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List of works by Metin Avkiran

A chemical genetic approach reveals that p38alpha MAPK activation by diphosphorylation aggravates myocardial infarction and is prevented by the direct binding of SB203580.

scientific article published on 7 December 2009

A critical function for Ser-282 in cardiac Myosin binding protein-C phosphorylation and cardiac function

scientific article (publication date: 8 July 2011)

A novel role for protein phosphatase 2A in receptor-mediated regulation of the cardiac sarcolemmal Na+/H+ exchanger NHE1

scientific article published on 16 May 2006

Activation of p38 Mitogen-Activated Protein Kinase Contributes to the Early Cardiodepressant Action of Tumor Necrosis Factor

article

Anti-arrhythmic effects of levcromakalim in the ischaemic rat heart: a dual mechanism of action?

scientific article published on 01 August 2000

Assessing structural and functional responses of murine hearts to acute and sustained β-adrenergic stimulation in vivo.

scientific article published on 30 January 2016

Blowing off acid: a new tool to study Na+/HCO3- co-transport.

scientific article published on 21 January 2008

Ca2+/calmodulin-dependent protein kinase IIdelta and protein kinase D overexpression reinforce the histone deacetylase 5 redistribution in heart failure

scientific article

Cardiovascular side effects of cancer therapies: a position statement from the Heart Failure Association of the European Society of Cardiology

scientific article published on January 2011

Distinct sarcomeric substrates are responsible for protein kinase D-mediated regulation of cardiac myofilament Ca2+ sensitivity and cross-bridge cycling ⬇️

scientific article

Distinct signaling pathways mediate cardiomyocyte phospholipase D stimulation by endothelin-1 and thrombin.

scientific article

Effects of bisindolylmaleimide PKC inhibitors on p90RSK activity in vitro and in adult ventricular myocytes.

scientific article published on June 2005

Effects of moderate hypothermia on sarcolemmal Na+/H+ exchanger activity and its inhibition by cariporide in cardiac ventricular myocytes ⬇️

scientific article published on December 1, 2001

Evidence for direct regulation of myocardial Na+/H+ exchanger isoform 1 phosphorylation and activity by 90-kDa ribosomal S6 kinase (RSK): effects of the novel and specific RSK inhibitor fmk on responses to alpha1-adrenergic stimulation

scientific article published on 01 December 2006

Exchanging cardiac phenotype: Is AKT-mediated NHE1 inhibition a permissive switch in physiological hypertrophy?

scientific article published on 23 October 2014

Expression and activity of protein kinase D/protein kinase C mu in myocardium: evidence for alpha1-adrenergic receptor- and protein kinase C-mediated regulation.

scientific article published in June 2000

Feeling the stress: MAPKKK-MAPKK-MAPK signaling cascades in heart failure

scientific article published in February 2010

Four-and-a-half LIM domains proteins are novel regulators of the protein kinase D pathway in cardiac myocytes

scientific article published on February 2014

Glycogen synthase kinase-3 inactivation is not required for ischemic preconditioning or postconditioning in the mouse

scientific article published on 26 June 2008

Increased myofilament Ca2+ sensitivity and diastolic dysfunction as early consequences of Mybpc3 mutation in heterozygous knock-in mice

scientific article

Influence of isoprostane F2α-III on reflow after myocardial infarction

scientific article published in May 2004

Inhibition of angiotensin-converting enzyme reduces susceptibility of hypertrophied rat myocardium to ventricular fibrillation.

scientific article published in November 2002

Monophosphorylation of cardiac troponin-I at Ser23/24 is sufficient to regulate cardiac myofibrillar Ca2+ sensitivity and calpain-induced proteolysis.

scientific article published on 18 April 2018

Normal passive viscoelasticity but abnormal myofibrillar force generation in human hypertrophic cardiomyopathy

scientific article

Novel role for p90 ribosomal S6 kinase in the regulation of cardiac myofilament phosphorylation

scientific article

Paradoxical resistance to myocardial ischemia and age-related cardiomyopathy in NHE1 transgenic mice: a role for ER stress?

scientific article published on 5 November 2008

Phosphoregulation of the titin-cap protein telethonin in cardiac myocytes

scientific article

Protein kinase B/Akt phosphorylates and inhibits the cardiac Na+/H+ exchanger NHE1.

scientific article published on 28 August 2008

Protein kinase D is a novel mediator of cardiac troponin I phosphorylation and regulates myofilament function

scientific article

Protein kinase D selectively targets cardiac troponin I and regulates myofilament Ca2+ sensitivity in ventricular myocytes

scientific article published on 22 February 2007

Protein kinase d in the cardiovascular system: emerging roles in health and disease.

scientific article published on February 2008

Proteomics analysis of the cardiac myofilament subproteome reveals dynamic alterations in phosphatase subunit distribution

scientific article

Regulation of PP2AC carboxylmethylation and cellular localisation by inhibitory class G-protein coupled receptors in cardiomyocytes.

scientific article published on 27 January 2014

Regulation of protein kinase D activity in adult myocardium: novel counter-regulatory roles for protein kinase Cepsilon and protein kinase A.

scientific article published on 4 October 2007

Regulation of sarcolemmal Na(+)/H(+) exchange by hydrogen peroxide in adult rat ventricular myocytes.

scientific article published in February 2002

Regulation of the extracellular signal-regulated kinase pathway in adult myocardium: differential roles of G(q/11), Gi and G(12/13) proteins in signalling by alpha1-adrenergic, endothelin-1 and thrombin-sensitive protease-activated receptors.

scientific article published in May 2005

Regulatory effects of G protein-coupled receptors on cardiac sarcolemmal Na+/H+ exchanger activity: signalling and significance.

scientific article

Roles and post-translational regulation of cardiac class IIa histone deacetylase isoforms.

scientific article published on 25 November 2014

Sarcolemmal Na+/H+ exchanger activity and expression in human ventricular myocardium

scientific article published on 01 August 2000

Specificity of action of bisindolylmaleimide protein kinase C inhibitors: do they inhibit the 70kDa ribosomal S6 kinase in cardiac myocytes?

scientific article published in November 2004

Stimulation of the plasma membrane Na+/H+ exchanger NHE1 by sustained intracellular acidosis. Evidence for a novel mechanism mediated by the ERK pathway.

scientific article

Susceptibility to ischemia and reperfusion arrhythmias in myocardial hypertrophy: due to flow of injury current?

scientific article published on 01 November 2003

Targeting Na+/H+ exchanger regulation for cardiac protection: a RSKy approach?

scientific article published on 28 January 2008

The ERK pathway regulates Na(+)-HCO(3)(-) cotransport activity in adult rat cardiomyocytes.

scientific article published in November 2002

The salt of the earth: focus on Na⁺ regulation in the cardiac myocyte

scientific article published on 11 June 2013

Translating molecular target into drug therapy in cardiovascular disease

scientific article published on 21 February 2008

cMyBP-C as a promiscuous substrate: phosphorylation by non-PKA kinases and its potential significance.

scientific article

β-Adrenergic regulation of cardiac type 2A protein phosphatase through phosphorylation of regulatory subunit B56δ at S573.

scientific article published on 30 December 2017

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