List of works - Elisabeth Ehler

"MLP: A Stress Sensor Goes Nuclear" by Sylvia Gunkel, Jörg Heineke, Denise Hilfiker-Kleiner, Ralph Knöll, J Mol Cell Cardiol. 2009;47(4):423-5.

scientific article published on 30 October 2009

A formin-g role during development and disease

scientific article

A novel desmocollin-2 mutation reveals insights into the molecular link between desmosomes and gap junctions

scientific article

A novel marker for vertebrate embryonic heart, the EH-myomesin isoform

scientific journal article

Actin in striated muscle: recent insights into assembly and maintenance

scientific article

Actin-associated proteins and cardiomyopathy-the 'unknown' beyond troponin and tropomyosin.

scientific article published on 5 June 2018

Adaptations of cytoarchitecture in human dilated cardiomyopathy

scientific article published on 11 December 2014

Alterations at the intercalated disk associated with the absence of muscle LIM protein

scientific article (publication date: 14 May 2001)

Back to square one: what do we know about the functions of muscle LIM protein in the heart?

scientific article

Beyond the sarcomere: CSRP3 mutations cause hypertrophic cardiomyopathy

scientific article

Beyond the sarcomere: CSRP3 mutations cause hypertrophic cardiomyopathy

CHAP is a newly identified Z-disc protein essential for heart and skeletal muscle function

scientific journal article

Cardiac cytoarchitecture - why the "hardware" is important for heart function!

scientific article

Cardiomyocyte cytoskeleton and myofibrillogenesis in healthy and diseased heart.

scientific article

Cardiomyocyte growth and sarcomerogenesis at the intercalated disc

scientific article

Cell electrospinning cardiac patches for tissue engineering the heart

scholarly article by Elisabeth Ehler & Suwan N. Jayasinghe published 2014 in Analyst

Characterisation of postnatal growth of the murine heart

scientific article published in September 2001

Combination of Whole Genome Sequencing, Linkage, and Functional Studies Implicates a Missense Mutation in Titin as a Cause of Autosomal Dominant Cardiomyopathy With Features of Left Ventricular Noncompaction.

scientific article published on 13 September 2016

DRAL is a p53-responsive gene whose four and a half LIM domain protein product induces apoptosis

scientific article

Delayed embryonic lethality in mice lacking protein phosphatase 2A catalytic subunit Calpha

scientific journal article

Design of artificial myocardial microtissues.

scientific article published in January 2004

Different Behaviour of the Non-sarcomeric Cytoskeleton in Neonatal and Adult Rat Cardiomyocytes

scientific article published on 01 January 1998

Dilated cardiomyopathy: a disease of the intercalated disc?

scientific article (publication date: 2003)

Dimerisation of myomesin: implications for the structure of the sarcomeric M-band

scientific article

Distinct role of protein phosphatase 2A subunit Calpha in the regulation of E-cadherin and beta-catenin during development

scientific journal article

EH-myomesin splice isoform is a novel marker for dilated cardiomyopathy

scientific article

Establishment of cardiac cytoarchitecture in the developing mouse heart

article by Alain Hirschy et al published January 2006 in Developmental Biology

Estrogen receptor alpha up-regulation and redistribution in human heart failure

scientific article (publication date: May 2006)

Expression of Tiam-1 in the developing brain suggests a role for the Tiam-1-Rac signaling pathway in cell migration and neurite outgrowth.

scientific article published in January 1997

Extracellular signal-regulated protein kinase activation during reoxygenation is required to restore ischaemia-induced endothelial barrier failure

scientific article published in November 2002

FHOD1 is needed for directed forces and adhesion maturation during cell spreading and migration

scientific article published on December 2013

Formin follows function: a muscle-specific isoform of FHOD3 is regulated by CK2 phosphorylation and promotes myofibril maintenance ⬇️

scientific article

Four-and-a-half LIM domains proteins are novel regulators of the protein kinase D pathway in cardiac myocytes

scientific article published on February 2014

From A to Z and back? Multicompartment proteins in the sarcomere.

scientific article

Gett'N-WASP Stripes

scientific article published in Science

Heterogeneity of smooth muscle-associated proteins in mammalian brain microvasculature

scientific article published on 01 February 1995

High salt intake increases uroguanylin expression in mouse kidney

scientific article published in July 2001

Identification of an emerin-beta-catenin complex in the heart important for intercalated disc architecture and beta-catenin localisation

scientific article

Identification, characterization, and expression of a novel alpha-tropomyosin isoform in cardiac tissues in developing chicken

scientific article published in June 2003

Immature human NT2 cells grafted into mouse brain differentiate into neuronal and glial cell types.

scientific article

Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188

scientific journal article

Increased field resistance to Tilletia caries provided by a specific antifungal virus gene in genetically engineered wheat

scientific article published on January 2006

Interactions with M-band titin and calpain 3 link myospryn (CMYA5) to tibial and limb-girdle muscular dystrophies

scientific article published on 15 July 2010

Intermediate filament-co-localized molecules with myosin heavy chain epitopes define distinct cellular domains in hair follicles and epidermis

scientific article

Involvement of palladin and alpha-actinin in targeting of the Abl/Arg kinase adaptor ArgBP2 to the actin cytoskeleton

scientific article

Involvement of unconventional myosin VI in myoblast function and myotube formation.

scientific article published on 21 April 2015

Isolation and culture of neonatal mouse cardiomyocytes.

scientific article published on 6 September 2013

Knockdown of embryonic myosin heavy chain reveals an essential role in the morphology and function of the developing heart

scientific article

Left but not right cardiac hypertrophy in atrial natriuretic peptide receptor-deficient mice is prevented by angiotensin type 1 receptor antagonist losartan

scientific article published in November 2002

M-band: a safeguard for sarcomere stability?

scientific article published on January 2003

MLP and CARP are linked to chronic PKCα signalling in dilated cardiomyopathy

scientific article published on 29 June 2016

Measles virus spreads in rat hippocampal neurons by cell-to-cell contact and in a polarized fashion

scientific article

Mechanistic insights into arrhythmogenic right ventricular cardiomyopathy caused by desmocollin-2 mutations

scientific article

Molecular changes in the heart of a severe case of arrhythmogenic right ventricular cardiomyopathy caused by a desmoglein-2 null allele

article

Muscle Research and Gene Ontology: New standards for improved data integration

scientific article

Myofibrillogenesis in the developing chicken heart: role of actin isoforms and of the pointed end actin capping protein tropomodulin during thin filament assembly

scientific article published in April 2004

Myomesin 3, a novel structural component of the M-band in striated muscle

scientific journal article

Myosin VI in skeletal muscle: its localization in the sarcoplasmic reticulum, neuromuscular junction and muscle nuclei.

scientific article published on 30 December 2012

Myosin VI localization and expression in striated muscle pathology.

scientific article

Neutral Endopeptidase Is Activated in Cardiomyocytes in Human Aortic Valve Stenosis and Heart Failure

scientific article published on 01 January 2002

Non-muscle myosin IIB (Myh10) is required for epicardial function and coronary vessel formation during mammalian development

scientific article published on 30 October 2017

Non-sarcomeric causes of heart failure

scientific article published on 14 July 2018

Normal passive viscoelasticity but abnormal myofibrillar force generation in human hypertrophic cardiomyopathy

scientific article

Novel missense mutations in exon 15 of desmoglein-2: role of the intracellular cadherin segment in arrhythmogenic right ventricular cardiomyopathy?

scientific article

Novel role for p90 ribosomal S6 kinase in the regulation of cardiac myofilament phosphorylation

scientific article

OBSCN Mutations Associated with Dilated Cardiomyopathy and Haploinsufficiency.

scientific article published on 25 September 2015

Obscurin, a giant sarcomeric Rho guanine nucleotide exchange factor protein involved in sarcomere assembly

scientific article

Overexpression of the transcription factor Hand1 causes predisposition towards arrhythmia in mice.

scientific article published on 17 April 2009

PINCH2 is a new five LIM domain protein, homologous to PINCHand localized to focal adhesions

scientific journal article

PKC and PKN in heart disease

scientific article published on 08 February 2019

Palladin interacts with SH3 domains of SPIN90 and Src and is required for Src-induced cytoskeletal remodeling

scientific article

Paxillin and ponsin interact in nascent costameres of muscle cells

scientific article

Ponsin interacts with Nck adapter proteins: implications for a role in cytoskeletal remodelling during differentiation of skeletal muscle cells

scientific article

Probing the role of septins in cardiomyocytes.

scientific article

Proteomics analysis of the cardiac myofilament subproteome reveals dynamic alterations in phosphatase subunit distribution

scientific article

Prox1 maintains muscle structure and growth in the developing heart

scientific journal article

Prox1 maintains muscle structure and growth in the developing heart.

scientific article published on 23 January 2009

RBM24: a 'regional business manager' in charge of the maintenance of sarcomeric protein expression 24 h a day?

scientific article published on 16 April 2012

Re-expression of proteins involved in cytokinesis during cardiac hypertrophy.

scientific article published on 27 January 2007

Ryanodine receptors are part of the myospryn complex in cardiac muscle.

scientific article

Sarcoplasmic reticulum is an intermediary of mitochondrial and myofibrillar growth at the intercalated disc

scientific article published on 21 June 2016

Sequential myofibrillar breakdown accompanies mitotic division of mammalian cardiomyocytes

scientific article published in July 2004

Stabilised beta-catenin in postnatal ventricular myocardium leads to dilated cardiomyopathy and premature death

scientific article

Subcellular targeting of metabolic enzymes to titin in heart muscle may be mediated by DRAL/FHL-2

scientific article (publication date: 15 December 2002)

Targeted disruption of the mouse Csrp2 gene encoding the cysteine- and glycine-rich LIM domain protein CRP2 result in subtle alteration of cardiac ultrastructure

scientific article

The Cardiac Stress Response Factor Ms1 Can Bind to DNA and Has a Function in the Nucleus

scientific article published on 14 December 2015

The LIM-only protein DRAL/FHL2 interacts with and is a corepressor for the promyelocytic leukemia zinc finger protein

scientific article (publication date: 4 October 2002)

The Sydney Heart Bank: improving translational research while eliminating or reducing the use of animal models of human heart disease.

scientific article published on 14 August 2017

The formin FHOD1 in cardiomyocytes

scientific journal article

The intercalated disc: a mechanosensing signalling node in cardiomyopathy

scientific article published on 13 July 2020

The kinase domain of titin controls muscle gene expression and protein turnover

scientific article

The molecular composition of the sarcomeric M-band correlates with muscle fiber type

scientific article

The sarcomere and sarcomerogenesis.

scientific article published in January 2008

The sarcomeric M-band during development and in disease

article

The sensitive giant: the role of titin-based stretch sensing complexes in the heart

scientific article published on March 2004

Thick filament assembly occurs after the formation of a cytoskeletal scaffold.

scientific article published in August 1999

Thymosin β4 facilitates epicardial neovascularization of the injured adult heart

scientific article published on 01 April 2010

Tissue-transplant fusion and vascularization of myocardial microtissues and macrotissues implanted into chicken embryos and rats

scientific article published in September 2006

Tropomyosin 1: Multiple roles in the developing heart and in the formation of congenital heart defects

scientific article

Two distinct phosphorylation events govern the function of muscle FHOD3.

scientific article published on 04 October 2012

Unusual splicing events result in distinct Xin isoforms that associate differentially with filamin c and Mena/VASP

scientific article

VEGF profiling and angiogenesis in human microtissues

scientific article published in August 2005

WNT-3, Expressed by Motoneurons, Regulates Terminal Arborization of Neurotrophin-3-Responsive Spinal Sensory Neurons

scientific article published on 01 September 2002

α5β1 integrin recycling promotes Arp2/3-independent cancer cell invasion via the formin FHOD3.

scientific article

List of works by Elisabeth Ehler

"MLP: A Stress Sensor Goes Nuclear" by Sylvia Gunkel, Jörg Heineke, Denise Hilfiker-Kleiner, Ralph Knöll, J Mol Cell Cardiol. 2009;47(4):423-5.

A formin-g role during development and disease

A novel desmocollin-2 mutation reveals insights into the molecular link between desmosomes and gap junctions

A novel marker for vertebrate embryonic heart, the EH-myomesin isoform

Actin in striated muscle: recent insights into assembly and maintenance

Actin-associated proteins and cardiomyopathy-the 'unknown' beyond troponin and tropomyosin.

Adaptations of cytoarchitecture in human dilated cardiomyopathy

Alterations at the intercalated disk associated with the absence of muscle LIM protein

Back to square one: what do we know about the functions of muscle LIM protein in the heart?

Beyond the sarcomere: CSRP3 mutations cause hypertrophic cardiomyopathy

Beyond the sarcomere: CSRP3 mutations cause hypertrophic cardiomyopathy

CHAP is a newly identified Z-disc protein essential for heart and skeletal muscle function

Cardiac cytoarchitecture - why the "hardware" is important for heart function!

Cardiomyocyte cytoskeleton and myofibrillogenesis in healthy and diseased heart.

Cardiomyocyte growth and sarcomerogenesis at the intercalated disc

Cell electrospinning cardiac patches for tissue engineering the heart

Characterisation of postnatal growth of the murine heart

Combination of Whole Genome Sequencing, Linkage, and Functional Studies Implicates a Missense Mutation in Titin as a Cause of Autosomal Dominant Cardiomyopathy With Features of Left Ventricular Noncompaction.

DRAL is a p53-responsive gene whose four and a half LIM domain protein product induces apoptosis

Delayed embryonic lethality in mice lacking protein phosphatase 2A catalytic subunit Calpha

Design of artificial myocardial microtissues.

Different Behaviour of the Non-sarcomeric Cytoskeleton in Neonatal and Adult Rat Cardiomyocytes

Dilated cardiomyopathy: a disease of the intercalated disc?

Dimerisation of myomesin: implications for the structure of the sarcomeric M-band

Distinct role of protein phosphatase 2A subunit Calpha in the regulation of E-cadherin and beta-catenin during development

EH-myomesin splice isoform is a novel marker for dilated cardiomyopathy

Establishment of cardiac cytoarchitecture in the developing mouse heart

Estrogen receptor alpha up-regulation and redistribution in human heart failure

Expression of Tiam-1 in the developing brain suggests a role for the Tiam-1-Rac signaling pathway in cell migration and neurite outgrowth.

Extracellular signal-regulated protein kinase activation during reoxygenation is required to restore ischaemia-induced endothelial barrier failure

FHOD1 is needed for directed forces and adhesion maturation during cell spreading and migration

Formin follows function: a muscle-specific isoform of FHOD3 is regulated by CK2 phosphorylation and promotes myofibril maintenance ⬇️

Four-and-a-half LIM domains proteins are novel regulators of the protein kinase D pathway in cardiac myocytes

From A to Z and back? Multicompartment proteins in the sarcomere.

Gett'N-WASP Stripes

Heterogeneity of smooth muscle-associated proteins in mammalian brain microvasculature

High salt intake increases uroguanylin expression in mouse kidney

Identification of an emerin-beta-catenin complex in the heart important for intercalated disc architecture and beta-catenin localisation

Identification, characterization, and expression of a novel alpha-tropomyosin isoform in cardiac tissues in developing chicken

Immature human NT2 cells grafted into mouse brain differentiate into neuronal and glial cell types.

Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188

Increased field resistance to Tilletia caries provided by a specific antifungal virus gene in genetically engineered wheat

Interactions with M-band titin and calpain 3 link myospryn (CMYA5) to tibial and limb-girdle muscular dystrophies

Intermediate filament-co-localized molecules with myosin heavy chain epitopes define distinct cellular domains in hair follicles and epidermis

Involvement of palladin and alpha-actinin in targeting of the Abl/Arg kinase adaptor ArgBP2 to the actin cytoskeleton

Involvement of unconventional myosin VI in myoblast function and myotube formation.

Isolation and culture of neonatal mouse cardiomyocytes.

Knockdown of embryonic myosin heavy chain reveals an essential role in the morphology and function of the developing heart

Left but not right cardiac hypertrophy in atrial natriuretic peptide receptor-deficient mice is prevented by angiotensin type 1 receptor antagonist losartan

M-band: a safeguard for sarcomere stability?

MLP and CARP are linked to chronic PKCα signalling in dilated cardiomyopathy

Measles virus spreads in rat hippocampal neurons by cell-to-cell contact and in a polarized fashion

Mechanistic insights into arrhythmogenic right ventricular cardiomyopathy caused by desmocollin-2 mutations

Molecular changes in the heart of a severe case of arrhythmogenic right ventricular cardiomyopathy caused by a desmoglein-2 null allele

Muscle Research and Gene Ontology: New standards for improved data integration

Myofibrillogenesis in the developing chicken heart: role of actin isoforms and of the pointed end actin capping protein tropomodulin during thin filament assembly

Myomesin 3, a novel structural component of the M-band in striated muscle

Myosin VI in skeletal muscle: its localization in the sarcoplasmic reticulum, neuromuscular junction and muscle nuclei.

Myosin VI localization and expression in striated muscle pathology.

Neutral Endopeptidase Is Activated in Cardiomyocytes in Human Aortic Valve Stenosis and Heart Failure

Non-muscle myosin IIB (Myh10) is required for epicardial function and coronary vessel formation during mammalian development

Non-sarcomeric causes of heart failure

Normal passive viscoelasticity but abnormal myofibrillar force generation in human hypertrophic cardiomyopathy

Novel missense mutations in exon 15 of desmoglein-2: role of the intracellular cadherin segment in arrhythmogenic right ventricular cardiomyopathy?

Novel role for p90 ribosomal S6 kinase in the regulation of cardiac myofilament phosphorylation

OBSCN Mutations Associated with Dilated Cardiomyopathy and Haploinsufficiency.

Obscurin, a giant sarcomeric Rho guanine nucleotide exchange factor protein involved in sarcomere assembly

Overexpression of the transcription factor Hand1 causes predisposition towards arrhythmia in mice.

PINCH2 is a new five LIM domain protein, homologous to PINCHand localized to focal adhesions

PKC and PKN in heart disease

Palladin interacts with SH3 domains of SPIN90 and Src and is required for Src-induced cytoskeletal remodeling

Paxillin and ponsin interact in nascent costameres of muscle cells

Ponsin interacts with Nck adapter proteins: implications for a role in cytoskeletal remodelling during differentiation of skeletal muscle cells

Probing the role of septins in cardiomyocytes.

Proteomics analysis of the cardiac myofilament subproteome reveals dynamic alterations in phosphatase subunit distribution

Prox1 maintains muscle structure and growth in the developing heart

Prox1 maintains muscle structure and growth in the developing heart.

RBM24: a 'regional business manager' in charge of the maintenance of sarcomeric protein expression 24 h a day?

Re-expression of proteins involved in cytokinesis during cardiac hypertrophy.