List of works - Daniel Lietha

A new crystal form of the NK1 splice variant of HGF/SF demonstrates extensive hinge movement and suggests that the NK1 dimer originates by domain swapping

scientific article

Allosteric regulation of focal adhesion kinase by PIP₂ and ATP.

scientific article

Alternative Activation Mechanisms of Protein Kinase B Trigger Distinct Downstream Signaling Responses

scientific article

Crystal Structures of the FAK Kinase in Complex with TAE226 and Related Bis-Anilino Pyrimidine Inhibitors Reveal a Helical DFG Conformation

scientific article

Crystal structures of NK1-heparin complexes reveal the basis for NK1 activity and enable engineering of potent agonists of the MET receptor.

scientific article

Design, synthesis, and evaluation of novel imidazo[1,2-a][1,3,5]triazines and their derivatives as focal adhesion kinase inhibitors with antitumor activity

scientific article published on 11 September 2014

Expression, Purification, Crystallisation and X-ray Crystallographic Analysis of a Truncated Form of Human Src Homology 2 Containing Inositol 5-Phosphatase 2.

scientific article

Forcing FAK into Transcriptional Activity.

scientific article published in August 2016

Inhibition of both focal adhesion kinase and fibroblast growth factor receptor 2 pathways induces anti-tumor and anti-angiogenic activities

scientific article

Phosphatidylinositol 4,5-bisphosphate triggers activation of focal adhesion kinase by inducing clustering and conformational changes

scientific article

Spatial and temporal regulation of focal adhesion kinase activity in living cells.

scientific article published on 29 October 2007

Structural basis for interdomain communication in SHIP2 providing high phosphatase activity

scientific article

Structural basis for the autoinhibition of focal adhesion kinase

scientific article

Structural basis of Focal Adhesion Kinase activation on lipid membranes

scientific article published on 11 August 2020

Synthesis of novel 1,2,4-triazine scaffold as FAK inhibitors with antitumor activity

scientific article published on 28 February 2017

Synthesis of novel diarylamino-1,3,5-triazine derivatives as FAK inhibitors with anti-angiogenic activity

scientific article

The FERM domain: organizing the structure and function of FAK.

scientific article

The interactions of hepatocyte growth factor/scatter factor and its NK1 and NK2 variants with glycosaminoglycans using a modified gel mobility shift assay. Elucidation of the minimal size of binding and activatory oligosaccharides

scientific article

Tyrosine phosphorylation of Rac1: a role in regulation of cell spreading

scientific article

List of works by Daniel Lietha

A new crystal form of the NK1 splice variant of HGF/SF demonstrates extensive hinge movement and suggests that the NK1 dimer originates by domain swapping

Allosteric regulation of focal adhesion kinase by PIP₂ and ATP.

Alternative Activation Mechanisms of Protein Kinase B Trigger Distinct Downstream Signaling Responses

Crystal Structures of the FAK Kinase in Complex with TAE226 and Related Bis-Anilino Pyrimidine Inhibitors Reveal a Helical DFG Conformation

Crystal structures of NK1-heparin complexes reveal the basis for NK1 activity and enable engineering of potent agonists of the MET receptor.

Design, synthesis, and evaluation of novel imidazo[1,2-a][1,3,5]triazines and their derivatives as focal adhesion kinase inhibitors with antitumor activity

Expression, Purification, Crystallisation and X-ray Crystallographic Analysis of a Truncated Form of Human Src Homology 2 Containing Inositol 5-Phosphatase 2.

Forcing FAK into Transcriptional Activity.

Inhibition of both focal adhesion kinase and fibroblast growth factor receptor 2 pathways induces anti-tumor and anti-angiogenic activities

Phosphatidylinositol 4,5-bisphosphate triggers activation of focal adhesion kinase by inducing clustering and conformational changes

Spatial and temporal regulation of focal adhesion kinase activity in living cells.

Structural basis for interdomain communication in SHIP2 providing high phosphatase activity

Structural basis for the autoinhibition of focal adhesion kinase

Structural basis of Focal Adhesion Kinase activation on lipid membranes

Synthesis of novel 1,2,4-triazine scaffold as FAK inhibitors with antitumor activity

Synthesis of novel diarylamino-1,3,5-triazine derivatives as FAK inhibitors with anti-angiogenic activity

The FERM domain: organizing the structure and function of FAK.

The interactions of hepatocyte growth factor/scatter factor and its NK1 and NK2 variants with glycosaminoglycans using a modified gel mobility shift assay. Elucidation of the minimal size of binding and activatory oligosaccharides

Tyrosine phosphorylation of Rac1: a role in regulation of cell spreading