Search filters

List of works by Francesco Forconi

13q14 deletion size and number of deleted cells both influence prognosis in chronic lymphocytic leukemia

scientific article published on 11 May 2011

2-Chlorodeoxyadenosine in the treatment of relapsed/refractory chronic lymphoproliferative disorders

scientific article published on 01 January 1997

A pilot monocentric analysis of efficacy and safety of Fludarabine-Campath combination (Flucam) as first line treatment in elderly patients with chronic lymphocytic leukaemia and Tp53 disfunction

scientific article published on 26 April 2011

A variant of the LRP4 gene affects the risk of chronic lymphocytic leukaemia transformation to Richter syndrome

article

Absence of surface CD27 distinguishes hairy cell leukemia from other leukemic B-cell malignancies

scientific article published on 01 February 2005

Alternative methods of cladribine administration

scientific article published on 19 April 2011

Analysis of the chronic lymphocytic leukemia coding genome: role of NOTCH1 mutational activation

scientific article

Angiopoietin-2 plasma dosage predicts time to first treatment and overall survival in chronic lymphocytic leukemia

scientific article published on 9 April 2010

Are surrogates of IGHV gene mutational status useful in B-cell chronic lymphocytic leukemia? The example of Septin-10.

scientific article

Association between molecular lesions and specific B-cell receptor subsets in chronic lymphocytic leukemia.

scientific article published in May 2013

B-cell receptor dependent phagocytosis and presentation of particulate antigen by chronic lymphocytic leukemia cells

scientific article published on 01 February 2022

B-cell receptor, clinical course and prognosis in chronic lymphocytic leukaemia: the growing saga of the IGHV3 subgroup gene usage

scientific article published on 08 February 2011

BCR signaling contributes to autophagy regulation in chronic lymphocytic leukemia

scientific article published on 28 August 2019

BRAF mutations in hairy-cell leukemia

scientific article

BTK-independent regulation of calcium signalling downstream of the B-cell receptor in malignant B-cells

Bidirectional linkage between the B-cell receptor and NOTCH1 in chronic lymphocytic leukemia and in Richter's syndrome: therapeutic implications

scientific article published on 29 August 2019

CD30 positive (non-anaplastic) peripheral T-cell lymphoma of the thyroid gland

scientific article published on 01 October 1999

Changes in Bcl-2 members in response to ibrutinib or venetoclax uncover functional hierarchy in determining resistance to venetoclax in CLL

scientific article published on 30 June 2020

Chromosome 14q32 translocations involving the immunoglobulin heavy chain locus in chronic lymphocytic leukaemia identify a disease subset with poor prognosis

scientific article published on 28 June 2008

Clinical heterogeneity of de novo 11q deletion chronic lymphocytic leukaemia: prognostic relevance of extent of 11q deleted nuclei inside leukemic clone.

scientific article published on 2 October 2012

Combination therapies to improve the long-term outcome in hairy cell leukemia.

scientific article published on October 2009

Complete molecular remission induced by concomitant cladribine--rituximab treatment in a case of multi-resistant hairy cell leukemia

scientific article published in December 2007

Comprehensive characterization of IGHV3-21-expressing B-cell chronic lymphocytic leukemia: an Italian multicenter study

article

Consensus guidelines for the diagnosis and management of patients with classic hairy cell leukemia

scientific article

Correction: Bidirectional linkage between the B-cell receptor and NOTCH1 in chronic lymphocytic leukemia and in Richter's syndrome: therapeutic implications

scientific article published on 13 December 2019

DC-SIGN binding to mannosylated B-cell receptors in follicular lymphoma down-modulates receptor signaling capacity

scientific article published on 03 June 2021

DNA methylation profiling identifies two splenic marginal zone lymphoma subgroups with different clinical and genetic features

scientific article published on 22 January 2015

Defining origins of malignant B cells: a new circulating normal human IgM(+)D(+) B-cell subset lacking CD27 expression and displaying somatically mutated IGHV genes as a relevant memory population.

scientific article published on 24 September 2009

Del(13q14.3) length matters: an integrated analysis of genomic, fluorescence in situ hybridization and clinical data in 169 chronic lymphocytic leukaemia patients with 13q deletion alone or a normal karyotype

scientific article published on 13 June 2011

Different impact of NOTCH1 and SF3B1 mutations on the risk of chronic lymphocytic leukemia transformation to Richter syndrome

scientific article published on 10 May 2012

Disruption of BIRC3 associates with fludarabine chemorefractoriness in TP53 wild-type chronic lymphocytic leukemia

scientific article published on 3 February 2012

Effect of a p210 multipeptide vaccine associated with imatinib or interferon in patients with chronic myeloid leukaemia and persistent residual disease: a multicentre observational trial

scientific article

Efficacy of anti-CD20 monoclonal antibodies (Mabthera) in patients with progressed hairy cell leukemia

scientific article

Endothelin-1 promotes survival and chemoresistance in chronic lymphocytic leukemia B cells through ETA receptor

scientific article (publication date: 2014)

Endothelium-mediated survival of leukemic cells and angiogenesis-related factors are affected by lenalidomide treatment in chronic lymphocytic leukemia

scientific article

Engagement of the B-cell receptor of chronic lymphocytic leukemia cells drives global and MYC-specific mRNA translation.

scientific article published on 21 October 2015

Exploring the pathways to chronic lymphocytic leukemia

Expression of Mutated IGHV3-23 Genes in Chronic Lymphocytic Leukemia Identifies a Disease Subset with Peculiar Clinical and Biological Features

article

Favorable impact of low-dose fludarabine plus epirubicin and cyclophosphamide regimen (FLEC) as treatment for low-grade non-Hodgkin's lymphomas.

scientific article published on August 1999

Five years of ibrutinib in CLL

scholarly article by Francesco Forconi published 24 May 2018 in Blood

Genetics and Prognostication in Splenic Marginal Zone Lymphoma: Revelations from Deep Sequencing

scientific article published on 16 March 2015

Genome-wide DNA analysis identifies recurrent imbalances predicting outcome in chronic lymphocytic leukaemia with 17p deletion

article

Genome-wide DNA profiling better defines the prognosis of chronic lymphocytic leukaemia.

scientific article published on 12 July 2011

Genome-wide DNA profiling of marginal zone lymphomas identifies subtype-specific lesions with an impact on the clinical outcome

scientific article published on 29 November 2010

Genome-wide high resolution DNA profiling of hairy cell leukaemia

scientific article published on 21 May 2013

Genome-wide promoter methylation of hairy cell leukemia

scientific article published on 01 February 2019

Genomic disruption of the histone methyltransferase SETD2 in chronic lymphocytic leukaemia.

scientific article published on 10 June 2016

Genomic profiling of Richter's syndrome: recurrent lesions and differences with de novo diffuse large B-cell lymphomas

HLA-G is a component of the chronic lymphocytic leukemia escape repertoire to generate immune suppression: impact of the HLA-G 14 base pair (rs66554220) polymorphism

scientific article

Hairy cell leukaemia: biological and clinical overview from immunogenetic insights ⬇️

scientific article published on November 2, 2010

Hairy cell leukemia cell lines expressing annexin A1 and displaying B-cell receptor signals characteristic of primary tumor cells lack the signature BRAF mutation to reveal unrepresentative origins.

scientific article published on 18 June 2012

Hairy cell leukemia: at the crossroad of somatic mutation and isotype switch

scientific article

Hedgehog activation in CLL

scientific article published on 01 June 2019

High bcl-2 expression in acute myeloid leukemia cells correlates with CD34 positivity and complete remission rate ⬇️

scientific article published on December 1, 1997

High density genome-wide DNA profiling reveals a remarkably stable profile in hairy cell leukaemia.

scientific article

High surface IgM levels associate with shorter response to ibrutinib and BTK bypass in patients with CLL

Higher levels of reactive oxygen species are associated with anergy in chronic lymphocytic leukemia.

scientific article published on 6 March 2015

IGHD3-3fails to behave as unfavourable prognostic marker in chronic lymphocytic leukaemia

IGHV gene mutational status and 17p deletion are independent molecular predictors in a comprehensive clinical-biological prognostic model for overall survival prediction in chronic lymphocytic leukemia

scientific article published on 30 January 2012

IGHV sequencing reveals acquired N-glycosylation sites as a clonal and stable event during follicular lymphoma evolution

scientific article published on 01 March 2020

IL-10 production by CLL cells is enhanced in the anergic IGHV mutated subset and associates with reduced DNA methylation of the IL10 locus

scientific article published on 28 November 2016

IL-4 enhances expression and function of surface IgM in CLL cells.

scientific article

Ibrutinib therapy releases leukemic surface IgM from antigen drive in chronic lymphocytic leukemia patients

scientific article published on 29 October 2018

Identification in CLL of circulating intraclonal subgroups with varying B-cell receptor expression and function

scientific article

Imatinib does not impair specific antitumor T-cell immunity in patients with chronic myeloid leukemia

scientific article

Immunogenetics features and genomic lesions in splenic marginal zone lymphoma

scientific article published on 01 December 2010

Impact of the host genetic background on prognosis of chronic lymphocytic leukemia

scientific article published on 01 February 2010

Impaired expression of p66Shc, a novel regulator of B-cell survival, in chronic lymphocytic leukemia

scientific article published on 8 January 2010

Incidence of novel N-glycosylation sites in the B-cell receptor of lymphomas associated with immunodeficiency.

scientific article published in March 2004

Insertion of atypical glycans into the tumor antigen-binding site identifies DLBCLs with distinct origin and behavior

Insight into the behavior of hairy cell leukemia by immunogenetic analysis

scientific article published on 19 April 2011

Insight into the potential for DNA idiotypic fusion vaccines designed for patients by analysing xenogeneic anti-idiotypic antibody responses

article

Integrated DNA copy number and methylation profiling of lymphoid neoplasms using a single array

scientific article published on 25 November 2011

Integrated mutational and cytogenetic analysis identifies new prognostic subgroups in chronic lymphocytic leukemia

scientific article

Intrinsic and extrinsic factors influencing the clinical course of B-cell chronic lymphocytic leukemia: prognostic markers with pathogenetic relevance

scientific article published on 28 August 2009

Lack of allelic exclusion by secondary rearrangements of tumour B-cell receptor light chains in hairy cell leukaemia

scientific article published on 01 March 2011

Large genomic aberrations detected by SNP array are independent prognosticators of a shorter time to first treatment in chronic lymphocytic leukemia patients with normal FISH.

scientific article published on 31 January 2013

Long-lasting complete remission in patients with hairy cell leukemia treated with 2-CdA: a 5-year survey

scientific article published on May 1997

Long-term follow-up of 233 patients with hairy cell leukaemia, treated initially with pentostatin or cladribine, at a median of 16 years from diagnosis

scientific article

Long-term follow-up of non-Hodgkin's lymphoma patients treated with ProMACE-CytaBOM: an effective regimen for the intermediate grade subtype

scientific article published on 01 September 1998

Low-dose oral fludarabine plus cyclophosphamide in elderly patients with chronic lymphoproliferative disorders

scientific article published in January 2004

Low-dose oral fludarabine plus cyclophosphamide in elderly patients with untreated and relapsed or refractory chronic lymphocytic Leukaemia

scientific article published in December 2008

Low-grade non Hodgkin's lymphomas in the elderly: impact of a low-dose fludarabine-based combination regimen (mini-FLEC).

scientific article published in March 2003

MDM4 (MDMX) is overexpressed in chronic lymphocytic leukaemia (CLL) and marks a subset of p53wild-type CLL with a poor cytotoxic response to Nutlin-3.

scientific article published on 28 April 2010

MGA, a suppressor of MYC, is recurrently inactivated in high risk chronic lymphocytic leukemia

scientific article

Massive intravascular hemolysis: a fatal complication ofClostridium perfringenssepticemia in a patient with acute lymphoblastic leukemia

scientific article published on 01 May 2005

Molecular Cytogenetic Analysis of B-CLL Patients with Aggressive Disease

article

Molecular and clinical features of chronic lymphocytic leukaemia with stereotyped B cell receptors: results from an Italian multicentre study

article

Molecular and clinical features of chronic lymphocytic leukemia with stereotyped B-cell receptors in a Ukrainian cohort

scientific article

Molecular history of Richter syndrome: origin from a cell already present at the time of chronic lymphocytic leukemia diagnosis

scientific article published on 25 August 2011

Molecular insight into the biology and clinical course of hairy cell leukemia utilizing immunoglobulin gene analysis

scientific article published on 06 December 2010

Molecular prediction of durable remission after first-line fludarabine-cyclophosphamide-rituximab in chronic lymphocytic leukemia

scientific article published on 14 August 2015

Multicentre validation of a prognostic index for overall survival in chronic lymphocytic leukaemia

scientific article

Multiple myeloma shows no intra-disease clustering of immunoglobulin heavy chain genes.

scientific article published on 29 December 2011

Mutation of BAX occurs infrequently in acquired immunodeficiency syndrome-related non-Hodgkin's lymphomas.

scientific article

Mutations of NOTCH1 are an independent predictor of survival in chronic lymphocytic leukemia

scientific article

Mutations of the SF3B1 splicing factor in chronic lymphocytic leukemia: association with progression and fludarabine-refractoriness

scientific article (publication date: 28 October 2011)

Origins of the malignant clone in typical Waldenstrom's macroglobulinemia

scientific article published in April 2003

Overlapping morphologic and immunophenotypic profiles in small B-cell lymphoma. A report of two cases

scientific article published on 18 July 2006

PEITC-mediated inhibition of mRNA translation is associated with both inhibition of mTORC1 and increased eIF2α phosphorylation in established cell lines and primary human leukemia cells.

scientific article published on 27 August 2016

PI3Kδ inhibition elicits anti-leukemic effects through Bim-dependent apoptosis

scientific article

Perturbation of the normal immune system in patients with CLL

scientific article

Phenotypic heterogeneity in IGHV-mutated CLL patients has prognostic impact and identifies a subset with increased sensitivity to BTK and PI3Kδ inhibition

scientific article published on 28 October 2014

Pilot Study of Gemtuzumab Ozogamicin (GO), Fludarabine, Cytarabine and Idarubicin Combined Regimen (GO-FLAI) as First-Line Induction Therapy plus GO Alone as Consolidation Therapy for Elderly Acute Myeloid Leukemia Patients

scientific article published on 22 March 2007

Preclinical Evaluation of a Novel SHIP1 Phosphatase Activator for Inhibition of PI3K Signaling in Malignant B Cells

scientific article published on 12 December 2019

Predicting the clinical course of Hodgkin lymphoma

scientific article published on August 2010

Promoter methylation patterns in Richter syndrome affect stem-cell maintenance and cell cycle regulation and differ from de novo diffuse large B-cell lymphoma

scientific article published on 21 August 2013

Revisiting the definition of somatic mutational status in B-cell tumors: does 98% homology mean that a V(H)-gene is unmutated?

scientific article published in April 2004

Rituximab with pentostatin or cladribine: an effective combination treatment for hairy cell leukemia after disease recurrence

scientific article published on 19 April 2011

S1P1 expression is controlled by the pro-oxidant activity of p66Shc and is impaired in B-CLL patients with unfavorable prognosis

scientific article published on 01 October 2012

Selective influences in the expressed immunoglobulin heavy and light chain gene repertoire in hairy cell leukemia

article

Simple genetic diagnosis of hairy cell leukemia by sensitive detection of the BRAF-V600E mutation

scientific article

Stereotyped B-Cell Receptor Is an Independent Risk Factor of Chronic Lymphocytic Leukemia Transformation to Richter Syndrome

scientific article published on 09 June 2009

Stereotyped patterns of B-cell receptor in splenic marginal zone lymphoma

scientific article (publication date: October 2010)

Stimulation of surface IgM of chronic lymphocytic leukemia cells induces an unfolded protein response dependent on BTK and SYK.

scientific article

Surface IgM expression and function are associated with clinical behavior, genetic abnormalities, and DNA methylation in CLL.

scientific article published on 14 June 2016

The Dual Syk/JAK Inhibitor Cerdulatinib Antagonizes B-cell Receptor and Microenvironmental Signaling in Chronic Lymphocytic Leukemia

scientific article published on 3 October 2016

The IGHV1-69/IGHJ3 recombinations of unmutated CLL are distinct from those of normal B cells.

scientific article published on 10 January 2012

The PI3K/mTOR inhibitor PF-04691502 induces apoptosis and inhibits microenvironmental signaling in CLL and the Eµ-TCL1 mouse model

scientific article published on 8 May 2015

The SF3B1 inhibitor spliceostatin A (SSA) elicits apoptosis in chronic lymphocytic leukaemia cells through downregulation of Mcl-1.

scientific article published on 21 October 2015

The coexistence of chronic lymphocytic leukemia and myeloproliperative neoplasms: A retrospective multicentric GIMEMA experience

article

The genetics of Richter syndrome reveals disease heterogeneity and predicts survival after transformation

scientific article published on 25 January 2011

The host genetic background of DNA repair mechanisms is an independent predictor of survival in diffuse large B-cell lymphoma

scientific article

The meaning and relevance of B-cell receptor structure and function in chronic lymphocytic leukemia.

scientific article

The normal IGHV1-69-derived B-cell repertoire contains stereotypic patterns characteristic of unmutated CLL.

scientific article published on 3 November 2009

The occurrence and significance of V gene mutations in B cell-derived human malignancy

scientific article

The outcome of B-cell receptor signaling in chronic lymphocytic leukemia: proliferation or anergy

scientific article

The outcome of Chronic lymphocytic leukaemia patients with 97% IGHV gene identity to germline is distinct from cases with <97% identity and similar to those with 98% identity

scientific article published on 5 February 2016

The prognosis of clinical monoclonal B cell lymphocytosis differs from prognosis of Rai 0 chronic lymphocytic leukaemia and is recapitulated by biological risk factors

scientific article published on 5 May 2009

The prognostic value of TP53 mutations in chronic lymphocytic leukemia is independent of Del17p13: implications for overall survival and chemorefractoriness

scientific article published in February 2009

The role of rituximab in combination with pentostatin or cladribine for the treatment of recurrent/refractory hairy cell leukemia

scientific article published on November 2007

Three years of ibrutinib in CLL.

scientific article published in April 2015

Thrombotic Thrombocytopenic Purpura Secondary to an Occult Adenocarcinoma

scientific article published on 01 April 2005

Trisomy 12 and t(14;22)(q32;q11) in a Patient with B-cell Chronic Lymphocytic Leukemia

scientific article published on 01 October 2004

Tumor cells of hairy cell leukemia express multiple clonally related immunoglobulin isotypes via RNA splicing

scientific article published on 01 August 2001

Two main genetic pathways lead to the transformation of chronic lymphocytic leukemia to Richter syndrome.

scientific article published on 4 September 2013

Typical Waldenstrom macroglobulinemia is derived from a B-cell arrested after cessation of somatic mutation but prior to isotype switch events

scientific article published on 01 August 2002

Variant B cell receptor isotype functions differ in hairy cell leukemia with mutated BRAF and IGHV genes

scientific article published on 30 January 2014

Paulina is supported by:

About Paulina

Help