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List of works by William E. Klunk

11C PiB and structural MRI provide complementary information in imaging of Alzheimer's disease and amnestic mild cognitive impairment

scientific article

11C-PIB PET imaging in Alzheimer disease and frontotemporal lobar degeneration

scientific article

11C-PiB PET assessment of change in fibrillar amyloid-beta load in patients with Alzheimer's disease treated with bapineuzumab: a phase 2, double-blind, placebo-controlled, ascending-dose study

scientific article published on 26 February 2010

2014 Report on the Milestones for the US National Plan to Address Alzheimer's Disease

scientific article

A lipophilic thioflavin-T derivative for positron emission tomography (PET) imaging of amyloid in brain

scientific article

A survey of attitudes toward clinical trials and genetic disclosure in autosomal dominant Alzheimer's disease

scientific article published on 22 July 2015

Absence of Pittsburgh compound B detection of cerebral amyloid beta in a patient with clinical, cognitive, and cerebrospinal fluid markers of Alzheimer disease: a case report

scientific article published on December 2009

Alteration of a clinically meaningful outcome in the natural history of Alzheimer's disease by cholinesterase inhibition.

scientific article published in January 2005

Alzheimer's beta-amyloid protein is covalently modified when dissolved in formic acid

scientific article published in June 1990

Alzheimer's disease phenotypes and genotypes associated with mutations in presenilin 2.

scientific article

Amyloid and neurodegeneration: Converging and diverging paths

scientific article published on 16 October 2013

Amyloid burden and neural function in people at risk for Alzheimer's Disease

scientific article

Amyloid deposition begins in the striatum of presenilin-1 mutation carriers from two unrelated pedigrees

scientific article published on June 2007

Amyloid imaging as a biomarker for cerebral β-amyloidosis and risk prediction for Alzheimer dementia

scientific article published on December 2011

Amyloid imaging in dementias with atypical presentation

scientific article

Amyloid imaging in mild cognitive impairment subtypes.

scientific article

Amyloid imaging with carbon 11-labeled Pittsburgh compound B for traumatic brain injury

scientific article

An Abeta sequestration approach using non-antibody Abeta binding agents

scientific article published in April 2005

Analysis of magnetic resonance spectra by mole percent: comparison to absolute units

scientific article published in January 1994

Anomalous PiB enhancement in the superior sagittal and transverse venous sinuses

scientific article published in April 2012

Anti-Amyloid Effects of Small Molecule Aβ-Binding Agents in PS1/APP Mice

scientific article

Anti-Aβ antibody treatment promotes the rapid recovery of amyloid-associated neuritic dystrophy in PDAPP transgenic mice

Antioxidant activity of X-34 in synaptosomal and neuronal systems

scientific article published in October 2003

Apolipoprotein D is a component of compact but not diffuse amyloid-beta plaques in Alzheimer's disease temporal cortex.

scientific article

Arterial stiffness and β-amyloid progression in nondemented elderly adults.

scientific article

Association of Cerebral Amyloid-β Aggregation With Cognitive Functioning in Persons Without Dementia

scientific article published on 29 November 2017

Aβ Imaging: feasible, pertinent, and vital to progress in Alzheimer's disease

scientific article published in February 2012

Basal cerebral metabolism may modulate the cognitive effects of Abeta in mild cognitive impairment: an example of brain reserve.

scientific article

Beta amyloid in Alzheimer's disease: increased deposition in brain is reflected in reduced concentration in cerebrospinal fluid

scientific article published on 06 March 2009

Beta-amyloid imaging and memory in non-demented individuals: evidence for preclinical Alzheimer's disease

scientific article published on 10 October 2007

Binding of the positron emission tomography tracer Pittsburgh compound-B reflects the amount of amyloid-beta in Alzheimer's disease brain but not in transgenic mouse brain.

scientific article

Biological Markers of Alzheimer’s Disease ⬇️

scientific article published on March 1, 1998

Biomarkers for the early diagnosis of Alzheimer's disease

scientific article published in March 2006

Biopsy support for the validity of Pittsburgh compound B positron emission tomography with a twist

scientific article published in October 2008

Blood and CSF biomarkers for AD revisited: what's new, what's good, and is this where we should be looking?

scientific article published in July 2002

Brain imaging in Alzheimer disease

scientific article

Carbon 11-labeled Pittsburgh Compound B and carbon 11-labeled (R)-PK11195 positron emission tomographic imaging in Alzheimer disease.

scientific article published on January 2009

Changes in brain membrane phospholipid and high-energy phosphate metabolism precede dementia

scientific article published on 01 November 1995

Characterizing regional correlation, laterality and symmetry of amyloid deposition in mild cognitive impairment and Alzheimer's disease with Pittsburgh Compound B.

scientific article published on 16 May 2008

Chrysamine G and its derivative reduce amyloid beta-induced neurotoxicity in mice

scientific article published on November 2002

Chrysamine-G binding to Alzheimer and control brain: autopsy study of a new amyloid probe

scientific article published in July 1995

Chrysamine-G, a lipophilic analogue of Congo red, inhibits A beta-induced toxicity in PC12 cells

scientific article published in January 1998

Classification of amyloid-positivity in controls: comparison of visual read and quantitative approaches.

scientific article

Clinical and biomarker changes in dominantly inherited Alzheimer's disease

scientific article

Clinical and neurochemical effects of acetyl-L-carnitine in Alzheimer's disease

scientific article published in January 1995

Clinical severity of Alzheimer's disease is associated with PIB uptake in PET.

scientific article

Cognitive aging in persons with minimal amyloid-β and white matter hyperintensities

scientific article published on August 2013

Cognitive and behavioral correlates of low vitamin B12 levels in elderly patients with progressive dementia.

scientific article published in May 2002

Cognitive trajectories associated with β-amyloid deposition in the oldest-old without dementia

scientific article

Commentary on “Diagnosis of Alzheimer’s disease: Two decades of progress.” Diagnosis of Alzheimer’s disease: Walking a well-paved path

scientific article published on 01 October 2005

Comparison of Pittsburgh compound B and florbetapir in cross-sectional and longitudinal studies

article

Consideration of optimal time window for Pittsburgh compound B PET summed uptake measurements

scientific article published on 17 February 2009

Correction: Quantitative Amyloid Imaging in Autosomal Dominant Alzheimer's Disease: Results from the DIAN Study Group

scientific article published on 20 September 2016

Correspondence between in vivo (11)C-PiB-PET amyloid imaging and postmortem, region-matched assessment of plaques

scientific article published on 5 August 2012

Dendritic spine density, morphology, and fibrillar actin content surrounding amyloid-β plaques in a mouse model of amyloid-β deposition

scientific article published on August 2013

Design, synthesis and structure-activity relationship of rhenium 2-arylbenzothiazoles as β-amyloid plaque binding agents

scientific article published on 24 January 2013

Developing an international network for Alzheimer research: The Dominantly Inherited Alzheimer Network

scientific article (publication date: October 2012)

Development and screening of contrast agents for in vivo imaging of Parkinson's disease

scientific article

Development of positron emission tomography β-amyloid plaque imaging agents

scientific article

Development of small molecule probes for the Beta-amyloid protein of Alzheimer's Disease

article

Disclosure of amyloid imaging results to research participants: has the time come?

scientific article published on 13 February 2013

Dissecting phenotypic traits linked to human resilience to Alzheimer's pathology

scientific article published on 03 July 2013

Dynamics of the microglial/amyloid interaction indicate a role in plaque maintenance

scientific article published on April 2008

Early AD pathology in a [C-11]PiB-negative case: a PiB-amyloid imaging, biochemical, and immunohistochemical study

scientific article

Early detection of Alzheimer's disease using PiB and FDG PET

scientific article

Early risk assessment for Alzheimer's disease

scientific article published on March 2009

Effects of lipophilicity on the affinity and nonspecific binding of iodinated benzothiazole derivatives

scientific article published in January 2003

Evaluation of voxel-based methods for the statistical analysis of PIB PET amyloid imaging studies in Alzheimer's disease

scientific article published on 14 August 2006

Fibrillar amyloid-beta burden in cognitively normal people at 3 levels of genetic risk for Alzheimer's disease

scholarly article

Fluid and PET biomarkers for amyloid pathology in Alzheimer's disease

scientific article published on 08 December 2018

Four-dimensional multiphoton imaging of brain entry, amyloid binding, and clearance of an amyloid-beta ligand in transgenic mice

scientific article

Frequent amyloid deposition without significant cognitive impairment among the elderly

scientific article

Genome-wide association study of brain amyloid deposition as measured by Pittsburgh Compound-B (PiB)-PET imaging

scientific article published on 25 October 2018

Imaging Alzheimer pathology in late-life depression with PET and Pittsburgh Compound-B

scientific article published on July 2008

Imaging beta-amyloid burden in aging and dementia.

scientific article

Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B

scientific article (publication date: 21 January 2004)

Imaging brain amyloid in nondemented young adults with Down syndrome using Pittsburgh compound B.

scientific article

Imaging of CNS myelin by positron-emission tomography

scholarly article

Imaging of amyloid burden and distribution in cerebral amyloid angiopathy

scientific article published in September 2007

Imaging of amyloid plaques and cerebral glucose metabolism in semantic dementia and Alzheimer's disease

scientific article published on 21 September 2007

Imaging technology for neurodegenerative diseases: progress toward detection of specific pathologies

scientific article

Imaging the pathology of Alzheimer's disease: amyloid-imaging with positron emission tomography

scientific article published on November 2003

Impact of amyloid imaging on drug development in Alzheimer's disease

scientific article

In vivo assessment of amyloid-β deposition in nondemented very elderly subjects

scientific article

In vivo fibrillar beta-amyloid detected using [11C]PiB positron emission tomography and neuropathologic assessment in older adults

scientific article

In vivo optical imaging of amyloid aggregates in brain: design of fluorescent markers

scientific article

Inactivity of phosphoethanolamine, an endogenous GABA analog decreased in Alzheimer's disease, at GABA binding sites

scientific article published in January 1995

Inhibition of polyglutamine aggregation in R6/2 HD brain slices-complex dose-response profiles

scientific article published in December 2001

Inter-rater reliability of manual and automated region-of-interest delineation for PiB PET.

scientific article

Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Abeta42 in humans

scientific article published in March 2006

Kinetic modeling of amyloid binding in humans using PET imaging and Pittsburgh Compound-B.

scientific article

L-phosphoserine, a metabolite elevated in Alzheimer's disease, interacts with specific L-glutamate receptor subtypes

scientific article published in June 1991

Lack of association between 11C-PiB and longitudinal brain atrophy in non-demented older individuals

scientific article published on 21 February 2010

Longitudinal assessment of Aβ and cognition in aging and Alzheimer disease

scientific article

Longitudinal cerebral blood flow and amyloid deposition: an emerging pattern?

scientific article published on 14 August 2008

Longitudinal cognitive and biomarker changes in dominantly inherited Alzheimer disease

scientific article published on 14 September 2018

Magnetic Resonance Spectroscopy of Neural Tissue

Magnetic resonance spectroscopic changes in Alzheimer's disease.

scientific article published on September 1997

Markers of cholesterol transport are associated with amyloid deposition in the brain.

scientific article published on 3 October 2013

Measuring target effect of proposed disease-modifying therapies in Alzheimer's disease

scientific article published on July 2008

Mechanism of amyloid removal in patients with Alzheimer disease treated with gantenerumab

scientific article published on 10 October 2011

Metabolic alterations in postmortem Alzheimer's disease brain are exaggerated by Apo-E4.

scientific article published in November 1998

Molecular imaging with Pittsburgh Compound B confirmed at autopsy: a case report

scientific article published on March 2007

Molecular insights into neurodevelopmental and neurodegenerative diseases

scientific article

Molecular, structural, and functional characterization of Alzheimer's disease: evidence for a relationship between default activity, amyloid, and memory

scientific article (publication date: 24 August 2005)

Neuroimaging markers for the prediction and early diagnosis of Alzheimer's disease dementia

scientific article published on 21 June 2011

PK11195 labels activated microglia in Alzheimer's disease and in vivo in a mouse model using PET.

scientific article published on 21 February 2008

Partial volume correction in quantitative amyloid imaging

scientific article published on 5 December 2014

Patterns of change in the treatment of psychiatric symptoms in patients with probable Alzheimer's disease from 1983 to 2000.

scientific article published in January 2003

Phosphocreatine-dependent Glutamate Uptake by Synaptic Vesicles

scientific article published in Journal of Biological Chemistry

Plasma and cerebrospinal fluid alpha1-antichymotrypsin levels in Alzheimer's disease: correlation with cognitive impairment.

scientific article published in January 2003

Positron emission tomography radioligands for in vivo imaging of Aβ plaques

scientific article

Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer's disease

scientific article

Preclinical trials in autosomal dominant AD: implementation of the DIAN-TU trial.

scientific article

Precuneus amyloid burden is associated with reduced cholinergic activity in Alzheimer disease.

scientific article

Predicting positivity for a new era of Alzheimer disease prevention trials

scientific article published on 12 September 2012

Prevalence of amyloid PET positivity in dementia syndromes: a meta-analysis

scientific article published in May 2015

Prevalence of cerebral amyloid pathology in persons without dementia: a meta-analysis

scientific article published on May 2015

Prevalence of the apolipoprotein E ε4 allele in amyloid β positive subjects across the spectrum of Alzheimer's disease

scientific article published on 27 March 2018

Progression of cerebral amyloid load is associated with the apolipoprotein E ε4 genotype in Alzheimer's disease

scientific article

Psychiatric symptoms vary with the severity of dementia in probable Alzheimer's disease.

scientific article published in January 2003

Psychosis in Alzheimer disease: postmortem magnetic resonance spectroscopy evidence of excess neuronal and membrane phospholipid pathology.

scientific article

Psychotic symptoms in Alzheimer's disease are not associated with more severe neuropathologic features

scientific article published in December 2000

Pulse wave velocity is associated with β-amyloid deposition in the brains of very elderly adults.

scientific article

Quantifying amyloid beta-peptide (Abeta) aggregation using the Congo red-Abeta (CR-abeta) spectrophotometric assay

scientific article

Quantitative 1H and 31P MRS of PCA extracts of postmortem Alzheimer's disease brain

scientific article published in May 1996

Quantitative Amyloid Imaging in Autosomal Dominant Alzheimer's Disease: Results from the DIAN Study Group

scientific article

Quantitative PET and Histology of Brain Biopsy Reveal Lack of Selective Pittsburgh Compound-B Binding to Intracerebral Amyloidoma

scientific article published on 01 January 2018

Regional variability of imaging biomarkers in autosomal dominant Alzheimer's disease

scientific article

Role of biomarkers in studies of presymptomatic Alzheimer's disease

scientific article published on October 2005

Structural determinants of activity at the GABAB receptor

scientific article published on 01 September 1995

Synthesis and beta-amyloid binding properties of rhenium 2-phenylbenzothiazoles

scientific article published on 27 February 2009

Synthesis and evaluation of 11C-labeled 6-substituted 2-arylbenzothiazoles as amyloid imaging agents

scientific article

Synthesis and11C-labelling of (E,E)-1-(3?,4?-dihydroxystyryl)-4-(3?-methoxy-4?-hydroxystyryl) benzene for PET imaging of amyloid deposits?

The 5-HTTPR polymorphism confers liability to a combined phenotype of psychotic and aggressive behavior in Alzheimer disease

scientific article

The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

scientific article (publication date: May 2011)

The future of amyloid-beta imaging: a tale of radionuclides and tracer proliferation

scientific article published on December 2008

The long-term effects of conventional and atypical antipsychotics in patients with probable Alzheimer's disease

scientific article

The role of biomarkers in clinical trials for Alzheimer disease

scientific article

Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease

scientific article

Two-year follow-up of amyloid deposition in patients with Alzheimer's disease

scientific article published in November 2006

Uncharged thioflavin-T derivatives bind to amyloid-beta protein with high affinity and readily enter the brain

scientific article

Update on amyloid imaging: from healthy aging to Alzheimer's disease

scientific article published on September 2009

Using Pittsburgh Compound B for in vivo PET imaging of fibrillar amyloid-beta

scientific article published on January 2012

Using a reference tissue model with spatial constraint to quantify [11C]Pittsburgh compound B PET for early diagnosis of Alzheimer's disease

scientific article

Utility of perfusion PET measures to assess neuronal injury in Alzheimer's disease

scientific article published on 27 September 2018

Utilizing the Centiloid scale in cross-sectional and longitudinal PiB PET studies

scientific article published on 25 April 2018

Visualization of fibrillar amyloid deposits in living, transgenic Caenorhabditis elegans animals using the sensitive amyloid dye, X-34.

scientific article

Whatever happened to Pittsburgh Compound-A?

scientific article published on July 2008

X-34 labeling of abnormal protein aggregates during the progression of Alzheimer's disease

scientific article published on January 2006

[11C]PIB in a nondemented population: Potential antecedent marker of Alzheimer disease

scientific article published on 01 August 2006

β-Amyloid 42/40 ratio and kalirin expression in Alzheimer disease with psychosis

scientific article

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