List of works - Serena Cecchetti

A variant in the carboxyl-terminus of connexin 40 alters GAP junctions and increases risk for tetralogy of Fallot

scientific article

Aberrant HRAS transcript processing underlies a distinctive phenotype within the RASopathy clinical spectrum.

scientific article

Acridine Orange/exosomes increase the delivery and the effectiveness of Acridine Orange in human melanoma cells: A new prototype for theranostics of tumors.

scientific article published on December 2017

Activating mutations in RRAS underlie a phenotype within the RASopathy spectrum and contribute to leukaemogenesis

scientific article

Activation of Phosphatidylcholine-Specific Phospholipase C in Breast and Ovarian Cancer: Impact on MRS-Detected Choline Metabolic Profile and Perspectives for Targeted Therapy

scientific article published on 2 August 2016

Biallelic Mutations in TBCD, Encoding the Tubulin Folding Cofactor D, Perturb Microtubule Dynamics and Cause Early-Onset Encephalopathy

scientific journal article

Chemo-immunotherapy induces tumor regression in a mouse model of spontaneous mammary carcinogenesis

scientific article published on 28 July 2016

Chronic Isolation Stress Affects Central Neuroendocrine Signaling Leading to a Metabolically Active Microenvironment in a Mouse Model of Breast Cancer

scientific article published on 09 July 2021

Clinical and functional characterization of two novel ZBTB20 mutations causing Primrose syndrome

scientific article published on 7 May 2018

Defective kinesin binding of TUBB2A causes progressive spastic ataxia syndrome resembling sacsinopathy.

scientific article published on 14 March 2018

Dematin, a component of the erythrocyte membrane skeleton, is internalized by the malaria parasite and associates with Plasmodium 14-3-3.

scientific article published on 17 November 2010

Diesel exhaust particle exposure in vitro impacts T lymphocyte phenotype and function

scientific article

Effects of Mentha suaveolens Essential Oil Alone or in Combination with Other Drugs in Candida albicans

scientific article published on 27 February 2014

Exosomes from human colorectal cancer induce a tumor-like behavior in colonic mesenchymal stromal cells

scientific article

Giardia duodenalis 14-3-3 protein is polyglycylated by a tubulin tyrosine ligase-like member and deglycylated by two metallocarboxypeptidases

scientific article published on 6 December 2010

Immune surveillance properties of human NK cell-derived exosomes.

scientific article published on 17 August 2012

In Vivo Targeting of Cutaneous Melanoma Using an Melanoma Stimulating Hormone-Engineered Human Protein Cage with Fluorophore and Magnetic Resonance Imaging Tracers.

scientific article published on January 2015

In vivo targeting of cutaneous melanoma using an MSH-engineered human protein cage bearing fluorophore and MRI tracers.

scientific article published on 6 May 2014

Inhibition of Phosphatidylcholine-Specific Phospholipase C Interferes with Proliferation and Survival of Tumor Initiating Cells in Squamous Cell Carcinoma

scientific article published on 24 September 2015

Inhibition of phosphatidylcholine-specific phospholipase C downregulates HER2 overexpression on plasma membrane of breast cancer cells

scientific article

Inhibition of phosphatidylcholine-specific phospholipase C results in loss of mesenchymal traits in metastatic breast cancer cells

scientific article

Integrase Defective Lentiviral Vector as a Vaccine Platform for Delivering Influenza Antigens

scientific article published on 5 February 2018

Interaction network of the 14-3-3 protein in the ancient protozoan parasite Giardia duodenalis

scientific article published on 11 April 2012

Involvement of 14-3-3 protein post-translational modifications in Giardia duodenalis encystation.

scientific article published on 3 September 2009

Key Players in Choline Metabolic Reprograming in Triple-Negative Breast Cancer

scientific article

Macrophages and Phospholipases at the Intersection between Inflammation and the Pathogenesis of HIV-1 Infection

scientific article published on 29 June 2017

Mutations Impairing GSK3-Mediated MAF Phosphorylation Cause Cataract, Deafness, Intellectual Disability, Seizures, and a Down Syndrome-like Facies

scientific article

Mutations in ZBTB20 cause Primrose syndrome

scientific article

Nuclear phosphoinositide-specific phospholipase C β1 controls cytoplasmic CCL2 mRNA levels in HIV-1 gp120-stimulated primary human macrophages

scientific article

P-glycoprotein binds to ezrin at amino acid residues 149-242 in the FERM domain and plays a key role in the multidrug resistance of human osteosarcoma.

scientific article

Phosphatidylcholine-specific phospholipase C activation in epithelial ovarian cancer cells

scientific article published in August 2008

Phosphatidylcholine-specific phospholipase C activation is required for CCR5-dependent, NF-kB-driven CCL2 secretion elicited in response to HIV-1 gp120 in human primary macrophages

scientific article

Phosphatidylcholine-specific phospholipase C inhibition down- regulates CXCR4 expression and interferes with proliferation, invasion and glycolysis in glioma cells

scientific article

Phosphatidylcholine-specific phospholipase C inhibition reduces HER2-overexpression, cell proliferation and in vivo tumor growth in a highly tumorigenic ovarian cancer model

scientific article

Phospholipases: at the crossroads of the immune system and the pathogenesis of HIV-1 infection

scientific article published on November 2016

Pleiotropic function of ezrin in human metastatic melanomas.

scientific article published in June 2009

Proteomic and functional analyses reveal pleiotropic action of the anti-tumoral compound NBDHEX in Giardia duodenalis

scientific article published on 29 March 2017

SHOC2 subcellular shuttling requires the KEKE motif-rich region and N-terminal leucine-rich repeat domain and impacts on ERK signalling

scientific article published on 27 July 2016

TBCE Mutations Cause Early-Onset Progressive Encephalopathy with Distal Spinal Muscular Atrophy

scientific journal article

Targeting CXCR4 by a selective peptide antagonist modulates tumor microenvironment and microglia reactivity in a human glioblastoma model

scientific article published on 25 March 2016

The FAD-dependent glycerol-3-phosphate dehydrogenase of Giardia duodenalis: an unconventional enzyme that interacts with the g14-3-3 and it is a target of the antitumoral compound NBDHEX.

scientific article published on June 2015

The Fatty Acid and Protein Profiles of Circulating CD81-Positive Small Extracellular Vesicles Are Associated with Disease Stage in Melanoma Patients

scientific article published in 2021

List of works by Serena Cecchetti

A variant in the carboxyl-terminus of connexin 40 alters GAP junctions and increases risk for tetralogy of Fallot

Aberrant HRAS transcript processing underlies a distinctive phenotype within the RASopathy clinical spectrum.

Acridine Orange/exosomes increase the delivery and the effectiveness of Acridine Orange in human melanoma cells: A new prototype for theranostics of tumors.

Activating mutations in RRAS underlie a phenotype within the RASopathy spectrum and contribute to leukaemogenesis

Activation of Phosphatidylcholine-Specific Phospholipase C in Breast and Ovarian Cancer: Impact on MRS-Detected Choline Metabolic Profile and Perspectives for Targeted Therapy

Biallelic Mutations in TBCD, Encoding the Tubulin Folding Cofactor D, Perturb Microtubule Dynamics and Cause Early-Onset Encephalopathy

Chemo-immunotherapy induces tumor regression in a mouse model of spontaneous mammary carcinogenesis

Chronic Isolation Stress Affects Central Neuroendocrine Signaling Leading to a Metabolically Active Microenvironment in a Mouse Model of Breast Cancer

Clinical and functional characterization of two novel ZBTB20 mutations causing Primrose syndrome

Defective kinesin binding of TUBB2A causes progressive spastic ataxia syndrome resembling sacsinopathy.

Dematin, a component of the erythrocyte membrane skeleton, is internalized by the malaria parasite and associates with Plasmodium 14-3-3.

Diesel exhaust particle exposure in vitro impacts T lymphocyte phenotype and function

Effects of Mentha suaveolens Essential Oil Alone or in Combination with Other Drugs in Candida albicans

Exosomes from human colorectal cancer induce a tumor-like behavior in colonic mesenchymal stromal cells

Giardia duodenalis 14-3-3 protein is polyglycylated by a tubulin tyrosine ligase-like member and deglycylated by two metallocarboxypeptidases

Immune surveillance properties of human NK cell-derived exosomes.

In Vivo Targeting of Cutaneous Melanoma Using an Melanoma Stimulating Hormone-Engineered Human Protein Cage with Fluorophore and Magnetic Resonance Imaging Tracers.

In vivo targeting of cutaneous melanoma using an MSH-engineered human protein cage bearing fluorophore and MRI tracers.

Inhibition of Phosphatidylcholine-Specific Phospholipase C Interferes with Proliferation and Survival of Tumor Initiating Cells in Squamous Cell Carcinoma

Inhibition of phosphatidylcholine-specific phospholipase C downregulates HER2 overexpression on plasma membrane of breast cancer cells

Inhibition of phosphatidylcholine-specific phospholipase C results in loss of mesenchymal traits in metastatic breast cancer cells

Integrase Defective Lentiviral Vector as a Vaccine Platform for Delivering Influenza Antigens

Interaction network of the 14-3-3 protein in the ancient protozoan parasite Giardia duodenalis

Involvement of 14-3-3 protein post-translational modifications in Giardia duodenalis encystation.

Key Players in Choline Metabolic Reprograming in Triple-Negative Breast Cancer

Macrophages and Phospholipases at the Intersection between Inflammation and the Pathogenesis of HIV-1 Infection

Mutations Impairing GSK3-Mediated MAF Phosphorylation Cause Cataract, Deafness, Intellectual Disability, Seizures, and a Down Syndrome-like Facies

Mutations in ZBTB20 cause Primrose syndrome

Nuclear phosphoinositide-specific phospholipase C β1 controls cytoplasmic CCL2 mRNA levels in HIV-1 gp120-stimulated primary human macrophages

P-glycoprotein binds to ezrin at amino acid residues 149-242 in the FERM domain and plays a key role in the multidrug resistance of human osteosarcoma.

Phosphatidylcholine-specific phospholipase C activation in epithelial ovarian cancer cells

Phosphatidylcholine-specific phospholipase C activation is required for CCR5-dependent, NF-kB-driven CCL2 secretion elicited in response to HIV-1 gp120 in human primary macrophages

Phosphatidylcholine-specific phospholipase C inhibition down- regulates CXCR4 expression and interferes with proliferation, invasion and glycolysis in glioma cells

Phosphatidylcholine-specific phospholipase C inhibition reduces HER2-overexpression, cell proliferation and in vivo tumor growth in a highly tumorigenic ovarian cancer model

Phospholipases: at the crossroads of the immune system and the pathogenesis of HIV-1 infection

Pleiotropic function of ezrin in human metastatic melanomas.

Proteomic and functional analyses reveal pleiotropic action of the anti-tumoral compound NBDHEX in Giardia duodenalis

SHOC2 subcellular shuttling requires the KEKE motif-rich region and N-terminal leucine-rich repeat domain and impacts on ERK signalling

TBCE Mutations Cause Early-Onset Progressive Encephalopathy with Distal Spinal Muscular Atrophy

Targeting CXCR4 by a selective peptide antagonist modulates tumor microenvironment and microglia reactivity in a human glioblastoma model

The FAD-dependent glycerol-3-phosphate dehydrogenase of Giardia duodenalis: an unconventional enzyme that interacts with the g14-3-3 and it is a target of the antitumoral compound NBDHEX.

The Fatty Acid and Protein Profiles of Circulating CD81-Positive Small Extracellular Vesicles Are Associated with Disease Stage in Melanoma Patients