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List of works by Timothy Stinear

1,2,4-Oxadiazole antimicrobials act synergistically with daptomycin and display rapid kill kinetics against MDR Enterococcus faecium

scientific article published on 6 March 2018

A Genomic Approach to Resolving Relapse versus Reinfection among Four Cases of Buruli Ulcer.

scientific article published on 30 November 2015

A diagnostic PCR assay for the detection of an Australian epidemic strain of Pseudomonas aeruginosa

scientific article published on 16 July 2010

A glimpse into the past and predictions for the future: the molecular evolution of the tuberculosis agent

scientific article published on 3 August 2014

A major role for mammals in the ecology of Mycobacterium ulcerans.

scientific article

A nanomechanical study of the effects of colistin on the Klebsiella pneumoniae AJ218 capsule.

scientific article

A novel mycolactone from a clinical isolate of Mycobacterium ulcerans provides evidence for additional toxin heterogeneity as a result of specific changes in the modular polyketide synthase

scientific article

A novel mycolactone toxin obtained by biosynthetic engineering

scientific article

A supervised statistical learning approach for accurate Legionella pneumophila source attribution during outbreaks.

scientific article

A sustained hospital outbreak of vancomycin-resistant Enterococcus faecium bacteremia due to emergence of vanB E. faecium sequence type 203.

scientific article published on October 2010

Accessible Platform for High-Throughput COVID-19 Molecular Diagnostics and Genome Sequencing Using a Repurposed 3D Printer for RNA Extraction

scientific article published on 26 August 2021

Adaptive change inferred from genomic population analysis of the ST93 epidemic clone of community-associated methicillin-resistant Staphylococcus aureus

scientific article published on February 2014

Analysis of Rhizonin Biosynthesis Reveals Origin of Pharmacophoric Furylalanine Moieties in Diverse Cyclopeptides

scientific article published in 2023

Analysis of a Novel pncA Mutation for Susceptibility to Pyrazinamide Therapy

scientific article published on 25 April 2018

Analysis of the Mycobacterium ulcerans genome sequence reveals new loci for variable number tandem repeats (VNTR) typing

scientific article published on May 2007

Analysis of the small RNA transcriptional response in multidrug-resistant Staphylococcus aureus after antimicrobial exposure

scientific article

Analysis of the vaccine potential of plasmid DNA encoding nine mycolactone polyketide synthase domains in Mycobacterium ulcerans infected mice

scientific article (publication date: 2014)

Aquatic plants stimulate the growth of and biofilm formation by Mycobacterium ulcerans in axenic culture and harbor these bacteria in the environment

scientific article published on February 2004

Bacterial membrane vesicles transport their DNA cargo into host cells.

scientific article

Biosynthesis and Ether-Bridge Formation in Nargenicin Macrolides

scientific article published on 11 February 2019

Burkholderia lata Infections from Intrinsically Contaminated Chlorhexidine Mouthwash, Australia, 2016

article

Buruli ulcer (M. ulcerans infection): new insights, new hope for disease control

scientific article

Buruli ulcer: reductive evolution enhances pathogenicity of Mycobacterium ulcerans

scientific article published on January 2009

Buruli ulcers in a Spanish aid worker after a stay in Peru

scientific article published on 25 October 2018

Bystander Activation of Pulmonary Trm Cells Attenuates the Severity of Bacterial Pneumonia by Enhancing Neutrophil Recruitment

scientific article published on 01 December 2019

Changes in protein abundance are observed in bacterial isolates from a natural host

scientific article

Comment on: Benchmarking of methods for identification of antimicrobial resistance genes in bacterial whole genome data.

scientific article published on 20 December 2016

Common evolutionary origin for the unstable virulence plasmid pMUM found in geographically diverse strains of Mycobacterium ulcerans

scientific article

Comparative Transcriptomic and Functional Assessments of Linezolid-Responsive Small RNA Genes in Staphylococcus aureus

scientific article published on 07 January 2020

Comparative analysis of the complete genome of an epidemic hospital sequence type 203 clone of vancomycin-resistant Enterococcus faecium

scientific article

Comparative genetic analysis of Mycobacterium ulcerans and Mycobacterium marinum reveals evidence of recent divergence

scientific article

Comparative genomics shows Mycobacterium ulcerans migration and expansion has preceded the rise of Buruli ulcer in south-eastern Australia.

scientific article published on 9 February 2018

Complete Bypass of Restriction Systems for Major Staphylococcus aureus Lineages.

scientific article published on 26 May 2015

Complete genome sequence of Staphylococcus aureus strain JKD6008, an ST239 clone of methicillin-resistant Staphylococcus aureus with intermediate-level vancomycin resistance

scientific article

Complete genome sequence of Staphylococcus aureus strain JKD6159, a unique Australian clone of ST93-IV community methicillin-resistant Staphylococcus aureus

scientific article

Complete genome sequence of the frog pathogen Mycobacterium ulcerans ecovar Liflandii

scientific article

Comprehensive antibiotic-linked mutation assessment by resistance mutation sequencing (RM-seq)

scientific article published on 31 August 2018

Comprehensive proteome analysis of Mycobacterium ulcerans and quantitative comparison of mycolactone biosynthesis

scientific article

Convergent Evolution Driven by Rifampin Exacerbates the Global Burden of Drug-Resistant Staphylococcus aureus.

scientific article published on 24 January 2018

Convergent adaptation in the dominant global hospital clone ST239 of methicillin-resistant Staphylococcus aureus.

scientific article

Correction: Buruli Ulcer (M. ulcerans Infection): New Insights, New Hope for Disease Control

scientific article

Correction: Whole Genome Comparisons Suggest Random Distribution of Mycobacterium ulcerans Genotypes in a Buruli Ulcer Endemic Region of Ghana

scientific article published on 13 May 2015

Correspondence: Spontaneous secondary mutations confound analysis of the essential two-component system WalKR in Staphylococcus aureus

scientific article published on 06 February 2017

Deciphering the genetic basis for polyketide variation among mycobacteria producing mycolactones

scientific article

Decreased vancomycin susceptibility in Staphylococcus aureus caused by IS256 tempering of WalKR expression

scientific article published on 29 April 2013

Detection of Mycobacterium ulcerans in environmental samples during an outbreak of ulcerative disease

scientific article published on October 1, 1997

Development and application of two multiplex real-time PCR assays for the detection of Mycobacterium ulcerans in clinical and environmental samples

scientific article

Different bacterial gene expression patterns and attenuated host immune responses are associated with the evolution of low-level vancomycin resistance during persistent methicillin-resistant Staphylococcus aureus bacteraemia

scientific article

Dual Gene Expression Analysis Identifies Factors Associated with Staphylococcus aureus Virulence in Diabetic Mice

scientific article published on 01 March 2019

Emergence of a ribotype 244 strain of Clostridium difficile associated with severe disease and related to the epidemic ribotype 027 strain

scientific article published on 4 April 2014

Emergence of endemic MLST non-typeable vancomycin-resistant Enterococcus faecium

scientific article published on 15 August 2016

Emergence of multidrug resistance in locally-acquired human infections with Salmonella Typhimurium in Australia owing to a new clade harbouring blaCTX-M-9.

scientific article published on 2 May 2017

Enterococcal vanB resistance locus in anaerobic bacteria in human faeces

scientific article

Evaluation of VNTR typing for the identification of Mycobacterium ulcerans in environmental samples from Victoria, Australia

scientific article published on 27 August 2008

Evolution of multidrug resistance during Staphylococcus aureus infection involves mutation of the essential two component regulator WalKR

scientific article

Evolution of two distinct phylogenetic lineages of the emerging human pathogen Mycobacterium ulcerans

scientific article

Evolution of virulence in Enterococcus faecium, a hospital-adapted opportunistic pathogen.

scientific article

Evolutionary origins of the emergent ST796 clone of vancomycin resistant Enterococcus faecium.

scientific article published on 24 January 2017

Exposure Risk for Infection and Lack of Human-to-Human Transmission of Mycobacterium ulcerans Disease, Australia

scientific article

First isolation of Mycobacterium ulcerans from an aquatic environment: the end of a 60-year search?

scientific article

Functional analysis and annotation of the virulence plasmid pMUM001 from Mycobacterium ulcerans

scientific article

Functional analysis of the first complete genome sequence of a multidrug resistant sequence type 2 Staphylococcus epidermidis.

scientific article

Functional genomics of Staphylococcus aureus

scientific article published on 21 February 2013

Genome Mining Reveals Endopyrroles from a Nonribosomal Peptide Assembly Line Triggered in Fungal-Bacterial Symbiosis

scientific article published on 22 July 2019

Genome Mining and Heterologous Expression Reveal Two Distinct Families of Lasso Peptides Highly Conserved in Endofungal Bacteria

scientific article published on 18 December 2019

Genome comparisons provide insights into the role of secondary metabolites in the pathogenic phase of the Photorhabdus life cycle

scientific article

Genomewide Profiling of the Enterococcus faecalis Transcriptional Response to Teixobactin Reveals CroRS as an Essential Regulator of Antimicrobial Tolerance

scientific article published on 08 May 2019

Genomic Insights into a Sustained National Outbreak of Yersinia pseudotuberculosis.

scientific article

Genomic analysis of ST88 community-acquired methicillin resistant Staphylococcus aureus in Ghana

scientific article published on 28 February 2017

Genomic analysis of multi-resistant associated with neonatal sepsis

scientific article published on 24 October 2018

Genomic analysis of smooth tubercle bacilli provides insights into ancestry and pathoadaptation of Mycobacterium tuberculosis

scientific article published on 06 January 2013

Genomic analysis of teicoplanin resistance emerging during treatment of vanB vancomycin-resistant Enterococcus faecium infections in solid organ transplant recipients including donor-derived cases.

scientific article published on 23 April 2013

Genomic analysis reveals a point mutation in the two-component sensor gene graS that leads to intermediate vancomycin resistance in clinical Staphylococcus aureus

scientific article published on 21 July 2008

Genomic epidemiology and antimicrobial resistance of Neisseria gonorrhoeae in New Zealand.

scientific article published on 22 November 2017

Genomic exploration of sequential clinical isolates reveals a distinctive molecular signature of persistent Staphylococcus aureus bacteraemia

scientific article published on 23 August 2018

Genomic insights to control the emergence of vancomycin-resistant enterococci

scientific article published on 13 August 2013

Genomic investigation of Staphylococcus aureus recovered from Gambian women and newborns following an oral dose of intra-partum azithromycin

scientific article published on 01 November 2019

Genomics for Molecular Epidemiology and Detecting Transmission of Carbapenemase-Producing Enterobacterales in Victoria, Australia, 2012 to 2016

scientific article published on 26 August 2019

Genomics of vancomycin-resistant Enterococcus faecium

scientific article published on 22 July 2019

Genomics-Driven Discovery of NO-Donating Diazeniumdiolate Siderophores in Diverse Plant-Associated Bacteria

scientific article published on 05 August 2019

Genomics‐Driven Discovery of NO‐Donating Diazeniumdiolate Siderophores in Diverse Plant‐Associated Bacteria

scientific article published in 2019

Giant plasmid-encoded polyketide synthases produce the macrolide toxin of Mycobacterium ulcerans

scientific article

Global analysis of adenylate-forming enzymes reveals β-lactone biosynthesis pathway in pathogenic Nocardia

scientific article published on 21 August 2020

Global spread of three multidrug-resistant lineages of Staphylococcus epidermidis

scientific article published on 03 September 2018

Human blood MAIT cell subsets defined using MR1 tetramers.

scientific article published on 13 February 2018

Hyperexpression of α-hemolysin explains enhanced virulence of sequence type 93 community-associated methicillin-resistant Staphylococcus aureus

scientific article

IFN-γ and IL-5 whole blood response directed against mycolactone polyketide synthase domains in patients with infection

scientific article published on 31 July 2018

Identification and Mobilization of a Cryptic Antibiotic Biosynthesis Gene Locus from a Human-Pathogenic Nocardia Isolate

scientific article published on 14 November 2019

Identification of Mycobacterium ulcerans in the environment from regions in Southeast Australia in which it is endemic with sequence capture-PCR.

scientific article

Identification of the Mycobacterium ulcerans protein MUL_3720 as a promising target for the development of a diagnostic test for Buruli ulcer

scientific article

In Vivo Imaging of Bioluminescent Mycobacterium ulcerans: A Tool to Refine the Murine Buruli Ulcer Tail Model

scientific article published on 01 December 2019

In silico serotyping of E. coli from short read data identifies limited novel O-loci but extensive diversity of O:H serotype combinations within and between pathogenic lineages.

scientific article

In-vitro activity of avermectins against Mycobacterium ulcerans

scientific article (publication date: March 2015)

Increasing tolerance of hospital Enterococcus faecium to handwash alcohols

scientific article published on 01 August 2018

Insights from the complete genome sequence of Mycobacterium marinum on the evolution of Mycobacterium tuberculosis

scientific article

Investigating the Role of Free-living Amoebae as a Reservoir for Mycobacterium ulcerans

scientific article (publication date: September 2014)

Isolates with low-level vancomycin resistance associated with persistent methicillin-resistant Staphylococcus aureus bacteremia

scientific article

Key experimental evidence of chromosomal DNA transfer among selected tuberculosis-causing mycobacteria

scientific article published on 15 August 2016

Lack of insertional-deletional polymorphism in a collection of mycobacterium ulcerans isolates from Ghanaian buruli ulcer patients

scientific article published on 02 September 2009

Leprosy in red squirrels.

scientific article published on November 2016

Low incidence of recurrent Buruli ulcers in treated Australian patients living in an endemic region

scientific article

Low-Cost, Open-Source Device for High-Performance Fluorescence Detection of Isothermal Nucleic Acid Amplification Reactions

scientific article published in 2021

Metabolomic profiles delineate mycolactone signature in Buruli ulcer disease.

scientific article

Methicillin Resistant Staphylococcus aureus Transmission in a Ghanaian Burn Unit: The Importance of Active Surveillance in Resource-Limited Settings.

scientific article

Microbe-Metabolite Associations Linked to the Rebounding Murine Gut Microbiome Postcolonization with Vancomycin-Resistant Enterococcus faecium

scientific article published on 18 August 2020

Mining Symbionts of a Spider-Transmitted Fungus Illuminates Uncharted Biosynthetic Pathways to Cytotoxic Benzolactones

scientific article published on 10 February 2020

Mining Symbionts of a Spider‐Transmitted Fungus Illuminates Uncharted Biosynthetic Pathways to Cytotoxic Benzolactones

scientific article published in 2020

Mining the Methylome Reveals Extensive Diversity in Staphylococcus epidermidis Restriction Modification

scientific article published on 17 December 2019

Molecular epidemiology of enterococcal bacteremia in Australia

scientific article published on 03 January 2014

Multiple Introductions and Recent Spread of the Emerging Human Pathogen Mycobacterium ulcerans across Africa

scientific article

Mycobacterial toxin induces analgesia in buruli ulcer by targeting the angiotensin pathways

scientific article published in June 2014

Mycobacterium chimaera Spread from Heating and Cooling Units in Heart Surgery.

scientific article

Mycobacterium ulcerans DNA not detected in faecal samples from Buruli ulcer patients: results of a pilot study

scientific article

Mycobacterium ulcerans Population Genomics To Inform on the Spread of Buruli Ulcer across Central Africa

scientific article published on 06 February 2019

Mycobacterium ulcerans and other mycolactone-producing mycobacteria should be considered a single species

scientific article

Mycobacterium ulcerans low infectious dose and mechanical transmission support insect bites and puncturing injuries in the spread of Buruli ulcer.

scientific article

Mycolactones and Mycobacterium ulcerans disease

scientific article

Mycolactones: immunosuppressive and cytotoxic polyketides produced by aquatic mycobacteria

scientific article published on 17 April 2008

NGMASTER:in silico multi-antigen sequence typing for Neisseria gonorrhoeae.

scientific article published on 25 August 2016

Natural product diversity associated with the nematode symbionts Photorhabdus and Xenorhabdus

scientific article published on 9 October 2017

Niche-specific genome degradation and convergent evolution shaping Staphylococcus aureus adaptation during severe infections

scientific article published on 14 June 2022

On the origin of mycobacterium ulcerans, the causative agent of buruli ulcer

scientific article

Optimising genomic approaches for identifying vancomycin-resistant Enterococcus faecium transmission in healthcare settings

scientific article published on 26 January 2022

Outbreak investigation using high-throughput genome sequencing within a diagnostic microbiology laboratory

scientific article published on 13 February 2013

Pathogenicity in the tubercle bacillus: molecular and evolutionary determinants

scientific article published on April 2009

Population genetics and the evolution of virulence in Staphylococcus aureus

scientific article published on 27 April 2013

Population genomics provides insights into the evolution and adaptation to humans of the waterborne pathogen Mycobacterium kansasii

scientific article published on 03 May 2021

Possible healthcare-associated transmission as a cause of secondary infection and population structure of Staphylococcus aureus isolates from two wound treatment centres in Ghana

scientific article published on 12 July 2016

Predicting nitroimidazole antibiotic resistance mutations in Mycobacterium tuberculosis with protein engineering

scientific article published on 07 February 2020

Prospective Whole-Genome Sequencing Enhances National Surveillance of Listeria monocytogenes.

scientific article published on 25 November 2015

Proteomic characterization of a natural host-pathogen interaction: repertoire of in vivo expressed bacterial and host surface-associated proteins.

scientific article published on 30 October 2014

Rapid Emergence and Evolution of Staphylococcus aureus Clones Harboring fusC-Containing Staphylococcal Cassette Chromosome Elements.

scientific article published on 8 February 2016

Rapid and sensitive detection of mycobacterium ulcerans by use of a loop-mediated isothermal amplification test

scientific article published on 22 February 2012

Reconstruction of the Genomes of Drug-Resistant Pathogens for Outbreak Investigation through Metagenomic Sequencing

scientific article published on 16 January 2019

Reduced vancomycin susceptibility in Staphylococcus aureus, including vancomycin-intermediate and heterogeneous vancomycin-intermediate strains: resistance mechanisms, laboratory detection, and clinical implications

scientific article

Reductive evolution and niche adaptation inferred from the genome of Mycobacterium ulcerans, the causative agent of Buruli ulcer

scientific article published on 8 January 2007

Regulation of mycolactone, the Mycobacterium ulcerans toxin, depends on nutrient source

scientific article (publication date: November 2013)

Regulation of the 18 kDa heat shock protein in Mycobacterium ulcerans: an alpha-crystallin orthologue that promotes biofilm formation

scientific article

Remodelling of pSK1 Family Plasmids and Enhanced Chlorhexidine Tolerance in a Dominant Hospital Lineage of Methicillin-Resistant Staphylococcus aureus

scientific article published on 25 April 2019

Reply to "Internet-based solutions for analysis of next-generation sequence data"

scientific article published on September 2013

Serological evaluation of Mycobacterium ulcerans antigens identified by comparative genomics

scientific article

Sharing Is Caring: International Sharing of Data Enhances Genomic Surveillance of Listeria monocytogenes.

scientific article published on 9 June 2016

Single nucleotide polymorphism typing of mycobacterium ulcerans reveals focal transmission of buruli ulcer in a highly endemic region of Ghana

scientific article

Snapshot fecal survey of domestic animals in rural Ghana for Mycobacterium ulcerans

scientific article published on June 2016

Staphylococcus aureus induces cell-surface expression of immune stimulatory NKG2D ligands on human monocytes

scientific article published on 30 June 2020

Structure and Biosynthesis of Isatropolones, Bioactive Amine-Scavenging Fluorescent Natural Products from Streptomyces Gö66.

scientific article published on 30 March 2017

Subtractive hybridization reveals a type I polyketide synthase locus specific to Mycobacterium ulcerans

scientific article published on December 2003

Symbiosis, virulence and natural-product biosynthesis in entomopathogenic bacteria are regulated by a small RNA

scientific article published on 02 November 2020

Target-Specific Assay for Rapid and Quantitative Detection of Mycobacterium chimaera DNA.

scientific article published on 5 April 2017

The First Isolation and Whole Genome Sequencing of Murray Valley Encephalitis Virus from Cerebrospinal Fluid of a Patient with Encephalitis.

scientific article published on 11 June 2018

The RpoB H₄₈₁Y rifampicin resistance mutation and an active stringent response reduce virulence and increase resistance to innate immune responses in Staphylococcus aureus

scientific article published on 18 December 2012

The cell wall-associated mycolactone polyketide synthases are necessary but not sufficient for mycolactone biosynthesis

scientific article (publication date: 2013)

The changing landscape of vancomycin-resistant Enterococcus faecium in Australia: a population-level genomic study

article

The evolution of vancomycin intermediate Staphylococcus aureus (VISA) and heterogenous-VISA

scientific article published on 06 April 2013

The genome, evolution and diversity of Mycobacterium ulcerans

scientific article published on 28 January 2012

The lipoprotein LpqW is essential for the mannosylation of periplasmic glycolipids in Corynebacteria.

scientific article

The molecular epidemiology of the highly virulent ST93 Australian community Staphylococcus aureus strain

scientific article

The ΦBT1 large serine recombinase catalyzes DNA integration at pseudo-attB sites in the genus Nocardia.

scientific article

Topical Antibiotic Use Coselects for the Carriage of Mobile Genetic Elements Conferring Resistance to Unrelated Antimicrobials in Staphylococcus aureus.

scientific article

Tracking the COVID-19 pandemic in Australia using genomics

scientific article published on 17 May 2020

Tracking the COVID-19 pandemic in Australia using genomics

scientific article published on 01 September 2020

Transfer, stable maintenance and expression of the mycolactone polyketide megasynthase mls genes in a recombination-impaired Mycobacterium marinum

scientific article published on 21 April 2009

Translating genomics into practice for real-time surveillance and response to carbapenemase-producing Enterobacteriaceae: evidence from a complex multi-institutional KPC outbreak.

scientific article published on 3 January 2018

Two novel point mutations in clinical Staphylococcus aureus reduce linezolid susceptibility and switch on the stringent response to promote persistent infection

scientific article

Unstable chromosome rearrangements in Staphylococcus aureus cause phenotype switching associated with persistent infections

scientific article published on 16 September 2019

Use of bacterial whole-genome sequencing to understand and improve the management of invasive Staphylococcus aureus infections

scientific article

Vaccine-Specific Immune Responses against Mycobacterium ulcerans Infection in a Low-Dose Murine Challenge Model

scientific article published on 20 February 2020

Validation of a single-step, single-tube reverse transcription-loop-mediated isothermal amplification assay for rapid detection of SARS-CoV-2 RNA

scientific article published on 30 April 2020

Vancomycin-intermediate Staphylococcus aureus isolates are attenuated for virulence when compared with susceptible progenitors.

scientific article published on 7 April 2017

Vancomycin-resistant Enterococcus faecium sequence type 796 - rapid international dissemination of a new epidemic clone.

scientific article published on 22 March 2018

Whole Genome Comparisons Suggest Random Distribution of Mycobacterium ulcerans Genotypes in a Buruli Ulcer Endemic Region of Ghana

scientific article

Whole-genome sequencing reveals transmission of gonococcal antibiotic resistance among men who have sex with men: an observational study

scientific article published on 15 December 2017

YycH and YycI Regulate Expression of Staphylococcus aureus Autolysins by Activation of WalRK Phosphorylation

scientific article published on 09 June 2020

Zinc-binding to the cytoplasmic PAS domain regulates the essential WalK histidine kinase of Staphylococcus aureus

scientific article published on 11 July 2019

pks5-recombination-mediated surface remodelling in Mycobacterium tuberculosis emergence

scientific article published on 27 January 2016