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List of works by Timothy Billiar

"Thinking" vs. "Talking": Differential Autocrine Inflammatory Networks in Isolated Primary Hepatic Stellate Cells and Hepatocytes under Hypoxic Stress

scientific article published on 22 December 2017

'Til cell death do us part: nitric oxide and mechanisms of hepatotoxicity

scientific article published on January 2004

A DNA microarray study of nitric oxide-induced genes in mouse hepatocytes: implications for hepatic heme oxygenase-1 expression in ischemia/reperfusion

article

A Janus Tale of Two Active High Mobility Group Box 1 (HMGB1) Redox States ⬇️

scientific article published on December 20, 2012

A Role for Angiotensin II in the Activation of Extracellular Signal-Regulated Kinases in the Liver During Hemorrhagic Shock ⬇️

scientific article published on October 1, 2003

A Role for cGMP in Inducible Nitric-oxide Synthase (iNOS)-induced Tumor Necrosis Factor (TNF) α-converting Enzyme (TACE/ADAM17) Activation, Translocation, and TNF Receptor 1 (TNFR1) Shedding in Hepatocytes ⬇️

scientific article published on August 16, 2012

A brief episode of hypotension increases mortality in critically ill trauma patients

scientific article published on 01 August 2002

A computational analysis of dynamic, multi-organ inflammatory crosstalk induced by endotoxin in mice

scientific article published on 6 November 2018

A critical role for IFN regulatory factor 1 in NKT cell-mediated liver injury induced by alpha-galactosylceramide

scientific article published on 12 July 2010

A genomic storm in critically injured humans

scientific article published on 21 November 2011

A nitric oxide scavenger protects against pulmonary inflammation following hemorrhagic shock

scientific article published on 01 February 2002

A novel PINK1- and PARK2-dependent protective neuroimmune pathway in lethal sepsis

scientific article published on 18 October 2016

A novel inhibitory peptide of Toll-like receptor signaling limits lipopolysaccharide-induced production of inflammatory mediators and enhances survival in mice

scientific article published in April 2007

A roadmap from single-cell transcriptome to patient classification for the immune response to trauma

scientific article published on 15 December 2020

A small molecule binding HMGB1 inhibits caspase-11-mediated lethality in sepsis

scientific article published on 14 April 2021

A two-compartment mathematical model of endotoxin-induced inflammatory and physiologic alterations in swine* ⬇️

scientific article published on April 1, 2012

ADAR1 Prevents Liver Injury from Inflammation and Suppresses Interferon Production in Hepatocytes

scientific article published on 7 October 2015

ADAR1 Suppresses the Activation of Cytosolic RNA-Sensing Signaling Pathways to Protect the Liver from Ischemia/Reperfusion Injury

scientific article published on February 2016

ALK is a therapeutic target for lethal sepsis.

scientific article

Activation of Pregnane X Receptor Sensitizes Mice to Hemorrhagic Shock-Induced Liver Injury

scientific article published on 24 June 2019

Acute traumatic coagulopathy in a critically injured pediatric population: Definition, trend over time, and outcomes

scientific article published on 16 February 2016

Adenovirus-mediated inducible nitric oxide synthase gene transfer inhibits hepatocyte apoptosis

article

Aged Human Stored Red Blood Cell Supernatant Inhibits Macrophage Phagocytosis in an HMGB1 Dependent Manner After Trauma in a Murine Model

scientific article published on 2 August 2016

Aging-Impaired Filamentous Actin Polymerization Signaling Reduces Alveolar Macrophage Phagocytosis of Bacteria

scientific article

Aging-related Atg5 defect impairs neutrophil extracellular traps formation.

scientific article published on 4 April 2017

Amelioration of rat cardiac cold ischemia/reperfusion injury with inhaled hydrogen or carbon monoxide, or both.

scientific article published on 24 December 2009

American College of Surgeons trauma center verification versus state designation: are Level II centers slipping through the cracks?

scientific article published on July 2013

An Aging-Related Single-Nucleotide Polymorphism is Associated With Altered Clinical Outcomes and Distinct Inflammatory Profiles in Aged Blunt Trauma Patients

scientific article published on 01 February 2020

An FFP:PRBC transfusion ratio >/=1:1.5 is associated with a lower risk of mortality after massive transfusion

scientific article published in November 2008

Analysis of factorial time-course microarrays with application to a clinical study of burn injury

scientific article

Anti-HMGB1 neutralizing antibody ameliorates gut barrier dysfunction and improves survival after hemorrhagic shock

scientific article

Application of genome-wide expression analysis to human health and disease

scientific article

Application of heme oxygenase-1, carbon monoxide and biliverdin for the prevention of intestinal ischemia/reperfusion injury

scientific article published in March 2008

Assessment of platelet transfusion for reversal of aspirin after traumatic brain injury ⬇️

scientific article published on October 1, 2011

Association Between Preoperative Metformin Exposure and Postoperative Outcomes in Adults With Type 2 Diabetes

scientific article published on 08 April 2020

Association of Prehospital Plasma With Survival in Patients With Traumatic Brain Injury: A Secondary Analysis of the PAMPer Cluster Randomized Clinical Trial

scientific article published on 01 October 2020

Augmenting autophagy to treat acute kidney injury during endotoxemia in mice

scientific article

Author Correction: Caspase-11 signaling enhances graft-versus-host disease

scientific article published on 09 March 2020

Bacterial Endotoxin Activates the Coagulation Cascade through Gasdermin D-Dependent Phosphatidylserine Exposure

scientific article published on 10 December 2019

Benchmarking outcomes in the critically injured trauma patient and the effect of implementing standard operating procedures.

scientific article published in May 2012

Benzyl alcohol attenuates acetaminophen-induced acute liver injury in a Toll-like receptor-4-dependent pattern in mice

scientific article published on 14 July 2014

Beta2-integrin-induced p38 MAPK activation is a key mediator in the CD14/TLR4/MD2-dependent uptake of lipopolysaccharide by hepatocytes

scientific article published on 13 August 2008

Biliverdin administration prevents the formation of intimal hyperplasia induced by vascular injury

scientific article published on 18 July 2005

Biology and Metabolism of Sepsis: Innate Immunity, Bioenergetics, and Autophagy

scientific article published on 19 April 2016

Blood soluble drag-reducing polymers prevent lethality from hemorrhagic shock in acute animal experiments

scientific article published on 01 January 2004

Blunt cerebrovascular injury in elderly fall patients: are we screening enough?

scientific article published on 4 July 2018

Body adipose content is independently associated with a higher risk of organ failure and nosocomial infection in the nonobese patient postinjury

scientific article

CCL2-CCR2 signaling promotes hepatic ischemia/reperfusion injury.

scientific article

CD14 contributes to warm hepatic ischemia-reperfusion injury in mice

scientific article published on August 2013

Calcium/calmodulin-dependent protein kinase (CaMK) IV mediates nucleocytoplasmic shuttling and release of HMGB1 during lipopolysaccharide stimulation of macrophages

scientific article published on October 2008

Calcium/calmodulin-dependent protein kinase IV limits organ damage in hepatic ischemia-reperfusion injury through induction of autophagy ⬇️

scientific article published on May 10, 2012

Carbon monoxide activates NF-kappaB via ROS generation and Akt pathways to protect against cell death of hepatocytes

scientific article published on 22 May 2008

Carbon monoxide decreases the level of iNOS protein and active dimer in IL-1beta-stimulated hepatocytes

scientific article published on 15 February 2008

Carbon monoxide inhibits T lymphocyte proliferation via caspase-dependent pathway

scientific article

Carbon monoxide prevents multiple organ injury in a model of hemorrhagic shock and resuscitation.

scientific article published in June 2005

Carbon monoxide protects against liver failure through nitric oxide-induced heme oxygenase 1.

scientific article

Carbon monoxide protects hepatocytes from TNF-alpha/Actinomycin D by inhibition of the caspase-8-mediated apoptotic pathway.

scientific article

Carbon monoxide reverses established pulmonary hypertension

scientific article

Carbon monoxide signals via inhibition of cytochrome c oxidase and generation of mitochondrial reactive oxygen species

scientific article published on 30 January 2007

Carbon monoxide suppresses arteriosclerotic lesions associated with chronic graft rejection and with balloon injury

scientific article published on 21 January 2003

Caspase-11 signaling enhances graft-versus-host disease

scientific article published on 06 September 2019

Cathepsin L activity correlates with proteinuria in chronic kidney disease in humans

scientific article published on 22 May 2017

Cathepsin L promotes Vascular Intimal Hyperplasia after Arterial Injury

scientific article

Cellular-specific role of toll-like receptor 4 in hepatic ischemia-reperfusion injury in mice

scientific article published on 27 May 2013

Central role for MCP-1/CCL2 in injury-induced inflammation revealed by in vitro, in silico, and clinical studies

scientific article

Changes in FADD levels, distribution, and phosphorylation in TNFalpha-induced apoptosis in hepatocytes is caspase-3, caspase-8 and BID dependent

scientific article published in August 2008

Changes in massive transfusion over time: an early shift in the right direction?

scientific article published on January 2012

Characterization of DISC Formation and TNFR1 Translocation to Mitochondria in TNF-α–Treated Hepatocytes ⬇️

scientific article published on July 8, 2011

Characterization of acute coagulopathy and sexual dimorphism after injury: females and coagulopathy just do not mix.

scientific article published on December 2012

Characterization of sex dimorphism following severe thermal injury

scientific article

Characterizing injury severity in non-accidental trauma: Does injury severity score miss the mark?

scientific article published on 17 February 2018

Cisplatin prevents high mobility group box 1 release and is protective in a murine model of hepatic ischemia/reperfusion injury

scientific article published on 01 August 2009

Cold-inducible RNA-binding protein through TLR4 signaling induces mitochondrial DNA fragmentation and regulates macrophage cell death after trauma

scientific article published on 11 May 2017

Combined in silico, in vivo, and in vitro studies shed insights into the acute inflammatory response in middle-aged mice

scientific article

Comparing the Air Medical Prehospital Triage Score With Current Practice for Triage of Injured Patients to Helicopter Emergency Medical Services: A Cost-effectiveness Analysis

scientific article

Complement C3 Deficiency Attenuates Chronic Hypoxia-Induced Pulmonary Hypertension in Mice ⬇️

scientific article published on December 14, 2011

Complement factor 3 deficiency attenuates hemorrhagic shock-related hepatic injury and systemic inflammatory response syndrome

scientific article

Computational Analysis Supports an Early, Type 17 Cell-Associated Divergence of Blunt Trauma Survival and Mortality

scientific article

Computational evidence for an early, amplified systemic inflammation program in polytrauma patients with severe extremity injuries

scientific article published on 04 June 2019

Computed tomography abbreviated assessment of sarcopenia following trauma: The CAAST measurement predicts 6-month mortality in older adult trauma patients

scientific article published on 16 February 2016

Crystalloid to packed red blood cell transfusion ratio in the massively transfused patient: when a little goes a long way.

scientific article

Cumulative effects of bone and soft tissue injury on systemic inflammation: a pilot study

scientific article published on September 2013

Cutting edge: high-mobility group box 1 preconditioning protects against liver ischemia-reperfusion injury

scientific article published on 01 June 2006

Cyclic stretch induced IL-33 production through HMGB1/TLR-4 signaling pathway in murine respiratory epithelial cells.

scientific article published on 12 September 2017

Cytosolic HMGB1 controls the cellular autophagy/apoptosis checkpoint during inflammation.

scientific article

DNA attenuates enterocyte Toll-like receptor 4-mediated intestinal mucosal injury after remote trauma ⬇️

scientific article published on January 13, 2011

Damage-associated molecular pattern-activated neutrophil extracellular trap exacerbates sterile inflammatory liver injury

scientific article

Debunking the survival bias myth: characterization of mortality during the initial 24 hours for patients requiring massive transfusion.

scientific article published in August 2012

Defining geographic emergency medical services coverage in trauma systems

scientific article published on 01 July 2019

Delay to therapeutic interventional radiology postinjury: time is of the essence

scientific article published in June 2010

Delayed neutralization of interleukin 6 reduces organ injury, selectively suppresses inflammatory mediator, and partially normalizes immune dysfunction following trauma and hemorrhagic shock

scientific article

Design of the Study of Tranexamic Acid during Air Medical Prehospital Transport (STAAMP) Trial: Addressing the Knowledge Gaps

scientific article

Development and Validation of the Air Medical Prehospital Triage Score for Helicopter Transport of Trauma Patients.

scientific article

Development and stability of Th17 cells in ovarian cancer requires nitric oxide and endogenous NOS2 activity in cancer-associated CD4+ T cells

scientific article published on 7 November 2013

Diagnosis and Management of Polytraumatized Patients With Severe Extremity Trauma

scientific article published in March 2018

Dichotomous Role of Plasmin in Regulation of Macrophage Function after Acetaminophen Overdose

scientific article published on 02 August 2019

Disparities in rural versus urban field triage: risk and mitigating factors for undertriage

scientific article published on 18 March 2020

Distance matters: Effect of geographic trauma system resource organization on fatal motor vehicle collisions

scientific article published on 18 April 2017

Diurnal Variation in Systemic Acute Inflammation and Clinical Outcomes Following Severe Blunt Trauma

scientific article published on 20 November 2019

Early Dynamic Orchestration of Immunologic Mediators Identifies Multiply Injured Patients who are Tolerant or Sensitive to Hemorrhage

scientific article published on 20 October 2020

Early Immunologic Response in Multiply Injured Patients With Orthopaedic Injuries Is Associated With Organ Dysfunction

scientific article published on 01 May 2019

Early Lower Extremity Fracture Fixation and the Risk of Early Pulmonary Embolus: Filter Before Fixation? ⬇️

scientific article published on June 1, 2011

Early events in the recognition of danger signals after tissue injury

scientific article

Early growth response 1 mediates the systemic and hepatic inflammatory response initiated by hemorrhagic shock

scientific article published in February 2007

Elevated Admission Base Deficit Is Associated with a Complex Dynamic Network of Systemic Inflammation Which Drives Clinical Trajectories in Blunt Trauma Patients.

scientific article

Elevations in Circulating sST2 Levels Are Associated With In-Hospital Mortality and Adverse Clinical Outcomes After Blunt Trauma

scientific article published on 03 July 2019

Emerging paradigm: toll-like receptor 4-sentinel for the detection of tissue damage.

scientific article published on November 2006

Endogenous histones function as alarmins in sterile inflammatory liver injury through Toll-like receptor 9 in mice ⬇️

scientific article published on September 2, 2011

Endothelial TLR4 activation impairs intestinal microcirculatory perfusion in necrotizing enterocolitis via eNOS-NO-nitrite signaling

scientific article published on 6 May 2013

Endotoxin uptake in mouse liver is blocked by endotoxin pretreatment through a suppressor of cytokine signaling-1-dependent mechanism

scientific article

Enterocyte TLR4 mediates phagocytosis and translocation of bacteria across the intestinal barrier

scientific article published on March 2006

Eritoran attenuates tissue damage and inflammation in hemorrhagic shock/trauma

scientific article published on 27 March 2013

Estrogen Sulfotransferase Is an Oxidative Stress-responsive Gene That Gender-specifically Affects Liver Ischemia/Reperfusion Injury

scientific article published on 28 April 2015

Evidence-based improvement of the National Trauma Triage Protocol: The Glasgow Coma Scale versus Glasgow Coma Scale motor subscale

scientific article

Evolving role of endovascular techniques for traumatic vascular injury: a changing landscape?

scientific article published on January 2012

Ex vivo carbon monoxide delivery inhibits intimal hyperplasia in arterialized vein grafts

scientific article

Expression and subcellular localization of BNIP3 in hypoxic hepatocytes and liver stress

scientific article published on 15 January 2009

External validation of the Air Medical Prehospital Triage score for identifying trauma patients likely to benefit from scene helicopter transport

scientific article published on 30 November 2016

Extracellular SQSTM1 mediates bacterial septic death in mice through insulin receptor signalling

scientific article published on 19 October 2020

FXR-mediated regulation of angiotensin type 2 receptor expression in vascular smooth muscle cells

scientific article published on 13 November 2007

Factors Associated With Nontransfer in Trauma Patients Meeting American College of Surgeons' Criteria for Transfer at Nontertiary Centers

scientific article published on 4 January 2017

Fas-associating death domain protein overexpression induces apoptosis in lung cancer cells.

scientific article published in June 2003

Fatty acid binding protein-4 (FABP4) is a hypoxia inducible gene that sensitizes mice to liver ischemia/reperfusion injury

scientific article published on 9 June 2015

Fixed Volume or Fixed Pressure: A Murine Model of Hemorrhagic Shock ⬇️

scientific article published on June 6, 2011

Fresh frozen plasma is independently associated with a higher risk of multiple organ failure and acute respiratory distress syndrome.

scientific article published in August 2009

Frontline Science: Macrophage-derived exosomes promote neutrophil necroptosis following hemorrhagic shock.

scientific article

Galantamine and carbon monoxide protect brain microvascular endothelial cells by heme oxygenase-1 induction

scientific article published on 2 January 2008

Genetic and Pharmacologic Manipulation of TLR4 Has Minimal Impact on Ethanol Consumption in Rodents.

scientific article

Genetic deletion of toll-like receptor 4 on platelets attenuates experimental pulmonary hypertension

scientific article

Genomic responses in mouse models poorly mimic human inflammatory diseases

scientific article (publication date: 26 February 2013)

Geographic Variation in Outcome Benefits of Helicopter Transport for Trauma in the United States: A Retrospective Cohort Study.

scientific article

Geographic distribution of trauma centers and injury-related mortality in the United States

scientific article

Glutathione and thioredoxin type 1 cooperatively denitrosate HepG2 cells-derived cytosolic S-nitrosoproteins

scientific article

Goal-directed resuscitation in the prehospital setting: a propensity-adjusted analysis.

scientific article published on May 2013

HIV protease inhibitors in pulmonary hypertension: rationale and design of a pilot trial in idiopathic pulmonary arterial hypertension

scientific article

HMGB1 Controls Liver Cancer Initiation through YAP-dependent Aerobic Glycolysis.

scientific article published on 17 November 2017

HMGB1 as a potential biomarker and therapeutic target for severe COVID-19

scientific article published on 07 December 2020

HMGB1 in health and disease

scientific article

HMGB1 is a Central Driver of Dynamic Pro-inflammatory Networks in Pediatric Acute Liver Failure induced by Acetaminophen

scientific article published on 12 April 2019

HMGB1 release induced by liver ischemia involves Toll-like receptor 4 dependent reactive oxygen species production and calcium-mediated signaling

scientific article

HMGB1 released from nociceptors mediates inflammation

scientific article

HMGB1-Driven Inflammation and Intimal Hyperplasia After Arterial Injury Involves Cell-Specific Actions Mediated by TLR4.

scientific article published on 29 October 2015

HMGB1: endogenous danger signaling

scientific article

Helicopter transport improves survival following injury in the absence of a time-saving advantage

scientific article published on 22 October 2015

Helicopters and injured kids: Improved survival with scene air medical transport in the pediatric trauma population

scientific article published on 21 January 2016

Heme oxygenase-1: a cellular Hercules

scientific article published on 01 April 2003

Hemorrhagic Shock Activation of NLRP3 Inflammasome in Lung Endothelial Cells ⬇️

scientific article published on September 21, 2011

Hemorrhagic shock activates lung endothelial reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase via neutrophil NADPH oxidase

scientific article published on 23 April 2010

Hemorrhagic shock augments Nlrp3 inflammasome activation in the lung through impaired pyrin induction

scientific article published on 12 April 2013

Hemorrhagic shock augments lung endothelial cell activation: role of temporal alterations of TLR4 and TLR2.

scientific article

Hemorrhagic shock induces NAD(P)H oxidase activation in neutrophils: role of HMGB1-TLR4 signaling

scientific article published on 01 May 2007

Hemorrhagic shock-activated neutrophils augment TLR4 signaling-induced TLR2 upregulation in alveolar macrophages: role in hemorrhage-primed lung inflammation

scientific article published on 04 November 2005

Hepatic ischemia/reperfusion injury involves functional TLR4 signaling in nonparenchymal cells.

scientific article

Hepatocyte-specific high-mobility group box 1 deletion worsens the injury in liver ischemia/reperfusion: a role for intracellular high-mobility group box 1 in cellular protection

scientific article published on April 2014

Hepatocytes enhance effects of lipopolysaccharide on liver nonparenchymal cells through close cell interactions

scientific article published on 01 May 2005

High Mobility Group Box 1 Release from Hepatocytes during Ischemia and Reperfusion Injury Is Mediated by Decreased Histone Deacetylase Activity ⬇️

scientific article published on October 11, 2010

High mobility group Box 1 inhibits human pulmonary artery endothelial cell migration via a Toll-like receptor 4- and interferon response factor 3-dependent mechanism(s)

scientific article

High mobility group box 1 (HMGB1) phenotypic role revealed with stress

scientific article

High mobility group box 1 contributes to the pathogenesis of experimental pulmonary hypertension via activation of Toll-like receptor 4

scientific article published on January 2012

High-Mobility Group Box 1 Is Essential for Mitochondrial Quality Control ⬇️

scientific article published on June 8, 2011

Histidine-Tryptophan-Ketoglutarate or Celsior: Which Is More Suitable for Cold Preservation for Cardiac Grafts From Older Donors? ⬇️

scientific article published on March 1, 2011

Histones activate the NLRP3 inflammasome in Kupffer cells during sterile inflammatory liver injury

scientific article published on 31 July 2013

Hospital-acquired pneumonia is an independent predictor of poor global outcome in severe traumatic brain injury up to 5 years after discharge

scientific article published on February 2015

Hydrogen inhalation ameliorates ventilator-induced lung injury

scientific article published on 25 December 2010

Hydrogen inhalation protects against acute lung injury induced by hemorrhagic shock and resuscitation

scientific article published on 14 May 2015

Hydrogen inhalation reduced epithelial apoptosis in ventilator-induced lung injury via a mechanism involving nuclear factor-kappa B activation ⬇️

scientific article published on 05 April 2011

Hydrogen therapy may reduce the risks related to radiation-induced oxidative stress in space flight

scientific article published on 20 September 2010

Hydrogen-Enriched Preservation Protects the Isogeneic Intestinal Graft and Amends Recipient Gastric Function During Transplantation ⬇️

scientific article published on November 15, 2011

Hypoxia activates c-Jun N-terminal kinase via Rac1-dependent reactive oxygen species production in hepatocytes

scientific article published on 01 September 2007

Hypoxia inhibition of apoptosis induced by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL).

scientific article published in February 2002

Hypoxia inhibits tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by blocking Bax translocation

scientific article published on June 2004

Hypoxia-Induced Overexpression of BNIP3 is Not Dependent on Hypoxia-Inducible Factor 1α in Mouse Hepatocytes ⬇️

scientific article published on August 1, 2011

IFN-gamma inhibition of TRAIL-induced IAP-2 upregulation, a possible mechanism of IFN-gamma-enhanced TRAIL-induced apoptosis.

scientific article published in February 2002

IL-33-mediated IL-13 secretion by ST2+ Tregs controls inflammation after lung injury

scientific article published on 21 March 2019

IL33-mediated ILC2 activation and neutrophil IL5 production in the lung response after severe trauma: A reverse translation study from a human cohort to a mouse trauma model.

scientific article

IRF-1 expression induces apoptosis and inhibits tumor growth in mouse mammary cancer cells in vitro and in vivo

scientific article published on February 2004

Identification of a novel pathway of transforming growth factor-β1 regulation by extracellular NAD+ in mouse macrophages: in vitro and in silico studies

scientific article

Identification of pharmacological modulators of HMGB1-induced inflammatory response by cell-based screening

scientific article (publication date: 2013)

Identifying patients with time-sensitive injuries: Association of mortality with increasing prehospital time

scientific article published on 01 June 2019

Immune Activation in the Liver by Nucleic Acids

scientific article

Impact of Injury Severity on Dynamic Inflammation Networks Following Blunt Trauma.

scientific article published in August 2015

Impact of Volume Change Over Time on Trauma Mortality in the United States

scientific article published on 15 June 2016

In silico and in vivo approach to elucidate the inflammatory complexity of CD14-deficient mice

scientific article

In silico modeling: methods and applications to trauma and sepsis

scientific article

In silico models of acute inflammation in animals.

scientific article published on September 2006

Incidental radiographic findings after injury: dedicated attention results in improved capture, documentation, and management

scientific article

Increased interactive format for Morbidity & Mortality conference improves educational value and enhances confidence

scientific article published on September 2007

Increasing numbers of hepatic dendritic cells promote HMGB1-mediated ischemia-reperfusion injury

scientific article published on 24 October 2006

Individual-specific principal component analysis of circulating inflammatory mediators predicts early organ dysfunction in trauma patients.

scientific article published on 11 July 2016

Induced nitric oxide promotes intestinal inflammation following hemorrhagic shock

scientific article

Inducible Nitric Oxide Synthase Contributes to Immune Dysfunction Following Trauma ⬇️

scientific article published on November 1, 2012

Inducible protein-10, a potential driver of neurally controlled interleukin-10 and morbidity in human blunt trauma

scientific article

Induction and stability of human Th17 cells require endogenous NOS2 and cGMP-dependent NO signaling

scientific article published on July 2013

Induction of IL-6 within the rodent intestinal muscularis after intestinal surgical stress

scientific article published on 01 April 2005

Inflammasome and autophagy regulation - a two-way street

scientific article

Inhaled Hydrogen Gas Therapy for Prevention of Lung Transplant-Induced Ischemia/Reperfusion Injury in Rats ⬇️

scientific article published on December 27, 2010

Injury-induced MRP8/MRP14 stimulates IP-10/CXCL10 in monocytes/macrophages

scientific article

Innate immune mechanisms in ischemia/reperfusion.

scientific article published on June 2009

Innate-Like Lymphocytes Are Immediate Participants in the Hyper-Acute Immune Response to Trauma and Hemorrhagic Shock

scientific article published on 11 July 2019

Insights into the Role of Chemokines, Damage-Associated Molecular Patterns, and Lymphocyte-Derived Mediators from Computational Models of Trauma-Induced Inflammation

scientific article

Interacting neuroendocrine and innate and acquired immune pathways regulate neutrophil mobilization from bone marrow following hemorrhagic shock

scientific article published on January 2009

Interferon Regulatory Factor-1 Regulates the Autophagic Response in LPS-Stimulated Macrophages through Nitric Oxide ⬇️

scientific article published on March 27, 2012

Interferon regulatory factor 1 mediates acetylation and release of high mobility group box 1 from hepatocytes during murine liver ischemia-reperfusion injury

scientific article published on 01 March 2011

Interferon regulatory factor 1-Rab27a regulated extracellular vesicles promote liver ischemia/reperfusion injury

scientific article published on 23 October 2017

Interleukin-33 contributes to ILC2 activation and early inflammation-associated lung injury during abdominal sepsis

scientific article published on 17 May 2018

Intestinal Epithelial TLR-4 Activation Is Required for the Development of Acute Lung Injury after Trauma/Hemorrhagic Shock via the Release of HMGB1 from the Gut

scientific article published on 10 April 2015

Intestinal Microbiota Mediates the Susceptibility to Polymicrobial Sepsis-Induced Liver Injury by Granisetron Generation in Mice

scientific article published on 05 March 2019

Intestinal epithelial Toll-like receptor 4 regulates goblet cell development and is required for necrotizing enterocolitis in mice.

scientific article published on 13 July 2012

Intra-abdominal activation of a local inflammatory response within the human muscularis externa during laparotomy.

scientific article published in March 2003

Intracellular HMGB1 as a novel tumor suppressor of pancreatic cancer

scientific article

Intracellular Hmgb1 inhibits inflammatory nucleosome release and limits acute pancreatitis in mice

scientific article published on 17 December 2013

Ischemic preconditioning of the murine liver protects through the Akt kinase pathway

scientific article published on 01 September 2006

JTC801 Induces pH-dependent Death Specifically in Cancer Cells and Slows Growth of Tumors in Mice

scientific article published on 14 December 2017

LPS Induces Active HMGB1 Release From Hepatocytes Into Exosomes Through the Coordinated Activities of TLR4 and Caspase-11/GSDMD Signaling

scientific article published on 03 April 2020

Lack of Benefit on Brain Edema, Blood-Brain Barrier Permeability, or Cognitive Outcome in Global Inducible High Mobility Group Box 1 Knockout Mice Despite Tissue Sparing after Experimental Traumatic Brain Injury

article

Leukocyte-derived inducible nitric oxide synthase mediates murine postoperative ileus

scientific article published on 01 August 2006

Linking oxidative stress to inflammation: Toll-like receptors

scientific article published on 18 January 2010

Lipid Peroxidation Drives Gasdermin D-Mediated Pyroptosis in Lethal Polymicrobial Sepsis

scientific article published on 21 June 2018

Lipopolysaccharide clearance, bacterial clearance, and systemic inflammatory responses are regulated by cell type-specific functions of TLR4 during sepsis

scientific article published on 5 April 2013

Local exposure of bone components to injured soft tissue induces Toll-like receptor 4-dependent systemic inflammation with acute lung injury

scientific article published on 01 December 2008

Logistics of air medical transport: When and where does helicopter transport reduce prehospital time for trauma?

scientific article published on 01 July 2018

Low-dose carbon monoxide inhalation prevents ischemia/reperfusion injury of transplanted rat lung grafts

scientific article published on 01 August 2006

Low-dose cisplatin administration in murine cecal ligation and puncture prevents the systemic release of HMGB1 and attenuates lethality

scientific article

MD-2 is required for disulfide HMGB1-dependent TLR4 signaling

scientific article

MPPED2 Polymorphism Is Associated With Altered Systemic Inflammation and Adverse Trauma Outcomes

scientific article published on 08 November 2019

Male gender is associated with excessive IL-6 expression following severe injury

scientific article published on 01 March 2008

Mammalian DNA Is an Endogenous Danger Signal That Stimulates Local Synthesis and Release of Complement Factor B ⬇️

scientific article published on July 18, 2012

Mast Cells Play a Critical Role in the Systemic Inflammatory Response and End-Organ Injury Resulting from Trauma ⬇️

scientific article published on September 14, 2011

Maternity policy and practice during surgery residency: how we do it

scientific article published on 01 October 2002

Mechanical Ventilation With Moderate Tidal Volume Exacerbates Extrapulmonary Sepsis-Induced Lung Injury via IL33-WISP1 Signaling Pathway

scientific article published on 24 December 2020

Mechanical ventilation enhances extrapulmonary sepsis-induced lung injury: role of WISP1-αvβ5 integrin pathway in TLR4-mediated inflammation and injury

Mechanisms of Toll-like receptor 4 (TLR4)-mediated inflammation after cold ischemia/reperfusion in the heart.

scientific article published on May 2009

Mechanisms of hepatoprotection by nitric oxide

scientific article

Models of Lower Extremity Damage in Mice: Time Course of Organ Damage and Immune Response ⬇️

scientific article published on December 23, 2010

Multidisciplinary acute care research organization (MACRO): if you build it, they will come

scientific article published on July 2013

Myocyte TLR4 enhances enteric and systemic inflammation driving late murine endotoxic ileus

scientific article published on 6 March 2015

NK1.1+ cells promote sustained tissue injury and inflammation after trauma with hemorrhagic shock.

scientific article published on 17 May 2017

NO and hepatocellular cancer

scientific article published on 18 August 2019

Neutrophil NAD(P)H oxidase is required for hemorrhagic shock-enhanced TLR2 up-regulation in alveolar macrophages in response to LPS

scientific article published on 01 August 2007

Neutrophils counteract autophagy-mediated anti-inflammatory mechanisms in alveolar macrophage: role in posthemorrhagic shock acute lung inflammation

scientific article

Nitric oxide (NO) pretreatment increases cytokine-induced NO production in cultured rat hepatocytes by suppressing GTP cyclohydrolase I feedback inhibitory protein level and promoting inducible NO synthase dimerization

scientific article published on 30 September 2002

Nitric oxide facilitates cardiomyogenesis in mouse embryonic stem cells

scholarly article

Nitric oxide prevents 6-hydroxydopamine-induced apoptosis in PC12 cells through cGMP-dependent PI3 kinase/Akt activation

scientific article published in June 2003

Nitric oxide, a protective molecule in the cardiovascular system

scientific article published on October 2013

Nitric oxide-mediated inhibition of caspase-dependent T lymphocyte proliferation

scientific article published in September 2003

Nitric oxide: a clinical primer

scientific article

Non‑canonical Wnt signaling contributes to ventilator‑induced lung injury through upregulation of WISP1 expression

scholarly article by Yue-Feng Xia et al published March 2019 in International Journal of Molecular Medicine

Not all prehospital time is equal: Influence of scene time on mortality

scientific article published on 16 February 2016

Notch signaling protects CD4 T cells from STING-mediated apoptosis during acute systemic inflammation

scientific article published on 23 September 2020

Novel chemokine-like activities of histones in tumor metastasis

scientific article published on 11 August 2016

Oestrogen sulfotransferase ablation sensitizes mice to sepsis

scientific article

Oral hydrogen water prevents chronic allograft nephropathy in rats

scientific article

Oral intake of hydrogen-rich water inhibits intimal hyperplasia in arterialized vein grafts in rats

scientific article published on 27 January 2012

Orally administered nitrite attenuates cardiac allograft rejection in rats.

scientific article published in August 2009

Over Resuscitation With Plasma is Associated With Sustained Fibrinolysis Shutdown and Death in Pediatric Traumatic Brain Injury

scientific article published on 14 February 2018

Over reliance on computed tomography imaging in patients with severe abdominal injury: is the delay worth the risk?

scientific article

Overexpression of the human inducible nitric oxide synthase gene enhances radiation-induced apoptosis in colorectal cancer cells via a caspase-dependent mechanism

scientific article published on March 2003

PEX7 and EBP50 target iNOS to the peroxisome in hepatocytes

scientific article published on 5 March 2013

PKM2 regulates the Warburg effect and promotes HMGB1 release in sepsis

scientific article

PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation

scientific article published on 25 October 2016

Parenteral calcium for intensive care unit patients

scientific article

Patterns of cytokine release and evolution of remote organ dysfunction after bilateral femur fracture

scientific article published in July 2008

Peroxisomal localization of inducible nitric oxide synthase in hepatocytes

scientific article

Pivotal advance: The pattern recognition receptor ligands lipopolysaccharide and polyinosine-polycytidylic acid stimulate factor B synthesis by the macrophage through distinct but overlapping mechanisms

scientific article

Platelet-Monocyte Aggregates: Understanding Mechanisms and Functions in Sepsis

scientific article published on 15 July 2020

Plumbagin Protects Mice from Lethal Sepsis by Modulating Immunometabolism Upstream of PKM2

scientific article published on 09 March 2016

Possible novel therapy for malignant gliomas with secretable trimeric TRAIL.

scientific article

Pre-trauma center red blood cell transfusion is associated with improved early outcomes in air medical trauma patients.

scientific article published on 24 January 2015

Preactivation of NKT cells with alpha-GalCer protects against hepatic ischemia-reperfusion injury in mouse by a mechanism involving IL-13 and adenosine A2A receptor

scientific article published on 25 June 2009

Precision Medicine for Critical Illness and Injury

scientific article published on 01 September 2016

Preconditioning with high mobility group box 1 (HMGB1) induces lipopolysaccharide (LPS) tolerance

scientific article published on 07 August 2008

Prehospital Blood Product and Crystalloid Resuscitation in the Severely Injured Patient: A Secondary Analysis of the Prehospital Air Medical Plasma Trial

scientific article published on 13 April 2019

Prehospital Hypotension Is Associated With Altered Inflammation Dynamics and Worse Outcomes Following Blunt Trauma in Humans

scientific article published on July 2015

Prehospital Plasma during Air Medical Transport in Trauma Patients at Risk for Hemorrhagic Shock

scientific article published on 01 July 2018

Prehospital lactate improves accuracy of prehospital criteria for designating trauma activation level.

scientific article published on 26 April 2016

Prehospital plasma is associated with distinct biomarker expression following injury

scientific article published on 31 March 2020

Prehospital use of nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with a reduced incidence of trauma-induced coagulopathy

scientific article

Preinjury statin use is associated with a higher risk of multiple organ failure after injury: a propensity score adjusted analysis.

scientific article published on September 2009

Pretrauma center red blood cell transfusion is associated with reduced mortality and coagulopathy in severely injured patients with blunt trauma.

scientific article

Principal component analysis of coagulation assays in severely injured children

scientific article published on 13 December 2017

Prostaglandin-dependent modulation of dopaminergic neurotransmission elicits inflammation-induced aversion in mice

scientific article published on 21 December 2015

Protection against ischemia/reperfusion injury in cardiac and renal transplantation with carbon monoxide, biliverdin and both

scientific article published in February 2005

Pseudofracture: An Acute Peripheral Tissue Trauma Model ⬇️

scientific article published on April 18, 2011

Quality Control Measures and Validation in Gene Association Studies: Lessons for Acute Illness

scientific article published on 01 March 2020

RAGE-induced ILC2 expansion in acute lung injury due to haemorrhagic shock

scientific article published on 14 January 2020

REDD-1 aggravates endotoxin-induced inflammation via atypical NF-κB activation.

scientific article published on 16 March 2018

Racial Disparities and Sex-Based Outcomes Differences after Severe Injury ⬇️

scientific article published on April 21, 2012

Radiographic assessment of ground-level falls in elderly patients: Is the "PAN-SCAN" overdoing it?

scientific article published in October 2013

Radiographic assessment of splenic injury without contrast: is contrast truly needed?

scientific article

Redefining acute care surgery: Surgical rescue.

scientific article published on August 2015

Redox-dependent regulation of hepatocyte absent in melanoma 2 inflammasome activation in sterile liver injury in mice

scientific article

Regulation of Posttranslational Modifications of HMGB1 During Immune Responses

scientific article published on 30 December 2015

Reply: To PMID 24798499.

scientific article published on 17 March 2015

Requirements for NF-kappaB activation in hemorrhagic shock

scientific article published on 01 February 2002

RhoA influences the nuclear localization of extracellular signal-regulated kinases to modulate p21Waf/Cip1 expression

scientific article published on 21 July 2003

Role of Macrophages in Mobilization of Hematopoietic Progenitor Cells From Bone Marrow After Hemorrhagic Shock ⬇️

scientific article published on May 1, 2012

Role of heme oxygenase 1 in TNF/TNF receptor-mediated apoptosis after hepatic ischemia/reperfusion in rats

scientific article published in April 2013

Role of hemorrhage in the induction of systemic inflammation and remote organ damage: Analysis of combined pseudo‐fracture and hemorrhagic shock ⬇️

scientific article published on 01 February 2011

Role of nitric oxide in liver injury

scientific article published on September 2003

Role of the IL-33-ST2 axis in sepsis

scientific article published on 02 February 2017

Role of toll-like receptors in changes in gene expression and NF-kappa B activation in mouse hepatocytes stimulated with lipopolysaccharide

scientific article published on July 2002

Selective jejunal manipulation causes postoperative pan-enteric inflammation and dysmotility

scientific article published on 01 January 2004

Sepsis Up-Regulates CD14 Expression in a MyD88 Dependent and Trif Independent Pathway

scientific article published on 29 May 2017

Sepsis: Something old, something new, and a systems view

scientific article published on 27 July 2011

Signaling of high mobility group box 1 (HMGB1) through toll-like receptor 4 in macrophages requires CD14.

scientific article published on 20 May 2013

Significant sex-based outcome differences in severely injured Chinese trauma patients

scientific article published in July 2014

Speed isn't everything: Identifying patients who may benefit from helicopter transport despite faster ground transport

scientific article

Splenocyte Apoptosis and Autophagy Is Mediated by Interferon Regulatory Factor 1 During Murine Endotoxemia ⬇️

scientific article published on May 1, 2012

Stearoyl Lysophosphatidylcholine Inhibits Endotoxin-Induced Caspase-11 Activation

scientific article

Superior myocardial preservation with HTK solution over Celsior in rat hearts with prolonged cold ischemia

scientific article published on 2 June 2010

Surgical rescue: The next pillar of acute care surgery.

scientific article

Systemic inflammation and end organ damage following trauma involves functional TLR4 signaling in both bone marrow-derived cells and parenchymal cells

scientific article published on 9 October 2007

Systemic inflammation and remote organ damage following bilateral femur fracture requires Toll-like receptor 4

scientific article published on 04 May 2006

Systemic inflammation and remote organ injury following trauma require HMGB1

scientific article published on 25 July 2007

Systolic blood pressure criteria in the National Trauma Triage Protocol for geriatric trauma: 110 is the new 90.

scientific article

TBK1/IKKε Negatively Regulate LPS-Induced Neutrophil Necroptosis and Lung Inflammation

scientific article published on 09 September 2020

TIFA upregulation after hypoxia-reoxygenation is TLR4- and MyD88-dependent and associated with HMGB1 upregulation and release

scientific article published on 28 May 2013

TLR4 Deters Perfusion Recovery and Upregulates Toll-like Receptor 2 (TLR2) in Ischemic Skeletal Muscle and Endothelial Cells

scientific article

TLR4 Signaling augments monocyte chemotaxis by regulating G protein-coupled receptor kinase 2 translocation

scientific article published on 14 June 2013

TLR4-Upregulated IL-1β and IL-1RI Promote Alveolar Macrophage Pyroptosis and Lung Inflammation through an Autocrine Mechanism.

scientific article published on 16 August 2016

TLR9 signaling in fibroblastic reticular cells regulates peritoneal immunity

scientific article published on 05 August 2019

TMEM173 Drives Lethal Coagulation in Sepsis

scientific article published on 05 March 2020

TRISS unexpected survivors: an outdated standard?

scientific article

TSLP protects against liver I/R injury via activation of the PI3K/Akt pathway

scientific article published on 14 November 2019

Taking the Blood Bank to the Field: The Design and Rationale of the Prehospital Air Medical Plasma (PAMPer) Trial

scientific article

Temporal Patterns of Circulating Inflammation Biomarker Networks Differentiate Susceptibility to Nosocomial Infection Following Blunt Trauma in Humans.

scientific article

The Circadian Clock Controls Immune Checkpoint Pathway in Sepsis

scientific article published on 01 July 2018

The Endotoxin Delivery Protein HMGB1 Mediates Caspase-11-Dependent Lethality in Sepsis

scientific article published on 09 October 2018

The HIV protease inhibitor saquinavir inhibits HMGB1 driven inflammation by targeting the interaction of cathepsin V with TLR4/MyD88

scientific article

The IL-33-ST2 Pathway Contributes to Ventilator-Induced Lung Injury in Septic Mice in a Tidal Volume-Dependent Manner

scientific article published on 01 September 2019

The Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 Activity

scientific article published in August 2017

The acute inflammatory response in diverse shock states

scientific article published on 01 July 2005

The central role of arginine catabolism in T-cell dysfunction and increased susceptibility to infection after physical injury

scientific article

The early evolving sex hormone environment is associated with significant outcome and inflammatory response differences after injury.

scientific article

The effect of donor treatment with hydrogen on lung allograft function in rats

scientific article published on 01 August 2011

The importance of empiric abdominal computed tomography after urgent laparotomy for trauma: do they reveal unexpected injuries?

scientific article

The nitric oxide donor S-nitrosoglutathione reduces apoptotic primary liver cell loss in a three-dimensional perfusion bioreactor culture model developed for liver support

scientific article

The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion

scientific article

The protective effect of PNU-282987, a selective α7 nicotinic acetylcholine receptor agonist, on the hepatic ischemia-reperfusion injury is associated with the inhibition of high-mobility group box 1 protein expression and nuclear factor κB activati

scientific article published on 01 February 2013

The research agenda for trauma critical care.

scientific article

The role of NIGMS P50 sponsored team science in our understanding of multiple organ failure

scientific article published on 22 May 2017

The role of RAGE in the pathogenesis of intestinal barrier dysfunction after hemorrhagic shock

scientific article published on 01 June 2006

The role of fracture-associated soft tissue injury in the induction of systemic inflammation and remote organ dysfunction after bilateral femur fracture

scientific article published in July 2008

The role of hepatic type 1 plasminogen activator inhibitor (PAI-1) during murine hemorrhagic shock.

scientific article published on August 2005

The role of initial trauma in the host's response to injury and hemorrhage: insights from a correlation of mathematical simulations and hepatic transcriptomic analysis

scientific article published in December 2006

The role of type 1 interferons in coagulation induced by gram-negative bacteria

scientific article published on 01 April 2020

The swinging pendulum: a national perspective of nonoperative management in severe blunt liver injury.

scientific article published in October 2013

The value of the injury severity score in pediatric trauma: Time for a new definition of severe injury?

scientific article published on 20 March 2017

Therapeutic antioxidant medical gas.

scientific article published on 27 December 2008

Thioredoxin catalyzes the denitrosation of low-molecular mass and protein S-nitrosothiols

scientific article

Thrombospondin-1/CD36 pathway contributes to bone marrow-derived angiogenic cell dysfunction in type 1 diabetes via Sonic hedgehog pathway suppression

scientific article published on 22 October 2013

Time for trauma immunology

scientific article published on 11 July 2017

Tissue hypoxia activates JNK in the liver during hemorrhagic shock.

scientific article

Tlr2 on Bone Marrow and Non-Bone Marrow Derived Cells Regulates Inflammation and Organ Injury in Cooperation with Tlr4 During Resuscitated Hemorrhagic Shock

scientific article

Toll-Like Receptor 4 on both Myeloid Cells and Dendritic Cells Is Required for Systemic Inflammation and Organ Damage after Hemorrhagic Shock with Tissue Trauma in Mice

scientific article published on 28 November 2017

Toll-Like Receptors and Myocardial Ischemia/Reperfusion, Inflammation, and Injury ⬇️

scientific article published on August 1, 2009

Toll-Like Receptors in Hepatic Ischemia/Reperfusion and Transplantation ⬇️

scientific article published on August 5, 2010

Toll-like Receptor 4 Signaling on Dendritic Cells Suppresses Polymorphonuclear Leukocyte CXCR2 Expression and Trafficking via Interleukin 10 During Intra-abdominal Sepsis

scientific article published on 24 November 2015

Toll-like receptor 4 (TLR4) antagonist eritoran tetrasodium attenuates liver ischemia and reperfusion injury through inhibition of high-mobility group box protein B1 (HMGB1) signaling

scientific article

Toll-like receptor 4 mediates the early inflammatory response after cold ischemia/reperfusion

scientific article published on 01 November 2007

Toll-like receptor 4 regulates platelet function and contributes to coagulation abnormality and organ injury in hemorrhagic shock and resuscitation

scientific article

Toll-like receptor 4-mediated endoplasmic reticulum stress in intestinal crypts induces necrotizing enterocolitis.

scientific article published on 11 February 2014

Toll-like receptor-4 signaling mediates hepatic injury and systemic inflammation in hemorrhagic shock

scientific article published on 18 January 2006

Tranexamic Acid During Prehospital Transport in Patients at Risk for Hemorrhage After Injury: A Double-blind, Placebo-Controlled, Randomized Clinical Trial

scientific article published on 05 October 2020

Transcriptomic response of murine liver to severe injury and hemorrhagic shock: a dual-platform microarray analysis.

scientific article published on 9 August 2011

Transcriptomic responses from improved murine sepsis models can better mimic human surgical sepsis

scientific article published on 02 November 2020

Trauma in silico: Individual-specific mathematical models and virtual clinical populations.

scientific article published in April 2015

Unsupervised Clustering Analysis Based on MODS Severity Identifies Four Distinct Organ Dysfunction Patterns in Severely Injured Blunt Trauma Patients

scientific article published on 25 February 2020

WISP1-αvβ3 integrin signaling positively regulates TLR-triggered inflammation response in sepsis induced lung injury

scientific article published on 28 June 2016

X chromosome-linked IRAK-1 polymorphism is a strong predictor of multiple organ failure and mortality postinjury.

scientific article

Young and Aged Blunt Trauma Patients Display Major Differences in Circulating Inflammatory Mediator Profiles after Severe Injury

scientific article published on 16 November 2018

cAMP metabolism controls caspase-11 inflammasome activation and pyroptosis in sepsis

scientific article published on 22 May 2019

iNOS promotes CD24CD133 liver cancer stem cell phenotype through a TACE/ADAM17-dependent Notch signaling pathway

article published in the Proceedings of the National Academy of Sciences of the United States of America

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