Search filters

List of works by Pal Pacher

A Mechanistic Review of Cell Death in Alcohol-Induced Liver Injury

scientific article

A new cannabinoid CB2 receptor agonist HU-910 attenuates oxidative stress, inflammation and cell death associated with hepatic ischaemia/reperfusion injury

scientific article

A new, potent poly(ADP-ribose) polymerase inhibitor improves cardiac and vascular dysfunction associated with advanced aging

scientific article published on 22 June 2004

A peroxynitrite decomposition catalyst counteracts sensory neuropathy in streptozotocin-diabetic mice.

scientific article

A(2B) adenosine receptors in immunity and inflammation.

scientific article published on 07 May 2009

A2A adenosine receptors and C/EBPbeta are crucially required for IL-10 production by macrophages exposed to Escherichia coli

scientific article

A2A adenosine receptors control pancreatic dysfunction in high-fat-diet induced obesity

scientific article

A2A receptors in inflammation and injury: lessons learned from transgenic animals

scientific article

A2B adenosine receptors prevent insulin resistance by inhibiting adipose tissue inflammation via maintaining alternative macrophage activation.

scientific article

A2B adenosine receptors protect against sepsis-induced mortality by dampening excessive inflammation

scientific article

Activation of poly(ADP-ribose) polymerase contributes to development of doxorubicin-induced heart failure

scientific article published in March 2002

Activation of the peripheral endocannabinoid system in human obesity

scientific article

Activity-based protein profiling of the human failing ischemic heart reveals alterations in hydrolase activities involving the endocannabinoid system

scientific article published on 30 November 2019

Adenosine A2A receptor activation inhibits T helper 1 and T helper 2 cell development and effector function.

scientific article published on 14 July 2008

Adenosine A2A receptor activation protects CD4+ T lymphocytes against activation-induced cell death.

scientific article

Adenosine augments IL-10 production by microglial cells through an A2B adenosine receptor-mediated process

scientific article

Adenosine augments IL-10-induced STAT3 signaling in M2c macrophages

scientific article published on 06 August 2013

Adenosine promotes alternative macrophage activation via A2A and A2B receptors

scientific article published on 16 September 2011

Adenosine receptor activation ameliorates type 1 diabetes.

scientific article published on 3 April 2007

Adenosine receptor signaling in the brain immune system

scientific article

Adenosine receptors differentially regulate type 2 cytokine production by IL-33-activated bone marrow cells, ILC2s, and macrophages

scientific article published on 5 October 2017

Adenosine receptors: therapeutic aspects for inflammatory and immune diseases

scientific article

Adenosine signalling and the immune system: when a lot could be too much.

scientific article published on 24 April 2018

Adenosine signalling in diabetes mellitus--pathophysiology and therapeutic considerations

scientific article

Ado-Trastuzumab Emtansine Targets Hepatocytes Via Human Epidermal Growth Factor Receptor 2 to Induce Hepatotoxicity

scientific article published on 28 December 2015

Aerosolized linear polyethylenimine-nitric oxide/nucleophile adduct attenuates endotoxin-induced lung injury in sheep

scientific article published in December 2002

Age-dependent cardiovascular effects of sepsis in a murine model of cecal ligation and puncture: implications for the design of interventional studies

scientific article published on 03 August 2018

Aging aggravates alcoholic liver injury and fibrosis in mice by downregulating sirtuin 1 expression

scientific article published on 18 November 2016

Alcohol Binge-Induced Cardiovascular Dysfunction Involves Endocannabinoid-CB1-R Signaling

scientific article published on 23 September 2019

Alcohol Misuse and Kidney Injury: Epidemiological Evidence and Potential Mechanisms

scientific article published on January 2017

Alcohol and mitochondria in cardiac apoptosis: mechanisms and visualization

scientific article

Alcohol inhibits T-cell glucose metabolism and hepatitis in ALDH2-deficient mice and humans: roles of acetaldehyde and glucocorticoids

scientific article published on 18 August 2018

Aldose reductase inhibition counteracts nitrosative stress and poly(ADP-ribose) polymerase activation in diabetic rat kidney and high-glucose-exposed human mesangial cells

scientific article

Aldose reductase inhibition counteracts oxidative-nitrosative stress and poly(ADP-ribose) polymerase activation in tissue sites for diabetes complications

scientific article published on January 2005

Alternative Splicing of NOX4 in the Failing Human Heart.

scientific article published on 22 November 2017

Anaphylatoxin C5a contributes to the pathogenesis of cisplatin-induced nephrotoxicity

scientific article

Anti-CD73 in cancer immunotherapy: awakening new opportunities.

scientific article published on February 2016

Anti-inflammatory and anti-apoptotic roles of endothelial cell STAT3 in alcoholic liver injury

scientific article

Anti-inflammatory effects of inosine in human monocytes, neutrophils and epithelial cells in vitro

scientific article published on December 1, 2001

Bacterial flagellin elicits widespread innate immune defense mechanisms, apoptotic signaling, and a sepsis-like systemic inflammatory response in mice.

scientific article

Bacterial flagellin triggers cardiac innate immune responses and acute contractile dysfunction

scientific journal article

Beyond THC and Endocannabinoids

scientific article published on 03 October 2019

Blood pressure regulation by endocannabinoids and their receptors

scientific article

CB1 cannabinoid receptor inhibition: promising approach for heart failure?

scientific article

CB1 cannabinoid receptors promote oxidative stress and cell death in murine models of doxorubicin-induced cardiomyopathy and in human cardiomyocytes

scientific article

CB1 cannabinoid receptors promote oxidative/nitrosative stress, inflammation and cell death in a murine nephropathy model

scientific article

CB2 cannabinoid receptor agonists attenuate TNF-alpha-induced human vascular smooth muscle cell proliferation and migration

scientific article

CB2 cannabinoid receptors contribute to bacterial invasion and mortality in polymicrobial sepsis

scientific article

CB2-receptor stimulation attenuates TNF-alpha-induced human endothelial cell activation, transendothelial migration of monocytes, and monocyte-endothelial adhesion

scientific article

CD39 and CD73 in immunity and inflammation

scientific article published on 17 April 2013

CD39 improves survival in microbial sepsis by attenuating systemic inflammation

scientific article

Ca2+ marks: miniature calcium signals in single mitochondria driven by ryanodine receptors

scientific article

Can simvastatin promote tumor growth by inducing angiogenesis similar to VEGF?

scientific article published in January 2002

Can the electrophysiological action of rosiglitazone explain its cardiac side effects?

scientific article

Cannabidiol Protects against Doxorubicin-Induced Cardiomyopathy by Modulating Mitochondrial Function and Biogenesis

scientific article published on 6 January 2015

Cannabidiol attenuates alcohol-induced liver steatosis, metabolic dysregulation, inflammation and neutrophil-mediated injury

scientific article

Cannabidiol attenuates cardiac dysfunction, oxidative stress, fibrosis, and inflammatory and cell death signaling pathways in diabetic cardiomyopathy

scientific article

Cannabidiol attenuates cisplatin-induced nephrotoxicity by decreasing oxidative/nitrosative stress, inflammation, and cell death

scientific article published on 12 December 2008

Cannabidiol attenuates high glucose-induced endothelial cell inflammatory response and barrier disruption

scientific article

Cannabidiol limits Tcell-mediated chronic autoimmune myocarditis: implications to autoimmune disorders and organ transplantation

scientific article published on 08 January 2016

Cannabidiol protects against hepatic ischemia/reperfusion injury by attenuating inflammatory signaling and response, oxidative/nitrative stress, and cell death

scientific article

Cannabinoid 1 receptor activation contributes to vascular inflammation and cell death in a mouse model of diabetic retinopathy and a human retinal cell line

scientific article

Cannabinoid 1 receptor promotes cardiac dysfunction, oxidative stress, inflammation, and fibrosis in diabetic cardiomyopathy

scientific article published on 7 February 2012

Cannabinoid CB1 receptor antagonists for atherosclerosis and cardiometabolic disorders: new hopes, old concerns?

scientific article published in January 2009

Cannabinoid CB1 receptor inhibition decreases vascular smooth muscle migration and proliferation

scientific article

Cannabinoid CB2 receptor ligand profiling reveals biased signalling and off-target activity.

scientific article published on 03 January 2017

Cannabinoid antagonist SR-141716 inhibits endotoxic hypotension by a cardiac mechanism not involving CB1 or CB2 receptors

scientific article published on April 2004

Cannabinoid receptor CB2 protects against balloon-induced neointima formation

scientific article published on 06 January 2012

Cannabinoid-1 receptor activation induces reactive oxygen species-dependent and -independent mitogen-activated protein kinase activation and cell death in human coronary artery endothelial cells

scientific article

Cannabinoid-1 receptor deletion in podocytes mitigates both glomerular and tubular dysfunction in a mouse model of diabetic nephropathy

scientific article published on 6 November 2017

Cannabinoid-2 receptor activation ameliorates hepatorenal syndrome

scientific article published on 23 November 2019

Cannabinoid-2 receptor agonist HU-308 protects against hepatic ischemia/reperfusion injury by attenuating oxidative stress, inflammatory response, and apoptosis

scientific article

Cannabinoid-2 receptor limits inflammation, oxidative/nitrosative stress, and cell death in nephropathy

scientific article

Cannabinoid-2 receptor mediates protection against hepatic ischemia/reperfusion injury

scientific article

Cannabinoids ameliorate pain and reduce disease pathology in cerulein-induced acute pancreatitis

scientific article

Cannabinoids cool the intestine

scientific article published on July 2004

Cannabinoids in pancreatic cancer: correlation with survival and pain

scientific article

Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors

scientific article

Cannabinoids reduce markers of inflammation and fibrosis in pancreatic stellate cells

scientific article

Cardiac NO signalling in the metabolic syndrome

scientific article

Cardiac electrophysiological effects of citalopram in guinea pig papillary muscle Comparison with clomipramine

scientific article published on 01 January 2000

Cardiovascular effects of marijuana and synthetic cannabinoids: the good, the bad, and the ugly

scientific article

Cardiovascular side effects of new antidepressants and antipsychotics: new drugs, old concerns?

scientific article published in January 2004

Cell type-dependent pro- and anti-inflammatory role of signal transducer and activator of transcription 3 in alcoholic liver injury

scientific article published on 11 January 2008

Changes in cardiac electrophysiology, morphology, tissue biochemistry and vascular reactions in glutathione depleted animals

scientific article

Chronic plus binge ethanol feeding induces myocardial oxidative stress, mitochondrial and cardiovascular dysfunction, and steatosis

scientific article published on 22 April 2016

Circulating anandamide and blood pressure in patients with obstructive sleep apnea

scientific article published in December 2012

Cirrhotic cardiomyopathy: an endocannabinoid connection?

scientific article published in October 2005

Cisplatin nephrotoxicity involves mitochondrial injury with impaired tubular mitochondrial enzyme activity

scientific article

Comparative study of cardiac electrophysiological effects of atrial natriuretic peptide

scientific article published in July 1996

Comparison of inflammation, organ damage, and oxidant stress induced by Salmonella enterica serovar Muenchen flagellin and serovar Enteritidis lipopolysaccharide

scientific article

Control of apoptosis by IP(3) and ryanodine receptor driven calcium signals

scientific article

Correction: Trastuzumab Alters the Expression of Genes Essential for Cardiac Function and Induces Ultrastructural Changes of Cardiomyocytes in Mice

scientific article published in PLoS ONE

Critical Role of TFEB-Mediated Lysosomal Biogenesis in Alcohol-Induced Pancreatitis in Mice and Humans

scientific article published on 25 January 2020

Cutting edge: IL-1α is a crucial danger signal triggering acute myocardial inflammation during myocardial infarction

scientific article

DEPTOR Suppresses Lipogenesis and Ameliorates Hepatic Steatosis and Acute-on-Chronic Liver Injury in Alcoholic Liver Disease

scientific article published on 19 February 2018

Decreased age-related cardiac dysfunction, myocardial nitrative stress, inflammatory gene expression, and apoptosis in mice lacking fatty acid amide hydrolase

scientific article

Definition of hidden drug cardiotoxicity: paradigm change in cardiac safety testing and its clinical implications

scientific article published on 01 June 2019

Design, Synthesis, and Biological Evaluation of Novel, Non-Brain-Penetrant, Hybrid Cannabinoid CB1R Inverse Agonist/Inducible Nitric Oxide Synthase (iNOS) Inhibitors for the Treatment of Liver Fibrosis.

scientific article published on 13 January 2017

Diastolic dysfunction in prediabetic male rats: Role of mitochondrial oxidative stress.

scientific article published on 12 August 2016

Digoxin Suppresses Pyruvate Kinase M2-Promoted HIF-1α Transactivation in Steatohepatitis.

scientific article published in February 2018

Digoxin Suppresses Pyruvate Kinase M2-Promoted HIF-1α Transactivation in Steatohepatitis.

scientific article

Discovery of a NAPE-PLD inhibitor that modulates emotional behavior in mice

scientific article published on 11 May 2020

Disruption of renal arginine metabolism promotes kidney injury in hepatorenal syndrome

scientific article published on 6 April 2018

Dissociation between liver inflammation and hepatocellular damage induced by carbon tetrachloride in myeloid cell-specific signal transducer and activator of transcription 3 gene knockout mice

scientific article

Drug-induced mitochondrial dysfunction and cardiotoxicity

scientific article

Dysregulation of the peripheral and adipose tissue endocannabinoid system in human abdominal obesity

scientific article

Early diabetes-induced biochemical changes in the retina: comparison of rat and mouse models

scientific article

Ecto-5'-nucleotidase (CD73) decreases mortality and organ injury in sepsis

scientific article

Editorial [Hot Topic: Role of Oxidative-Nitrostative Stress and Poly(ADP-ribose) Polymerase in Cardiovascular Pathophysiology (Guest Editor: Pal Pacher)]

scientific article published on 01 July 2005

Effects of a potent peroxynitrite decomposition catalyst in murine models of endotoxemia and sepsis

scientific article

Electrophysiological changes in rat ventricular and atrial myocardium at different stages of experimental diabetes

scientific article published on 01 May 1999

Electrophysiological effects of fluoxetine in mammalian cardiac tissues

scientific article published in January 2000

Electrophysiological effects of homocysteine in isolated rat right ventricular papillary muscles and left atria

scientific article published on 01 April 1999

Electrophysiological effects of risperidone in mammalian cardiac cells

scientific article published on 25 July 2002

Endocannabinoid signaling at the periphery: 50 years after THC.

scientific article published on 18 March 2015

Endocannabinoids acting at CB1 receptors mediate the cardiac contractile dysfunction in vivo in cirrhotic rats

scientific article

Endocannabinoids acting at cannabinoid-1 receptors regulate cardiovascular function in hypertension

scientific article published on 27 September 2004

Endocannabinoids and cannabinoid receptors in ischaemia-reperfusion injury and preconditioning

scientific article

Endocannabinoids and cardiac contractile function: pathophysiological implications

scientific article published on August 2009

Endocannabinoids and liver disease. III. Endocannabinoid effects on immune cells: implications for inflammatory liver diseases

scientific article published on 31 January 2008

Endocannabinoids in cerebrovascular regulation

scientific article published on 29 January 2016

Endogenous cannabinoid receptor CB1 activation promotes vascular smooth-muscle cell proliferation and neointima formation

scientific article published on 11 March 2013

Endothelial Nrf2 activation: a new target for resveratrol?

scientific article published on 14 May 2010

Endothelial dysfunction and angiogenesis impairment in the ageing vasculature

scientific article published on 01 September 2018

Endothelial function and vascular oxidative stress in long-lived GH/IGF-deficient Ames dwarf mice

scientific article published on 29 August 2008

Endotoxin impairs cardiac hemodynamics by affecting loading conditions but not by reducing cardiac inotropism

scientific article

Evaluation of PMI-5011, an ethanolic extract of Artemisia dracunculus L., on peripheral neuropathy in streptozotocin-diabetic mice

scientific article

Evaluation of orally active poly(ADP-ribose) polymerase inhibitor in streptozotocin-diabetic rat model of early peripheral neuropathy

scientific article published on April 2004

Evidence for novel cannabinoid receptors

scientific article

Execution of superoxide-induced cell death by the proapoptotic Bcl-2-related proteins Bid and Bak.

scientific article published on 30 March 2009

Extracellular ATP protects against sepsis through macrophage P2X7 purinergic receptors by enhancing intracellular bacterial killing

scientific article

Fat-Specific Protein 27/CIDEC Promotes Development of Alcoholic Steatohepatitis in Mice and Humans

scientific article

Feasibility Evaluation of Myocardial Cannabinoid Type 1 Receptor Imaging in Obesity: A Translational Approach.

scientific article published in February 2018

Female X-chromosome mosaicism for NOX2 deficiency presents unique inflammatory phenotype and improves outcome in polymicrobial sepsis

scientific article

G protein-coupled endothelial receptor for atypical cannabinoid ligands modulates a Ca2+-dependent K+ current

scientific article published on 2 September 2003

Glucocorticoid receptor dimerization is required for proper recovery of LPS-induced inflammation, sickness behavior and metabolism in mice

scientific article published on 23 October 2012

Glycogen phosphorylase inhibition improves beta cell function.

scientific article published on 13 April 2017

Haemodynamic profile and responsiveness to anandamide of TRPV1 receptor knock-out mice

scientific article published on 30 April 2004

Hemodynamic profile, responsiveness to anandamide, and baroreflex sensitivity of mice lacking fatty acid amide hydrolase

scientific article

Homocysteine induces cell death in H9C2 cardiomyocytes through the generation of peroxynitrite

scientific article

Hybrid inhibitor of peripheral cannabinoid-1 receptors and inducible nitric oxide synthase mitigates liver fibrosis

scientific article published on July 2016

Hyperglycaemia alters the endothelium-dependent relaxation of canine coronary arteries

scientific article published on 01 July 2000

Immunity, inflammation and cancer: a leading role for adenosine

scientific article

Impaired TFEB-mediated lysosomal biogenesis promotes the development of pancreatitis in mice and is associated with human pancreatitis

scientific article published on 30 March 2019

Increased fear- and stress-related anxiety-like behavior in mice lacking tuberoinfundibular peptide of 39 residues

scientific article

Increased myogenic tone in skeletal muscle arterioles of diabetic rats. Possible role of increased activity of smooth muscle Ca2+ channels and protein kinase C

scientific article published on 01 September 1999

Inflammation is independent of steatosis in a murine model of steatohepatitis

scientific article

Inhibition of matrix metalloproteinase-2 by PARP inhibitors

scientific article published on 18 July 2009

Inhibition of voltage-gated calcium channels by fluoxetine in rat hippocampal pyramidal cells

scientific article published on 01 April 2000

Inosine Reduces Systemic Inflammation and Improves Survival in Septic Shock Induced by Cecal Ligation and Puncture ⬇️

scientific article published on October 1, 2001

Inosine exerts a broad range of antiinflammatory effects in a murine model of acute lung injury

scientific article published on April 2002

Interleukin-22 ameliorates acute-on-chronic liver failure by reprogramming impaired regeneration pathways in mice

scientific article published on 29 November 2019

Interplay of Liver-Heart Inflammatory Axis and Cannabinoid 2 Receptor Signaling in an Experimental Model of Hepatic Cardiomyopathy

scientific article published on 24 January 2020

Interplay of cannabinoid 2 (CB2) receptors with nitric oxide synthases, oxidative and nitrative stress, and cell death during remote neurodegeneration ⬇️

scientific article published on April 1, 2012

Interplay of cardiovascular mediators, oxidative stress and inflammation in liver disease and its complications

scientific article published on 30 September 2020

Interplay of oxidative, nitrosative/nitrative stress, inflammation, cell death and autophagy in diabetic cardiomyopathy

scientific article published in February 2015

Intrapulmonary G-CSF rescues neutrophil recruitment to the lung and neutrophil release to blood in Gram-negative bacterial infection in MCP-1-/- mice

scientific article

Investigational A₃ adenosine receptor targeting agents

scientific article published on 2 April 2011

Is lipid signaling through cannabinoid 2 receptors part of a protective system?

scientific article

Left ventricular pressure-volume relationship in a rat model of advanced aging-associated heart failure

scientific article published on July 2004

Lipopolysaccharide induces anandamide synthesis in macrophages via CD14/MAPK/phosphoinositide 3-kinase/NF-kappaB independently of platelet-activating factor

scientific article published on 29 August 2003

Longevity is associated with increased vascular resistance to high glucose-induced oxidative stress and inflammatory gene expression in Peromyscus leucopus

scientific article published on 30 January 2009

Macrophage P2X4 receptors augment bacterial killing and protect against sepsis.

scientific article published on 7 June 2018

Measurement of cardiac function using pressure-volume conductance catheter technique in mice and rats

scientific article

Mice lacking GPR3 receptors display late-onset obese phenotype due to impaired thermogenic function in brown adipose tissue

scientific article

MicroRNA signatures of resveratrol in the ischemic heart

scientific article

Mitochondrial reactive oxygen species generation triggers inflammatory response and tissue injury associated with hepatic ischemia-reperfusion: therapeutic potential of mitochondrially targeted antioxidants.

scientific article

Mitochondrial-targeted antioxidants represent a promising approach for prevention of cisplatin-induced nephropathy

scientific article published on 10 November 2011

Modulating the endocannabinoid system in human health and disease--successes and failures

scientific article published on 22 April 2013

Modulation of the endocannabinoid system in cardiovascular disease: therapeutic potential and limitations

scientific article published on 08 September 2008

Monoacylglycerol lipase controls endocannabinoid and eicosanoid signaling and hepatic injury in mice

scientific article published on 4 January 2013

N-arachidonoyl L-serine, an endocannabinoid-like brain constituent with vasodilatory properties

scientific article

NLRC4 inflammasome-mediated production of IL-1β modulates mucosal immunity in the lung against gram-negative bacterial infection

scientific article

Na+/H+-exchanger-1 inhibition counteracts diabetic cataract formation and retinal oxidative-nitrative stress and apoptosis

scientific journal article

Neuroprotection in Oxidative Stress-Related Neurodegenerative Diseases: Role of Endocannabinoid System Modulation

scientific article published on 12 May 2017

Neutrophil-Hepatic Stellate Cell Interactions Promote Fibrosis in Experimental Steatohepatitis

scientific article published on 8 January 2018

New Piece in the Jigsaw Puzzle: Adipose Tissue-Derived Stem Cells From Obese Subjects Drive Th17 Polarization

scientific article

Nicotine exerts an anti-inflammatory effect in a murine model of acute lung injury

scientific article

Nicotine reduces the incidence of type I diabetes in mice

scientific article published in March 2002

Nitric oxide and peroxynitrite in health and disease

scientific article

Nitrosative stress and pharmacological modulation of heart failure

scientific article

Novel Myocardial PET/CT Receptor Imaging and Potential Therapeutic Targets

scientific article published on 18 May 2019

Novel modulators of poly(ADP-ribose) polymerase

scientific article

Opportunities for the repurposing of PARP inhibitors for the therapy of non-oncological diseases

scientific article published on 18 February 2017

Overactive cannabinoid 1 receptor in podocytes drives type 2 diabetic nephropathy

scientific article

Oxidants positively or negatively regulate nuclear factor kappaB in a context-dependent manner

scientific article

Oxidative inactivation of key mitochondrial proteins leads to dysfunction and injury in hepatic ischemia reperfusion

scientific article published on 25 June 2008

Oxidative stress-induced isoprostane formation may contribute to aspirin resistance in platelets

scientific article

Oxidative-nitrosative stress and poly(ADP-ribose) polymerase (PARP) activation in experimental diabetic neuropathy: the relation is revisited

scientific article

Oxidative/Nitrative Stress and Inflammation Drive Progression of Doxorubicin-Induced Renal Fibrosis in Rats as Revealed by Comparing a Normal and a Fibrosis-Resistant Rat Strain

scientific article published on 18 June 2015

P2X4 receptors, immunity, and sepsis

scientific article published on 25 March 2019

PARP inhibition in leukocytes diminishes inflammation via effects on integrins/cytoskeleton and protects the blood-brain barrier

scientific article

PARP inhibition protects against alcoholic and non-alcoholic steatohepatitis

scientific article

PCB-induced endothelial cell dysfunction: role of poly(ADP-ribose) polymerase

scientific article published on 21 June 2009

PCSK9 inhibition as a novel therapeutic target for alcoholic liver disease

scientific article published on 20 November 2019

Parenteral administration of glipizide sodium salt, an inhibitor of adenosine triphosphate-sensitive potassium channels, prolongs short-term survival after severe controlled hemorrhage in rats

scientific article published in October 2003

Pathophysiological mechanisms of catecholamine and cocaine-mediated cardiotoxicity

scientific article

Pepcan-12 (RVD-hemopressin) is a CB2 receptor positive allosteric modulator constitutively secreted by adrenals and in liver upon tissue damage

scientific article published on 25 August 2017

Peripheral endocannabinoid system activity in patients treated with sibutramine

scientific article published on 6 March 2008

Peroxynitrite activates ERK via Raf-1 and MEK, independently from EGF receptor and p21Ras in H9C2 cardiomyocytes

scientific article

Peroxynitrite induces HMGB1 release by cardiac cells in vitro and HMGB1 upregulation in the infarcted myocardium in vivo.

scientific article

Peroxynitrite is a key mediator of the cardioprotection afforded by ischemic postconditioning in vivo

scientific article

Peroxynitrite is a major trigger of cardiomyocyte apoptosis in vitro and in vivo

scientific article

Peroxynitrite is a potent inhibitor of NF-{kappa}B activation triggered by inflammatory stimuli in cardiac and endothelial cell lines

scientific article

Pharmacologic inhibition of poly(adenosine diphosphate-ribose) polymerase may represent a novel therapeutic approach in chronic heart failure

scientific article published in September 2002

Pharmacological inhibition of CB1 cannabinoid receptor protects against doxorubicin-induced cardiotoxicity

scientific article

Pharmacological inhibition of poly(ADP-ribose) polymerase inhibits angiogenesis

scientific article published on 20 September 2006

Pleiotropic effects of the CB2 cannabinoid receptor activation on human monocyte migration: implications for atherosclerosis and inflammatory diseases

scientific article

Poly (ADP-ribose) polymerase-1 is a key mediator of liver inflammation and fibrosis

scientific article published on April 2014

Poly(ADP-Ribose) polymerase inhibition reduces reperfusion injury after heart transplantation

scientific article published in January 2002

Poly(ADP-Ribose) polymerase is activated in subjects at risk of developing type 2 diabetes and is associated with impaired vascular reactivity

scientific article published in November 2002

Poly(ADP-ribose) polymerase inhibition alleviates experimental diabetic sensory neuropathy

scientific article

Poly(ADP-ribose) polymerase inhibition as a novel therapeutic approach against intraepidermal nerve fiber loss and neuropathic pain associated with advanced diabetic neuropathy: a commentary on "PARP Inhibition or gene deficiency counteracts intraep

scientific article published on 14 January 2008

Poly(ADP-ribose) polymerase regulates myocardial calcium handling in doxorubicin-induced heart failure

scientific article published on 12 January 2005

Poly(ADP-ribose) polymerase-1 is a key mediator of cisplatin-induced kidney inflammation and injury

scientific article published on 17 August 2011

Poly(ADP-ribose) polymerases as modulators of mitochondrial activity

scientific article

Poly(ADP-ribose)polymerase inhibition counteracts renal hypertrophy and multiple manifestations of peripheral neuropathy in diabetic Akita mice

scientific article

Poly(ADP-ribose)polymerase inhibition decreases angiogenesis

scientific article published on 9 October 2006

Post-partum prolongation of the atrial repolarization in rabbit

scientific article published on 01 May 1999

Potent metalloporphyrin peroxynitrite decomposition catalyst protects against the development of doxorubicin-induced cardiac dysfunction

scientific article published in February 2003

Potential role for 8-oxoguanine DNA glycosylase in regulating inflammation

scientific article

Propagation of the apoptotic signal by mitochondrial waves

scientific article

Protection from Radiation-Induced Pulmonary Fibrosis by Peripheral Targeting of Cannabinoid Receptor-1.

scientific article published on October 2015

Psoriasis-Related Visceral Adiposity and Arterial Inflammation: A New Adiposity Disease Entity?

scientific article published on 14 October 2017

Quantification of calcium signal transmission from sarco-endoplasmic reticulum to the mitochondria

scientific article

Quorum sensing in the immune system

scientific article published on 01 September 2018

Regulation of macrophage function by adenosine

scientific article

Restoration of altered microRNA expression in the ischemic heart with resveratrol

scientific article

Restoration of the endothelial function in the aortic rings of apolipoprotein E deficient mice by pharmacological inhibition of the nuclear enzyme poly(ADP-ribose) polymerase

scientific article

Resveratrol attenuates azidothymidine-induced cardiotoxicity by decreasing mitochondrial reactive oxygen species generation in human cardiomyocytes

scientific article

Resveratrol attenuates mitochondrial oxidative stress in coronary arterial endothelial cells

scientific article published on 11 September 2009

Resveratrol induces mitochondrial biogenesis in endothelial cells

scientific article published on 08 May 2009

Rethinking Communication in the Immune System: The Quorum Sensing Concept

scientific article published on 02 January 2019

Review of cardiovascular effects of fluoxetine, a selective serotonin reuptake inhibitor, compared to tricyclic antidepressants

scientific article published on October 1, 1998

Role of A(2A) adenosine receptors in regulation of opsonized E. coli-induced macrophage function

scientific article

Role of endocannabinoids and cannabinoid-1 receptors in cerebrocortical blood flow regulation

scientific article

Role of intracellular calcium mobilization and cell-density-dependent signaling in oxidative-stress-induced cytotoxicity in HaCaT keratinocytes.

scientific article published on July 2003

Role of nonsynaptic communication in regulating the immune response.

scientific article

Role of oxidative and nitrosative stress, longevity genes and poly(ADP-ribose) polymerase in cardiovascular dysfunction associated with aging

scientific article published in July 2005

Role of oxidative-nitrosative stress and downstream pathways in various forms of cardiomyopathy and heart failure.

scientific article published in July 2005

Role of peroxynitrite in the pathogenesis of cardiovascular complications of diabetes

scientific article

Role of poly(ADP-ribose) polymerase 1 (PARP-1) in cardiovascular diseases: the therapeutic potential of PARP inhibitors

scientific article

Role of poly(ADP-ribose) polymerase activation in diabetic neuropathy

scientific article published in March 2004

Role of poly(ADP-ribose) polymerase activation in endotoxin-induced cardiac collapse in rodents

scientific article

Role of poly(ADP-ribose) polymerase-1 activation in the pathogenesis of diabetic complications: endothelial dysfunction, as a common underlying theme

scientific article

Role of poly(ADP-ribosyl)ation in a 'two-hit' model of hypoxia and oxidative stress in human A549 epithelial cells in vitro

scientific article published on 29 May 2013

Role of slow delayed rectifier K+-current in QT prolongation in the alloxan-induced diabetic rabbit heart

scientific article published on 29 October 2007

Role of superoxide, nitric oxide, and peroxynitrite in doxorubicin-induced cell death in vivo and in vitro

scientific article published on 13 March 2009

Role of the endocannabinoid system in diabetes and diabetic complications

scientific article published on 16 June 2015

Role of the peroxynitrite-poly(ADP-ribose) polymerase pathway in human disease

scientific article published on 5 June 2008

Selective Photoaffinity Probe That Enables Assessment of Cannabinoid CB2 Receptor Expression and Ligand Engagement in Human Cells.

scientific article

Selective activation of cannabinoid receptor 2 in leukocytes suppresses their engagement of the brain endothelium and protects the blood-brain barrier

scientific article published on 18 September 2013

Selective serotonin-reuptake inhibitor antidepressants increase the risk of falls and hip fractures in elderly people by inhibiting cardiovascular ion channels

scientific article

Serotonin Reuptake Inhibitor Fluoxetine Decreases Arteriolar Myogenic Tone by Reducing Smooth Muscle [Ca2+]i

scientific article published on 01 June 2000

Serotonin reuptake inhibitor, fluoxetine, dilates isolated skeletal muscle arterioles. Possible role of altered Ca2+ sensitivity

scientific article

Serotonin reuptake inhibitors fluoxetine and citalopram relax intestinal smooth muscle

scientific article published in July 2001

Serotonin reuptake inhibitors fluoxetine and citalopram relax intestinal smooth muscle

scholarly article by Pal Pacher et al published 2001 in Canadian Journal of Physiology and Pharmacology

Shaping of monocyte and macrophage function by adenosine receptors

scientific article

Simple quantitative detection of mitochondrial superoxide production in live cells

scientific article

Simultaneous detection of apoptosis and mitochondrial superoxide production in live cells by flow cytometry and confocal microscopy

scientific article

Soluble guanylate cyclase agonists inhibit expression and procoagulant activity of tissue factor

scientific article

Soluble guanylate cyclase as an emerging therapeutic target in cardiopulmonary disease

scientific article

Spatio-temporal organization of the mitochondrial phase of apoptosis

scientific article

Stimulation of A2B adenosine receptors protects against trauma-hemorrhagic shock-induced lung injury

scientific article published on 13 April 2013

Sulforaphane, a natural constituent of broccoli, prevents cell death and inflammation in nephropathy

scientific article

Suppression of intestinal polyposis in Apcmin/+ mice by targeting the nitric oxide or poly(ADP-ribose) pathways

scientific article published in April 2004

Suppression of tumorigenicity 2: a janus-faced player in sepsis

scientific article

Targeting cannabinoid receptor CB(2) in cardiovascular disorders: promises and controversies

scientific article

Testing hypotheses of aging in long-lived mice of the genus Peromyscus: association between longevity and mitochondrial stress resistance, ROS detoxification pathways, and DNA repair efficiency

scientific article published on 14 June 2008

The Flagellin-TLR5 Axis: Therapeutic Opportunities.

scientific article published in September 2002

The Outsiders: Emerging Roles of Ectonucleotidases in Inflammation

article published in 2012

The Purinergic System as a Pharmacological Target for the Treatment of Immune-Mediated Inflammatory Diseases

scientific article published on 01 July 2019

The adenosine A2A receptor agonist CGS 21680 fails to ameliorate the course of dextran sulphate-induced colitis in mice

scientific article

The adenosine A3 receptor agonist, N6-(3-iodobenzyl)-adenosine-5'-N-methyluronamide, is protective in two murine models of colitis

scientific article published in April 2003

The emerging role of the endocannabinoid system in cardiovascular disease

scientific article published on 09 April 2009

The endocannabinoid system and plant-derived cannabinoids in diabetes and diabetic complications

scientific article

The endocannabinoid system of the skin in health and disease: novel perspectives and therapeutic opportunities

scientific article published on 14 July 2009

The endogenous brain constituent N-arachidonoyl L-serine is an activator of large conductance Ca2+-activated K+ channels

scientific article published on 15 October 2008

The novel inosine analogue INO-2002 exerts an anti-inflammatory effect in a murine model of acute lung injury

scientific article published on September 2009

The novel inosine analogue, INO-2002, protects against diabetes development in multiple low-dose streptozotocin and non-obese diabetic mouse models of type I diabetes

scientific article published on 18 June 2008

The novel, orally available and peripherally restricted selective cannabinoid CB2 receptor agonist LEI-101 prevents cisplatin-induced nephrotoxicity

scientific article published on 23 September 2015

Therapeutic effects of xanthine oxidase inhibitors: renaissance half a century after the discovery of allopurinol

scientific article

Toll-like receptor 5 deficiency exacerbates cardiac injury and inflammation induced by myocardial ischaemia-reperfusion in the mouse.

scientific article

Topical administration of a novel nitric oxide donor, linear polyethylenimine-nitric oxide/nucleophile adduct (DS1), selectively increases vaginal blood flow in anesthetized rats

scientific article

Towards the use of non-psychoactive cannabinoids for prostate cancer

scientific article published on January 2013

Transcriptional basis for exercise limitation in male eNOS-knockout mice with age: heart failure and the fetal phenotype

scientific article published on 6 May 2005

Trastuzumab alters the expression of genes essential for cardiac function and induces ultrastructural changes of cardiomyocytes in mice

scientific article

Trastuzumab cardiotoxicity: from clinical trials to experimental studies

scientific article

Trends in the development of new antidepressants. Is there a light at the end of the tunnel?

scientific article published on April 2004

Uncoupling of ER-mitochondrial calcium communication by transforming growth factor-beta

scientific article published on 23 July 2008

Vascular dysfunction in aging: potential effects of resveratrol, an anti-inflammatory phytoestrogen

scientific article

Vasoprotective effects of resveratrol and SIRT1: attenuation of cigarette smoke-induced oxidative stress and proinflammatory phenotypic alterations

scientific article published on 18 April 2008

Xanthine oxidase inhibitor allopurinol attenuates the development of diabetic cardiomyopathy

scientific article

Δ8-Tetrahydrocannabivarin prevents hepatic ischaemia/reperfusion injury by decreasing oxidative stress and inflammatory responses through cannabinoid CB2 receptors

scientific article

β-Caryophyllene ameliorates cisplatin-induced nephrotoxicity in a cannabinoid 2 receptor-dependent manner

scientific article published on 31 January 2012

β-Caryophyllene protects against alcoholic steatohepatitis by attenuating inflammation and metabolic dysregulation in mice

scientific article published on 20 January 2017

Paulina is supported by:

About Paulina

Help