List of works - Flavien Charpentier

A Dominant Negative Isoform of the Long QT Syndrome 1 Gene Product

scientific article published in Journal of Biological Chemistry

A consistent arrhythmogenic trait in Brugada syndrome cellular phenotype

scientific article published on 07 June 2021

Abnormal cardiac repolarization and impulse initiation in German shepherd dogs with inherited ventricular arrhythmias and sudden death.

scientific article published on April 1999

Adult KCNE1-knockout mice exhibit a mild cardiac cellular phenotype

scientific article published on 01 October 1998

Amiodarone reduces transmural heterogeneity of repolarization in the human heart

scientific article published on 01 October 1998

Arrhythmias precede cardiomyopathy and remodeling of Ca2+ handling proteins in a novel model of long QT syndrome

scientific article published on 23 August 2018

Autologous myoblast transplantation after myocardial infarction increases the inducibility of ventricular arrhythmias.

scientific article

Biological pacemaker engineered by nonviral gene transfer in a mouse model of complete atrioventricular block

scientific article published on 23 September 2008

Bradycardia and slowing of the atrioventricular conduction in mice lacking CaV3.1/alpha1G T-type calcium channels

scientific journal article

C-terminal phosphorylation of NaV1.5 impairs FGF13-dependent regulation of channel inactivation.

scientific article

Cardiac FKBP12.6 overexpression protects against triggered ventricular tachycardia in pressure overloaded mouse hearts.

scientific article published on 4 February 2012

Cardiac cell therapy: overexpression of connexin43 in skeletal myoblasts and prevention of ventricular arrhythmias

scientific article

Cardiac channelopathies: from men to mice

scientific article

Chronic heart rate reduction remodels ion channel transcripts in the mouse sinoatrial node but not in the ventricle

scientific article

Conditional FKBP12.6 overexpression in mouse cardiac myocytes prevents triggered ventricular tachycardia through specific alterations in excitation-contraction coupling.

scientific article published on 31 March 2008

Conditional mineralocorticoid receptor expression in the heart leads to life-threatening arrhythmias

scientific article published on 6 June 2005

Delayed rectifier K(+) currents and cardiac repolarization.

scientific article published on 14 August 2009

Dysfunction of the Voltage-Gated K+ Channel β2 Subunit in a Familial Case of Brugada Syndrome

scientific article published on 10 June 2016

Early ion-channel remodeling and arrhythmias precede hypertrophy in a mouse model of complete atrioventricular block

scientific article published on 20 July 2011

Electropharmacological characterization of cardiac repolarization in German shepherd dogs with an inherited syndrome of sudden death: abnormal response to potassium channel blockers

scientific article published on 01 September 2000

Electrophysiologic characteristics of cells spanning the left ventricular wall of human heart: evidence for presence of M cells

scientific article published on 01 July 1995

Endomyocardial biopsies: a new approach for studying the electrical and mechanical properties of human ventricular myocardium

scientific article published on 01 October 1994

Expression of human ERG K+ channels in the mouse heart exerts anti-arrhythmic activity

scientific article published in January 2005

Familial Catecholamine-Induced QT Prolongation in Unexplained Sudden Cardiac Death.

scientific article

Functional Impact of BeKm-1, a High-Affinity hERG Blocker, on Cardiomyocytes Derived from Human-Induced Pluripotent Stem Cells

scientific article published on 28 September 2020

Functional genomics of cardiac ion channel genes

scientific article

G protein-gated IKACh channels as therapeutic targets for treatment of sick sinus syndrome and heart block.

scientific article published in February 2016

HIV-Tat induces a decrease in IKr and IKsvia reduction in phosphatidylinositol-(4,5)-bisphosphate availability

scientific article published on 30 August 2016

Identifying potential functional impact of mutations and polymorphisms: linking heart failure, increased risk of arrhythmias and sudden cardiac death

scientific article

Impaired impulse propagation in Scn5a-knockout mice: combined contribution of excitability, connexin expression, and tissue architecture in relation to aging

scientific journal article

KCNE1-KCNQ1 osmoregulation by interaction of phosphatidylinositol-4,5-bisphosphate with Mg2+ and polyamines

scientific article published on 26 July 2010

KCNQ1 channels voltage dependence through a voltage-dependent binding of the S4-S5 linker to the pore domain.

scientific article

KV4.3 Expression Modulates NaV1.5 Sodium Current.

scientific article published on 12 March 2018

Long-term amiodarone administration remodels expression of ion channel transcripts in the mouse heart

scientific article published in November 2004

Mass spectrometry-based identification of native cardiac Nav1.5 channel α subunit phosphorylation sites.

scientific article

Mental stress test: a rapid, simple, and efficient test to unmask long QT syndrome

scientific article published on 01 December 2018

Microarray analysis reveals complex remodeling of cardiac ion channel expression with altered thyroid status: relation to cellular and integrated electrophysiology.

scientific article

Mouse Models of SCN5A-Related Cardiac Arrhythmias

scientific article published on 22 June 2012

Mouse model of SCN5A-linked hereditary Lenègre's disease: age-related conduction slowing and myocardial fibrosis

scientific journal article

Mouse models of SCN5A-related cardiac arrhythmias

scientific article published on October 2008

Multifocal ectopic Purkinje-related premature contractions: a new SCN5A-related cardiac channelopathy

scientific article

Normal interventricular differences in tissue architecture underlie right ventricular susceptibility to conduction abnormalities in a mouse model of Brugada syndrome

scientific article published on 18 December 2017

Osteopontin expression in cardiomyocytes induces dilated cardiomyopathy

scientific article

Phosphatidylinositol-4,5-bisphosphate (PIP(2)) stabilizes the open pore conformation of the Kv11.1 (hERG) channel

scientific article

Phosphatidylinositol-4,5-bisphosphate, PIP2, controls KCNQ1/KCNE1 voltage-gated potassium channels: a functional homology between voltage-gated and inward rectifier K+ channels.

scientific article

Phosphodiesterase 4B in the cardiac L-type Ca²⁺ channel complex regulates Ca²⁺ current and protects against ventricular arrhythmias in mice

scientific journal article

Physiological and Pathophysiological Insights of Nav1.4 and Nav1.5 Comparison

scientific article

Rabbit, a relevant model for the study of cardiac beta 3-adrenoceptors

scientific article published on 16 January 2009

Remodeling of excitation-contraction coupling in transgenic mice expressing ATP-insensitive sarcolemmal KATP channels

scientific article

Sinus node dysfunction following targeted disruption of the murine cardiac sodium channel gene Scn5a

scientific journal article

T-type calcium current contributes to escape automaticity and governs the occurrence of lethal arrhythmias after atrioventricular block in mice

scientific article published on 24 July 2013

The Sodium-Glucose Cotransporter 2 Inhibitor Dapagliflozin Prevents Cardiomyopathy in a Diabetic Lipodystrophic Mouse Model

scientific article published on 4 January 2017

Toward Personalized Medicine: Using Cardiomyocytes Differentiated From Urine-Derived Pluripotent Stem Cells to Recapitulate Electrophysiological Characteristics of Type 2 Long QT Syndrome

scientific article

Trafficking-deficient long QT syndrome mutation KCNQ1-T587M confers severe clinical phenotype by impairment of KCNH2 membrane localization: evidence for clinically significant IKr-IKs alpha-subunit interaction.

scientific article

Transfer of rolf S3-S4 linker to HERG eliminates activation gating but spares inactivation

scientific article published on September 2009

Transforming growth factor β receptor inhibition prevents ventricular fibrosis in a mouse model of progressive cardiac conduction disease.

scientific article published on 17 February 2017

Triggered activity as a possible mechanism for arrhythmias in ventricular hypertrophy

scientific article published on 01 November 1991

Understanding the cardiac role of K2P channels: a new TASK for electrophysiologists

scientific article published on 22 May 2007

Variable Na(v)1.5 protein expression from the wild-type allele correlates with the penetrance of cardiac conduction disease in the Scn5a(+/-) mouse model

scientific article

alpha1-adrenergic stimulation induces early afterdepolarizations in ferret Purkinje fibers

scientific article published on 01 March 1996

List of works by Flavien Charpentier

A Dominant Negative Isoform of the Long QT Syndrome 1 Gene Product

A consistent arrhythmogenic trait in Brugada syndrome cellular phenotype

Abnormal cardiac repolarization and impulse initiation in German shepherd dogs with inherited ventricular arrhythmias and sudden death.

Adult KCNE1-knockout mice exhibit a mild cardiac cellular phenotype

Amiodarone reduces transmural heterogeneity of repolarization in the human heart

Arrhythmias precede cardiomyopathy and remodeling of Ca2+ handling proteins in a novel model of long QT syndrome

Autologous myoblast transplantation after myocardial infarction increases the inducibility of ventricular arrhythmias.

Biological pacemaker engineered by nonviral gene transfer in a mouse model of complete atrioventricular block

Bradycardia and slowing of the atrioventricular conduction in mice lacking CaV3.1/alpha1G T-type calcium channels

C-terminal phosphorylation of NaV1.5 impairs FGF13-dependent regulation of channel inactivation.

Cardiac FKBP12.6 overexpression protects against triggered ventricular tachycardia in pressure overloaded mouse hearts.

Cardiac cell therapy: overexpression of connexin43 in skeletal myoblasts and prevention of ventricular arrhythmias

Cardiac channelopathies: from men to mice

Chronic heart rate reduction remodels ion channel transcripts in the mouse sinoatrial node but not in the ventricle

Conditional FKBP12.6 overexpression in mouse cardiac myocytes prevents triggered ventricular tachycardia through specific alterations in excitation-contraction coupling.

Conditional mineralocorticoid receptor expression in the heart leads to life-threatening arrhythmias

Delayed rectifier K(+) currents and cardiac repolarization.

Dysfunction of the Voltage-Gated K+ Channel β2 Subunit in a Familial Case of Brugada Syndrome

Early ion-channel remodeling and arrhythmias precede hypertrophy in a mouse model of complete atrioventricular block

Electropharmacological characterization of cardiac repolarization in German shepherd dogs with an inherited syndrome of sudden death: abnormal response to potassium channel blockers

Electrophysiologic characteristics of cells spanning the left ventricular wall of human heart: evidence for presence of M cells

Endomyocardial biopsies: a new approach for studying the electrical and mechanical properties of human ventricular myocardium

Expression of human ERG K+ channels in the mouse heart exerts anti-arrhythmic activity

Familial Catecholamine-Induced QT Prolongation in Unexplained Sudden Cardiac Death.

Functional Impact of BeKm-1, a High-Affinity hERG Blocker, on Cardiomyocytes Derived from Human-Induced Pluripotent Stem Cells

Functional genomics of cardiac ion channel genes

G protein-gated IKACh channels as therapeutic targets for treatment of sick sinus syndrome and heart block.

HIV-Tat induces a decrease in IKr and IKsvia reduction in phosphatidylinositol-(4,5)-bisphosphate availability

Identifying potential functional impact of mutations and polymorphisms: linking heart failure, increased risk of arrhythmias and sudden cardiac death

Impaired impulse propagation in Scn5a-knockout mice: combined contribution of excitability, connexin expression, and tissue architecture in relation to aging

KCNE1-KCNQ1 osmoregulation by interaction of phosphatidylinositol-4,5-bisphosphate with Mg2+ and polyamines

KCNQ1 channels voltage dependence through a voltage-dependent binding of the S4-S5 linker to the pore domain.

KV4.3 Expression Modulates NaV1.5 Sodium Current.

Long-term amiodarone administration remodels expression of ion channel transcripts in the mouse heart

Mass spectrometry-based identification of native cardiac Nav1.5 channel α subunit phosphorylation sites.

Mental stress test: a rapid, simple, and efficient test to unmask long QT syndrome

Microarray analysis reveals complex remodeling of cardiac ion channel expression with altered thyroid status: relation to cellular and integrated electrophysiology.

Mouse Models of SCN5A-Related Cardiac Arrhythmias

Mouse model of SCN5A-linked hereditary Lenègre's disease: age-related conduction slowing and myocardial fibrosis

Mouse models of SCN5A-related cardiac arrhythmias

Multifocal ectopic Purkinje-related premature contractions: a new SCN5A-related cardiac channelopathy

Normal interventricular differences in tissue architecture underlie right ventricular susceptibility to conduction abnormalities in a mouse model of Brugada syndrome

Osteopontin expression in cardiomyocytes induces dilated cardiomyopathy

Phosphatidylinositol-4,5-bisphosphate (PIP(2)) stabilizes the open pore conformation of the Kv11.1 (hERG) channel

Phosphatidylinositol-4,5-bisphosphate, PIP2, controls KCNQ1/KCNE1 voltage-gated potassium channels: a functional homology between voltage-gated and inward rectifier K+ channels.

Phosphodiesterase 4B in the cardiac L-type Ca²⁺ channel complex regulates Ca²⁺ current and protects against ventricular arrhythmias in mice

Physiological and Pathophysiological Insights of Nav1.4 and Nav1.5 Comparison

Rabbit, a relevant model for the study of cardiac beta 3-adrenoceptors

Remodeling of excitation-contraction coupling in transgenic mice expressing ATP-insensitive sarcolemmal KATP channels

Sinus node dysfunction following targeted disruption of the murine cardiac sodium channel gene Scn5a

T-type calcium current contributes to escape automaticity and governs the occurrence of lethal arrhythmias after atrioventricular block in mice

The Sodium-Glucose Cotransporter 2 Inhibitor Dapagliflozin Prevents Cardiomyopathy in a Diabetic Lipodystrophic Mouse Model

Toward Personalized Medicine: Using Cardiomyocytes Differentiated From Urine-Derived Pluripotent Stem Cells to Recapitulate Electrophysiological Characteristics of Type 2 Long QT Syndrome

Trafficking-deficient long QT syndrome mutation KCNQ1-T587M confers severe clinical phenotype by impairment of KCNH2 membrane localization: evidence for clinically significant IKr-IKs alpha-subunit interaction.

Transfer of rolf S3-S4 linker to HERG eliminates activation gating but spares inactivation

Transforming growth factor β receptor inhibition prevents ventricular fibrosis in a mouse model of progressive cardiac conduction disease.

Triggered activity as a possible mechanism for arrhythmias in ventricular hypertrophy

Understanding the cardiac role of K2P channels: a new TASK for electrophysiologists

Variable Na(v)1.5 protein expression from the wild-type allele correlates with the penetrance of cardiac conduction disease in the Scn5a(+/-) mouse model

alpha1-adrenergic stimulation induces early afterdepolarizations in ferret Purkinje fibers