List of works - Birte Höcker

A biosensor for the direct visualization of auxin

scientific article published on 07 April 2021

A common evolutionary origin of two elementary enzyme folds

scientific article

A highly stable protein chimera built from fragments of different folds.

scientific article published on 18 October 2012

A metalloenzyme reloaded ⬇️

scientific article published on February 15, 2012

A newly introduced salt bridge cluster improves structural and biophysical properties of de novo TIM barrels

scientific article published on 16 December 2021

A robust protein host for anchoring chelating ligands and organocatalysts

scientific article

A -barrel built by the combination of fragments from different folds

scientific article

Automated scaffold selection for enzyme design

scientific article

Binding pocket optimization by computational protein design

scientific article

Catalytic versatility, stability, and evolution of the (betaalpha)8-barrel enzyme fold

scientific article

Change in protein-ligand specificity through binding pocket grafting

scientific article

Computational design of ligand binding is not a solved problem

scientific article

De novo design of a four-fold symmetric TIM-barrel protein with atomic-level accuracy

scientific article

Design of chimeric proteins by combination of subdomain-sized fragments

scientific article published in January 2013

Design of proteins from smaller fragments-learning from evolution

scientific article published on 25 May 2014

Directed evolution of (betaalpha)(8)-barrel enzymes

scientific article

Divergent evolution of (betaalpha)8-barrel enzymes.

scientific article

Engineering chimaeric proteins from fold fragments: 'hopeful monsters' in protein design

scientific article

Engineering the enolase magnesium II binding site: implications for its evolution

scientific article

Enzyme am Reißbrett

Establishing wild-type levels of catalytic activity on natural and artificial ( )8-barrel protein scaffolds

scientific article

Evolutionary mechanism as a template for protein engineering

scientific article published on October 2010

Evolutionary relationship of two ancient protein superfolds

scientific article

Extension of a de novo TIM barrel with a rationally designed secondary structure element

publication published on 20 March 2021

High-resolution crystal structure of an artificial (betaalpha)(8)-barrel protein designed from identical half-barrels

scientific article

Identification of residues important for NAD+ binding by the Thermotoga maritima alpha-glucosidase AglA, a member of glycoside hydrolase family 4.

scientific article

Metals make proteins stick

scientific article published in February 2010

Mimicking enzyme evolution by generating new (betaalpha)8-barrels from (betaalpha)4-half-barrels

scientific article

Molecular Engineering of Organophosphate Hydrolysis Activity from a Weak Promiscuous Lactonase Template

scientific article

PocketOptimizer and the Design of Ligand Binding Sites.

scientific article

Potential of fragment recombination for rational design of proteins

scientific article

ProteinTools: a toolkit to analyze protein structures

scientific article published on 01 July 2021

Reconstructing the Remote Origins of a Fold Singleton from a Flavodoxin-Like Ancestor

scientific article published on 20 November 2019

Stability, catalytic versatility and evolution of the (beta alpha)(8)-barrel fold.

scientific article

Structural Frameworks Suitable for Engineering

Structural biology: A toolbox for protein design.

scientific article

Structure-based design of robust glucose biosensors using aThermotoga maritimaperiplasmic glucose-binding protein

scientific article

List of works by Birte Höcker

A biosensor for the direct visualization of auxin

A common evolutionary origin of two elementary enzyme folds

A highly stable protein chimera built from fragments of different folds.

A metalloenzyme reloaded ⬇️

A newly introduced salt bridge cluster improves structural and biophysical properties of de novo TIM barrels

A robust protein host for anchoring chelating ligands and organocatalysts

A -barrel built by the combination of fragments from different folds

Automated scaffold selection for enzyme design

Binding pocket optimization by computational protein design

Catalytic versatility, stability, and evolution of the (betaalpha)8-barrel enzyme fold

Change in protein-ligand specificity through binding pocket grafting

Computational design of ligand binding is not a solved problem

De novo design of a four-fold symmetric TIM-barrel protein with atomic-level accuracy

Design of chimeric proteins by combination of subdomain-sized fragments

Design of proteins from smaller fragments-learning from evolution

Directed evolution of (betaalpha)(8)-barrel enzymes

Divergent evolution of (betaalpha)8-barrel enzymes.

Engineering chimaeric proteins from fold fragments: 'hopeful monsters' in protein design

Engineering the enolase magnesium II binding site: implications for its evolution

Enzyme am Reißbrett

Establishing wild-type levels of catalytic activity on natural and artificial ( )8-barrel protein scaffolds

Evolutionary mechanism as a template for protein engineering

Evolutionary relationship of two ancient protein superfolds

Extension of a de novo TIM barrel with a rationally designed secondary structure element

High-resolution crystal structure of an artificial (betaalpha)(8)-barrel protein designed from identical half-barrels

Identification of residues important for NAD+ binding by the Thermotoga maritima alpha-glucosidase AglA, a member of glycoside hydrolase family 4.

Metals make proteins stick

Mimicking enzyme evolution by generating new (betaalpha)8-barrels from (betaalpha)4-half-barrels

Molecular Engineering of Organophosphate Hydrolysis Activity from a Weak Promiscuous Lactonase Template

PocketOptimizer and the Design of Ligand Binding Sites.

Potential of fragment recombination for rational design of proteins

ProteinTools: a toolkit to analyze protein structures

Reconstructing the Remote Origins of a Fold Singleton from a Flavodoxin-Like Ancestor

Stability, catalytic versatility and evolution of the (beta alpha)(8)-barrel fold.

Structural Frameworks Suitable for Engineering

Structural biology: A toolbox for protein design.

Structure-based design of robust glucose biosensors using aThermotoga maritimaperiplasmic glucose-binding protein