List of works - Micah Steffek

A novel inhibitor of the alternative pathway of complement reverses inflammation and bone destruction in experimental arthritis

scientific article

ATP-dependent L-cysteine:1D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase, mycothiol biosynthesis enzyme MshC, is related to class I cysteinyl-tRNA synthetases

scientific journal article

Allosteric peptides bind a caspase zymogen and mediate caspase tetramerization ⬇️

scientific article published on June 10, 2012

An allosteric switch for pro-HGF/Met signaling using zymogen activator peptides

scientific article

Characterization of Mycobacterium tuberculosis Mycothiol S-Conjugate Amidase ⬇️

scientific article published on October 21, 2003

Conformational dynamics control ubiquitin-deubiquitinase interactions and influence in vivo signaling

scientific article

Design and evaluation of novel 8-oxo-pyridopyrimidine Jak1/2 inhibitors

scientific article

Discovery and optimization of C-2 methyl imidazopyrrolopyridines as potent and orally bioavailable JAK1 inhibitors with selectivity over JAK2

scientific article

Discovery of novel pyrazolo[1,5-a]pyrimidines as potent pan-Pim inhibitors by structure- and property-based drug design

scientific article

Identification of C-2 hydroxyethyl imidazopyrrolopyridines as potent JAK1 inhibitors with favorable physicochemical properties and high selectivity over JAK2

scientific article

Identification of imidazo-pyrrolopyridines as novel and potent JAK1 inhibitors

scientific article

Mechanistic and Structural Understanding of Uncompetitive Inhibitors of Caspase-6

scientific article

Structural and Functional Analysis of a C3b-specific Antibody That Selectively Inhibits the Alternative Pathway of Complement

scientific article

Structure of C3b in complex with CRIg gives insights into regulation of complement activation

scientific article

Structure-based discovery of C-2 substituted imidazo-pyrrolopyridine JAK1 inhibitors with improved selectivity over JAK2

scientific article

Tailoring small molecules for an allosteric site on procaspase-6

scientific article

List of works by Micah Steffek

A novel inhibitor of the alternative pathway of complement reverses inflammation and bone destruction in experimental arthritis

ATP-dependent L-cysteine:1D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase, mycothiol biosynthesis enzyme MshC, is related to class I cysteinyl-tRNA synthetases

Allosteric peptides bind a caspase zymogen and mediate caspase tetramerization ⬇️

An allosteric switch for pro-HGF/Met signaling using zymogen activator peptides

Characterization of Mycobacterium tuberculosis Mycothiol S-Conjugate Amidase ⬇️

Conformational dynamics control ubiquitin-deubiquitinase interactions and influence in vivo signaling

Design and evaluation of novel 8-oxo-pyridopyrimidine Jak1/2 inhibitors

Discovery and optimization of C-2 methyl imidazopyrrolopyridines as potent and orally bioavailable JAK1 inhibitors with selectivity over JAK2

Discovery of novel pyrazolo[1,5-a]pyrimidines as potent pan-Pim inhibitors by structure- and property-based drug design

Identification of C-2 hydroxyethyl imidazopyrrolopyridines as potent JAK1 inhibitors with favorable physicochemical properties and high selectivity over JAK2

Identification of imidazo-pyrrolopyridines as novel and potent JAK1 inhibitors

Mechanistic and Structural Understanding of Uncompetitive Inhibitors of Caspase-6

Structural and Functional Analysis of a C3b-specific Antibody That Selectively Inhibits the Alternative Pathway of Complement

Structure of C3b in complex with CRIg gives insights into regulation of complement activation

Structure-based discovery of C-2 substituted imidazo-pyrrolopyridine JAK1 inhibitors with improved selectivity over JAK2

Tailoring small molecules for an allosteric site on procaspase-6