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List of works by Hugues Abriel

8th Ascona International Workshop on Cardiomyocyte Biology, 3-7 May, 2015 Integration of Developmental and Environmental Cues in the Heart Congressi Stefano Franscini, Monte Verità, Ascona, Switzerland

scientific article published on 14 April 2016

A Distinct Pool of Nav1.5 Channels at the Lateral Membrane of Murine Ventricular Cardiomyocytes

scientific article published on 03 July 2019

A Modern Approach to Classify Missense Mutations in Cardiac Channelopathy Genes ⬇️

scientific article published on 01 October 2012

A novel dominant mutation of the Nav1.4 alpha-subunit domain I leading to sodium channel myotonia.

scientific article

A phosphoinositide 3-kinase (PI3K)-serum- and glucocorticoid-inducible kinase 1 (SGK1) pathway promotes Kv7.1 channel surface expression by inhibiting Nedd4-2 protein

scientific article

A-Kinase Anchoring Protein Lbc Coordinates a p38 Activating Signaling Complex Controlling Compensatory Cardiac Hypertrophy.

scientific article published in September 2013

A-kinase anchoring protein Lbc coordinates a p38 activating signaling complex controlling compensatory cardiac hypertrophy

scientific journal article

Aldosterone increases voltage-gated sodium current in ventricular myocytes.

scientific article published on 20 January 2006

Analyses of a novel SCN5A mutation (C1850S): conduction vs. repolarization disorder hypotheses in the Brugada syndrome

scientific article published on 5 February 2008

Annotation of functional impact of voltage-gated sodium channel mutations

scientific article

Antiarrhythmic Action of Flecainide in Polymorphic Ventricular Arrhythmias Caused by a Gain-of-Function Mutation in the Nav 1.5 Sodium Channel.

scientific article published on 7 October 2015

Biochemical, single-channel, whole-cell patch clamp, and pharmacological analyses of endogenous TRPM4 channels in HEK293 cells.

scientific article published on 18 February 2013

Biophysical Characterization of Epigallocatechin-3-Gallate Effect on the Cardiac Sodium Channel Nav1.5.

scientific article published on 18 February 2020

Block of the hERG channel by bupivacaine: Electrophysiological and modeling insights towards stereochemical optimization

scientific article

Brugada Syndrome Unmasked by Accidental Inhalation of Gasoline Vapors

scientific article published on 01 October 2007

Brugada syndrome ECG provoked by the selective serotonin reuptake inhibitor fluvoxamine

scientific article published on 29 October 2009

Brugada syndrome and fever: genetic and molecular characterization of patients carrying SCN5A mutations.

scientific article

Calmodulin binds to the N-terminal domain of the cardiac sodium channel Nav1.5.

scientific article published on 01 December 2020

Cardiac Sodium Channel Na v 1.5 Mechanosensitivity Is Inhibited by Ranolazine ⬇️

scientific article published on May 7, 2012

Cardiac Sodium Current Under Sympathetic ControlProtein Phosphatase 2A Regulates Cardiac Na+ Channels

scientific article published on 01 March 2019

Cardiac channelopathies: Genetic and molecular mechanisms ⬇️

scientific article published on December 22, 2012

Cardiac sodium channel Na(v)1.5 and interacting proteins: Physiology and pathophysiology

scientific article

Cardiac sodium channel Na(v)1.5 interacts with and is regulated by the protein tyrosine phosphatase PTPH1

scientific article

Cardiac sodium channel NaV1.5 distribution in myocytes via interacting proteins: the multiple pool model

scientific article published on 31 October 2012

Cardiac sodium channel Nav1.5 is regulated by a multiprotein complex composed of syntrophins and dystrophin.

scientific article

Cardiac voltage-gated calcium channel macromolecular complexes

scientific article published on 18 December 2015

Cardiac voltage-gated sodium channel Nav1.5 is regulated by Nedd4-2 mediated ubiquitination

scientific article

Cardiac-specific ablation of synapse-associated protein SAP97 in mice decreases potassium currents but not sodium current

scientific journal article

Cardiovascular response to beta-adrenergic blockade or activation in 23 inbred mouse strains

scientific article

Cellular hyper-excitability caused by mutations that alter the activation process of voltage-gated sodium channels

scientific article

Channel openings are necessary but not sufficient for use-dependent block of cardiac Na(+) channels by flecainide: evidence from the analysis of disease-linked mutations

scientific article published on July 2002

Characterization of 2 genetic variants of Na(v) 1.5-arginine 689 found in patients with cardiac arrhythmias

scientific article published on 20 May 2013

Chronic angiotensin II stimulation in the heart produces an acquired long QT syndrome associated with IK1 potassium current downregulation

scientific article published on 30 October 2006

Complex genetic background in a large family with Brugada syndrome

scientific article

Complexity of cardiac ion channel macromolecular complexes

scientific article published on 16 March 2016

Computational tools to investigate genetic cardiac channelopathies.

scientific article published on 26 December 2013

Correction: Mapping Genetic Variants Associated with Beta-Adrenergic Responses in Inbred Mice.

scientific article published on 3 January 2014

Corrigendum: Transcriptomic analyses of murine ventricular cardiomyocytes

scholarly article published in Scientific Data

Crosstalk between cardiac ion channel subunits: an encrypted language to be deciphered

scientific article published on 03 June 2008

Defective regulation of the epithelial Na+ channel by Nedd4 in Liddle's syndrome.

scientific article

Deubiquitylating enzyme USP2 counteracts Nedd4-2-mediated downregulation of KCNQ1 potassium channels

scientific article

Distribution of cardiac sodium channels in clusters potentiates ephaptic interactions in the intercalated disc

scientific article

Dynamic of ion channel expression at the plasma membrane of cardiomyocytes

scientific article published on July 2012

Dysregulation of voltage-gated sodium channels by ubiquitin ligase NEDD4-2 in neuropathic pain.

scientific article

Dystrophin and calcium current are decreased in cardiomyocytes expressing Cre enzyme driven by αMHC but not TNT promoter

scientific article published on 19 December 2019

Editorial: Ion Channel Trafficking and Cardiac Arrhythmias

scientific article published on 25 September 2018

Effects of heart failure on brain-type Na+ channels in rabbit ventricular myocytes

scientific article published on 03 December 2007

Electrophysiological properties of mouse and epitope-tagged human cardiac sodium channel Na v1.5 expressed in HEK293 cells.

scientific article published on 13 February 2013

Elucidating sodium channel NaV1.5 clustering in cardiac myocytes using super-resolution techniques

scientific article published on 23 October 2014

Expression, purification, and projection structure by single particle electron microscopy of functional human TRPM4 heterologously expressed in Xenopus laevis oocytes

scientific article published on 10 December 2013

Feedback inhibition of rat amiloride-sensitive epithelial sodium channels expressed in Xenopus laevis oocytes

scientific article published in April 1999

Force-controlled patch clamp of beating cardiac cells

scientific article published on 6 February 2015

Four TRPM4 Cation Channel Mutations Found in Cardiac Conduction Diseases Lead to Altered Protein Stability.

scientific article published on 8 March 2018

Functional Consequences of the SCN5A-p.Y1977N Mutation within the PY Ubiquitylation Motif: Discrepancy between HEK293 Cells and Transgenic Mice

scientific article published on 11 October 2019

Functional characterization of a novel SCN5A variant associated with long QT syndrome and sudden cardiac death

scientific article published on 27 August 2019

Functional implications of a rare variant in the sodium channel β1B subunit (SCN1B) in a 5-month-old male sudden infant death syndrome case.

scientific article

Functional interaction between S1 and S4 segments in voltage-gated sodium channels revealed by human channelopathies

scientific article

Gain-of-function mutation of the SCN5A gene causes exercise-induced polymorphic ventricular arrhythmias

scientific article published on 10 September 2014

Generation of an alveolar epithelial type II cell line from induced pluripotent stem cells

scientific article published on 13 September 2018

Genetic background of Brugada syndrome is more complex than what we would like it to be!

scientific article published on 29 April 2015

Glycosylation of TRPM4 and TRPM5 channels: molecular determinants and functional aspects

scientific article published on 24 February 2014

ICEPO: the ion channel electrophysiology ontology

scientific article published on 7 April 2016

Identification of a novel loss-of-function calcium channel gene mutation in short QT syndrome (SQTS6)

scientific journal article

Identification of potent and selective small molecule inhibitors of the cation channel TRPM4.

scientific article published on 26 March 2018

Inherited Brugada and long QT-3 syndrome mutations of a single residue of the cardiac sodium channel confer distinct channel and clinical phenotypes

scientific article published on 15 June 2001

Inherited progressive cardiac conduction disorders

scientific article

Ion channel macromolecular complexes in cardiomyocytes: roles in sudden cardiac death

scientific article

Ion transport across the early chick embryo: I. Electrical measurements, ionic fluxes and regional heterogeneity

scientific article

Ion transport across the early chick embryo: II. Characterization and pH sensitivity of the transembryonic short-circuit current

scientific article published on 01 August 1994

KChAP: a novel chaperone for specific K(+) channels key to repolarization of the cardiac action potential. Focus on "KChAP as a chaperone for specific K(+) channels"

scientific article published on 01 May 2000

Kv4 potassium channels form a tripartite complex with the anchoring protein SAP97 and CaMKII in cardiac myocytes

scientific journal article

Late cardiac sodium current can be assessed using automated patch-clamp

scientific article

Lateral Membrane-Specific MAGUK CASK Down-Regulates NaV1.5 Channel in Cardiac Myocytes.

scientific article published on 30 June 2016

Long-term amiodarone administration remodels expression of ion channel transcripts in the mouse heart

scientific article published in November 2004

Male and female equality: still far from goal

scientific article published in June 2008

Mapping genetic variants associated with beta-adrenergic responses in inbred mice

scientific article

Mice carrying ubiquitin-specific protease 2 (Usp2) gene inactivation maintain normal sodium balance and blood pressure.

scientific article published on 3 April 2013

Mineralocorticoid receptor is essential for corticosteroid-induced up-regulation of L-type calcium currents in cultured neonatal cardiomyocytes.

scientific article published on 27 November 2007

Modeling Depolarization Delay, Sodium Currents, and Electrical Potentials in Cardiac Transverse Tubules

scientific article published on 10 December 2019

Modulation of Nav1.5 channel function by an alternatively spliced sequence in the DII/DIII linker region.

scientific article published on 8 February 2006

Molecular and clinical determinants of drug-induced long QT syndrome: an iatrogenic channelopathy.

scientific article

Molecular autopsy in sudden cardiac death and its implication for families: discussion of the practical, legal and ethical aspects of the multidisciplinary collaboration

scientific article published on December 2009

Molecular characterization of two founder mutations causing long QT syndrome and identification of compound heterozygous patients

scientific article published on 01 January 2006

Molecular determinants of voltage-gated sodium channel regulation by the Nedd4/Nedd4-like proteins

scientific article

Molecular genetics and functional anomalies in a series of 248 Brugada cases with 11 mutations in the TRPM4 channel

scientific article

Na+ channel function, regulation, structure, trafficking and sequestration

scientific article

NaV1.5 and interacting proteins in human arrhythmogenic cardiomyopathy.

scientific article

Nedd4-2-dependent ubiquitylation and regulation of the cardiac potassium channel hERG1

scientific article

Nedd4.1-mediated ubiquitination and subsequent recruitment of Tsg101 ensure HTLV-1 Gag trafficking towards the multivesicular body pathway prior to virus budding

scientific article

Negative-dominance phenomenon with genetic variants of the cardiac sodium channel Nav1.5.

scientific article published on 20 February 2016

Nervous and immune systems as targets for developmental effects of benzodiazepines. A review of recent studies

scientific article published on January 1, 1992

Neurohormonal regulation of cardiac ion channels in chronic heart failure

scientific article published on August 2009

Neuronal expression of the ubiquitin ligase Nedd4-2 in rat dorsal root ganglia: modulation in the spared nerve injury model of neuropathic pain.

scientific article

Neuronal precursor cell-expressed developmentally down-regulated 4-1 (NEDD4-1) controls the sorting of newly synthesized Ca(V)1.2 calcium channels

scientific article

Novel arrhythmogenic mechanism revealed by a long-QT syndrome mutation in the cardiac Na(+) channel.

scientific article published on April 2001

Optimizing TRPM4 inhibitors in the MHFP6 chemical space

scientific article published on 24 January 2019

PDZ domain-binding motif regulates cardiomyocyte compartment-specific NaV1.5 channel expression and function.

scientific article

Patient with syncope and LQTS carrying a mutation in the PAS domain of the hERG1 channel.

scientific article published in April 2011

Post-translational modifications of voltage-gated sodium channels in chronic pain syndromes

scientific article

Prevalence of Significant Genetic Variants in Congenital Long QT Syndrome is Largely Underestimated ⬇️

scientific article published on April 27, 2012

Proteasome inhibitor (MG132) rescues Nav1.5 protein content and the cardiac sodium current in dystrophin-deficient mdx (5cv) mice.

scientific article published on 26 March 2013

Refining the molecular organization of the cardiac intercalated disc

scientific article published on 8 January 2017

Regulation of the cardiac Na+ channel NaV1.5 by post-translational modifications.

scientific article

Regulation of the cardiac sodium channel Nav1.5 by utrophin in dystrophin-deficient mice

scientific article published on 14 October 2010

Regulation of the cardiac voltage-gated Na+ channel (H1) by the ubiquitin-protein ligase Nedd4.

scientific article published in January 2000

Regulation of the voltage-gated cardiac sodium channel Nav1.5 by interacting proteins.

scientific article

Role of the intracellular domain of the beta subunit in Na,K pump function

scientific article published in April 1999

Role of “non-cardiac” voltage-gated sodium channels in cardiac cells ⬇️

scientific article published on August 19, 2012

Roles and regulation of the cardiac sodium channel Na v 1.5: recent insights from experimental studies.

scientific article published on 08 August 2007

Rufinamide attenuates mechanical allodynia in a model of neuropathic pain in the mouse and stabilizes voltage-gated sodium channel inactivated state

scientific article

SAP97 and dystrophin macromolecular complexes determine two pools of cardiac sodium channels Nav1.5 in cardiomyocytes

scientific article

Selective inhibition of persistent sodium current by F 15845 prevents ischaemia-induced arrhythmias.

scientific article published on September 2010

Single-molecule Localization of Nav1.5 Reveals Different Modes of Reorganization at Cardiomyocyte Membrane Domains

scientific article published on 15 June 2020

Stereoselective Block of hERG Channel by (S)-Methadone and QT Interval Prolongation in CYP2B6 Slow Metabolizers

scientific article published on 28 February 2007

Stereoselective Inhibition of the hERG1 Potassium Channel.

scientific article

TRPM4 channels in the cardiovascular system: physiology, pathophysiology, and pharmacology.

scientific article published on 27 June 2012

Takotsubo cardiomyopathy and congenital long QT syndrome in a patient with a novel duplication in the Per-Arnt-Sim (PAS) domain of hERG1.

scientific article published on 24 September 2009

Targeted resequencing identifies TRPM4 as a major gene predisposing to progressive familial heart block type I

article

Targeting the sodium channel NaV1.5 to specific membrane compartments of cardiac cells: not a simple task!

scientific article published on 01 November 2014

The KCNQ1 potassium channel is down-regulated by ubiquitylating enzymes of the Nedd4/Nedd4-like family

scientific article

The ion channel TRPM4 in murine experimental autoimmune encephalomyelitis and in a model of glutamate-induced neuronal degeneration

scientific article published on 11 July 2018

Transcriptomic analyses of murine ventricular cardiomyocytes ⬇️

scientific article published on 21 August 2018

Ubiquitin-specific protease USP2-45 acts as a molecular switch to promote α2δ-1-induced downregulation of Cav1.2 channels.

scientific article

Ubiquitylation and SUMOylation of cardiac ion channels

scientific article published on July 2010

Ubiquitylation of ion channels

scientific article

Ubiquitylation of voltage-gated sodium channels.

scientific article published on January 2014

Unexpected dominance: Brugada syndrome SCN5A variants exert negative dominance via α-subunit interaction

scientific article published on 07 August 2012

Unexpected α-α interactions with NaV1.5 genetic variants in Brugada syndrome

scientific article published on 01 April 2014

Variable Na(v)1.5 protein expression from the wild-type allele correlates with the penetrance of cardiac conduction disease in the Scn5a(+/-) mouse model

scientific article

Variants of Transient Receptor Potential Melastatin Member 4 in Childhood Atrioventricular Block

scientific journal article

Ventricular tachycardia in a Brugada syndrome patient caused by a novel deletion in SCN5A

scientific article published in March 2009

p.L1612P, a novel voltage-gated sodium channel Nav1.7 mutation inducing a cold sensitive paroxysmal extreme pain disorder.

scientific article published on February 2015

β1- and β3- voltage-gated sodium channel subunits modulate cell surface expression and glycosylation of Nav1.7 in HEK293 cells

scientific article published on 30 August 2013

β‐Blockers in Congenital Short‐QT Syndrome as Ion Channel Blockers ⬇️

scientific article published on July 25, 2013

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