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List of works by Janine Kutzsche

Aβ Oligomer Elimination Restores Cognition in Transgenic Alzheimer's Mice with Full-blown Pathology

scientific article published on 12 July 2018

Aβ oligomer eliminating compounds interfere successfully with pEAβ(3-42) induced motor neurodegenerative phenotype in transgenic mice.

scientific article published on 27 November 2017

Combining independent drug classes into superior, synergistically acting hybrid molecules.

scientific article published in November 2010

Comparison of blood-brain barrier penetration efficiencies between linear and cyclic all-d-enantiomeric peptides developed for the treatment of Alzheimer's disease

scientific article

Competitive Mirror Image Phage Display Derived Peptide Modulates Amyloid Beta Aggregation and Toxicity

scientific article

Correction: Competitive Mirror Image Phage Display Derived Peptide Modulates Amyloid Beta Aggregation and Toxicity

scientific article published on 12 July 2016

Development and validation of an UHPLC-ESI-QTOF-MS method for quantification of the highly hydrophilic amyloid-β oligomer eliminating all-D-enantiomeric peptide RD2 in mouse plasma

scientific article published on 8 December 2017

In Vitro Potency and Preclinical Pharmacokinetic Comparison of All-D-Enantiomeric Peptides Developed for the Treatment of Alzheimer's Disease

scientific article published on 01 January 2018

Increase of Positive Net Charge and Conformational Rigidity Enhances the Efficacy of d-Enantiomeric Peptides Designed to Eliminate Cytotoxic Aβ Species.

scientific article published on 31 May 2016

Large-Scale Oral Treatment Study with the Four Most Promising D3-Derivatives for the Treatment of Alzheimer's Disease

scientific article

Optimization of d-Peptides for Aβ Monomer Binding Specificity Enhances Their Potential to Eliminate Toxic Aβ Oligomers.

scientific article published on 5 June 2017

Optimization of the All-D Peptide D3 for Aβ Oligomer Elimination

scientific article

Pharmacokinetic Properties of a Novel D-Peptide Developed to be Therapeutically Active Against Toxic β-Amyloid Oligomers.

scientific article published on 17 September 2015

Pharmacokinetic properties of tandem d-peptides designed for treatment of Alzheimer's disease.

scientific article published on 13 April 2016

Preclinical Pharmacokinetic Studies of the Tritium Labelled D-Enantiomeric Peptide D3 Developed for the Treatment of Alzheimer´s Disease

scientific article (publication date: 2015)

QIAD assay for quantitating a compound's efficacy in elimination of toxic Aβ oligomers

scientific article

Structure characterization of unexpected covalent O-sulfonation and ion-pairing on an extremely hydrophilic peptide with CE-MS and FT-ICR-MS.

scientific article published on 28 June 2015

Surprisingly high stability of the Aβ oligomer eliminating all-d-enantiomeric peptide D3 in media simulating the route of orally administered drugs

scientific article published on 12 July 2017

The Aβ oligomer eliminating D-enantiomeric peptide RD2 improves cognition without changing plaque pathology

scientific article published on 24 November 2017

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