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List of works by Milton Packer

Angiotensin Receptor Neprilysin Inhibition in Heart Failure With Preserved Ejection Fraction: Rationale and Design of the PARAGON-HF Trial

scientific article published on 26 June 2017

Angiotensin receptor neprilysin inhibition compared with enalapril on the risk of clinical progression in surviving patients with heart failure

scientific article

Angiotensin-Neprilysin Inhibition in Heart Failure with Preserved Ejection Fraction

scientific article published on 01 September 2019

Angiotensin-neprilysin inhibition versus enalapril in heart failure

scientific article (publication date: 11 September 2014)

Association between renal function and cardiovascular structure and function in heart failure with preserved ejection fraction

scientific article published on 30 June 2014

Autophagy-dependent and -independent modulation of oxidative and organellar stress in the diabetic heart by glucose-lowering drugs

scientific article published on 13 May 2020

Baseline Characteristics of Patients With Heart Failure and Preserved Ejection Fraction in the PARAGON-HF Trial

scientific article published on 01 July 2018

Beta-blockers for heart failure with reduced, mid-range, and preserved ejection fraction: an individual patient-level analysis of double-blind randomized trials

scientific article published on 10 October 2017

Cardiovascular and Renal Outcomes with Empagliflozin in Heart Failure

scientific article published on 29 August 2020

Clinical effects of endothelin receptor antagonism with bosentan in patients with severe chronic heart failure: results of a pilot study

scientific article published in February 2005

Comparison of omapatrilat and enalapril in patients with chronic heart failure: the Omapatrilat Versus Enalapril Randomized Trial of Utility in Reducing Events (OVERTURE).

scientific article published in August 2002

Conducting clinical trials in heart failure during (and after) the COVID-19 pandemic: an Expert Consensus Position Paper from the Heart Failure Association (HFA) of the European Society of Cardiology (ESC)

scientific article published on 04 June 2020

Contemporary Characteristics and Outcomes in Chagasic Heart Failure Compared With Other Nonischemic and Ischemic Cardiomyopathy

scientific article published in November 2017

Contrasting effects on the risk of macrovascular and microvascular events of antihyperglycemic drugs that enhance sodium excretion and lower blood pressure

scientific article published on 11 April 2018

Critical Reanalysis of the Mechanisms Underlying the Cardiorenal Benefits of SGLT2 Inhibitors and Reaffirmation of the Nutrient Deprivation Signaling/Autophagy Hypothesis

scientific article published in 2022

Critical role of the epicardium in mediating cardiac inflammation and fibrosis in patients with type 2 diabetes

scientific article published on 17 June 2019

Declining Risk of Sudden Death in Heart Failure

scientific article

Dementia-related adverse events in PARADIGM-HF and other trials in heart failure with reduced ejection fraction

scientific article

Differential Impact of Heart Failure With Reduced Ejection Fraction on Men and Women

scientific article published on 01 January 2019

Digoxin Discontinuation and Outcomes in Patients With Heart Failure With Reduced Ejection Fraction

scientific article published on 01 August 2019

Digoxin Use and Outcomes in Patients With Heart Failure With Reduced Ejection Fraction

scientific article published on 29 May 2019

Disease-treatment interactions in the management of patients with obesity and diabetes who have atrial fibrillation: the potential mediating influence of epicardial adipose tissue

scientific article published on 24 September 2019

Do Sodium-Glucose Cotransporter-2 Inhibitors Prevent Heart Failure With a Preserved Ejection Fraction by Counterbalancing the Effects of Leptin? A Novel Hypothesis.

scientific article

Early Effects of Starting Doses of Enalapril in Patients with Chronic Heart Failure in the SOLVD Treatment Trial

scientific article published on 08 August 2019

Effect of Extended-Release Niacin on Carotid Intima Media Thickness, Reactive Hyperemia, and Endothelial Progenitor Cell Mobilization: Insights From the Atherosclerosis Lesion Progression Intervention Using Niacin Extended Release in Saphenous Vein G

Effect of Extended-Release Niacin on Saphenous Vein Graft Atherosclerosis: Insights from the Atherosclerosis Lesion Progression Intervention Using Niacin Extended Release in Saphenous Vein Grafts (ALPINE-SVG) Pilot Trial

scientific article published on 01 October 2015

Effect of Ularitide on Cardiovascular Mortality in Acute Heart Failure

scientific article published on 12 April 2017

Effects of Sacubitril-Valsartan Versus Valsartan in Women Compared With Men With Heart Failure and Preserved Ejection Fraction: Insights From PARAGON-HF

scientific article published on 17 November 2019

Effects of Sacubitril/Valsartan in the PARADIGM-HF Trial (Prospective Comparison of ARNI with ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure) According to Background Therapy

scientific article published on September 2016

Elevation in high-sensitivity troponin T in heart failure and preserved ejection fraction and influence of treatment with the angiotensin receptor neprilysin inhibitor LCZ696.

scientific article published on 02 October 2014

Erratum to "Traditional and new composite endpoints in heart failure clinical trials: facilitating comprehensive efficacy assessments and improving trial efficiency" [Eur J Heart Fail 2016;18:482-489].

scientific article published in June 2016

Estimating the Long-Term Treatment Benefits of Sacubitril–Valsartan

article

Factors Associated With Noncompletion During the Run-In Period Before Randomization and Influence on the Estimated Benefit of LCZ696 in the PARADIGM-HF Trial

scientific article published on June 2016

Have dipeptidyl peptidase-4 inhibitors ameliorated the vascular complications of type 2 diabetes in large-scale trials? The potential confounding effect of stem-cell chemokines.

scientific article published on 8 January 2018

Have we really demonstrated the cardiovascular safety of anti-hyperglycaemic drugs? Rethinking the concepts of macrovascular and microvascular disease in type 2 diabetes.

scientific article published on 5 January 2018

Health-Related Quality of Life Outcomes in PARADIGM-HF.

scientific article

Health-Related Quality of Life in Heart Failure With Preserved Ejection Fraction: The PARAGON-HF Trial

scientific article published on 10 July 2019

Heart Failure End Points in Cardiovascular Outcome Trials of Sodium Glucose Cotransporter 2 Inhibitors in Patients With Type 2 Diabetes Mellitus: A Critical Evaluation of Clinical and Regulatory Issues

scientific article published on 16 December 2019

Heart Failure: The Most Important, Preventable, and Treatable Cardiovascular Complication of Type 2 Diabetes

scientific article published in January 2018

Heart failure with reduced ejection fraction: comparison of patient characteristics and clinical outcomes within Asia and between Asia, Europe and the Americas

scientific article published on 10 December 2018

Heightened risk of intensive rate control in patients with atrial fibrillation who are obese or have type 2 diabetes: A critical review and re-evaluation

scientific article published on 29 October 2019

Higher mortality rate in patients with heart failure who are taking commonly prescribed antidiabetic medications and achieve recommended levels of glycaemic control

scientific article published on 22 March 2018

IGFBP7 (Insulin-Like Growth Factor-Binding Protein-7) and Neprilysin Inhibition in Patients With Heart Failure

scientific article published on 01 October 2018

Impact of Renal Impairment on Beta-Blocker Efficacy in Patients With Heart Failure

scientific article published on 01 December 2019

Impaired left atrial function in heart failure with preserved ejection fraction.

scientific article published on 19 August 2014

Impaired systolic function by strain imaging in heart failure with preserved ejection fraction.

scientific article published on 30 October 2013

Importance of Clinical Worsening of Heart Failure Treated in the Outpatient Setting: Evidence From the Prospective Comparison of ARNI With ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure Trial (PARADIGM-HF).

scientific article published on 20 April 2016

Incidence, Predictors, and Outcomes Associated With Hypotensive Episodes Among Heart Failure Patients Receiving Sacubitril/Valsartan or Enalapril: The PARADIGM-HF Trial (Prospective Comparison of Angiotensin Receptor Neprilysin Inhibitor With Angiot

scientific article

Income Inequality and Outcomes in Heart Failure: A Global Between-Country Analysis

scientific article published on 06 February 2019

Independence of the blood pressure lowering effect and efficacy of the angiotensin receptor neprilysin inhibitor, LCZ696, in patients with heart failure with preserved ejection fraction: an analysis of the PARAMOUNT trial

article

Influence of Ejection Fraction on Outcomes and Efficacy of Sacubitril/Valsartan (LCZ696) in Heart Failure with Reduced Ejection Fraction: The Prospective Comparison of ARNI with ACEI to Determine Impact on Global Mortality and Morbidity in Heart Fai

scientific article published on March 2016

Influence of Sacubitril/Valsartan (LCZ696) on 30-Day Readmission After Heart Failure Hospitalization

scientific article published in July 2016

Interplay of adenosine monophosphate-activated protein kinase/sirtuin-1 activation and sodium influx inhibition mediates the renal benefits of sodium-glucose co-transporter-2 inhibitors in type 2 diabetes: A novel conceptual framework

scientific article published on 20 February 2020

Left ventricular dyssynchrony in patients with heart failure and preserved ejection fraction.

scientific article

Long-Term Effect of Endothelin Receptor Antagonism With Bosentan on the Morbidity and Mortality of Patients With Severe Chronic Heart Failure: Primary Results of the ENABLE Trials

scientific article published in May 2017

Natriuretic Peptides as Biomarkers of Treatment Response in Clinical Trials of Heart Failure

scientific article published on 4 March 2018

PARADIGM-HF — The Experts' Discussion

article

Prevalence and incidence of intraventricular conduction delays and outcomes in patients with heart failure and reduced ejection fraction: Insights from PARADIGM-HF and ATMOSPHERE

scientific article published on 28 July 2020

Prognostic Models Derived in PARADIGM-HF and Validated in ATMOSPHERE and the Swedish Heart Failure Registry to Predict Mortality and Morbidity in Chronic Heart Failure

scientific article published on 29 January 2020

Prognostic Value of N-Terminal Pro-B-Type Natriuretic Peptide Levels in Heart Failure Patients With and Without Atrial Fibrillation

scientific article

Rationale for and design of the TRUE-AHF trial: the effects of ularitide on the short-term clinical course and long-term mortality of patients with acute heart failure

scientific article published on 13 November 2016

Reduced Risk of Hyperkalemia During Treatment of Heart Failure With Mineralocorticoid Receptor Antagonists by Use of Sacubitril/Valsartan Compared With Enalapril: A Secondary Analysis of the PARADIGM-HF Trial

scientific article

Relationship between heart rate and outcomes in patients in sinus rhythm or atrial fibrillation with heart failure and reduced ejection fraction

scientific article published on 17 December 2019

Renal Effects and Associated Outcomes During Angiotensin-Neprilysin Inhibition in Heart Failure

scientific article published on 5 April 2018

Renal effects of the angiotensin receptor neprilysin inhibitor LCZ696 in patients with heart failure and preserved ejection fraction.

scientific article published on 6 February 2015

Reply: does speckle tracking really improve diagnosis and risk stratification in patients with HF with normal EF?

scientific article published in October 2014

Risk Related to Pre-Diabetes Mellitus and Diabetes Mellitus in Heart Failure With Reduced Ejection Fraction: Insights From Prospective Comparison of ARNI With ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure Trial

scientific article

Role of Impaired Nutrient and Oxygen Deprivation Signaling and Deficient Autophagic Flux in Diabetic CKD Development: Implications for Understanding the Effects of Sodium-Glucose Cotransporter 2-Inhibitors

scientific article published on 10 April 2020

Role of the sodium-hydrogen exchanger in mediating the renal effects of drugs commonly used in the treatment of type 2 diabetes.

scientific article

SGLT2 Inhibitors Produce Cardiorenal Benefits by Promoting Adaptive Cellular Reprogramming to Induce a State of Fasting Mimicry: A Paradigm Shift in Understanding Their Mechanism of Action

scientific article published on 01 March 2020

Sex-specific cardiovascular structure and function in heart failure with preserved ejection fraction

scientific article published on 23 February 2014

Targeted anticytokine therapy in patients with chronic heart failure: results of the Randomized Etanercept Worldwide Evaluation (RENEWAL).

scientific article published on 15 March 2004

The Seattle Heart Failure Model: prediction of survival in heart failure

scientific article published on 13 March 2006

The Warfarin and Antiplatelet Therapy in Heart Failure trial (WATCH): rationale, design, and baseline patient characteristics

scientific article (publication date: April 2004)

The angiotensin receptor neprilysin inhibitor LCZ696 in heart failure with preserved ejection fraction: a phase 2 double-blind randomised controlled trial

scientific article published on 26 August 2012

The effects of sacubitril/valsartan on coronary outcomes in PARADIGM-HF.

scientific article published on 14 March 2017

The prevalence and importance of frailty in heart failure with reduced ejection fraction - an analysis of PARADIGM-HF and ATMOSPHERE

scientific article published on 30 April 2020

Traditional and new composite endpoints in heart failure clinical trials: facilitating comprehensive efficacy assessments and improving trial efficiency

scientific article published on 12 April 2016

Type of Atrial Fibrillation and Outcomes in Patients With Heart Failure and Reduced Ejection Fraction

scientific article published in November 2017

Utility of Impedance Cardiography for the Identification of Short-Term Risk of Clinical Decompensation in Stable Patients With Chronic Heart Failure

article

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