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List of works by Raphael Scharfmann

A human beta cell line with drug inducible excision of immortalizing transgenes

scientific article published on 20 October 2015

A nanobody-based tracer targeting DPP6 for non-invasive imaging of human pancreatic endocrine cells.

scientific article published on 9 November 2017

A new strategy to generate functional insulin-producing cell lines by somatic gene transfer into pancreatic progenitors

scientific article

A search for tyrosine kinase receptors expressed in the rat embryonic pancreas.

scientific article published in December 1998

Activating mutations in the ABCC8 gene in neonatal diabetes mellitus

scientific article

Activation of the transcription factor carbohydrate-responsive element-binding protein by glucose leads to increased pancreatic beta cell differentiation in rats

scientific article

Age-Dependent Pancreatic Gene Regulation Reveals Mechanisms Governing Human β Cell Function

scientific article published on 27 April 2016

Aggregation of Engineered Human β-Cells Into Pseudoislets: Insulin Secretion and Gene Expression Profile in Normoxic and Hypoxic Milieu

scientific article published on 12 August 2016

Alternative sources of beta cells for cell therapy of diabetes.

scientific article

Blood glucose normalization upon transplantation of human embryonic pancreas into beta-cell-deficient SCID mice.

scientific article published in November 2001

Bromodomain and Extra Terminal Protein Inhibitors Promote Pancreatic Endocrine Cell Fate

scientific article published on 17 January 2019

Calsenilin is required for endocrine pancreas development in zebrafish.

scientific article published in June 2007

Characterization of beta cells developed in vitro from rat embryonic pancreatic epithelium.

scientific article published in February 1999

Characterization of stimulus-secretion coupling in the human pancreatic EndoC-βH1 beta cell line.

scientific article

Child health, developmental plasticity, and epigenetic programming

scientific article

Comparison of Human and Murine Enteroendocrine Cells by Transcriptomic and Peptidomic Profiling

scientific article published on 07 February 2019

Concise Review: In Search of Unlimited Sources of Functional Human Pancreatic Beta Cells ⬇️

scientific article published on December 19, 2012

Control of beta-cell differentiation by the pancreatic mesenchyme

scientific article published on 23 February 2007

Control of early development of the pancreas in rodents and humans: implications of signals from the mesenchyme.

scientific article

Control of pancreatic development by intercellular signals.

scientific article published on June 2008

Conventional and Neo-antigenic Peptides Presented by β Cells Are Targeted by Circulating Naïve CD8+ T Cells in Type 1 Diabetic and Healthy Donors

scientific article published on 02 August 2018

Culture, differentiation, and transduction of mouse E12.5 pancreatic spheres: an <i>in vitro</i> model for the secondary transition of pancreas development

scientific article published on 01 March 2021

Cytotoxic and regulatory roles of mucosal-associated invariant T cells in type 1 diabetes

scientific article published on 9 October 2017

DYRK1A BAC transgenic mouse: a new model of thyroid dysgenesis in Down syndrome.

scientific article published on 9 December 2014

Development of a conditionally immortalized human pancreatic β cell line.

scientific article published on 25 March 2014

Development of the pancreas in medaka.

scientific article

Diabetes in very young children and mutations in the insulin-secreting cell potassium channel genes: therapeutic consequences.

scientific article published in January 2007

Differentiation and growth of pancreatic beta cells.

scientific article

Disruption of a novel Kruppel-like transcription factor p300-regulated pathway for insulin biosynthesis revealed by studies of the c.-331 INS mutation found in neonatal diabetes mellitus.

scientific article

Dyrk1A induces pancreatic β cell mass expansion and improves glucose tolerance.

scientific article published on 28 May 2014

Dyrk1a haploinsufficiency induces diabetes in mice through decreased pancreatic beta cell mass

scientific article published on 30 January 2014

EGF-induced proliferation of adult human pancreatic duct cells is mediated by the MEK/ERK cascade.

scientific article published in January 2005

Early pattern of differentiation in the human pancreas

scientific article published on 01 February 2000

Efficient Generation of Glucose-Responsive Beta Cells from Isolated GP2+ Human Pancreatic Progenitors.

scientific article

Efficient restricted gene expression in beta cells by lentivirus-mediated gene transfer into pancreatic stem/progenitor cells.

scientific article published on 10 March 2005

Electrophysiological properties of human beta-cell lines EndoC-βH1 and -βH2 conform with human beta-cells

scientific article published in Scientific Reports

EndoC-βH1 cells display increased sensitivity to sodium palmitate when cultured in DMEM/F12 medium.

scientific article

Epidermal growth factor increases undifferentiated pancreatic embryonic cells in vitro: a balance between proliferation and differentiation.

scientific article

Ex Vivo Expansion and Differentiation of Human and Mouse Fetal Pancreatic Progenitors Are Modulated by Epidermal Growth Factor

scientific article published on 08 June 2015

Ex vivo analysis of acinar and endocrine cell development in the human embryonic pancreas.

scientific article published in October 2005

Expanding human beta cells

scientific article published on 15 February 2008

Expression and functional assessment of candidate type 2 diabetes susceptibility genes identify four new genes contributing to human insulin secretion

scientific article

Expression of functional nerve growth factor receptors in pancreatic beta-cell lines and fetal rat islets in primary culture.

scientific article published on December 1993

Expression of nerve growth factor and its high-affinity receptor Trk-A in the rat pancreas during embryonic and fetal life

scientific article published on 01 March 1998

Expression of neuronal traits in pancreatic beta cells. Implication of neuron-restrictive silencing factor/repressor element silencing transcription factor, a neuron-restrictive silencer.

scientific article published on January 1997

Extracellular acidification stimulates GPR68 mediated IL-8 production in human pancreatic β cells.

scientific article published on 11 May 2016

Fetal pancreas transplants are dependent on prolactin for their development and prevent type 1 diabetes in syngeneic but not allogeneic mice.

scientific article published on 19 February 2013

Fgf10 is essential for maintaining the proliferative capacity of epithelial progenitor cells during early pancreatic organogenesis

scientific article published on 01 December 2001

Fibroblast Growth Factor 2 Promotes Pancreatic Epithelial Cell Proliferation Via Functional Fibroblast Growth Factor Receptors During Embryonic Life ⬇️

scientific article published on August 1, 1998

Follistatin regulates the relative proportions of endocrine versus exocrine tissue during pancreatic development.

scientific article

Fostering improved human islet research: a European perspective

scientific article published on 13 June 2019

Functional antagonism between c-Jun and MyoD proteins: a direct physical association

scientific article (publication date: 7 February 1992)

GATA6 inactivating mutations are associated with heart defects and, inconsistently, with pancreatic agenesis and diabetes

scientific article published on 18 July 2012

Glucocorticoid signalling affects pancreatic development through both direct and indirect effects.

scientific article published on 26 September 2006

Glucose is necessary for embryonic pancreatic endocrine cell differentiation.

scientific article published on 21 March 2007

Growth hormone and prolactin regulate the expression of nerve growth factor receptors in INS-1 cells.

scientific article published on June 1994

HIF1α and pancreatic β-cell development.

scientific article

Histone deacetylase inhibitors modify pancreatic cell fate determination and amplify endocrine progenitors

scientific article published on 18 August 2008

How to make beta cells from embryonic cells

scientific article published on 01 November 2006

Human fucci pancreatic Beta cell lines: new tools to study Beta cell cycle and terminal differentiation. ⬇️

scientific article

Human pancreas endocrine cell populations and activating ABCC8 mutations.

scientific article

Human β cell transcriptome analysis uncovers lncRNAs that are tissue-specific, dynamically regulated, and abnormally expressed in type 2 diabetes

scientific article

Imaging of Human Insulin Secreting Cells with Gd-DOTA-P88, a Paramagnetic Contrast Agent Targeting the Beta Cell Biomarker FXYD2γa

scientific article published on 21 August 2018

Implication of nitric oxide in NGF-induced cell differentiation: differences between neuronal and beta cells.

scientific article published on November 1997

In vivo presence of the high affinity nerve growth factor receptor Trk-A in the rat pancreas: differential localization during pancreatic development

scientific article published on 01 February 1995

Innate and adaptive immunity to human beta cell lines: implications for beta cell therapy

scientific article published on 21 October 2015

Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants

scientific article

Insulin, glucagon and somatostatin in fetal rat islets maintained free-floating in culture: immunocytochemistry and radioimmunoassay

scientific article published on 01 January 1992

Islet-reactive CD8+ T cell frequencies in the pancreas, but not in blood, distinguish type 1 diabetic patients from healthy donors

scientific article published in February 2018

Label-retaining cells in the rat pancreas: location and differentiation potential in vitro.

scientific article published in August 2003

Long-term Metabolic and Socioeducational Outcomes of Transient Neonatal Diabetes: A Longitudinal and Cross-sectional Study

scientific article published on 09 April 2020

Loss-of-Function Mutations in the Cell-Cycle Control Gene CDKN2A Impact on Glucose Homeostasis in Humans. ⬇️

scientific article

Mass production of functional human pancreatic β-cells: why and how?

scientific article published on September 2016

Mesenchymal bone morphogenetic protein signaling is required for normal pancreas development.

scientific article published on 3 June 2010

Mitochondrial Protein UCP2 Controls Pancreas Development

scientific article published on 27 October 2017

Molecular diagnosis of neonatal diabetes mellitus using next-generation sequencing of the whole exome.

scientific article

Molecular phenotyping of multiple mouse strains under metabolic challenge uncovers a role for Elovl2 in glucose-induced insulin secretion

scientific article published on 26 January 2017

MondoA is an Essential Glucose Responsive Transcription Factor in Human Pancreatic Beta Cells.

scientific article

Mouse muscle as an ectopic permissive site for human pancreatic development.

scientific article published on 08 July 2013

Mutations in BOREALIN cause thyroid dysgenesis.

scientific article published on 26 December 2016

Neonatal hyperglycaemia and abnormal development of the pancreas.

scientific article published on February 2008

Neuropsychological dysfunction and developmental defects associated with genetic changes in infants with neonatal diabetes mellitus: a prospective cohort study [corrected].

scientific article

Neurotrophin and neurotrophin receptors in islet cells.

scientific article published on June 1997

Neurotrophin-3 increases intracellular calcium in a rat insulin-secreting cell line through its action on a functional TrkC receptor.

scientific article published on April 1996

New α- and SIN γ-retrovectors for safe transduction and specific transgene expression in pancreatic β cell lines.

scientific article published on 17 June 2019

No evidence for linkage or for diabetes-associated mutations in the activin type 2B receptor gene (ACVR2B) in French patients with mature-onset diabetes of the young or type 2 diabetes.

scientific article

Ontogeny of two topologically distinct TRH-degrading pyroglutamate aminopeptidase activities in the rat liver ⬇️

scientific article published on February 1, 1991

Pancreatic acinar AR42J cells express functional nerve growth factor receptors

scientific article published on 01 March 1999

Pancreatic pattern of expression of thyrotropin-releasing hormone during rat embryonic development

scientific article published on 01 September 2000

Per-arnt-sim (PAS) domain-containing protein kinase is downregulated in human islets in type 2 diabetes and regulates glucagon secretion

scientific journal article

Presence of nerve growth factor and its receptors in an in vitro model of islet cell development: implication in normal islet morphogenesis

scientific article published on 01 July 1995

Pro-oxidant/antioxidant balance controls pancreatic β-cell differentiation through the ERK1/2 pathway

scientific article

RFX6 regulates insulin secretion by modulating Ca2+ homeostasis in human β cells

scientific article

Reconstructing human pancreatic differentiation by mapping specific cell populations during development.

scientific article

Regulation of pancreatic endocrine cell differentiation by sulphated proteoglycans

scientific journal article

Role of the AMP kinase in cytokine-induced human EndoC-βH1 cell death

scientific article published on 23 July 2015

Signaling through fibroblast growth factor receptor 2b plays a key role in the development of the exocrine pancreas.

scientific article published on May 1999

Small-molecule inhibitors of the cystic fibrosis transmembrane conductance regulator increase pancreatic endocrine cell development in rat and mouse

scientific journal article

Solid pseudopapillary neoplasms of the pancreas do not express major pancreatic markers in pediatric patients

scientific article published on 18 August 2018

Structure and function of the exocrine pancreas in patients with type 1 diabetes

scientific article published on 01 June 2019

Systematic Functional Characterization of Candidate Causal Genes for Type 2 Diabetes Risk Variants.

scientific article

TGF-beta activates genes identified by differential mRNA display in pancreatic rudiments

scientific article published on 01 January 2000

TUBB1 mutations cause thyroid dysgenesis associated with abnormal platelet physiology

scientific article published on 01 December 2018

The hexosamine biosynthesis pathway is essential for pancreatic beta cell development.

scientific article published on 07 July 2009

The mesenchyme controls the timing of pancreatic beta-cell differentiation

scientific article published on 01 March 2006

The supply chain of human pancreatic β cell lines

scientific article published on 01 September 2019

Tight hormonal control of PrP gene expression in endocrine pancreatic cells

scientific article published on 01 June 1994

Transcribing neonatal diabetes mellitus

scientific article published on 01 April 2010

Transcription Factor TCF7L2 Genetic Study in the French Population: Expression in Human -Cells and Adipose Tissue and Strong Association With Type 2 Diabetes

article

Transcription factors that shape the mammalian pancreas

scientific article published on 07 September 2020

Tumour suppressor menin is essential for development of the pancreatic endocrine cells.

scientific article published on 4 September 2008

Understanding human fetal pancreas development using subpopulation sorting, RNA sequencing and single-cell profiling

scientific article published on 15 August 2018

Virus-like infection induces human β cell dedifferentiation.

scientific article published on 8 February 2018

Xenotropic retrovirus Bxv1 in human pancreatic β cell lines.

scientific article published on 22 February 2016

[Apollinaire Bouchardat Award 1999. Development of endocrine pancreas cells]

scientific article published on 01 January 1999

[Control of pancreatic development]

scientific article published on 01 January 2003

[Do pancreatic stem cells exist?]

scientific article published on 01 August 2004

[First immortalised cell lines phenotypically and functionally equivalent to human insulin-secreting pancreatic beta cells]

scientific article published on 27 February 2012

[What is a pancreatic stem cell?] ⬇️

scientific article published on 01 June 2003

l-Leucine Alters Pancreatic β-Cell Differentiation and Function via the mTor Signaling Pathway ⬇️

scientific article published on December 30, 2011

mTOR-dependent proliferation defect in human ES-derived neural stem cells affected by myotonic dystrophy type 1.

scientific article published on 26 February 2013

von Hippel-Lindau gene disruption in mouse pancreatic progenitors and its consequences on endocrine differentiation in vivo: importance of HIF1-α and VEGF-A upregulation

scientific journal article

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