List of works - Siegfried Labeit

A regular pattern of Ig super-motifs defines segmental flexibility as the elastic mechanism of the titin chain

scientific article

ANKRD1, the gene encoding cardiac ankyrin repeat protein, is a novel dilated cardiomyopathy gene

scientific article

Alterations of cAMP-dependent signaling in dystrophic skeletal muscle

scientific article

Altered titin expression, myocardial stiffness, and left ventricular function in patients with dilated cardiomyopathy

scientific article

Antisense-mediated exon skipping: a therapeutic strategy for titin-based dilated cardiomyopathy.

scientific article published on 9 March 2015

Atrogin-1 and MuRF1 regulate cardiac MyBP-C levels via different mechanisms

scientific article

CARP interacts with titin at a unique helical N2A sequence and at the domain Ig81 to form a structured complex

scientific article

Cardiac titin: an adjustable multi-functional spring

scientific article

Cardiac titin: structure, functions and role in disease

scientific article published on 7 July 2006

Cooperative control of striated muscle mass and metabolism by MuRF1 and MuRF2.

scientific article

Degeneration of neuromuscular junction in age and dystrophy

scientific article

Deleting exon 55 from the nebulin gene induces severe muscle weakness in a mouse model for nemaline myopathy

scientific article published on 28 May 2013

Diaphragm muscle fiber weakness and ubiquitin-proteasome activation in critically ill patients

scientific article published on May 2015

Different molecular mechanics displayed by titin's constitutively and differentially expressed tandem Ig segments.

scientific article

Differential splicing of the large sarcomeric protein nebulin during skeletal muscle development

scientific article

Dimerization of the cardiac ankyrin protein CARP: implications for MARP titin-based signaling

scientific article

Dynamic distribution of muscle-specific calpain in mice has a key role in physical-stress adaptation and is impaired in muscular dystrophy.

scientific article

Dysregulated IER3 Expression is Associated with Enhanced Apoptosis in Titin-Based Dilated Cardiomyopathy

scientific article

Exploration of pathomechanisms triggered by a single-nucleotide polymorphism in titin's I-band: the cardiomyopathy-linked mutation T2580I.

scientific article

Expression of distinct classes of titin isoforms in striated and smooth muscles by alternative splicing, and their conserved interaction with filamins

scientific article

Fast Skeletal Muscle Troponin Activation Increases Force of Mouse Fast Skeletal Muscle and Ameliorates Weakness Due to Nebulin-Deficiency ⬇️

scientific article published on February 20, 2013

Genetic variation in titin in arrhythmogenic right ventricular cardiomyopathy-overlap syndromes

scientific article

Histone Deacetylase Inhibitor Suberoylanilide Hydroxamic Acid Improves Energetic Status and Cardiomyogenic Differentiation of Human Dilated Myocardium-Derived Primary Mesenchymal Cells

scientific article published on 08 July 2020

Identification of an N-terminal inhibitory extension as the primary mechanosensory regulator of twitchin kinase

scientific article

Induction and myofibrillar targeting of CARP, and suppression of the Nkx2.5 pathway in the MDM mouse with impaired titin-based signaling

scientific journal article

Induction of Ankrd1 in Dilated Cardiomyopathy Correlates with the Heart Failure Progression

scientific article

Inflammation-induced acute phase response in skeletal muscle and critical illness myopathy

scientific article

Leucine Supplementation Decreases <i>HDAC4</i> Expression and Nuclear Localization in Skeletal Muscle Fiber of Rats Submitted to Hindlimb Immobilization

scientific article published on 02 December 2020

MURF-1 and MURF-2 target a specific subset of myofibrillar proteins redundantly: towards understanding MURF-dependent muscle ubiquitination

scientific article

Mechanics on myocardium deficient in the N2B region of titin: the cardiac-unique spring element improves efficiency of the cardiac cycle

scientific article

Molecular basis for clinical heterogeneity in inherited cardiomyopathies due to myopalladin mutations

scientific article

Molecular basis for the fold organization and sarcomeric targeting of the muscle atrogin MuRF1

scientific article published on 26 March 2014

Molecular determinants for the recruitment of the ubiquitin-ligase MuRF-1 onto M-line titin

scientific article

Molecular mechanisms behind progressing chronic inflammatory dilated cardiomyopathy

scientific article published on 26 March 2015

MuRF1 is a muscle fiber-type II associated factor and together with MuRF2 regulates type-II fiber trophicity and maintenance.

scientific article

MuRF1-dependent regulation of systemic carbohydrate metabolism as revealed from transgenic mouse studies

scientific article

Multiple molecular interactions implicate the connectin/titin N2A region as a modulating scaffold for p94/calpain 3 activity in skeletal muscle

scientific article

Muscle RING-finger protein-1 (MuRF1) as a connector of muscle energy metabolism and protein synthesis

scientific article

Muscle-specific RING finger-1 interacts with titin to regulate sarcomeric M-line and thick filament structure and may have nuclear functions via its interaction with glucocorticoid modulatory element binding protein-1

scientific article

Myogenic stage, sarcomere length, and protease activity modulate localization of muscle-specific calpain

scientific article

Nebulette Mutations Are Associated With Dilated Cardiomyopathy and Endocardial Fibroelastosis ⬇️

scientific article published on October 26, 2010

Nebulin alters cross-bridge cycling kinetics and increases thin filament activation: a novel mechanism for increasing tension and reducing tension cost

scientific article published on 07 September 2009

Nebulin regulates thin filament length, contractility, and Z-disk structure in vivo

scientific article

Nebulin, a major player in muscle health and disease

scientific article

Nebulin: the nebulous, multifunctional giant of striated muscle

scientific article (publication date: July 2003)

Phosphorylating Titin's Cardiac N2B Element by ERK2 or CaMKIIδ Lowers the Single Molecule and Cardiac Muscle Force

scientific article

Reduced myofibrillar connectivity and increased Z-disk width in nebulin-deficient skeletal muscle

scientific article

Role of autophagy, SQSTM1, SH3GLB1, and TRIM63 in the turnover of nicotinic acetylcholine receptors

scientific article

Sarcoplasmic reticulum calcium uptake and speed of relaxation are depressed in nebulin-free skeletal muscle

scientific article published on 23 April 2008

Single molecule force spectroscopy on titin implicates immunoglobulin domain stability as a cardiac disease mechanism.

scientific article

Structural analysis of B-Box 2 from MuRF1: identification of a novel self-association pattern in a RING-like fold

scientific article

Suppressed disassembly of autolyzing p94/CAPN3 by N2A connectin/titin in a genetic reporter system.

scientific article

Sympathetic innervation controls homeostasis of neuromuscular junctions in health and disease

scientific article

The Binding Sites of miR-619-5p in the mRNAs of Human and Orthologous Genes.

scientific article

The E3 ligase MuRF2 plays a key role in the functional capacity of skeletal muscle fibroblasts

scientific article published on 29 August 2019

The Muscle Ankyrin Repeat Proteins: CARP, ankrd2/Arpp and DARP as a Family of Titin Filament-based Stress Response Molecules ⬇️

scientific article published on November 7, 2003

The function of elastic proteins in the oscillatory contraction of insect flight muscle

scientific article

The giant protein titin: a major player in myocardial mechanics, signaling, and disease

scientific article published on February 2004

The multifunctional Ca(2+)/calmodulin-dependent protein kinase II delta (CaMKIIδ) phosphorylates cardiac titin's spring elements.

scientific article published on 5 December 2012

The sarcomeric protein nebulin: another multifunctional giant in charge of muscle strength optimization

scientific article published on 27 February 2012

The structure of Lethocerus troponin C: insights into the mechanism of stretch activation in muscles

scientific article

Tibial muscular dystrophy is a titinopathy caused by mutations in TTN, the gene encoding the giant skeletal-muscle protein titin

scientific article

Titin and diaphragm dysfunction in chronic obstructive pulmonary disease

scientific article published on 09 December 2005

Titin and its associated proteins: the third myofilament system of the sarcomere

scientific article

Titin as a modular spring: emerging mechanisms for elasticity control by titin in cardiac physiology and pathophysiology

scientific article

Titin kinase is an inactive pseudokinase scaffold that supports MuRF1 recruitment to the sarcomeric M-line ⬇️

scientific article

Titin kinase ubiquitination aligns autophagy receptors with mechanical signals in the sarcomere

scientific article published on 17 August 2021

Titin-actin interaction: PEVK-actin-based viscosity in a large animal

scientific article published on 15 November 2011

Titin: an endosarcomeric protein that modulates myocardial stiffness in DCM.

scientific article

Tuning passive mechanics through differential splicing of titin during skeletal muscle development

scientific article published on October 2009

List of works by Siegfried Labeit

A regular pattern of Ig super-motifs defines segmental flexibility as the elastic mechanism of the titin chain

ANKRD1, the gene encoding cardiac ankyrin repeat protein, is a novel dilated cardiomyopathy gene

Alterations of cAMP-dependent signaling in dystrophic skeletal muscle

Altered titin expression, myocardial stiffness, and left ventricular function in patients with dilated cardiomyopathy

Antisense-mediated exon skipping: a therapeutic strategy for titin-based dilated cardiomyopathy.

Atrogin-1 and MuRF1 regulate cardiac MyBP-C levels via different mechanisms

CARP interacts with titin at a unique helical N2A sequence and at the domain Ig81 to form a structured complex

Cardiac titin: an adjustable multi-functional spring

Cardiac titin: structure, functions and role in disease

Cooperative control of striated muscle mass and metabolism by MuRF1 and MuRF2.

Degeneration of neuromuscular junction in age and dystrophy

Deleting exon 55 from the nebulin gene induces severe muscle weakness in a mouse model for nemaline myopathy

Diaphragm muscle fiber weakness and ubiquitin-proteasome activation in critically ill patients

Different molecular mechanics displayed by titin's constitutively and differentially expressed tandem Ig segments.

Differential splicing of the large sarcomeric protein nebulin during skeletal muscle development

Dimerization of the cardiac ankyrin protein CARP: implications for MARP titin-based signaling

Dynamic distribution of muscle-specific calpain in mice has a key role in physical-stress adaptation and is impaired in muscular dystrophy.

Dysregulated IER3 Expression is Associated with Enhanced Apoptosis in Titin-Based Dilated Cardiomyopathy

Exploration of pathomechanisms triggered by a single-nucleotide polymorphism in titin's I-band: the cardiomyopathy-linked mutation T2580I.

Expression of distinct classes of titin isoforms in striated and smooth muscles by alternative splicing, and their conserved interaction with filamins

Fast Skeletal Muscle Troponin Activation Increases Force of Mouse Fast Skeletal Muscle and Ameliorates Weakness Due to Nebulin-Deficiency ⬇️

Genetic variation in titin in arrhythmogenic right ventricular cardiomyopathy-overlap syndromes

Histone Deacetylase Inhibitor Suberoylanilide Hydroxamic Acid Improves Energetic Status and Cardiomyogenic Differentiation of Human Dilated Myocardium-Derived Primary Mesenchymal Cells

Identification of an N-terminal inhibitory extension as the primary mechanosensory regulator of twitchin kinase

Induction and myofibrillar targeting of CARP, and suppression of the Nkx2.5 pathway in the MDM mouse with impaired titin-based signaling

Induction of Ankrd1 in Dilated Cardiomyopathy Correlates with the Heart Failure Progression

Inflammation-induced acute phase response in skeletal muscle and critical illness myopathy

Leucine Supplementation Decreases <i>HDAC4</i> Expression and Nuclear Localization in Skeletal Muscle Fiber of Rats Submitted to Hindlimb Immobilization

MURF-1 and MURF-2 target a specific subset of myofibrillar proteins redundantly: towards understanding MURF-dependent muscle ubiquitination

Mechanics on myocardium deficient in the N2B region of titin: the cardiac-unique spring element improves efficiency of the cardiac cycle

Molecular basis for clinical heterogeneity in inherited cardiomyopathies due to myopalladin mutations

Molecular basis for the fold organization and sarcomeric targeting of the muscle atrogin MuRF1

Molecular determinants for the recruitment of the ubiquitin-ligase MuRF-1 onto M-line titin

Molecular mechanisms behind progressing chronic inflammatory dilated cardiomyopathy

MuRF1 is a muscle fiber-type II associated factor and together with MuRF2 regulates type-II fiber trophicity and maintenance.

MuRF1-dependent regulation of systemic carbohydrate metabolism as revealed from transgenic mouse studies

Multiple molecular interactions implicate the connectin/titin N2A region as a modulating scaffold for p94/calpain 3 activity in skeletal muscle

Muscle RING-finger protein-1 (MuRF1) as a connector of muscle energy metabolism and protein synthesis

Muscle-specific RING finger-1 interacts with titin to regulate sarcomeric M-line and thick filament structure and may have nuclear functions via its interaction with glucocorticoid modulatory element binding protein-1

Myogenic stage, sarcomere length, and protease activity modulate localization of muscle-specific calpain

Nebulette Mutations Are Associated With Dilated Cardiomyopathy and Endocardial Fibroelastosis ⬇️

Nebulin alters cross-bridge cycling kinetics and increases thin filament activation: a novel mechanism for increasing tension and reducing tension cost

Nebulin regulates thin filament length, contractility, and Z-disk structure in vivo

Nebulin, a major player in muscle health and disease

Nebulin: the nebulous, multifunctional giant of striated muscle

Phosphorylating Titin's Cardiac N2B Element by ERK2 or CaMKIIδ Lowers the Single Molecule and Cardiac Muscle Force

Reduced myofibrillar connectivity and increased Z-disk width in nebulin-deficient skeletal muscle

Role of autophagy, SQSTM1, SH3GLB1, and TRIM63 in the turnover of nicotinic acetylcholine receptors

Sarcoplasmic reticulum calcium uptake and speed of relaxation are depressed in nebulin-free skeletal muscle

Single molecule force spectroscopy on titin implicates immunoglobulin domain stability as a cardiac disease mechanism.

Structural analysis of B-Box 2 from MuRF1: identification of a novel self-association pattern in a RING-like fold

Suppressed disassembly of autolyzing p94/CAPN3 by N2A connectin/titin in a genetic reporter system.

Sympathetic innervation controls homeostasis of neuromuscular junctions in health and disease

The Binding Sites of miR-619-5p in the mRNAs of Human and Orthologous Genes.

The E3 ligase MuRF2 plays a key role in the functional capacity of skeletal muscle fibroblasts

The Muscle Ankyrin Repeat Proteins: CARP, ankrd2/Arpp and DARP as a Family of Titin Filament-based Stress Response Molecules ⬇️

The function of elastic proteins in the oscillatory contraction of insect flight muscle

The giant protein titin: a major player in myocardial mechanics, signaling, and disease

The multifunctional Ca(2+)/calmodulin-dependent protein kinase II delta (CaMKIIδ) phosphorylates cardiac titin's spring elements.

The sarcomeric protein nebulin: another multifunctional giant in charge of muscle strength optimization

The structure of Lethocerus troponin C: insights into the mechanism of stretch activation in muscles

Tibial muscular dystrophy is a titinopathy caused by mutations in TTN, the gene encoding the giant skeletal-muscle protein titin

Titin and diaphragm dysfunction in chronic obstructive pulmonary disease

Titin and its associated proteins: the third myofilament system of the sarcomere

Titin as a modular spring: emerging mechanisms for elasticity control by titin in cardiac physiology and pathophysiology

Titin kinase is an inactive pseudokinase scaffold that supports MuRF1 recruitment to the sarcomeric M-line ⬇️

Titin kinase ubiquitination aligns autophagy receptors with mechanical signals in the sarcomere

Titin-actin interaction: PEVK-actin-based viscosity in a large animal

Titin: an endosarcomeric protein that modulates myocardial stiffness in DCM.

Tuning passive mechanics through differential splicing of titin during skeletal muscle development