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List of works by Kalle Saksela

A crucial role in cell spreading for the interaction of Abl PxxP motifs with Crk and Nck adaptors

scientific article

A single-chain antibody/epitope system for functional analysis of protein-protein interactions

scientific article

ANKRD54 preferentially selects Bruton's Tyrosine Kinase (BTK) from a Human Src-Homology 3 (SH3) domain library

scientific article published on 3 April 2017

Activation of p21-activated kinase 2 and its association with Nef are conserved in murine cells but are not sufficient to induce an AIDS-like disease in CD4C/HIV transgenic mice

scientific article

Alternative splicing of ADAM15 regulates its interactions with cellular SH3 proteins

scientific article

Association of Nef with p21-activated kinase 2 is dispensable for efficient human immunodeficiency virus type 1 replication and cytopathicity in ex vivo-infected human lymphoid tissue

scientific article

Association with PAK2 Enables Functional Interactions of Lentiviral Nef Proteins with the Exocyst Complex

scientific article

Attenuation of Semliki Forest virus neurovirulence by microRNA-mediated detargeting

scientific article published on 17 October 2012

Autoimmune regulator induced changes in the gene expression profile of human monocyte-dendritic cell-lineage

scientific article

Avian and 1918 Spanish influenza a virus NS1 proteins bind to Crk/CrkL Src homology 3 domains to activate host cell signaling.

scientific article

Capacity of simian immunodeficiency virus strain mac Nef for high-affinity Src homology 3 (SH3) binding revealed by ligand-tailored SH3 domains

scientific article

Cdc42/Rac1-mediated activation primes PAK2 for superactivation by tyrosine phosphorylation

scientific article

Comprehensive analysis of interactions between the Src-associated protein in mitosis of 68 kDa and the human Src-homology 3 proteome

scientific article published in 2012

Conformation of the dileucine-based sorting motif in HIV-1 Nef revealed by intermolecular domain assembly

scientific article

Dystroglycan, Tks5 and Src mediated assembly of podosomes in myoblasts

scientific article

Enterohaemorrhagic Escherichia Coli Exploits a Tryptophan Switch to Hijack Host F-Actin Assembly

scientific article

Further studies on hepatitis C virus NS5A-SH3 domain interactions: identification of residues critical for binding and implications for viral RNA replication and modulation of cell signalling

scientific article

Generation of a conditionally replicating adenovirus based on targeted destruction of E1A mRNA by a cell type-specific MicroRNA.

scientific article

HIV Activates the Tyrosine Kinase Hck to Secrete ADAM Protease-Containing Extracellular Vesicles.

scientific article published on 4 January 2018

HIV Nef, paxillin, and Pak1/2 regulate activation and secretion of TACE/ADAM10 proteases

scientific article

HIV-Nef and ADAM17-Containing Plasma Extracellular Vesicles Induce and Correlate with Immune Pathogenesis in Chronic HIV Infection

scientific article published on 3 March 2016

Harnessing endogenous miRNAs to control virus tissue tropism as a strategy for developing attenuated virus vaccines

scientific article published on September 2008

Hepatitis C virus NS5A inhibits mixed lineage kinase 3 to block apoptosis ⬇️

scientific article

Hepatitis C virus NS5A protein blocks epidermal growth factor receptor degradation via a proline motif- dependent interaction ⬇️

scientific article published on 13 April 2015

High-affinity target binding engineered via fusion of a single-domain antibody fragment with a ligand-tailored SH3 domain

scientific article

High-throughput phosphotyrosine profiling using SH2 domains

scientific article

Human immunodeficiency virus type 1 Nef recruits the guanine exchange factor Vav1 via an unexpected interface into plasma membrane microdomains for association with p21-activated kinase 2 activity

scientific article

Identification of a highly conserved valine-glycine-phenylalanine amino acid triplet required for HIV-1 Nef function

scientific article published on 27 April 2012

Identification of preferred protein interactions by phage-display of the human Src homology-3 proteome

scientific article

Identification of specific residues in avian influenza A virus NS1 that enhance viral replication and pathogenicity in mammalian systems

scientific article published on 12 July 2016

Insulin receptor tyrosine kinase substrate links the E. coli O157:H7 actin assembly effectors Tir and EspF(U) during pedestal formation

scientific article

Interactions of the HIV/SIV Pathogenicity Factor Nef with SH3 Domain-Containing Host Cell Proteins ⬇️

scientific article published on October 1, 2011

Large-Scale Screening of Preferred Interactions of Human Src Homology-3 (SH3) Domains Using Native Target Proteins as Affinity Ligands

scientific article published on 20 July 2016

MC159 of Molluscum Contagiosum Virus Suppresses Autophagy by Recruiting Cellular SH3BP4 via an SH3 Domain-Mediated Interaction

scientific article published on 01 May 2019

Macrophage metalloelastase (MME) as adjuvant for intra-tumoral injection of oncolytic adenovirus and its influence on metastases development

article

MicroRNA-Attenuated Clone of Virulent Semliki Forest Virus Overcomes Antiviral Type I Interferon in Resistant Mouse CT-2A Glioma

scientific article

MicroRNA-mediated suppression of oncolytic adenovirus replication in human liver

scientific article

Modulation of cell spreading and cell-substrate adhesion dynamics by dystroglycan.

scientific article

Molecular priming of Lyn by GPVI enables an immune receptor to adopt a hemostatic role

scientific article

Nef associates with p21-activated kinase 2 in a p21-GTPase-dependent dynamic activation complex within lipid rafts.

scientific article published on December 2004

Nef proteins from simian immunodeficiency virus-infected chimpanzees interact with p21-activated kinase 2 and modulate cell surface expression of various human receptors

scientific article

Nuclear Translocation of Crk Adaptor Proteins by the Influenza A Virus NS1 Protein

scientific article published on 15 April 2016

Optimized mouse model for the imaging of tumor metastasis upon experimental therapy

scientific article

Patient mutation in AIRE disrupts P-TEFb binding and target gene transcription

scientific article

Preferred SH3 domain partners of ADAM metalloproteases include shared and ADAM-specific SH3 interactions

scientific article published on 31 March 2015

Primate lentiviral Nef proteins deregulate T-cell development by multiple mechanisms

scientific article

Reciprocal regulation of SH3 and SH2 domain binding via tyrosine phosphorylation of a common site in CD3epsilon

scientific article

Recognition of tandem PxxP motifs as a unique Src homology 3-binding mode triggers pathogen-driven actin assembly

scientific article

Regulation of T cell activation by HIV-1 accessory proteins: Vpr acts via distinct mechanisms to cooperate with Nef in NFAT-directed gene expression and to promote transactivation by CREB

scientific article (publication date: 25 May 2003)

Reorganization of the host cell Crk(L)-PI3 kinase signaling complex by the influenza A virus NS1 protein

scientific article published on 19 June 2015

Role of the Kaposi's sarcoma-associated herpesvirus K15 SH3 binding site in inflammatory signaling and B-cell activation

scientific article

SH3 domain ligand binding: What's the consensus and where's the specificity?

scientific article

SH3 domain-mediated recruitment of host cell amphiphysins by alphavirus nsP3 promotes viral RNA replication

scientific article published on 17 November 2011

Single-domain antibody-SH3 fusions for efficient neutralization of HIV-1 Nef functions

scientific article published on 15 February 2012

Structural Basis of the High Affinity Interaction between the Alphavirus Nonstructural Protein-3 (nsP3) and the SH3 Domain of Amphiphysin-2

scientific article published on 6 June 2016

Structural basis for the inhibition of HIV-1 Nef by a high-affinity binding single-domain antibody

scientific article

Structural basis of PxxDY motif recognition in SH3 binding

scientific article

The C terminus of NS1 protein of influenza A/WSN/1933(H1N1) virus modulates antiviral responses in infected human macrophages and mice.

scientific article published on May 2015

The mechanism of tissue-restricted antigen gene expression by AIRE.

scientific article published on March 2013

Therapeutic targeting of interactions between Nef and host cell proteins

scientific article

Tyrosine phosphorylation directs TACE into extracellular vesicles via unconventional secretion

scientific article published on 21 January 2019

Unmodified histone H3K4 and DNA-dependent protein kinase recruit autoimmune regulator to target genes

scientific article published on 6 February 2012

Versatile retargeting of SH3 domain binding by modification of non-conserved loop residues

scientific article

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