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List of works by Christoph Bock

A Comprehensive Analysis of the Dynamic Response to Aphidicolin-Mediated Replication Stress Uncovers Targets for ATM and ATMIN.

scientific article

A DNA methylation fingerprint of 1628 human samples

scientific article

A Prognostic DNA Methylation Signature for Stage I Non–Small-Cell Lung Cancer

article

A T cell-specific deletion of HDAC1 protects against experimental autoimmune encephalomyelitis.

scientific article published on 27 September 2017

A combinatorial screen of the CLOUD uncovers a synergy targeting the androgen receptor

scientific article published on 22 May 2017

A discrete subset of epigenetically primed human NK cells mediates antigen-specific immune responses

scientific article published on 01 October 2020

A kinase-independent function of CDK6 links the cell cycle to tumor angiogenesis

scientific article

A promoter DNA demethylation landscape of human hematopoietic differentiation

scientific article published on 12 September 2011

A reversible gene trap collection empowers haploid genetics in human cells

scientific article published on 25 August 2013

Ageing-associated DNA methylation dynamics are a molecular readout of lifespan variation among mammalian species.

scientific article published on 16 February 2018

An ERK-Dependent Feedback Mechanism Prevents Hematopoietic Stem Cell Exhaustion.

scientific article

Analysing and interpreting DNA methylation data ⬇️

scientific article published on October 1, 2012

Analyzing epigenome data in context of genome evolution and human diseases

scientific article

Artemisinins Target GABAA Receptor Signaling and Impair α Cell Identity

scientific article

Assembly of the MHC I peptide-loading complex determined by a conserved ionic lock-switch

scientific article

B cells sustain inflammation and predict response to immune checkpoint blockade in human melanoma

scientific article published on 13 September 2019

BLUEPRINT to decode the epigenetic signature written in blood.

scientific article

BiQ Analyzer HT: locus-specific analysis of DNA methylation by high-throughput bisulfite sequencing

scientific article published on 11 May 2011

BiQ Analyzer HiMod: an interactive software tool for high-throughput locus-specific analysis of 5-methylcytosine and its oxidized derivatives

scientific article

BiQ Analyzer: visualization and quality control for DNA methylation data from bisulfite sequencing.

scientific article

CDK6 coordinates JAK2 V617F mutant MPN via NF-κB and apoptotic networks

scientific article published on 11 January 2019

ChIPmentation: fast, robust, low-input ChIP-seq for histones and transcription factors.

scientific article published on 17 August 2015

Chromatin accessibility maps of chronic lymphocytic leukaemia identify subtype-specific epigenome signatures and transcription regulatory networks

scientific article

Chromatin mapping and single-cell immune profiling define the temporal dynamics of ibrutinib response in CLL

scientific article published on 29 January 2020

Chromatin-Based Classification of Genetically Heterogeneous AMLs into Two Distinct Subtypes with Diverse Stemness Phenotypes

scientific article published on 01 January 2019

Coloc-stats: a unified web interface to perform colocalization analysis of genomic features.

scientific article published in July 2018

Colocalization analyses of genomic elements: approaches, recommendations and challenges

scientific article published on 01 May 2019

Combined chemosensitivity and chromatin profiling prioritizes drug combinations in CLL

scientific article published on 28 January 2019

Comparative genome-wide DNA methylation analysis of colorectal tumor and matched normal tissues.

scientific article

Comparison of sequencing-based methods to profile DNA methylation and identification of monoallelic epigenetic modifications.

scientific article

Complex Interplay Between MAZR and Runx3 Regulates the Generation of Cytotoxic T Lymphocyte and Memory T Cells

scientific article published on 17 March 2021

Complex patterns of chromosome 11 aberrations in myeloid malignancies target CBL, MLL, DDB1 and LMO2.

scientific article

Comprehensive analysis of DNA methylation data with RnBeads

scientific article

Comprehensive genome and epigenome characterization of CHO cells in response to evolutionary pressures and over time.

scientific article published on 12 April 2016

Computational epigenetics

scientific article

CpG island mapping by epigenome prediction

scientific article

CpG island methylation in human lymphocytes is highly correlated with DNA sequence, repeats, and predicted DNA structure

scientific article

DNA Methylation Dynamics of Human Hematopoietic Stem Cell Differentiation

scientific article

DNA methylation analysis of chromosome 21 gene promoters at single base pair and single allele resolution

scientific article

DNA methylation biomarkers in cancer: progress towards clinical implementation

scientific article published on June 2012

DNA methylation dynamics during in vivo differentiation of blood and skin stem cells

scientific article published on 26 July 2012

DNA methylation heterogeneity defines a disease spectrum in Ewing sarcoma.

scientific article

DNA methylation signatures link prenatal famine exposure to growth and metabolism

scientific article

DNA methylation: a matter of culture

scientific article

DeepBlue epigenomic data server: programmatic data retrieval and analysis of epigenome region sets

scientific article

DeepBlueR: large-scale epigenomic analysis in R.

scientific article published on 22 February 2017

Differential DNA Methylation Analysis without a Reference Genome

scientific article

Dissecting the role of aberrant DNA methylation in human leukaemia

scientific article published on 22 May 2015

Disturbed mitochondrial dynamics in CD8+ TILs reinforce T cell exhaustion

scientific article published on 05 October 2020

Dnmt3a is essential for hematopoietic stem cell differentiation

scientific article

EpiExplorer: live exploration and global analysis of large epigenomic datasets

scientific article published on 3 October 2012

EpiGRAPH: user-friendly software for statistical analysis and prediction of (epi)genomic data

scientific article

Epigenetic Homogeneity Within Colorectal Tumors Predicts Shorter Relapse-Free and Overall Survival Times for Patients With Locoregional Cancer

scientific article published on 10 August 2016

Epigenetic biomarker development

scientific article published on October 1, 2009

Epigenom-Karten erstellen und nutzen

Epigenome mapping reveals distinct modes of gene regulation and widespread enhancer reprogramming by the oncogenic fusion protein EWS-FLI1.

scientific article

Epigenomic profiling of young and aged HSCs reveals concerted changes during aging that reinforce self-renewal

scientific article

Epigenomics and Single-Cell Sequencing Define a Developmental Hierarchy in Langerhans Cell Histiocytosis

scientific article published on 25 July 2019

Erosion of dosage compensation impacts human iPSC disease modeling

scientific article published on May 2012

Familial early-onset dementia with complex neuropathologic phenotype and genomic background

scientific article published on 21 March 2016

Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells

scientific article published on 19 July 2018

Functional analysis of a potassium-chloride co-transporter 3 (SLC12A6) promoter polymorphism leading to an additional DNA methylation site.

scientific article

Genome-scale CRISPR screens are efficient in non-homologous end-joining deficient cells

scientific article published on 31 October 2019

Genome-scale DNA methylation mapping of clinical samples at single-nucleotide resolution

scientific article published on 10 January 2010

Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation

scientific article

Genomic and transcriptional landscape of P2RY8-CRLF2-positive childhood acute lymphoblastic leukemia

scientific article published on 30 November 2016

Genomic distribution and inter-sample variation of non-CpG methylation across human cell types

scientific article

Genomic epidemiology of superspreading events in Austria reveals mutational dynamics and transmission properties of SARS-CoV-2

scientific article published on 23 November 2020

Genomic imprinting in mouse blastocysts is predominantly associated with H3K27me3

scientific article published on 21 June 2021

Global DNA demethylation during mouse erythropoiesis in vivo

scientific article published on November 2011

Guadecitabine Plus Ipilimumab in Unresectable Melanoma: The NIBIT-M4 Clinical Trial

scientific article published on 17 September 2019

HCV-Induced Epigenetic Changes Associated With Liver Cancer Risk Persist After Sustained Virologic Response

scientific article published on 02 March 2019

High-content CRISPR screening

scientific article published in 2022

High-resolution mapping of h1 linker histone variants in embryonic stem cells

scientific article

High-throughput bisulfite sequencing in mammalian genomes

scientific article published on 12 May 2009

Highly efficient derivation of ventricular cardiomyocytes from induced pluripotent stem cells with a distinct epigenetic signature

scientific article

Hyperglycemia Induces Trained Immunity in Macrophages and Their Precursors and Promotes Atherosclerosis

scientific article published on 13 July 2021

IVF: stars may have to consider the risk of stolen parenthood

scientific article

Identification of novel imprinted differentially methylated regions by global analysis of human-parthenogenetic-induced pluripotent stem cells

scientific article published on 4 June 2013

Imprinted expression in cystic embryoid bodies shows an embryonic and not an extra-embryonic pattern

scientific article published on 24 April 2015

Improving reference epigenome catalogs by computational prediction

scientific article published on April 2015

Inference of transcription factor binding from cell-free DNA enables tumor subtype prediction and early detection

scientific article published on 11 October 2019

Inherited DOCK2 Deficiency in Patients with Early-Onset Invasive Infections

scientific article published on June 2015

Integrative Proteomic Profiling Reveals PRC2-Dependent Epigenetic Crosstalk Maintains Ground-State Pluripotency

scientific article published on 21 November 2018

Inter-individual variation of DNA methylation and its implications for large-scale epigenome mapping

scientific article

KRAS and CREBBP mutations: a relapse-linked malicious liaison in childhood high hyperdiploid acute lymphoblastic leukemia

scientific article

Knowledge-primed neural networks enable biologically interpretable deep learning on single-cell sequencing data

scientific article published on 03 August 2020

LOLA: enrichment analysis for genomic region sets and regulatory elements in R and Bioconductor

scientific article

Life-long epigenetic programming of cortical architecture by maternal 'Western' diet during pregnancy

scientific article published on 18 November 2019

LifeTime and improving European healthcare through cell-based interceptive medicine

scientific article published on 07 September 2020

Long-term skin-resident memory T cells proliferate in situ and are involved in human graft-versus-host disease

scientific article published on 01 November 2020

Lung stem cell self-renewal relies on BMI1-dependent control of expression at imprinted loci.

scientific article

MIRA: An R package for DNA methylation-based inference of regulatory activity

scientific article published in March 2018

MTHFD1 interaction with BRD4 links folate metabolism to transcriptional regulation

scientific article published on 27 May 2019

Making sense of big data in health research: Towards an EU action plan

scientific article

Malondialdehyde epitopes are sterile mediators of hepatic inflammation in hypercholesterolemic mice

scientific article published on 16 December 2016

Managing drug resistance in cancer: lessons from HIV therapy ⬇️

scientific article published on June 7, 2012

Mapping the chemical chromatin reactivation landscape identifies BRD4-TAF1 cross-talk

scientific article

Mapping the mouse Allelome reveals tissue-specific regulation of allelic expression

scientific article published on 14 August 2017

MethMarker: user-friendly design and optimization of gene-specific DNA methylation assays

scientific article published on 5 October 2009

Mitochondria Are a Subset of Extracellular Vesicles Released by Activated Monocytes and Induce Type I IFN and TNF Responses in Endothelial Cells

scientific article published on 08 May 2019

Model-Based Whole-Genome Analysis of DNA Methylation Fidelity

Molecular design of hypothalamus development

scientific article published on 06 May 2020

Molecular interrogation of hypothalamic organization reveals distinct dopamine neuronal subtypes

scientific article

Multi-Omics of Single Cells: Strategies and Applications

scientific article published on 19 May 2016

Mutational landscape of the transcriptome offers putative targets for immunotherapy of myeloproliferative neoplasms

scientific article published on 07 May 2019

NK Cells Require Cell-Extrinsic and -Intrinsic TYK2 for Full Functionality in Tumor Surveillance and Antibacterial Immunity

scientific article published on 04 February 2019

NOTCH1 activation in breast cancer confers sensitivity to inhibition of SUMOylation

scientific article published on 29 September 2014

Next-generation sequencing identifies major DNA methylation changes during progression of Ph+ chronic myeloid leukemia

scientific article published on 23 May 2016

Notch inhibition allows oncogene-independent generation of iPS cells

scientific article

Notch-mediated expansion of cord blood progenitors: maintenance of transcriptional and epigenetic fidelity

scientific article

Optimization of quantitative MGMT promoter methylation analysis using pyrosequencing and combined bisulfite restriction analysis

scientific article published on July 2007

Parallel genome-wide screens identify synthetic viable interactions between the BLM helicase complex and Fanconi anemia

scientific article published in November 2017

Parallel reverse genetic screening in mutant human cells using transcriptomics

scientific article published on August 2016

Parental micronutrient deficiency distorts liver DNA methylation and expression of lipid genes associated with a fatty-liver-like phenotype in offspring

scientific article published on 14 February 2018

Paternally induced transgenerational environmental reprogramming of metabolic gene expression in mammals

scientific article

Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia

scientific article

Pooled CRISPR screening with single-cell transcriptome readout

scientific article

Preparation of reduced representation bisulfite sequencing libraries for genome-scale DNA methylation profiling

scientific article

Preserve personal freedom in networked societies

scientific article published on 31 August 2016

Proliferation-dependent alterations of the DNA methylation landscape underlie hematopoietic stem cell aging

scientific article published on 14 February 2013

Promoter hypermethylation of the phosphatase DUSP22 mediates PKA-dependent TAU phosphorylation and CREB activation in Alzheimer's disease

scientific article

Proposed Terminology and Classification of Pre-Malignant Neoplastic Conditions: A Consensus Proposal

scientific article published on 26 November 2017

Publisher Correction: Inference of transcription factor binding from cell-free DNA enables tumor subtype prediction and early detection

scientific article published on 20 April 2020

Publisher Correction: LifeTime and improving European healthcare through cell-based interceptive medicine

scientific article published on 17 March 2021

Quantitative comparison of genome-wide DNA methylation mapping technologies.

scientific article published on 19 September 2010

RANK links thymic regulatory T cells to fetal loss and gestational diabetes in pregnancy

scientific article published on 23 December 2020

RRBSMAP: a fast, accurate and user-friendly alignment tool for reduced representation bisulfite sequencing

scientific article published on 6 December 2011

Rational discovery of molecular glue degraders via scalable chemical profiling

scientific article published on 03 August 2020

Recommendations for the design and analysis of epigenome-wide association studies

scientific article published on October 2013

Reference Maps of human ES and iPS cell variation enable high-throughput characterization of pluripotent cell lines

scientific article

Regulation of DNA methylation patterns by CK2-mediated phosphorylation of Dnmt3a.

scientific article

Relationship between genome and epigenome--challenges and requirements for future research

scientific article published on 18 June 2014

RnBeads 2.0: comprehensive analysis of DNA methylation data

article by Fabian Müller et al published 14 March 2019 in Genome Biology

STAT5BN642H is a driver mutation for T cell neoplasia

scientific article published on 4 December 2017

Selective Mediator dependence of cell-type-specifying transcription

scientific article published on 01 June 2020

Sequential ChIP-bisulfite sequencing enables direct genome-scale investigation of chromatin and DNA methylation cross-talk

scientific article

Single-cell DNA methylome sequencing and bioinformatic inference of epigenomic cell-state dynamics

scientific article

Single-cell transcriptomes reveal characteristic features of human pancreatic islet cell types

scientific article published on 21 December 2015

Single-cell transcriptomics and epigenomics unravel the role of monocytes in neuroblastoma bone marrow metastasis

scientific article published in 2023

Somatic mutations of calreticulin in myeloproliferative neoplasms

scientific article

Spatiotemporal structure of cell fate decisions in murine neural crest

scientific article

Specification of tissue-resident macrophages during organogenesis.

scientific article

Structural and functional insights into the interaction and targeting hub TMD0 of the polypeptide transporter TAPL

scientific article published in Scientific Reports

Structural cells are key regulators of organ-specific immune responses

scientific article published on 01 July 2020

Structural conservation versus functional divergence of maternally expressed microRNAs in the Dlk1/Gtl2 imprinting region

scientific article

Synergy and competition between cancer genome sequencing and epigenome mapping projects

scientific article

Systematic characterization of BAF mutations provides insights into intracomplex synthetic lethalities in human cancers

scientific article published on 19 August 2019

Targeted mutation screening of 292 candidate genes in 38 children with inborn haematological cytopenias efficiently identifies novel disease-causing mutations

article

The DNA methylation landscape of glioblastoma disease progression shows extensive heterogeneity in time and space

The ERBB-STAT3 Axis Drives Tasmanian Devil Facial Tumor Disease

The ERBB-STAT3 Axis Drives Tasmanian Devil Facial Tumor Disease

The Organoid Cell Atlas

scientific article

The Organoid Cell Atlas: A Rosetta Stone for Biomedical Discovery and Regenerative Therapy ⬇️

journal article published in 2020

The cytoskeletal regulator HEM1 governs B cell development and prevents autoimmunity

scientific article published on 01 July 2020

The human genomic melting map.

scientific article

Toward understanding and exploiting tumor heterogeneity

scientific article

VCF.Filter: interactive prioritization of disease-linked genetic variants from sequencing data

scientific article

Web-based analysis of (Epi-) genome data using EpiGRAPH and Galaxy

scientific article

Whole-exome sequencing identifies novel MPL and JAK2 mutations in triple-negative myeloproliferative neoplasms

scientific article published on 30 September 2015

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