List of works - Siegfried Labeit

The giant protein titin: a major player in myocardial mechanics, signaling, and disease

scientific article published on February 2004

The Muscle Ankyrin Repeat Proteins: CARP, ankrd2/Arpp and DARP as a Family of Titin Filament-based Stress Response Molecules

scientific article published on November 7, 2003

Altered titin expression, myocardial stiffness, and left ventricular function in patients with dilated cardiomyopathy

scientific article

MURF-1 and MURF-2 target a specific subset of myofibrillar proteins redundantly: towards understanding MURF-dependent muscle ubiquitination

scientific article

Tibial muscular dystrophy is a titinopathy caused by mutations in TTN, the gene encoding the giant skeletal-muscle protein titin

scientific article

Nebulin regulates thin filament length, contractility, and Z-disk structure in vivo

scientific article

Genetic variation in titin in arrhythmogenic right ventricular cardiomyopathy-overlap syndromes

scientific article

Muscle-specific RING finger-1 interacts with titin to regulate sarcomeric M-line and thick filament structure and may have nuclear functions via its interaction with glucocorticoid modulatory element binding protein-1

scientific article

Cooperative control of striated muscle mass and metabolism by MuRF1 and MuRF2.

scientific article

Cardiac titin: an adjustable multi-functional spring

scientific article

Muscle RING-finger protein-1 (MuRF1) as a connector of muscle energy metabolism and protein synthesis

scientific article

ANKRD1, the gene encoding cardiac ankyrin repeat protein, is a novel dilated cardiomyopathy gene

scientific article

Atrogin-1 and MuRF1 regulate cardiac MyBP-C levels via different mechanisms

scientific article

Nebulin alters cross-bridge cycling kinetics and increases thin filament activation: a novel mechanism for increasing tension and reducing tension cost

scientific article published on 07 September 2009

Diaphragm muscle fiber weakness and ubiquitin-proteasome activation in critically ill patients

scientific article published on May 2015

Multiple molecular interactions implicate the connectin/titin N2A region as a modulating scaffold for p94/calpain 3 activity in skeletal muscle

scientific article

Degeneration of neuromuscular junction in age and dystrophy

scientific article

Induction and myofibrillar targeting of CARP, and suppression of the Nkx2.5 pathway in the MDM mouse with impaired titin-based signaling

scientific journal article

Cardiac titin: structure, functions and role in disease

scientific article published on 7 July 2006

Nebulin: the nebulous, multifunctional giant of striated muscle

scientific article (publication date: July 2003)

Molecular determinants for the recruitment of the ubiquitin-ligase MuRF-1 onto M-line titin

scientific article

Titin and its associated proteins: the third myofilament system of the sarcomere

scientific article

Different molecular mechanics displayed by titin's constitutively and differentially expressed tandem Ig segments.

scientific article

Nebulette Mutations Are Associated With Dilated Cardiomyopathy and Endocardial Fibroelastosis

scientific article published on October 26, 2010

Dynamic distribution of muscle-specific calpain in mice has a key role in physical-stress adaptation and is impaired in muscular dystrophy.

scientific article

Titin and diaphragm dysfunction in chronic obstructive pulmonary disease

scientific article published on 09 December 2005

Sarcoplasmic reticulum calcium uptake and speed of relaxation are depressed in nebulin-free skeletal muscle

scientific article published on 23 April 2008

Antisense-mediated exon skipping: a therapeutic strategy for titin-based dilated cardiomyopathy.

scientific article published on 9 March 2015

MuRF1-dependent regulation of systemic carbohydrate metabolism as revealed from transgenic mouse studies

scientific article

Reduced myofibrillar connectivity and increased Z-disk width in nebulin-deficient skeletal muscle

scientific article

Expression of distinct classes of titin isoforms in striated and smooth muscles by alternative splicing, and their conserved interaction with filamins

scientific article published in August 2006

MuRF1 is a muscle fiber-type II associated factor and together with MuRF2 regulates type-II fiber trophicity and maintenance.

scientific article

Molecular basis for clinical heterogeneity in inherited cardiomyopathies due to myopalladin mutations

scientific article

Tuning passive mechanics through differential splicing of titin during skeletal muscle development

scientific article published on October 2009

Role of autophagy, SQSTM1, SH3GLB1, and TRIM63 in the turnover of nicotinic acetylcholine receptors

scientific article published on November 8, 2013

Nebulin, a major player in muscle health and disease

scientific article

The multifunctional Ca(2+)/calmodulin-dependent protein kinase II delta (CaMKIIδ) phosphorylates cardiac titin's spring elements.

scientific article published on 5 December 2012

Suppressed disassembly of autolyzing p94/CAPN3 by N2A connectin/titin in a genetic reporter system.

scientific article

A regular pattern of Ig super-motifs defines segmental flexibility as the elastic mechanism of the titin chain

scientific article

The function of elastic proteins in the oscillatory contraction of insect flight muscle

scientific article

Dimerization of the cardiac ankyrin protein CARP: implications for MARP titin-based signaling

scientific article

Titin kinase is an inactive pseudokinase scaffold that supports MuRF1 recruitment to the sarcomeric M-line

scientific article

Myogenic stage, sarcomere length, and protease activity modulate localization of muscle-specific calpain

scientific article published on 19 March 2007

Deleting exon 55 from the nebulin gene induces severe muscle weakness in a mouse model for nemaline myopathy

scientific article published on 28 May 2013

Sympathetic innervation controls homeostasis of neuromuscular junctions in health and disease

scientific article published on January 5, 2016

Inflammation-induced acute phase response in skeletal muscle and critical illness myopathy

scientific article

Structural analysis of B-Box 2 from MuRF1: identification of a novel self-association pattern in a RING-like fold

scientific article

Differential splicing of the large sarcomeric protein nebulin during skeletal muscle development

scientific article published on February 20, 2010

Phosphorylating Titin's Cardiac N2B Element by ERK2 or CaMKIIδ Lowers the Single Molecule and Cardiac Muscle Force

scientific article

Single molecule force spectroscopy on titin implicates immunoglobulin domain stability as a cardiac disease mechanism.

scientific article

List of works by Siegfried Labeit

The giant protein titin: a major player in myocardial mechanics, signaling, and disease

The Muscle Ankyrin Repeat Proteins: CARP, ankrd2/Arpp and DARP as a Family of Titin Filament-based Stress Response Molecules

Altered titin expression, myocardial stiffness, and left ventricular function in patients with dilated cardiomyopathy

MURF-1 and MURF-2 target a specific subset of myofibrillar proteins redundantly: towards understanding MURF-dependent muscle ubiquitination

Tibial muscular dystrophy is a titinopathy caused by mutations in TTN, the gene encoding the giant skeletal-muscle protein titin

Nebulin regulates thin filament length, contractility, and Z-disk structure in vivo

Genetic variation in titin in arrhythmogenic right ventricular cardiomyopathy-overlap syndromes

Muscle-specific RING finger-1 interacts with titin to regulate sarcomeric M-line and thick filament structure and may have nuclear functions via its interaction with glucocorticoid modulatory element binding protein-1

Cooperative control of striated muscle mass and metabolism by MuRF1 and MuRF2.

Cardiac titin: an adjustable multi-functional spring

Muscle RING-finger protein-1 (MuRF1) as a connector of muscle energy metabolism and protein synthesis

ANKRD1, the gene encoding cardiac ankyrin repeat protein, is a novel dilated cardiomyopathy gene

Atrogin-1 and MuRF1 regulate cardiac MyBP-C levels via different mechanisms

Nebulin alters cross-bridge cycling kinetics and increases thin filament activation: a novel mechanism for increasing tension and reducing tension cost

Diaphragm muscle fiber weakness and ubiquitin-proteasome activation in critically ill patients

Multiple molecular interactions implicate the connectin/titin N2A region as a modulating scaffold for p94/calpain 3 activity in skeletal muscle

Degeneration of neuromuscular junction in age and dystrophy

Induction and myofibrillar targeting of CARP, and suppression of the Nkx2.5 pathway in the MDM mouse with impaired titin-based signaling

Cardiac titin: structure, functions and role in disease

Nebulin: the nebulous, multifunctional giant of striated muscle

Molecular determinants for the recruitment of the ubiquitin-ligase MuRF-1 onto M-line titin

Titin and its associated proteins: the third myofilament system of the sarcomere

Different molecular mechanics displayed by titin's constitutively and differentially expressed tandem Ig segments.

Nebulette Mutations Are Associated With Dilated Cardiomyopathy and Endocardial Fibroelastosis

Dynamic distribution of muscle-specific calpain in mice has a key role in physical-stress adaptation and is impaired in muscular dystrophy.

Titin and diaphragm dysfunction in chronic obstructive pulmonary disease

Sarcoplasmic reticulum calcium uptake and speed of relaxation are depressed in nebulin-free skeletal muscle

Antisense-mediated exon skipping: a therapeutic strategy for titin-based dilated cardiomyopathy.

MuRF1-dependent regulation of systemic carbohydrate metabolism as revealed from transgenic mouse studies

Reduced myofibrillar connectivity and increased Z-disk width in nebulin-deficient skeletal muscle

Expression of distinct classes of titin isoforms in striated and smooth muscles by alternative splicing, and their conserved interaction with filamins

MuRF1 is a muscle fiber-type II associated factor and together with MuRF2 regulates type-II fiber trophicity and maintenance.

Molecular basis for clinical heterogeneity in inherited cardiomyopathies due to myopalladin mutations

Tuning passive mechanics through differential splicing of titin during skeletal muscle development

Role of autophagy, SQSTM1, SH3GLB1, and TRIM63 in the turnover of nicotinic acetylcholine receptors

Nebulin, a major player in muscle health and disease

The multifunctional Ca(2+)/calmodulin-dependent protein kinase II delta (CaMKIIδ) phosphorylates cardiac titin's spring elements.

Suppressed disassembly of autolyzing p94/CAPN3 by N2A connectin/titin in a genetic reporter system.

A regular pattern of Ig super-motifs defines segmental flexibility as the elastic mechanism of the titin chain

The function of elastic proteins in the oscillatory contraction of insect flight muscle

Dimerization of the cardiac ankyrin protein CARP: implications for MARP titin-based signaling

Titin kinase is an inactive pseudokinase scaffold that supports MuRF1 recruitment to the sarcomeric M-line

Myogenic stage, sarcomere length, and protease activity modulate localization of muscle-specific calpain

Deleting exon 55 from the nebulin gene induces severe muscle weakness in a mouse model for nemaline myopathy

Sympathetic innervation controls homeostasis of neuromuscular junctions in health and disease

Inflammation-induced acute phase response in skeletal muscle and critical illness myopathy

Structural analysis of B-Box 2 from MuRF1: identification of a novel self-association pattern in a RING-like fold

Differential splicing of the large sarcomeric protein nebulin during skeletal muscle development

Phosphorylating Titin's Cardiac N2B Element by ERK2 or CaMKIIδ Lowers the Single Molecule and Cardiac Muscle Force

Single molecule force spectroscopy on titin implicates immunoglobulin domain stability as a cardiac disease mechanism.