List of works - Markus Missler

A rare autism-associated MINT2/APBA2 mutation disrupts neurexin trafficking and synaptic function

scientific article published on 15 April 2019

Alpha-neurexins couple Ca2+ channels to synaptic vesicle exocytosis

scientific journal article

Altered social behaviours in neurexin 1α knockout mice resemble core symptoms in neurodevelopmental disorders.

scientific article

Astrocyte pathology in a human neural stem cell model of frontotemporal dementia caused by mutant TAU protein.

scientific article published on 03 March 2017

Autocellular coupling by gap junctions in cultured astrocytes: A new view on cellular autoregulation during process formation ⬇️

scientific article published on September 1, 1998

Auxiliary α2δ1 and α2δ3 subunits of calcium channels drive excitatory and inhibitory neuronal network development

scientific article published on 15 May 2020

Common exonic missense variants in the C2 domain of the human KIBRA protein modify lipid binding and cognitive performance ⬇️

scientific article published on June 18, 2013

Complexins: cytosolic proteins that regulate SNAP receptor function

scientific article

Deletion of CASK in mice is lethal and impairs synaptic function

scientific article

Deletion of KIBRA, protein expressed in kidney and brain, increases filopodial-like long dendritic spines in neocortical and hippocampal neurons in vivo and in vitro

scientific article published on 20 February 2015

Deletion of alpha-neurexins does not cause a major impairment of axonal pathfinding or synapse formation

scientific article published in May 2007

Dendritic spine formation and synaptic function require neurobeachin.

scientific article published on 22 November 2011

Differential response to endothelial epithelial sodium channel inhibition ex vivo correlates with arterial stiffness in humans

scientific article published on 16 September 2015

Dynamic association of calcium channel subunits at the cellular membrane.

scientific article published on October 2016

Dystroglycan binding to α-neurexin competes with neurexophilin-1 and neuroligin in the brain.

scientific article published on 25 August 2014

Early defects of GABAergic synapses in the brain stem of a MeCP2 mouse model of Rett syndrome.

scientific article published on 21 November 2007

Enhanced LTP of population spikes in the dentate gyrus of mice haploinsufficient for neurobeachin

scientific article published on 29 September 2020

Essential functions of synapsins I and II in synaptic vesicle regulation

scientific journal article

Expression of C1ql3 in Discrete Neuronal Populations Controls Efferent Synapse Numbers and Diverse Behaviors

scientific article

Extracellular domains of alpha-neurexins participate in regulating synaptic transmission by selectively affecting N- and P/Q-type Ca2+ channels.

scientific article published in April 2005

Genetic targeting of NRXN2 in mice unveils role in excitatory cortical synapse function and social behaviors

scientific article

Imaging of molecular surface dynamics in brain slices using single-particle tracking

scientific article

Important contribution of alpha-neurexins to Ca2+-triggered exocytosis of secretory granules.

scientific article published on October 2006

MAGUKs end a tale of promiscuity.

scientific article

Modulation of synaptic function through the α-neurexin-specific ligand neurexophilin-1.

scientific article published on 17 March 2014

Molecular Dissection of Neurobeachin Function at Excitatory Synapses

scientific article published on 15 August 2018

Mutational analysis of the neurexin/neuroligin complex reveals essential and regulatory components

scientific article

Neurexin I alpha is a major alpha-latrotoxin receptor that cooperates in alpha-latrotoxin action

scientific journal article

Neurexins.

scientific article

Neurexins: three genes and 1001 products

scientific article

Neurexophilin 3 is highly localized in cortical and cerebellar regions and is functionally important for sensorimotor gating and motor coordination

scientific article

Neurexophilin binding to alpha-neurexins. A single LNS domain functions as an independently folding ligand-binding unit

scientific article

Neurexophilins form a conserved family of neuropeptide-like glycoproteins

scientific article

Neurobeachin, a protein implicated in membrane protein traffic and autism, is required for the formation and functioning of central synapses.

scientific article published in September 2009

Neuroligins determine synapse maturation and function

scientific journal article

Polarized targeting of neurexins to synapses is regulated by their C-terminal sequences

scientific journal article

Postnatal development of glial fibrillary acidic protein, vimentin and S100 protein in monkey visual cortex: evidence for a transient reduction of GFAP immunoreactivity

scientific article published on 01 October 1994

Postsynaptic N-methyl-D-aspartate receptor function requires alpha-neurexins

scientific article

Pre- and postnatal development of the primary visual cortex of the common marmoset. II. Formation, remodelling, and elimination of synapses as overlapping processes.

scientific article

Presynaptic αδ-2 Calcium Channel Subunits Regulate Postsynaptic GABA Receptor Abundance and Axonal Wiring

scientific article published on 25 January 2019

Promoter-like sequences regulating transcriptional activity in neurexin and neuroligin genes

scientific article published on 21 August 2013

Protein mutated in paroxysmal dyskinesia interacts with the active zone protein RIM and suppresses synaptic vesicle exocytosis

scientific article

Rapid and robust generation of long-term self-renewing human neural stem cells with the ability to generate mature astroglia.

scientific article

Rapid morphological changes in astrocytes are accompanied by redistribution but not by quantitative changes of cytoskeletal proteins.

scientific article published in October 2001

Regulated Dynamic Trafficking of Neurexins Inside and Outside of Synaptic Terminals.

scientific article published in October 2015

SV2A and SV2B function as redundant Ca2+ regulators in neurotransmitter release

scientific journal article

Structural dynamics of synapses and synaptic components

scientific article published on January 1995

Structure and evolution of neurexophilin

scientific article

Synaptic assembly of the brain in the absence of neurotransmitter secretion

scientific article

Synaptic cell adhesion

scientific article

Synaptic cell adhesion goes functional ⬇️

scientific article published on April 1, 2003

The Sushi domains of GABAB receptors function as axonal targeting signals

scientific article published in January 2010

The making of neurexins

scientific article

The resilient synapse: insights from genetic interference of synaptic cell adhesion molecules.

scientific article published on 20 July 2006

Unveiled α−Neurexins Take Center Stage ⬇️

scientific article published on 01 June 2011

alpha-Neurexins are required for efficient transmitter release and synaptic homeostasis at the mouse neuromuscular junction

scientific article published on 10 January 2006

p140Cap regulates memory and synaptic plasticity through Src-mediated and citron-N-mediated actin reorganization.

scientific article published in January 2014

α-Neurexins Together with α2δ-1 Auxiliary Subunits Regulate Ca2+ Influx through Cav2.1 Channels.

scientific article published on 13 August 2018

α2δ-4 and Cachd1 Proteins Are Regulators of Presynaptic Functions

scientific article published in 2022

List of works by Markus Missler

A rare autism-associated MINT2/APBA2 mutation disrupts neurexin trafficking and synaptic function

Alpha-neurexins couple Ca2+ channels to synaptic vesicle exocytosis

Altered social behaviours in neurexin 1α knockout mice resemble core symptoms in neurodevelopmental disorders.

Astrocyte pathology in a human neural stem cell model of frontotemporal dementia caused by mutant TAU protein.

Autocellular coupling by gap junctions in cultured astrocytes: A new view on cellular autoregulation during process formation ⬇️

Auxiliary α2δ1 and α2δ3 subunits of calcium channels drive excitatory and inhibitory neuronal network development

Common exonic missense variants in the C2 domain of the human KIBRA protein modify lipid binding and cognitive performance ⬇️

Complexins: cytosolic proteins that regulate SNAP receptor function

Deletion of CASK in mice is lethal and impairs synaptic function

Deletion of KIBRA, protein expressed in kidney and brain, increases filopodial-like long dendritic spines in neocortical and hippocampal neurons in vivo and in vitro

Deletion of alpha-neurexins does not cause a major impairment of axonal pathfinding or synapse formation

Dendritic spine formation and synaptic function require neurobeachin.

Differential response to endothelial epithelial sodium channel inhibition ex vivo correlates with arterial stiffness in humans

Dynamic association of calcium channel subunits at the cellular membrane.

Dystroglycan binding to α-neurexin competes with neurexophilin-1 and neuroligin in the brain.

Early defects of GABAergic synapses in the brain stem of a MeCP2 mouse model of Rett syndrome.

Enhanced LTP of population spikes in the dentate gyrus of mice haploinsufficient for neurobeachin

Essential functions of synapsins I and II in synaptic vesicle regulation

Expression of C1ql3 in Discrete Neuronal Populations Controls Efferent Synapse Numbers and Diverse Behaviors

Extracellular domains of alpha-neurexins participate in regulating synaptic transmission by selectively affecting N- and P/Q-type Ca2+ channels.

Genetic targeting of NRXN2 in mice unveils role in excitatory cortical synapse function and social behaviors

Imaging of molecular surface dynamics in brain slices using single-particle tracking

Important contribution of alpha-neurexins to Ca2+-triggered exocytosis of secretory granules.

MAGUKs end a tale of promiscuity.

Modulation of synaptic function through the α-neurexin-specific ligand neurexophilin-1.

Molecular Dissection of Neurobeachin Function at Excitatory Synapses

Mutational analysis of the neurexin/neuroligin complex reveals essential and regulatory components

Neurexin I alpha is a major alpha-latrotoxin receptor that cooperates in alpha-latrotoxin action

Neurexins.

Neurexins: three genes and 1001 products

Neurexophilin 3 is highly localized in cortical and cerebellar regions and is functionally important for sensorimotor gating and motor coordination

Neurexophilin binding to alpha-neurexins. A single LNS domain functions as an independently folding ligand-binding unit

Neurexophilins form a conserved family of neuropeptide-like glycoproteins

Neurobeachin, a protein implicated in membrane protein traffic and autism, is required for the formation and functioning of central synapses.

Neuroligins determine synapse maturation and function

Polarized targeting of neurexins to synapses is regulated by their C-terminal sequences

Postnatal development of glial fibrillary acidic protein, vimentin and S100 protein in monkey visual cortex: evidence for a transient reduction of GFAP immunoreactivity

Postsynaptic N-methyl-D-aspartate receptor function requires alpha-neurexins

Pre- and postnatal development of the primary visual cortex of the common marmoset. II. Formation, remodelling, and elimination of synapses as overlapping processes.

Presynaptic αδ-2 Calcium Channel Subunits Regulate Postsynaptic GABA Receptor Abundance and Axonal Wiring

Promoter-like sequences regulating transcriptional activity in neurexin and neuroligin genes

Protein mutated in paroxysmal dyskinesia interacts with the active zone protein RIM and suppresses synaptic vesicle exocytosis

Rapid and robust generation of long-term self-renewing human neural stem cells with the ability to generate mature astroglia.

Rapid morphological changes in astrocytes are accompanied by redistribution but not by quantitative changes of cytoskeletal proteins.

Regulated Dynamic Trafficking of Neurexins Inside and Outside of Synaptic Terminals.

SV2A and SV2B function as redundant Ca2+ regulators in neurotransmitter release

Structural dynamics of synapses and synaptic components

Structure and evolution of neurexophilin

Synaptic assembly of the brain in the absence of neurotransmitter secretion

Synaptic cell adhesion

Synaptic cell adhesion goes functional ⬇️

The Sushi domains of GABAB receptors function as axonal targeting signals

The making of neurexins

The resilient synapse: insights from genetic interference of synaptic cell adhesion molecules.

Unveiled α−Neurexins Take Center Stage ⬇️

alpha-Neurexins are required for efficient transmitter release and synaptic homeostasis at the mouse neuromuscular junction

p140Cap regulates memory and synaptic plasticity through Src-mediated and citron-N-mediated actin reorganization.

α-Neurexins Together with α2δ-1 Auxiliary Subunits Regulate Ca2+ Influx through Cav2.1 Channels.

α2δ-4 and Cachd1 Proteins Are Regulators of Presynaptic Functions