXCR4 signaling and overcome stromal cell-mediated drug resistance in chronic lymphocytic leukemia: a novel therapeutic approach

Isoform-specific phosphoinositide 3-kinase inhibitors from an arylmorpholine scaffold

Linking smell to metabolism and aging

Maintenance of hormone-sensitive phosphoinositide pools in the plasma membrane requires phosphatidylinositol 4-kinase IIIalpha

Making sense of the sensory regulation of hunger neurons

Molecular profiling of activated neurons by phosphorylated ribosome capture

Molecular profiling of neurons based on connectivity

Neural circuits underlying thirst and fluid homeostasis

Obesity causes selective and long-lasting desensitization of AgRP neurons to dietary fat

PI-103, a dual inhibitor of Class IA phosphatidylinositide 3-kinase and mTOR, has antileukemic activity in AML.

PIK3CA cooperates with other phosphatidylinositol 3'-kinase pathway mutations to effect oncogenic transformation

Phosphospecific proteolysis for mapping sites of protein phosphorylation

Rapid Sensing of Dietary Amino Acid Deficiency Does Not Require GCN2

Re-examination of Dietary Amino Acid Sensing Reveals a GCN2-Independent Mechanism

Regulation of Body Temperature by the Nervous System

Sensory detection of food rapidly modulates arcuate feeding circuits

Small molecule inhibitors of the PI3-kinase family

Sustained NPY signaling enables AgRP neurons to drive feeding

T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR.

Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases

Targeting the cancer kinome through polypharmacology

Targeting the gatekeeper residue in phosphoinositide 3-kinases

The Forebrain Thirst Circuit Drives Drinking through Negative Reinforcement

Thirst

Thirst neurons anticipate the homeostatic consequences of eating and drinking

To stabilize neutrophil polarity, PIP3 and Cdc42 augment RhoA activity at the back as well as signals at the front

Warm-Sensitive Neurons that Control Body Temperature