List of works - Lothar Gremer

A BAR domain-mediated autoinhibitory mechanism for RhoGAPs of the GRAF family

scientific article

A D-enantiomeric peptide interferes with hetero-association of amyloid-β oligomers and prion protein

scientific article published in Journal of Biological Chemistry

A near atomic-scale view at the composition of amyloid-beta fibrils by atom probe tomography

scientific article published in Scientific Reports

A novel binuclear [CuSMo] cluster at the active site of carbon monoxide dehydrogenase: characterization by X-ray absorption spectroscopy

scientific article

A restricted spectrum of NRAS mutations causes Noonan syndrome

scientific article

Analysis of the Bin1 SH3 interaction with peptides derived from the hepatitis C virus protein NS5A and c-Myc reveals that NS5A can competitively displace c-Myc in vitro.

scientific article

Arl2-GTP and Arl3-GTP regulate a GDI-like transport system for farnesylated cargo

scientific article

Arl3 regulates a transport system for farnesylated cargo

Atomic structure of PI3-kinase SH3 amyloid fibrils by cryo-electron microscopy

scientific article published on 21 August 2019

Binding modes of thioflavin T and Congo red to the fibril structure of amyloid-β(1-42)

scientific article published on 08 June 2020

Binding of Flavin Adenine Dinucleotide to Molybdenum-containing Carbon Monoxide Dehydrogenase fromOligotropha carboxidovorans

scientific article published in Journal of Biological Chemistry

Biochemical Assays to Characterize Rho GTPases ⬇️

scientific article published on January 1, 2012

Catalysis at a dinuclear [CuSMo(==O)OH] cluster in a CO dehydrogenase resolved at 1.1-A resolution

scientific article

Characterization of xanthine dehydrogenase from the anaerobic bacterium Veillonella atypica and identification of a molybdopterin-cytosine-dinucleotide-containing molybdenum cofactor

scientific article published in June 1996

Clustering of human prion protein and α-synuclein oligomers requires the prion protein N-terminus

scientific article published on 09 July 2020

Competitive Mirror Image Phage Display Derived Peptide Modulates Amyloid Beta Aggregation and Toxicity

scientific article

Correction: Competitive Mirror Image Phage Display Derived Peptide Modulates Amyloid Beta Aggregation and Toxicity

scientific article published on 12 July 2016

Cryo-EM structure of islet amyloid polypeptide fibrils reveals similarities with amyloid-β fibrils

scientific article published on 15 June 2020

Crystal structure of a carbon monoxide dehydrogenase reveals a [Ni-4Fe-5S] cluster

scientific article (publication date: 17 August 2001)

Diverging gain-of-function mechanisms of two novel KRAS mutations associated with Noonan and cardio-facio-cutaneous syndromes

scientific article

Duplication of Glu37 in the switch I region of HRAS impairs effector/GAP binding and underlies Costello syndrome by promoting enhanced growth factor-dependent MAPK and AKT activation

scientific article published on 8 December 2009

Engineered aggregation inhibitor fusion for production of highly amyloidogenic human islet amyloid polypeptide

scientific article

Fibril structure of amyloid-β(1-42) by cryo-electron microscopy

scientific article

Fluoride complexes of oncogenic Ras mutants to study the Ras-RasGap interaction

scientific article published in September 2008

Germline KRAS mutations cause aberrant biochemical and physical properties leading to developmental disorders

scientific article published on 9 December 2010

High-Affinity Binding of Monomeric but Not Oligomeric Amyloid-β to Ganglioside GM1 Containing Nanodiscs

scientific article published on 18 November 2016

IQGAP1 Interaction with RHO Family Proteins Revisited: KINETIC AND EQUILIBRIUM EVIDENCE FOR MULTIPLE DISTINCT BINDING SITES.

scientific article published on 4 November 2016

Impact of subunit linkages in an engineered homodimeric binding protein to α-synuclein

scientific article

Increase of Positive Net Charge and Conformational Rigidity Enhances the Efficacy of d-Enantiomeric Peptides Designed to Eliminate Cytotoxic Aβ Species.

scientific article published on 31 May 2016

Liposome reconstitution and modulation of recombinant prenylated human Rac1 by GEFs, GDI1 and Pak1.

scientific article

Mechanistic insights into specificity, activity, and regulatory elements of the regulator of G-protein signaling (RGS)-containing Rho-specific guanine nucleotide exchange factors (GEFs) p115, PDZ-RhoGEF (PRG), and leukemia-associated RhoGEF (LARG).

scientific article published on 28 March 2011

Opposed Effects of Dityrosine Formation in Soluble and Aggregated α-Synuclein on Fibril Growth

scientific article published on 13 September 2017

Optimization of d-Peptides for Aβ Monomer Binding Specificity Enhances Their Potential to Eliminate Toxic Aβ Oligomers.

scientific article published on 5 June 2017

Optimization of the All-D Peptide D3 for Aβ Oligomer Elimination

scientific article

Origin of metastable oligomers and their effects on amyloid fibril self-assembly

scientific article published on 13 June 2018

Phosphorylated tyrosine 93 of hepatitis C virus nonstructural protein 5A is essential for interaction with host c-Src and efficient viral replication

scientific article published on 12 March 2019

Platelets contribute to amyloid-β aggregation in cerebral vessels through integrin αIIbβ3-induced outside-in signaling and clusterin release

scientific article published on 24 May 2016

Preclinical Pharmacokinetic Studies of the Tritium Labelled D-Enantiomeric Peptide D3 Developed for the Treatment of Alzheimer´s Disease

scientific article (publication date: 2015)

Purification and Characterization of Recombinant N-Terminally Pyroglutamate-Modified Amyloid-β Variants and Structural Analysis by Solution NMR Spectroscopy

scientific article

Pyroglutamate-Modified Amyloid-β(3-42) Shows α-Helical Intermediates before Amyloid Formation

scientific article

QIAD assay for quantitating a compound's efficacy in elimination of toxic Aβ oligomers

scientific article

Relevance of N-terminal residues for amyloid-β binding to platelet integrin α IIb β 3 , integrin outside-in signaling and amyloid-β fibril formation

Rho-kinase: regulation, (dys)function, and inhibition

scientific article

Role of centrosomal adaptor proteins of the TACC family in the regulation of microtubule dynamics during mitotic cell division

scientific article

Stabilizing a weak binding state for effectors in the human ras protein by cyclen complexes

scientific article

Structural Analysis and Aggregation Propensity of Pyroglutamate Aβ(3-40) in Aqueous Trifluoroethanol

scientific article

Structural Characterization of Fibrils from Recombinant Human Islet Amyloid Polypeptide by Solid-State NMR: The Central FGAILS Segment Is Part of the β-Sheet Core

scientific article

Structural analysis of the pyroglutamate-modified isoform of the Alzheimer's disease-related amyloid-β using NMR spectroscopy

scientific article published on 24 September 2012

Surprisingly high stability of the Aβ oligomer eliminating all-d-enantiomeric peptide D3 in media simulating the route of orally administered drugs

scientific article published on 12 July 2017

Synthesis of the Rheb and K-Ras4B GTPases

The Aβ oligomer eliminating D-enantiomeric peptide RD2 improves cognition without changing plaque pathology

scientific article published on 24 November 2017

The C2 domain of SynGAP is essential for stimulation of the Rap GTPase reaction

scientific article

The centrosomal adaptor TACC3 and the microtubule polymerase chTOG interact via defined C-terminal subdomains in an Aurora-A kinase-independent manner.

scientific article published on 22 November 2013

The effect of intracellular molybdenum in Hydrogenophaga pseudoflava on the crystallographic structure of the seleno-molybdo-iron-sulfur flavoenzyme carbon monoxide dehydrogenase

scientific article

The role of Se, Mo and Fe in the structure and function of carbon monoxide dehydrogenase

scientific article

Two novel germline KRAS mutations: expanding the molecular and clinical phenotype

scientific article published on 18 August 2011

β-Hairpin of Islet Amyloid Polypeptide Bound to an Aggregation Inhibitor

scientific article published on 19 September 2016

List of works by Lothar Gremer

A BAR domain-mediated autoinhibitory mechanism for RhoGAPs of the GRAF family

A D-enantiomeric peptide interferes with hetero-association of amyloid-β oligomers and prion protein

A near atomic-scale view at the composition of amyloid-beta fibrils by atom probe tomography

A novel binuclear [CuSMo] cluster at the active site of carbon monoxide dehydrogenase: characterization by X-ray absorption spectroscopy

A restricted spectrum of NRAS mutations causes Noonan syndrome

Analysis of the Bin1 SH3 interaction with peptides derived from the hepatitis C virus protein NS5A and c-Myc reveals that NS5A can competitively displace c-Myc in vitro.

Arl2-GTP and Arl3-GTP regulate a GDI-like transport system for farnesylated cargo

Arl3 regulates a transport system for farnesylated cargo

Atomic structure of PI3-kinase SH3 amyloid fibrils by cryo-electron microscopy

Binding modes of thioflavin T and Congo red to the fibril structure of amyloid-β(1-42)

Binding of Flavin Adenine Dinucleotide to Molybdenum-containing Carbon Monoxide Dehydrogenase fromOligotropha carboxidovorans

Biochemical Assays to Characterize Rho GTPases ⬇️

Catalysis at a dinuclear [CuSMo(==O)OH] cluster in a CO dehydrogenase resolved at 1.1-A resolution

Characterization of xanthine dehydrogenase from the anaerobic bacterium Veillonella atypica and identification of a molybdopterin-cytosine-dinucleotide-containing molybdenum cofactor

Clustering of human prion protein and α-synuclein oligomers requires the prion protein N-terminus

Competitive Mirror Image Phage Display Derived Peptide Modulates Amyloid Beta Aggregation and Toxicity

Correction: Competitive Mirror Image Phage Display Derived Peptide Modulates Amyloid Beta Aggregation and Toxicity

Cryo-EM structure of islet amyloid polypeptide fibrils reveals similarities with amyloid-β fibrils

Crystal structure of a carbon monoxide dehydrogenase reveals a [Ni-4Fe-5S] cluster

Diverging gain-of-function mechanisms of two novel KRAS mutations associated with Noonan and cardio-facio-cutaneous syndromes

Duplication of Glu37 in the switch I region of HRAS impairs effector/GAP binding and underlies Costello syndrome by promoting enhanced growth factor-dependent MAPK and AKT activation

Engineered aggregation inhibitor fusion for production of highly amyloidogenic human islet amyloid polypeptide

Fibril structure of amyloid-β(1-42) by cryo-electron microscopy

Fluoride complexes of oncogenic Ras mutants to study the Ras-RasGap interaction

Germline KRAS mutations cause aberrant biochemical and physical properties leading to developmental disorders

High-Affinity Binding of Monomeric but Not Oligomeric Amyloid-β to Ganglioside GM1 Containing Nanodiscs

IQGAP1 Interaction with RHO Family Proteins Revisited: KINETIC AND EQUILIBRIUM EVIDENCE FOR MULTIPLE DISTINCT BINDING SITES.

Impact of subunit linkages in an engineered homodimeric binding protein to α-synuclein

Increase of Positive Net Charge and Conformational Rigidity Enhances the Efficacy of d-Enantiomeric Peptides Designed to Eliminate Cytotoxic Aβ Species.

Liposome reconstitution and modulation of recombinant prenylated human Rac1 by GEFs, GDI1 and Pak1.

Mechanistic insights into specificity, activity, and regulatory elements of the regulator of G-protein signaling (RGS)-containing Rho-specific guanine nucleotide exchange factors (GEFs) p115, PDZ-RhoGEF (PRG), and leukemia-associated RhoGEF (LARG).

Opposed Effects of Dityrosine Formation in Soluble and Aggregated α-Synuclein on Fibril Growth

Optimization of d-Peptides for Aβ Monomer Binding Specificity Enhances Their Potential to Eliminate Toxic Aβ Oligomers.

Optimization of the All-D Peptide D3 for Aβ Oligomer Elimination

Origin of metastable oligomers and their effects on amyloid fibril self-assembly

Phosphorylated tyrosine 93 of hepatitis C virus nonstructural protein 5A is essential for interaction with host c-Src and efficient viral replication

Platelets contribute to amyloid-β aggregation in cerebral vessels through integrin αIIbβ3-induced outside-in signaling and clusterin release

Preclinical Pharmacokinetic Studies of the Tritium Labelled D-Enantiomeric Peptide D3 Developed for the Treatment of Alzheimer´s Disease

Purification and Characterization of Recombinant N-Terminally Pyroglutamate-Modified Amyloid-β Variants and Structural Analysis by Solution NMR Spectroscopy

Pyroglutamate-Modified Amyloid-β(3-42) Shows α-Helical Intermediates before Amyloid Formation

QIAD assay for quantitating a compound's efficacy in elimination of toxic Aβ oligomers

Relevance of N-terminal residues for amyloid-β binding to platelet integrin α IIb β 3 , integrin outside-in signaling and amyloid-β fibril formation

Rho-kinase: regulation, (dys)function, and inhibition

Role of centrosomal adaptor proteins of the TACC family in the regulation of microtubule dynamics during mitotic cell division

Stabilizing a weak binding state for effectors in the human ras protein by cyclen complexes

Structural Analysis and Aggregation Propensity of Pyroglutamate Aβ(3-40) in Aqueous Trifluoroethanol

Structural Characterization of Fibrils from Recombinant Human Islet Amyloid Polypeptide by Solid-State NMR: The Central FGAILS Segment Is Part of the β-Sheet Core

Structural analysis of the pyroglutamate-modified isoform of the Alzheimer's disease-related amyloid-β using NMR spectroscopy

Surprisingly high stability of the Aβ oligomer eliminating all-d-enantiomeric peptide D3 in media simulating the route of orally administered drugs

Synthesis of the Rheb and K-Ras4B GTPases

The Aβ oligomer eliminating D-enantiomeric peptide RD2 improves cognition without changing plaque pathology

The C2 domain of SynGAP is essential for stimulation of the Rap GTPase reaction

The centrosomal adaptor TACC3 and the microtubule polymerase chTOG interact via defined C-terminal subdomains in an Aurora-A kinase-independent manner.

The effect of intracellular molybdenum in Hydrogenophaga pseudoflava on the crystallographic structure of the seleno-molybdo-iron-sulfur flavoenzyme carbon monoxide dehydrogenase

The role of Se, Mo and Fe in the structure and function of carbon monoxide dehydrogenase

Two novel germline KRAS mutations: expanding the molecular and clinical phenotype

β-Hairpin of Islet Amyloid Polypeptide Bound to an Aggregation Inhibitor