List of works by Jerzy Kupiec-Węgliński

A novel strategy against ischemia and reperfusion injury: cytoprotection with heme oxygenase system

scientific article

ASC/caspase-1/IL-1β signaling triggers inflammatory responses by promoting HMGB1 induction in liver ischemia/reperfusion injury

scientific article published on 15 May 2013

Absence of toll-like receptor 4 (TLR4) signaling in the donor organ reduces ischemia and reperfusion injury in a murine liver transplantation model

scientific article published in October 2007

Activation of alloreactive CD8+ T cells operates via CD4-dependent and CD4-independent mechanisms and is CD154 blockade sensitive

scientific article published in March 2003

Activation of cyclic adenosine monophosphate-dependent protein kinase a signaling prevents liver ischemia/reperfusion injury in mice

scientific article

Adoptive transfer of ex vivo HO-1 modified bone marrow-derived macrophages prevents liver ischemia and reperfusion injury

scientific article

Adoptive transfer of heme oxygenase-1 (HO-1)-modified macrophages rescues the nuclear factor erythroid 2-related factor (Nrf2) antiinflammatory phenotype in liver ischemia/reperfusion injury

scientific article

Allograft rejection by primed/memory CD8+ T cells is CD154 blockade resistant: therapeutic implications for sensitized transplant recipients.

scientific article published in October 2002

Alloreactive CD8 T-cell primed/memory responses and accelerated graft rejection in B-cell-deficient sensitized mice

scientific article published on May 2011

Anti-MHC class I antibody activation of proliferation and survival signaling in murine cardiac allografts

scientific article published on February 2008

Bag-1 up-regulation in anti-CD4 mAb treated allo-activated T cells confers resistance to apoptosis

scientific article

Bag-1 up-regulation in anti-CD4 mAb-treated allo-activated T cell confers resistance to activation-induced cell death (AICD).

scientific article

Basal rather than induced heme oxygenase-1 levels are crucial in the antioxidant cytoprotection

scientific article

Biliverdin therapy protects rat livers from ischemia and reperfusion injury

scientific article published in December 2004

Blockade of Janus kinase-2 signaling ameliorates mouse liver damage due to ischemia and reperfusion

scientific article

Bruton Tyrosine Kinase Inhibition Attenuates Liver Damage in a Mouse Warm Ischemia and Reperfusion Model.

scientific article published on 3 November 2016

Bucillamine, a thiol antioxidant, prevents transplantation-associated reperfusion injury

scientific article

CD154-CD40 T-cell costimulation pathway is required in the mechanism of hepatic ischemia/reperfusion injury, and its blockade facilitates and depends on heme oxygenase-1 mediated cytoprotection

scientific article published in August 2002

CD4 T cells promote tissue inflammation via CD40 signaling without de novo activation in a murine model of liver ischemia/reperfusion injury

scientific article

CD4+ T regulatory cell induction and function in transplant recipients after CD154 blockade is TLR4 independent

scientific article

CD62 blockade with P-Selectin glycoprotein ligand-immunoglobulin fusion protein reduces ischemia-reperfusion injury after rat intestinal transplantation.

scientific article published in January 2005

CXCL10 regulates liver innate immune response against ischemia and reperfusion injury

scientific article published in January 2008

CXCR3+CD4+ T cells mediate innate immune function in the pathophysiology of liver ischemia/reperfusion injury

scientific article published in May 2006

Class I MHC allochimeric presentation of composite immunogenic and self epitopes induces tolerance to genetically diverse rat strains

scientific article published on July 2007

Combined immunostimulation and conditional cytotoxic gene therapy provide long-term survival in a large glioma model.

scientific article

Critical role of CD4 help in CD154 blockade-resistant memory CD8 T cell activation and allograft rejection in sensitized recipients

scientific article

Cutting edge: TLR4 activation mediates liver ischemia/reperfusion inflammatory response via IFN regulatory factor 3-dependent MyD88-independent pathway

scientific article published in December 2004

Cyclosporine in renal transplantation: a review of clinical and experimental studies

scientific article published in 1987

Cytoprotective and antiapoptotic effects of IL-13 in hepatic cold ischemia/reperfusion injury are heme oxygenase-1 dependent

scientific article published in September 2003

Cytoprotective gene bi-1 is required for intrinsic protection from endoplasmic reticulum stress and ischemia-reperfusion injury

scholarly article

Defective alloreactive CD8 T cell function and memory response in allograft recipients in the absence of CD4 help

scientific article published in October 2007

Differential impact of CD154 costimulation blockade on alloreactive effector and regulatory T cells in murine renal transplant recipients.

scientific article published in May 2008

Disruption of P-selectin signaling modulates cell trafficking and results in improved outcomes after mouse warm intestinal ischemia and reperfusion injury.

scientific article published in September 2005

Endoplasmic reticulum stress modulates liver inflammatory immune response in the pathogenesis of liver ischemia and reperfusion injury

scientific article

Evaluation of gene promoters for liver expression by hydrodynamic gene transfer

scientific article published on 13 March 2008

Evidence for the pivotal role of endogenous toll-like receptor 4 ligands in liver ischemia and reperfusion injury

scientific article published in April 2008

Ex vivo exposure to carbon monoxide prevents hepatic ischemia/reperfusion injury through p38 MAP kinase pathway.

scientific article

FTY720 pretreatment reduces warm hepatic ischemia reperfusion injury through inhibition of T-lymphocyte infiltration

scientific article published in October 2002

Fibronectin-alpha 4 beta 1 integrin-mediated blockade protects genetically fat Zucker rat livers from ischemia/reperfusion injury

scientific article published on April 2003

Gene therapy for liver transplantation using adenoviral vectors: CD40-CD154 blockade by gene transfer of CD40Ig protects rat livers from cold ischemia and reperfusion injury

scientific article published on January 2004

Gene therapy in liver ischemia and reperfusion injury

scientific article published on January 2006

Gene transfer-induced local heme oxygenase-1 overexpression protects rat kidney transplants from ischemia/reperfusion injury

scientific article published in March 2003

Glycogen synthase kinase 3β promotes liver innate immune activation by restraining AMP-activated protein kinase activation.

scientific article published on 13 February 2018

HO-1-STAT3 axis in mouse liver ischemia/reperfusion injury: regulation of TLR4 innate responses through PI3K/PTEN signaling

scientific article published on 12 July 2011

Heme oxygenase 1 gene transfer prevents CD95/Fas ligand-mediated apoptosis and improves liver allograft survival via carbon monoxide signaling pathway

scientific article published on July 2002

Heme oxygenase 1 mediates the immunomodulatory and antiapoptotic effects of interleukin 13 gene therapy in vivo and in vitro

scientific journal article

Heme oxygenase system in ischemia and reperfusion injury

scientific article published in January 2004

Heme oxygenase-1 gene transfer inhibits inducible nitric oxide synthase expression and protects genetically fat Zucker rat livers from ischemia-reperfusion injury

scientific article

Heme oxygenase-1 mediated cytoprotection against liver ischemia and reperfusion injury: inhibition of type-1 interferon signaling

scientific article

Heme oxygenase-1 overexpression protects rat hearts from cold ischemia/reperfusion injury via an antiapoptotic pathway.

scientific article

Heme oxygenase-1 regulates sirtuin-1-autophagy pathway in liver transplantation: From mouse to human

scientific article published on 14 November 2017

Heme oxygenase-1 system in organ transplantation

scientific article

Hepatic ischemia/reperfusion injury--a fresh look

scientific article

Immunopathogenesis of accelerated allograft rejection in sensitized recipients: humoral and nonhumoral mechanisms

scientific article published in May 2002

In vivo mature immunological synapses forming SMACs mediate clearance of virally infected astrocytes from the brain

scientific article

Inflammatory responses in a new mouse model of prolonged hepatic cold ischemia followed by arterialized orthotopic liver transplantation

scientific article published in October 2005

Inhibition of glycogen synthase kinase 3 beta ameliorates liver ischemia reperfusion injury by way of an interleukin-10-mediated immune regulatory mechanism

scientific article

Innate Immune Regulations and Liver Ischemia-Reperfusion Injury

scientific article published on December 2016

Interleukin 13 gene transfer in liver ischemia and reperfusion injury: role of Stat6 and TLR4 pathways in cytoprotection

scientific article published in July 2004

Interleukin-13 gene transfer protects rat livers from antigen-independent injury induced by ischemia and reperfusion

scientific article published in April 2003

Interleukin-13 protects mouse intestine from ischemia and reperfusion injury through regulation of innate and adaptive immunity

scientific article published on April 2011

Interleukin-22: implications for liver ischemia-reperfusion injury

scientific article

Ischaemia-reperfusion injury in liver transplantation--from bench to bedside

scientific article published on 11 December 2012

Ischemia Reperfusion Injury and Its Relationship with Early Allograft Dysfunction in Liver Transplant patients

scientific article published on 26 July 2020

Ischemia/Reperfusion injury, its mechanisms, and prevention

scientific article published on 26 December 2012

KEAP1-NRF2 complex in ischemia-induced hepatocellular damage of mouse liver transplants

scientific article published on 16 July 2013

Macrophage heme oxygenase-1-SIRT1-p53 axis regulates sterile inflammation in liver ischemia-reperfusion injury

scientific article

Molecular characterization of rat leukocyte P-selectin glycoprotein ligand-1 and effect of its blockade: protection from ischemia-reperfusion injury in liver transplantation

scientific article

Molecular mediators of liver ischemia and reperfusion injury: a brief review

scientific article published on May 2008

Myeloid Notch1 Deficiency Activates RhoA/ROCK Pathway and Aggravates Hepatocellular Damage In Mouse Ischemic Livers.

scientific article published on 12 October 2017

Myeloid PTEN deficiency protects livers from ischemia reperfusion injury by facilitating M2 macrophage differentiation

scientific article

National conference to assess antibody-mediated rejection in solid organ transplantation

scientific article published in July 2004

Native macrophages genetically modified to express heme oxygenase 1 protect rat liver transplants from ischemia/reperfusion injury

scientific article published on February 2011

Negative CD4 + TIM-3 signaling confers resistance against cold preservation damage in mouse liver transplantation

scientific article published on 12 February 2015

Nuclear factor erythroid 2-related factor 2 regulates toll-like receptor 4 innate responses in mouse liver ischemia-reperfusion injury through Akt-forkhead box protein O1 signaling network

scientific article published on October 2014

Outside-in HLA class I signaling regulates ICAM-1 clustering and endothelial cell-monocyte interactions via mTOR in transplant antibody-mediated rejection

scientific article

PTEN-mediated Akt/β-catenin/Foxo1 signaling regulates innate immune responses in mouse liver ischemia/reperfusion injury

scientific article published on 4 December 2012

Peacekeepers are cross-dressed in the liver land

scientific article published in December 2017

Phosphatase and tensin homolog-β-catenin signaling modulates regulatory T cells and inflammatory responses in mouse liver ischemia/reperfusion injury

scientific article published on 2 February 2017

Posttransplant administration of allochimeric major histocompatibility complex class-I-molecules induces true transplantation tolerance

scientific article published in February 2003

Programmed death-1/B7-H1 negative costimulation protects mouse liver against ischemia and reperfusion injury ⬇️

scientific article published on October 1, 2010

Prolonged Ischemia Triggers Necrotic Depletion of Tissue-Resident Macrophages To Facilitate Inflammatory Immune Activation in Liver Ischemia Reperfusion Injury

scientific article

Rapamycin protection of livers from ischemia and reperfusion injury is dependent on both autophagy induction and mammalian target of rapamycin complex 2-Akt activation

scientific article

Recombinant Relaxin Protects Liver Transplants from Ischemia Damage via Hepatocyte Glucocorticoid Receptor: From Bench-to-Bedside

scientific article published on 19 January 2018

Regulated hepatic reperfusion mitigates ischemia-reperfusion injury and improves survival after prolonged liver warm ischemia: a pilot study on a novel concept of organ resuscitation in a large animal model

scientific article published on 7 February 2012

Reply: To PMID 23408710.

scientific article published on 11 October 2013

Serelaxin Induces Notch1 Signaling and Alleviates Hepatocellular Damage in Orthotopic Liver Transplantation

scientific article published on 21 February 2018

Sirtuin 1 attenuates inflammation and hepatocellular damage in liver transplant ischemia/Reperfusion: From mouse to human.

scientific article published on 18 July 2017

Small interfering RNA targeting heme oxygenase-1 (HO-1) reinforces liver apoptosis induced by ischemia-reperfusion injury in mice: HO-1 is necessary for cytoprotection

scientific article

Stat4 and Stat6 signaling in hepatic ischemia/reperfusion injury in mice: HO-1 dependence of Stat4 disruption-mediated cytoprotection

scientific article published in February 2003

Systemic rather than local heme oxygenase-1 overexpression improves cardiac allograft outcomes in a new transgenic mouse.

scientific article published in August 2003

T-cell immunoglobulin and mucin domain 4 (TIM-4) signaling in innate immune-mediated liver ischemia-reperfusion injury

scientific article

T-cell immunoglobulin mucin-3 determines severity of liver ischemia/reperfusion injury in mice in a TLR4-dependent manner

scientific article

T-cell receptor beta-chain usage in directly activated alloreactive CD4+ T cells: unrestricted Vbeta gene usage with CDR3 size limitations

scientific article published on February 2003

Tezosentan, a novel endothelin receptor antagonist, markedly reduces rat hepatic ischemia and reperfusion injury in three different models

scientific article

The CD154-CD40 T cell costimulation pathway is required for host sensitization of CD8(+) T cells by skin grafts via direct antigen presentation.

scientific article published in August 2002

The CD154-CD40 T-cell co-stimulation pathway in liver ischemia and reperfusion inflammatory responses

scientific article published on May 2005

The Dichotomy of Endoplasmic Reticulum Stress Response in Liver Ischemia-Reperfusion Injury

scientific article published on 17 December 2015

The emerging role of T cell immunoglobulin mucin-1 in the mechanism of liver ischemia and reperfusion injury in the mouse

scientific article

The inhibition of neutrophil elastase ameliorates mouse liver damage due to ischemia and reperfusion

scientific article published on August 2009

The innate immune system and transplantation

scientific article published on October 2013

The membrane attack complex (C5b-9) in liver cold ischemia and reperfusion injury

scientific article

The myeloid heat shock transcription factor 1/β-catenin axis regulates NLR family, pyrin domain-containing 3 inflammasome activation in mouse liver ischemia/reperfusion injury

scientific article

The protective function of neutrophil elastase inhibitor in liver ischemia/reperfusion injury

scientific article published on May 2010

Toll-like receptor and heme oxygenase-1 signaling in hepatic ischemia/reperfusion injury

scientific article published in August 2005

Treatment with antithymocyte globulin ameliorates intestinal ischemia and reperfusion injury in mice.

scientific article published on 8 May 2012

Type I interferon pathway mediates renal ischemia/reperfusion injury ⬇️

scientific article

Type I, but not type II, interferon is critical in liver injury induced after ischemia and reperfusion

scientific article published in January 2008

Upregulation of Bag-1 by ex vivo gene transfer protects rat livers from ischemia/reperfusion injury

scientific article published in August 2002

Vascular endothelial growth factor antagonist modulates leukocyte trafficking and protects mouse livers against ischemia/reperfusion injury

scientific article published on February 2006

Vasoactive intestinal peptide attenuates liver ischemia/reperfusion injury in mice via the cyclic adenosine monophosphate-protein kinase a pathway

scientific article published on 26 July 2013

Vertical Sleeve Gastrectomy Attenuates the Progression of Non-Alcoholic Steatohepatitis in Mice on a High-Fat High-Cholesterol Diet

scientific article published on 01 August 2019

Viral interleukin-10 gene transfer prevents liver ischemia-reperfusion injury: Toll-like receptor-4 and heme oxygenase-1 signaling in innate and adaptive immunity

scientific article

Wojciech A. Rowicski, M.D., Ph.D. (1935Y2014): humanist, transplant surgeon and scientist

scientific article published in August 2014

YSPSL (rPSGL-Ig) for improvement of early renal allograft function: a double-blind, placebo-controlled, multi-center Phase IIa study

scientific article published on 22 June 2010

β-catenin regulates innate and adaptive immunity in mouse liver ischemia-reperfusion injury

scientific article

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