List of works - Sjors Scheres

A Bayesian approach to beam-induced motion correction in cryo-EM single-particle analysis

article by Jasenko Zivanov et al published 1 January 2019 in IUCrJ

A Bayesian view on cryo-EM structure determination.

scientific article published on 12 November 2011

A pipeline approach to single-particle processing in RELION.

scientific article published on 20 April 2017

A thermostable, closed SARS-CoV-2 spike protein trimer

scientific article published on 31 July 2020

A thermostable, closed, SARS-CoV-2 spike protein trimer

preprint published on 17 June 2020

Accelerated cryo-EM structure determination with parallelisation using GPUs in RELION-2.

scientific article

Advances in Single-Particle Electron Cryomicroscopy Structure Determination applied to Sub-tomogram Averaging

scientific article published on 6 August 2015

Age-dependent formation of TMEM106B amyloid filaments in human brains

scientific article published in 2022

Amyloid structure determination in RELION-3.1.

scientific article published on 30 January 2020

An atomic structure of human γ-secretase

scientific journal article

An introduction to maximum-likelihood methods in cryo-EM.

scientific article

Atomic Structure of Type VI Contractile Sheath from Pseudomonas aeruginosa.

scientific article published on 21 December 2017

Atomic structure of the apoptosome: mechanism of cytochrome c- and dATP-mediated activation of Apaf-1

scientific article

Author response: New tools for automated high-resolution cryo-EM structure determination in RELION-3

Averaging of electron subtomograms and random conical tilt reconstructions through likelihood optimization.

scientific article

Beam-induced motion correction for sub-megadalton cryo-EM particles.

scientific article published on 13 August 2014

Characterisation of molecular motions in cryo-EM single-particle data by multi-body refinement in RELION.

scientific article

Classification of Structural Heterogeneity by Maximum-Likelihood Methods ⬇️

scientific article published on January 1, 2010

Classification of single-projection reconstructions for cryo-electron microscopy data of icosahedral viruses.

scientific article

Collaborative computational project for electron cryo-microscopy.

scientific article

Conditional optimization: a new formalism for protein structure refinement.

scientific article

Conformational rearrangements of SV40 large T antigen during early replication events.

scientific article published on 26 February 2010

Cryo-EM of dynein microtubule-binding domains shows how an axonemal dynein distorts the microtubule

scientific article published on 2 July 2019

Cryo-EM structure of a 3D DNA-origami object

scientific article

Cryo-EM structure of a metazoan separase-securin complex at near-atomic resolution.

scientific article published on 6 March 2017

Cryo-EM structure of a neuronal functional amyloid implicated in memory persistence in Drosophila

scientific article published on 01 March 2020

Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine

scientific article

Cryo-EM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 Å resolution

scientific article published on February 2016

Cryo-EM structures of amyloid-β 42 filaments from human brains

scientific article published in 2022

Cryo-EM structures of tau filaments from Alzheimer's disease.

scientific article published on 5 July 2017

Cryo-EM: A Unique Tool for the Visualization of Macromolecular Complexity

scientific article published on May 2015

CryoEM structure of MxB reveals a novel oligomerization interface critical for HIV restriction.

scientific article published on 15 September 2017

CryoEM structures of spliceosomal complexes reveal the molecular mechanism of pre-mRNA splicing.

scientific article published on 5 September 2017

Data management challenges in three-dimensional EM.

scientific article

Design of a molecular support for cryo-EM structure determination

scientific article

Development of a force field for conditional optimization of protein structures.

scientific article

Disentangling conformational states of macromolecules in 3D-EM through likelihood optimization.

scientific article published on 10 December 2006

Distinct Conformers of Assembled Tau in Alzheimer's and Pick's Diseases

scientific article published on 01 January 2018

Electron microscopy of Xrcc4 and the DNA ligase IV-Xrcc4 DNA repair complex.

scientific article published in December 2009

Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA

scientific article

Estimation of high-order aberrations and anisotropic magnification from cryo-EM data sets in RELION-3.1.

scientific article published on 11 February 2020

Fast maximum-likelihood refinement of electron microscopy images

scientific article published on September 2005

Helical reconstruction in RELION

scientific article published on 17 December 2016

Helical reconstruction in RELION.

scientific article

Heparin-induced tau filaments are polymorphic and differ from those in Alzheimer's and Pick's diseases

scientific article published on 05 February 2019

High-resolution noise substitution to measure overfitting and validate resolution in 3D structure determination by single particle electron cryomicroscopy

scientific article published on 21 June 2013

How cryo-EM is revolutionizing structural biology

scientific article

Image processing for electron microscopy single-particle analysis using XMIPP.

scientific article

Initiation of Translation by Cricket Paralysis Virus IRES Requires Its Translocation in the Ribosome

scientific article

Insights into the molecular architecture of the 26S proteasome

scientific article published on 06 July 2009

Introducing robustness to maximum-likelihood refinement of electron-microscopy data.

scientific article

Maximum likelihood based classification of electron tomographic data.

scientific article

Maximum likelihood refinement of electron microscopy data with normalization errors

scientific article

Maximum-likelihood multi-reference refinement for electron microscopy images

scientific article

Mechanistic insights into caspase-9 activation by the structure of the apoptosome holoenzyme.

scientific article published on 31 January 2017

Mefloquine targets the Plasmodium falciparum 80S ribosome to inhibit protein synthesis

scientific article

Modeling experimental image formation for likelihood-based classification of electron microscopy data

scientific article

Molecular architecture of a eukaryotic translational initiation complex

scientific article

New tools for automated high-resolution cryo-EM structure determination in RELION-3

scientific article published on 09 November 2018

Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules

scientific article published on 20 March 2019

Novel tau filament fold in corticobasal degeneration

scientific article published on 12 February 2020

Optimization problems in electron microscopy of single particles

Prevention of overfitting in cryo-EM structure determination

scientific article (publication date: September 2012)

Processing of Structurally Heterogeneous Cryo-EM Data in RELION.

scientific article

Quasi-atomic model of bacteriophage t7 procapsid shell: insights into the structure and evolution of a basic fold.

scientific article published in April 2007

RELION-3: new tools for automated high-resolution cryo-EM structure determination

RELION: implementation of a Bayesian approach to cryo-EM structure determination

scientific article (publication date: December 2012)

Resolving macromolecular structures from electron cryo-tomography data using subtomogram averaging in RELION

scientific article

Revealing the structures of megadalton-scale DNA complexes with nucleotide resolution

scientific article published on 04 December 2020

Ribosome structures to near-atomic resolution from thirty thousand cryo-EM particles

scientific article (publication date: 19 February 2013)

Ribosome. The structure of the human mitochondrial ribosome

scientific journal article

SPI-EM: towards a tool for predicting CATH superfamilies in 3D-EM maps.

scientific article published in January 2005

Sampling the conformational space of the catalytic subunit of human γ-secretase

scientific article

Self-correcting mismatches during high-fidelity DNA replication

scientific article published on 9 January 2017

Semi-automated selection of cryo-EM particles in RELION-1.3.

scientific article published on 6 December 2014

Single-particle cryo-EM at atomic resolution

scientific article published on 21 October 2020

Structure and uncoating of immature adenovirus.

scientific article published on 27 June 2009

Structure of active dimeric human telomerase

scientific article

Structure of hibernating ribosomes studied by cryoelectron tomography in vitro and in situ

scientific article

Structure of ratcheted ribosomes with tRNAs in hybrid states

scholarly article

Structure of the Fanconi anaemia monoubiquitin ligase complex

scientific article published on 30 October 2019

Structure of the MacAB-TolC ABC-type tripartite multidrug efflux pump.

scientific article published on 15 May 2017

Structure of the Mammalian Ribosome-Sec61 Complex to 3.4 Å Resolution

scientific article

Structure of the Yeast Mitochondrial Large Ribosomal Subunit

scientific article

Structure of the Yeast Mitochondrial Large Ribosomal Subunit

Structure of the apoptosome: mechanistic insights into activation of an initiator caspase from Drosophila

scientific article

Structure of the large ribosomal subunit from human mitochondria.

scientific article

Structure of the rabbit ryanodine receptor RyR1 at near-atomic resolution

scientific article

Structure-based classification of tauopathies

scientific article published on 29 September 2021

Structures and distributions of SARS-CoV-2 spike proteins on intact virions

scientific article published on 17 August 2020

Structures of filaments from Pick's disease reveal a novel tau protein fold

scientific article published in Nature

Structures of α-synuclein filaments from human brains with Lewy pathology

scientific article published in 2022

Structures of α-synuclein filaments from multiple system atrophy

scientific article published on 27 May 2020

Structures, conformations and distributions of SARS-CoV-2 spike protein trimers on intact virions

scientific article published on 27 June 2020

Subunit positioning and stator filament stiffness in regulation and power transmission in the V1 motor of the Manduca sexta V-ATPase ⬇️

scientific article

Tau filaments from multiple cases of sporadic and inherited Alzheimer's disease adopt a common fold

scientific article published on 01 October 2018

The architecture of the spliceosomal U4/U6.U5 tri-snRNP.

scientific article

The potentials of conditional optimization in phasing and model building of protein crystal structures.

scientific article

The structural basis of proton driven zinc transport by ZntB.

scientific article published on 3 November 2017

The structure of CCT-Hsc70 NBD suggests a mechanism for Hsp70 delivery of substrates to the chaperonin.

scientific article published on 27 July 2008

Three-dimensional structure of human γ-secretase

scientific article

Unravelling biological macromolecules with cryo-electron microscopy.

scientific article published on 14 September 2016

Visualizing molecular machines in action: Single-particle analysis with structural variability.

scientific article published on January 2010

X-ray and cryo-EM structures of monomeric and filamentous actin-like protein MamK reveal changes associated with polymerization

scientific article

XMIPP: a new generation of an open-source image processing package for electron microscopy.

scientific article

cryo-EM structures of the E. coli replicative DNA polymerase reveal its dynamic interactions with the DNA sliding clamp, exonuclease and τ.

scientific article published on 24 October 2015

tmRNA.SmpB complex mimics native aminoacyl-tRNAs in the A site of stalled ribosomes

scientific article

List of works by Sjors Scheres

A Bayesian approach to beam-induced motion correction in cryo-EM single-particle analysis

A Bayesian view on cryo-EM structure determination.

A pipeline approach to single-particle processing in RELION.

A thermostable, closed SARS-CoV-2 spike protein trimer

A thermostable, closed, SARS-CoV-2 spike protein trimer

Accelerated cryo-EM structure determination with parallelisation using GPUs in RELION-2.

Advances in Single-Particle Electron Cryomicroscopy Structure Determination applied to Sub-tomogram Averaging

Age-dependent formation of TMEM106B amyloid filaments in human brains

Amyloid structure determination in RELION-3.1.

An atomic structure of human γ-secretase

An introduction to maximum-likelihood methods in cryo-EM.

Atomic Structure of Type VI Contractile Sheath from Pseudomonas aeruginosa.

Atomic structure of the apoptosome: mechanism of cytochrome c- and dATP-mediated activation of Apaf-1

Author response: New tools for automated high-resolution cryo-EM structure determination in RELION-3

Averaging of electron subtomograms and random conical tilt reconstructions through likelihood optimization.

Beam-induced motion correction for sub-megadalton cryo-EM particles.

Characterisation of molecular motions in cryo-EM single-particle data by multi-body refinement in RELION.

Classification of Structural Heterogeneity by Maximum-Likelihood Methods ⬇️

Classification of single-projection reconstructions for cryo-electron microscopy data of icosahedral viruses.

Collaborative computational project for electron cryo-microscopy.

Conditional optimization: a new formalism for protein structure refinement.

Conformational rearrangements of SV40 large T antigen during early replication events.

Cryo-EM of dynein microtubule-binding domains shows how an axonemal dynein distorts the microtubule

Cryo-EM structure of a 3D DNA-origami object

Cryo-EM structure of a metazoan separase-securin complex at near-atomic resolution.

Cryo-EM structure of a neuronal functional amyloid implicated in memory persistence in Drosophila

Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine

Cryo-EM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 Å resolution

Cryo-EM structures of amyloid-β 42 filaments from human brains

Cryo-EM structures of tau filaments from Alzheimer's disease.

Cryo-EM: A Unique Tool for the Visualization of Macromolecular Complexity

CryoEM structure of MxB reveals a novel oligomerization interface critical for HIV restriction.

CryoEM structures of spliceosomal complexes reveal the molecular mechanism of pre-mRNA splicing.

Data management challenges in three-dimensional EM.

Design of a molecular support for cryo-EM structure determination

Development of a force field for conditional optimization of protein structures.

Disentangling conformational states of macromolecules in 3D-EM through likelihood optimization.

Distinct Conformers of Assembled Tau in Alzheimer's and Pick's Diseases

Electron microscopy of Xrcc4 and the DNA ligase IV-Xrcc4 DNA repair complex.

Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA

Estimation of high-order aberrations and anisotropic magnification from cryo-EM data sets in RELION-3.1.

Fast maximum-likelihood refinement of electron microscopy images

Helical reconstruction in RELION

Helical reconstruction in RELION.

Heparin-induced tau filaments are polymorphic and differ from those in Alzheimer's and Pick's diseases

High-resolution noise substitution to measure overfitting and validate resolution in 3D structure determination by single particle electron cryomicroscopy

How cryo-EM is revolutionizing structural biology

Image processing for electron microscopy single-particle analysis using XMIPP.

Initiation of Translation by Cricket Paralysis Virus IRES Requires Its Translocation in the Ribosome

Insights into the molecular architecture of the 26S proteasome

Introducing robustness to maximum-likelihood refinement of electron-microscopy data.

Maximum likelihood based classification of electron tomographic data.

Maximum likelihood refinement of electron microscopy data with normalization errors

Maximum-likelihood multi-reference refinement for electron microscopy images

Mechanistic insights into caspase-9 activation by the structure of the apoptosome holoenzyme.

Mefloquine targets the Plasmodium falciparum 80S ribosome to inhibit protein synthesis

Modeling experimental image formation for likelihood-based classification of electron microscopy data

Molecular architecture of a eukaryotic translational initiation complex

New tools for automated high-resolution cryo-EM structure determination in RELION-3

Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules

Novel tau filament fold in corticobasal degeneration

Optimization problems in electron microscopy of single particles

Prevention of overfitting in cryo-EM structure determination

Processing of Structurally Heterogeneous Cryo-EM Data in RELION.

Quasi-atomic model of bacteriophage t7 procapsid shell: insights into the structure and evolution of a basic fold.

RELION-3: new tools for automated high-resolution cryo-EM structure determination

RELION: implementation of a Bayesian approach to cryo-EM structure determination

Resolving macromolecular structures from electron cryo-tomography data using subtomogram averaging in RELION

Revealing the structures of megadalton-scale DNA complexes with nucleotide resolution

Ribosome structures to near-atomic resolution from thirty thousand cryo-EM particles

Ribosome. The structure of the human mitochondrial ribosome

SPI-EM: towards a tool for predicting CATH superfamilies in 3D-EM maps.

Sampling the conformational space of the catalytic subunit of human γ-secretase

Self-correcting mismatches during high-fidelity DNA replication

Semi-automated selection of cryo-EM particles in RELION-1.3.

Single-particle cryo-EM at atomic resolution

Structure and uncoating of immature adenovirus.

Structure of active dimeric human telomerase

Structure of hibernating ribosomes studied by cryoelectron tomography in vitro and in situ