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List of works by Lee Sweeney

A Myo6 mutation destroys coordination between the myosin heads, revealing new functions of myosin VI in the stereocilia of mammalian inner ear hair cells

scientific article

A force-dependent state controls the coordination of processive myosin V

scientific article published on 6 September 2005

A structural state of the myosin V motor without bound nucleotide ⬇️

scientific article published on September 25, 2003

Activin IIB receptor blockade attenuates dystrophic pathology in a mouse model of Duchenne muscular dystrophy.

scientific article published on November 2010

Adeno-associated virus (AAV) serotype 9 provides global cardiac gene transfer superior to AAV1, AAV6, AAV7, and AAV8 in the mouse and rat.

scientific article

Adeno-associated virus vector delivery to the heart

scientific article published in January 2011

Administration of a tumor necrosis factor inhibitor at the time of myocardial infarction attenuates subsequent ventricular remodeling

scientific article published on 01 September 2004

An intermediate along the recovery stroke of myosin VI revealed by X-ray crystallography and molecular dynamics

article published in the Proceedings of the National Academy of Sciences of the United States of America

Blocking the development of postischemic cardiomyopathy with viral gene transfer of the apoptosis repressor with caspase recruitment domain

scientific article published on 01 June 2003

Cardiac gene transfer of short hairpin RNA directed against phospholamban effectively knocks down gene expression but causes cellular toxicity in canines

scientific article

Chemical shift-based MRI to measure fat fractions in dystrophic skeletal muscle

scientific article

Chronic losartan administration reduces mortality and preserves cardiac but not skeletal muscle function in dystrophic mice

scientific article

Enhancing the utility of adeno-associated virus gene transfer through inducible tissue-specific expression

scientific article published on August 2013

Exon-skipped dystrophins for treatment of Duchenne muscular dystrophy: mass spectrometry mapping of most exons and cooperative domain designs based on single molecule mechanics

scientific article

Force Generation by Myosin Motors: A Structural Perspective

scientific article published on 05 November 2019

Force-producing ADP state of myosin bound to actin

scientific article published on 14 March 2016

Gene Transfer in Skeletal and Cardiac Muscle Using Recombinant Adeno‐Associated Virus ⬇️

scientific article published on January 1, 2013

Gene therapy in large animal models of human cardiovascular genetic disease

scientific article published on January 2009

Gene transfer of hepatocyte growth factor attenuates postinfarction heart failure

scientific article published in September 2003

How Actin Initiates the Motor Activity of Myosin

How actin initiates the motor activity of Myosin

scientific article published on 30 April 2015

How myosin motors power cellular functions: an exciting journey from structure to function: based on a lecture delivered at the 34th FEBS Congress in Prague, Czech Republic, July 2009

scientific article published on 09 January 2012

Induction of angiogenesis and inhibition of apoptosis by hepatocyte growth factor effectively treats postischemic heart failure

scientific article published on 01 January 2005

Inhibition of matrix metalloproteinase activity by TIMP-1 gene transfer effectively treats ischemic cardiomyopathy

scientific article published in September 2004

Is functional hypertrophy and specific force coupled with the addition of myonuclei at the single muscle fiber level?

scientific article published on 28 November 2011

Long-Term Systemic Myostatin Inhibition via Liver-Targeted Gene Transfer in Golden Retriever Muscular Dystrophy ⬇️

scientific article published on August 30, 2011

Long-term restoration of cardiac dystrophin expression in golden retriever muscular dystrophy following rAAV6-mediated exon skipping

scientific article published on 6 December 2011

Long-term wheel running compromises diaphragm function but improves cardiac and plantarflexor function in the mdx mouse

scientific article published on 03 July 2013

Matrix elasticity directs stem cell lineage specification

scientific article (publication date: 25 August 2006)

Membrane blebbing as an assessment of functional rescue of dysferlin-deficient human myotubes via nonsense suppression

scientific article

Mesenchymal stem cell injection after myocardial infarction improves myocardial compliance

scientific article

Myosin VI Dimerization Triggers an Unfolding of a Three-Helix Bundle in Order to Extend Its Reach

scientific article

Myosin VI Dimerizes And Walks Processively Along Actin

Myosin VI deafness mutation prevents the initiation of processive runs on actin

scientific article

Myosin VI undergoes a 180 degrees power stroke implying an uncoupling of the front lever arm.

scientific article

Myosin Va and myosin VI coordinate their steps while engaged in an in vitro tug of war during cargo transport ⬇️

scientific article published on August 23, 2011

Myostatin Is Elevated in Congenital Heart Disease and After Mechanical Unloading ⬇️

scientific article published on September 13, 2011

Myostatin activation in patients with advanced heart failure and after mechanical unloading.

scientific article

Myostatin is upregulated following stress in an Erk-dependent manner and negatively regulates cardiomyocyte growth in culture and in a mouse model

scientific article

Neovasculogenic therapy to augment perfusion and preserve viability in ischemic cardiomyopathy

scientific article

Overexpression of SERCA1a in the mdx diaphragm reduces susceptibility to contraction-induced damage

scientific article published on December 2010

PDE5 inhibition alleviates functional muscle ischemia in boys with Duchenne muscular dystrophy

scientific article

Percutaneous Transendocardial Delivery of Self-complementary Adeno-associated Virus 6 Achieves Global Cardiac Gene Transfer in Canines

article

Percutaneous transendocardial delivery of self-complementary adeno-associated virus 6 in the canine

scientific article published in January 2011

Processive Steps in the Reverse Direction Require Uncoupling of the Lead Head Lever Arm of Myosin VI

scientific article

Rescue of dystrophic skeletal muscle by PGC-1α involves a fast to slow fiber type shift in the mdx mouse

scientific article

Role of Insert-1 of Myosin VI in Modulating Nucleotide Affinity ⬇️

scientific article published on January 29, 2011

Sarcomeric-alpha-actinin defective in vinculin-binding causes Z-line expansion and nemaline-like body formation in cultured chick myotubes

scientific article

Skeletal Muscles of Ambulant Children with Duchenne Muscular Dystrophy: Validation of Multicenter Study of Evaluation with MR Imaging and MR Spectroscopy ⬇️

scientific article published on May 21, 2013

Status of therapeutic gene transfer to treat canine dilated cardiomyopathy in dogs

scientific article published on 14 May 2010

Status of therapeutic gene transfer to treat cardiovascular disease in dogs and cats ⬇️

scientific article published on 02 June 2011

Stromal cell-derived factor and granulocyte-monocyte colony-stimulating factor form a combined neovasculogenic therapy for ischemic cardiomyopathy

scientific article published in August 2005

Supraphysiological levels of GDF11 induce striated muscle atrophy

scientific article

Systemic myostatin inhibition via liver-targeted gene transfer in normal and dystrophic mice

scientific article

The Force Producing ADP State of Myosin Bound to Actin

article by Rasmus R. Schroeder et al published February 2016 in Biophysical Journal

The motor mechanism of myosin V: insights for muscle contraction

scientific article

The myosin X motor is optimized for movement on actin bundles

scientific article

The post-rigor structure of myosin VI and implications for the recovery stroke

scientific article

The structural basis for the large powerstroke of myosin VI

scientific article

The structure of the myosin VI motor reveals the mechanism of directionality reversal

scientific article

Three myosin V structures delineate essential features of chemo-mechanical transduction

scientific article

Too much of a good thing

scholarly article published in eLife vol 7, September 2018

Transendocardial delivery of AAV6 results in highly efficient and global cardiac gene transfer in rhesus macaques

scientific article published on 24 June 2011

Unregulated smooth-muscle myosin in human intestinal neoplasia

scientific article

Viral gene transfer of the antiapoptotic factor Bcl-2 protects against chronic postischemic heart failure

article

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