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List of works by Caroline Dive

A Pilot Study Assessing the Prognostic Value of CK18 and nDNA Biomarkers in Severe Sepsis Patients

A caspase-3 'death-switch' in colorectal cancer cells for induced and synchronous tumor apoptosis in vitro and in vivo facilitates the development of minimally invasive cell death biomarkers

scientific article published on 2 May 2013

A conserved YAP/Notch/REST network controls the neuroendocrine cell fate in the lungs

scientific article published on 16 May 2022

A hierarchical statistical modeling approach to analyze proteomic isobaric tag for relative and absolute quantitation data

scientific article

A new Alliance: biomedical societies in Europe unite to support research

scientific article published on 01 September 2011

A phase 1 trial of intravenous 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) in patients with advanced solid tumours

scientific article

A pilot study to explore circulating tumour cells in pancreatic cancer as a novel biomarker.

scientific article

A proof-of-principle gel-free proteomics strategy for the identification of predictive biomarkers for the onset of pre-eclampsia

scientific article published on 04 August 2009

A small molecule inhibitor of XIAP induces apoptosis and synergises with vinorelbine and cisplatin in NSCLC.

scientific article

A study to investigate dose escalation of doxorubicin in ABVD chemotherapy for Hodgkin lymphoma incorporating biomarkers of response and toxicity

scientific article published on 17 October 2013

AZD3514, an oral selective androgen receptor down-regulator in patients with castration-resistant prostate cancer - results of two parallel first-in-human phase I studies

scientific article published on 30 April 2015

Activated c-SRC in ductal carcinoma in situ correlates with high tumour grade, high proliferation and HER2 positivity

scientific article published on 24 October 2006

Activation of the Abelson tyrosine kinase activity is associated with suppression of apoptosis in hemopoietic cells

scientific article published on April 1993

Activity of the monocarboxylate transporter 1 inhibitor AZD3965 in small cell lung cancer

scientific article

Alliance for biomedical research in Europe

scientific article

An integrated characterization of serological, pathological, and functional events in doxorubicin-induced cardiotoxicity

scientific article published on 27 March 2014

Analysis and discrimination of necrosis and apoptosis (programmed cell death) by multiparameter flow cytometry

scientific article published in February 1992

Analysis of Circulating Tumor Cells in Patients with Non-small Cell Lung Cancer Using Epithelial Marker-Dependent and -Independent Approaches

article

Analysis of circulating cell-free DNA identifies KRAS copy number gain and mutation as a novel prognostic marker in Pancreatic cancer

scientific article published on 12 August 2019

Analytical validation of BRAF mutation testing from circulating free DNA using the amplification refractory mutation testing system

scientific article published on 12 March 2014

Apoptosis and cancer chemotherapy

scientific article published on 01 November 2001

Apoptosis pathway-targeted drugs--from the bench to the clinic

scientific article

Apoptotic death in epithelial cells: cleavage of DNA to 300 and/or 50 kb fragments prior to or in the absence of internucleosomal fragmentation.

scientific article

Application of Sequencing, Liquid Biopsies, and Patient-Derived Xenografts for Personalized Medicine in Melanoma.

scientific article published on 29 December 2015

Application of the β-expectation tolerance interval to method validation of the M30 and M65 ELISA cell death biomarker assays

scientific article

Assessment of circulating biomarkers for potential pharmacodynamic utility in patients with lymphoma

scientific article

Assessment of diurnal changes and confounding factors that affect circulating cell death biomarker levels: a short communication.

scientific article published on 21 June 2013

Author Correction: Molecular subtypes of small cell lung cancer: a synthesis of human and mouse model data

scientific article published on 01 July 2019

Avoidance of apoptosis as a mechanism of drug resistance

scientific article published on January 1, 1997

BMX acts downstream of PI3K to promote colorectal cancer cell survival and pathway inhibition sensitizes to the BH3 mimetic ABT-737.

scientific article published on February 2014

Bid, a widely expressed proapoptotic protein of the Bcl-2 family, displays lipid transfer activity.

scientific article

Biological mechanisms linking obesity and cancer risk: new perspectives

scientific article

Biology and clinical relevance of circulating tumour cells

scientific article published on October 2012

Biomarker method validation in anticancer drug development

scientific article

Biomarker utility of circulating tumor cells in metastatic cutaneous melanoma

scientific article published on 6 December 2012

Biomarkers for small cell lung cancer: neuroendocrine, epithelial and circulating tumour cells

scientific article published on 15 December 2011

Biomarkers of angiogenesis and their role in the development of VEGF inhibitors

scientific article published on 15 December 2009

Biomarkers of apoptosis

scientific article published on September 2008

Biomarkers of cell death applicable to early clinical trials

scientific article published on 27 March 2012

Blocking phosphoinositide 3-kinase activity in colorectal cancer cells reduces proliferation but does not increase apoptosis alone or in combination with cytotoxic drugs

scientific article

Blood cells with reduced mitochondrial membrane potential and cytosolic cytochrome C can survive and maintain clonogenicity given appropriate signals to suppress apoptosis.

scientific article published on December 1998

Both stromal cell and colonocyte epidermal growth factor receptors control HCT116 colon cancer cell growth in tumor xenografts

scientific article

CD47-blocking immunotherapies stimulate macrophage-mediated destruction of small-cell lung cancer

scientific article published on 13 June 2016

Can flow cytoenzymology be applied to measure membrane-bound enzyme kinetics? Assessment by analysis of gamma-glutamyl transpeptidase activity

scientific article published on August 1993

Cancer Moonshot Connecting International Liquid Biopsy Efforts Through Academic Partnership

scientific article published on 9 February 2017

Cediranib combined with carboplatin and paclitaxel in patients with metastatic or recurrent cervical cancer (CIRCCa): a randomised, double-blind, placebo-controlled phase 2 trial

scientific article

Cediranib or placebo in combination with cisplatin and gemcitabine chemotherapy for patients with advanced biliary tract cancer (ABC-03): a randomised phase 2 trial

scientific article

Cell Death, Inflammation, Tumor Burden, and Proliferation Blood Biomarkers Predict Lung Cancer Radiotherapy Response and Correlate With Tumor Volume and Proliferation Imaging

scientific article published on 11 December 2017

Cell Sensitivity Assays : Detection of Apoptotic Cells In Vitro Using the TUNEL Assay

scientific article

Cell cycle specific induction of HL-60 cell differentiation and apoptosis by mycophenolic acid

scientific article

Cell damage-induced conformational changes of the pro-apoptotic protein Bak in vivo precede the onset of apoptosis

scientific article

Cell sensitivity assays. Quantitative detection of apoptotic cells in vitro using the TUNEL assay

scientific article published on 01 January 2001

Cellular damage signals promote sequential changes at the N-terminus and BH-1 domain of the pro-apoptotic protein Bak.

scientific article published in November 2001

Changes in intercellular junctions during apoptosis precede nuclear condensation or phosphatidylserine exposure on the cell surface

Characterization of cell volume loss in CEM-C7A cells during dexamethasone-induced apoptosis

article

Characterization of drug resistance mediated via the suppression of apoptosis by Abelson protein tyrosine kinase ⬇️

scientific article published on August 1, 1995

Chronic hypoxia promotes hypoxia-inducible factor-1alpha-dependent resistance to etoposide and vincristine in neuroblastoma cells.

scientific article published on September 2006

Circulating Tumor Cell Enumeration in a Phase II Trial of a Four-Drug Regimen in Advanced Colorectal Cancer

scientific article published on 31 December 2014

Circulating Tumor Cells Detected in the Tumor-Draining Pulmonary Vein Are Associated with Disease Recurrence after Surgical Resection of NSCLC.

scientific article published on 30 June 2016

Circulating biomarkers in hepatocellular carcinoma

article

Circulating biomarkers of cell death after treatment with the BH-3 mimetic ABT-737 in a preclinical model of small-cell lung cancer

scientific article published on November 2008

Circulating tumor cells and CDX models as a tool for preclinical drug development

scientific article published on August 2017

Circulating tumor cells as a window on metastasis biology in lung cancer

scientific article

Circulating tumor cells, enumeration and beyond

scientific article published on 09 June 2010

Circulating tumour cells as tumour biomarkers in melanoma: detection methods and clinical relevance

scientific article

Circulating tumour cells: their utility in cancer management and predicting outcomes

scientific article

Cisplatin- and paclitaxel-induced apoptosis of ovarian carcinoma cells and the relationship between bax and bak up-regulation and the functional status of p53.

scientific article published on May 1998

Clinical Significance and Molecular Characteristics of Circulating Tumor Cells and Circulating Tumor Microemboli in Patients With Small-Cell Lung Cancer

article

Clinical evaluation of M30 and M65 ELISA cell death assays as circulating biomarkers in a drug-sensitive tumor, testicular cancer

scientific article published on October 2008

Clinical evaluation of a novel microfluidic device for epitope-independent enrichment of circulating tumour cells in patients with small cell lung cancer

scientific article published on 25 November 2015

Clinical utility of circulating tumour cell detection in non-small-cell lung cancer

scientific article published on December 2013

Comparative effects of Bcl-2 over-expression and ZVAD.FMK treatment on dexamethasone and VP16-induced apoptosis in CEM cells

Comparison of doxycycline delivery methods for Tet-inducible gene expression in a subcutaneous xenograft model

scientific article

Comparison of phosphatidylinositol-3-kinase signalling within a panel of human colorectal cancer cell lines with mutant or wild-type PIK3CA.

scientific article published in September 2005

Consensus on precision medicine for metastatic cancers: a report from the MAP conference.

scientific article published on 3 May 2016

Considerations for the use of plasma cytokeratin 18 as a biomarker in pancreatic cancer.

scientific article

Construction and characterization of multiple human colon cancer cell lines for inducibly regulated gene expression.

scientific article published on April 2005

Contribution of HIF-1 and drug penetrance to oxaliplatin resistance in hypoxic colorectal cancer cells.

scientific article

Corrigendum: Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution

scientific article published in Nature

Current status and future potential of somatic mutation testing from circulating free DNA in patients with solid tumours

scientific article

Cytoplasmic acidification is not an effector mechanism of VP16 or DEX-induced apoptosis in CEM T leukaemia cells

scientific article published on 01 June 1999

DNA-damaging agents induce both p53-dependent and p53-independent apoptosis in immature thymocytes

scientific article published on 01 October 1996

Damage-induced Bax N-terminal change, translocation to mitochondria and formation of Bax dimers/complexes occur regardless of cell fate

scientific article

Detection of BRAF mutations in the tumour and serum of patients enrolled in the AZD6244 (ARRY-142886) advanced melanoma phase II study.

scientific article published on 27 October 2009

Detection of PIK3CA mutations in circulating free DNA in patients with breast cancer

scientific article published on 28 January 2010

Development of a circulating miRNA assay to monitor tumor burden: From mouse to man

scientific article published on 28 October 2015

Diagnostic Mutation Profiling and Validation of Non-Small-Cell Lung Cancer Small Biopsy Samples using a High Throughput Platform

scientific article published in May 2015

Differences in resistance to 5-fluorouracil as a function of cell cycle delay and not apoptosis.

scientific article published on December 1995

Differential induction of etoposide-mediated apoptosis in human leukemia HL-60 and K562 cells

scientific article published on 01 October 1994

Differential sensitivity to the induction of apoptosis by cisplatin in proliferating and quiescent immature rat thymocytes is independent of the levels of drug accumulation and DNA adduct formation.

scientific article

Difluoro analogue of UCS15A triggers activation of exogenously expressed c-Src in HCT 116 human colorectal carcinoma cells

scientific article published on October 2007

Discovery and Validation of Predictive Biomarkers of Survival for Non-small Cell Lung Cancer Patients Undergoing Radical Radiotherapy: Two Proteins With Predictive Value

scientific article

Distinct subclonal tumour responses to therapy revealed by circulating cell-free DNA.

scientific article published on 08 August 2016

Down-regulation of XIAP by AEG35156 in paediatric tumour cells induces apoptosis and sensitises cells to cytotoxic agents

scientific article published on 31 January 2011

Drug-target interactions: only the first step in the commitment to a programmed cell death? ⬇️

scientific article published on July 1, 1991

Dynamic CT in pancreatic lymphoma

scientific article published on 01 January 1993

ERS is founding member of a new Alliance for Biomedical Research in Europe

scientific article published on 01 August 2011

Effect of prolonged formalin fixation on immunohistochemical staining for the proliferation marker Ki67

Effects of cisplatin on the induction of apoptosis in proliferating hepatoma cells and nonproliferating immature thymocytes

scientific article published on 01 May 1993

Epigenetic determinants of resistance to etoposide regulation of Bcl-X(L) and Bax by tumor microenvironmental factors

scientific article

Evaluation and Prognostic Significance of Circulating Tumor Cells in Patients With Non–Small-Cell Lung Cancer

article

Evaluation and validation of a robust single cell RNA-amplification protocol through transcriptional profiling of enriched lung cancer initiating cells.

scientific article

Evaluation of cell death mechanisms induced by the vascular disrupting agent OXi4503 during a phase I clinical trial

scientific article

Evaluation of circulating tumor cells and serological cell death biomarkers in small cell lung cancer patients undergoing chemotherapy

scientific article published on 23 July 2009

Expression of kinase-defective mutants of c-Src in human metastatic colon cancer cells decreases Bcl-xL and increases oxaliplatin- and Fas-induced apoptosis

scientific article

Expression of pro-apoptotic Bfk isoforms reduces during malignant transformation in the human gastrointestinal tract

scientific article published in July 2005

Expression of the proapoptotic protein Bid is an adverse prognostic factor for radiotherapy outcome in carcinoma of the cervix.

scientific article published on February 2005

External quality assurance of circulating tumor cell enumeration using the CellSearch® system: A feasibility study

article

Extracellular matrix regulates apoptosis in mammary epithelium through a control on insulin signaling

scientific article

Fit-for-purpose biomarker method validation for application in clinical trials of anticancer drugs

scientific article published on 05 October 2010

Fit-for-purpose biomarker method validation in anticancer drug development

scientific article published on 11 August 2010

Flow Cytometric Analysis of Steroidogenic Organelles in Differentiating Granulosa Cells1

scientific article published on 01 October 1992

Further characterisation of the in situ terminal deoxynucleotidyl transferase (TdT) assay for the flow cytometric analysis of apoptosis in drug resistant and drug sensitive leukaemic cells.

scientific article published in July 1995

Generation of cells expressing improved doxycycline-regulated reverse transcriptional transactivator rtTA2S-M2.

scientific article published on January 2006

Genetic profiling of tumours using both circulating free DNA and circulating tumour cells isolated from the same preserved whole blood sample.

scientific article published on 19 November 2015

Germinal center-derived signals act with Bcl-2 to decrease apoptosis and increase clonogenicity of drug-treated human B lymphoma cells.

scientific article

Hypoxia-driven splicing into noncoding isoforms regulates the DNA damage response

scientific article published on 20 July 2016

Hypoxia-induced cytotoxic drug resistance in osteosarcoma is independent of HIF-1Alpha

scientific article (publication date: 2013)

Hypoxia-mediated down-regulation of Bid and Bax in tumors occurs via hypoxia-inducible factor 1-dependent and -independent mechanisms and contributes to drug resistance

scientific article published on April 2004

Hypoxic human cancer cells are sensitized to BH-3 mimetic–induced apoptosis via downregulation of the Bcl-2 protein Mcl-1.

scientific article published on March 2011

IAPs as a target for anticancer therapy.

scientific article published on December 2007

Identification and Targeting of Long-Term Tumor-Propagating Cells in Small Cell Lung Cancer

scientific article published on 29 June 2016

Identification of early predictive imaging biomarkers and their relationship to serological angiogenic markers in patients with ovarian cancer with residual disease following cytotoxic therapy

scientific article published on 29 March 2010

Imaging biomarker roadmap for cancer studies ⬇️

scientific article

Improved methodology for intracellular enzyme reaction and inhibition kinetics by flow cytometry

scientific article

In silico screening and biological evaluation of inhibitors of Src-SH3 domain interaction with a proline-rich ligand

scientific article

Increases in c-Src expression level and activity do not promote the growth of human colorectal carcinoma cells in vitro and in vivo

scientific article

Increases in c-Yes expression level and activity promote motility but not proliferation of human colorectal carcinoma cells

scientific article

Inducible EGFR T790M-mediated gefitinib resistance in non-small cell lung cancer cells does not modulate sensitivity to PI103 provoked autophagy

scientific article published on June 2010

Inhibition of FGFR2 and FGFR1 increases cisplatin sensitivity in ovarian cancer

scientific article

Inhibition of PI3K/BMX Cell Survival Pathway Sensitizes to BH3 Mimetics in SCLC.

scientific article published on 29 March 2016

Inhibition of cellular esterases by the antitumour imidazotetrazines mitozolomide and temozolomide: demonstration by flow cytometry and conventional spectrofluorimetry

scientific article published in January 1989

Inhibition of intracellular esterases by antitumour chloroethylnitrosoureas

scientific article published on 01 October 1988

Investigation of the mechanism of higher order chromatin fragmentation observed in drug-induced apoptosis.

scientific article published on May 1995

Is Serum or Plasma More Appropriate for Intersubject Comparisons in Metabolomic Studies? An Assessment in Patients with Small-Cell Lung Cancer

article

Is metabolism an important arbiter of anticancer activity of ether lipids? Metabolism of SRI 62-834 and hexadecylphosphocholine by [31P]-NMR spectroscopy and comparison of their cytotoxicities with those of their metabolites

scientific article published on January 1992

Isolation and Extraction of Circulating Tumor DNA from Patients with Small Cell Lung Cancer

scientific article published on 01 August 2008

Issues on fit-for-purpose validation of a panel of ELISAs for application as biomarkers in clinical trials of anti-Angiogenic drugs.

scientific article

Liquid chromatography-mass spectrometry calibration transfer and metabolomics data fusion

scientific article

MCF-7 human mammary adenocarcinoma cell death in vitro in response to hormone-withdrawal and DNA damage

scientific article published on May 1995

Medical societies unite to support research in Europe

scientific article published on 01 May 2011

Method validation and preliminary qualification of pharmacodynamic biomarkers employed to evaluate the clinical efficacy of an antisense compound (AEG35156) targeted to the X-linked inhibitor of apoptosis protein XIAP.

scientific article published on July 2006

Method validation of circulating tumour cell enumeration at low cell counts

scientific article

Mitochondrial membrane permeabilisation by Bax/Bak ⬇️

scientific article published on May 9, 2003

Modulating sensitivity to drug-induced apoptosis: the future for chemotherapy?

scientific article

Molecular analysis of circulating tumor cells identifies distinct copy-number profiles in patients with chemosensitive and chemorefractory small-cell lung cancer

scientific article

Molecular analysis of circulating tumour cells-biology and biomarkers

scientific article published on 21 January 2014

Molecular analysis of single circulating tumour cells following long-term storage of clinical samples

scientific article published on 25 July 2017

Molecular subtypes of small cell lung cancer: a synthesis of human and mouse model data

scientific article published on 01 May 2019

Multi-level evidence that circulating CK18 is a biomarker of tumour burden in colorectal cancer ⬇️

scientific article

Multiparametric analysis of cell membrane permeability by two colour flow cytometry with complementary fluorescent probes

article

Multiparametric flow cytometry of the modulation of tumor cell membrane permeability by developmental antitumor ether lipid SRI 62-834 in EMT6 mouse mammary tumor and HL-60 human promyelocytic leukemia cells

scientific article published in February 1991

Multiplexed assays for detection of mutations in PIK3CA.

scientific article

Neuroendocrine and epithelial phenotypes in small-cell lung cancer: implications for metastasis and survival in patients

scientific article published on 21 March 2013

Next-Generation Sequencing Analysis and Algorithms for PDX and CDX Models

scientific article published on 25 April 2017

Non-genotoxic hepatocarcinogenesis in vitro: the FaO hepatoma line responds to peroxisome proliferators and retains the ability to undergo apoptosis

scientific article published on February 1993

Noninvasive tumor hypoxia measurement using magnetic resonance imaging in murine U87 glioma xenografts and in patients with glioblastoma.

scientific article published on 24 June 2013

Novel dynamic flow cytoenzymological determination of intracellular esterase inhibition by BCNU and related isocyanates

scientific article published on 01 November 1987

Novel risk models for early detection and screening of ovarian cancer

scientific article

Novel therapeutic targets in lung cancer: Inhibitor of apoptosis proteins from laboratory to clinic

scientific article published on 8 January 2007

Obesity and cancer: Pathophysiological and biological mechanisms

article

Obesity, insulin and chemoresistance in colon cancer

scientific article

Optimisation of an immunohistochemistry method for the determination of androgen receptor expression levels in circulating tumour cells

scientific article

Optimisation of circulating biomarkers of cell death for routine clinical use.

scientific article published on 27 February 2008

Optimisation of immunofluorescence methods to determine MCT1 and MCT4 expression in circulating tumour cells

scientific article published on 10 May 2015

Optimization of circulating biomarkers of obatoclax-induced cell death in patients with small cell lung cancer

scientific article

Oxaliplatin responses in colorectal cancer cells are modulated by CHK2 kinase inhibitors.

scientific article

PCAF is an HIF-1alpha cofactor that regulates p53 transcriptional activity in hypoxia.

scientific article

PDGFR-modulated miR-23b cluster and miR-125a-5p suppress lung tumorigenesis by targeting multiple components of KRAS and NF-kB pathways

scientific article published on 13 November 2017

PO-36 - Thrombin Inhibition Preoperatively (TIP) in early breast cancer, the first clinical trial of NOACs as an anti-cancer agent: trial methodology

scientific article

Parallel Evaluation of Circulating Tumor DNA and Circulating Tumor Cells in Metastatic Colorectal Cancer

scientific article published in November 2017

Pazopanib and Fosbretabulin in recurrent ovarian cancer (PAZOFOS): A multi-centre, phase 1b and open-label, randomised phase 2 trial

scientific article published on 10 January 2020

Phase I pharmacokinetic and pharmacodynamic study of the bioreductive drug RH1

Phase I study of Navitoclax (ABT-263), a novel Bcl-2 family inhibitor, in patients with small-cell lung cancer and other solid tumors

scientific article

Phase I trial of AEG35156 administered as a 7-day and 3-day continuous intravenous infusion in patients with advanced refractory cancer

scientific article

Phase II study of single-agent navitoclax (ABT-263) and biomarker correlates in patients with relapsed small cell lung cancer

scientific article

Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution

scientific article

Plasma Tie2 is a tumor vascular response biomarker for VEGF inhibitors in metastatic colorectal cancer

scientific article published in Nature Communications

Polar fluorescein derivatives as improved substrate probes for flow cytoenzymological assay of cellular esterases

scientific article published on 01 June 1988

Post-translational modification of Bid has differential effects on its susceptibility to cleavage by caspase 8 or caspase 3.

scientific article published on 21 February 2003

Preclinical efficacy of the bioreductive alkylating agent RH1 against paediatric tumours.

scientific article

Preclinical evaluation of M30 and M65 ELISAs as biomarkers of drug induced tumor cell death and antitumor activity

scientific article

Prevalence and heterogeneity of circulating tumour cells in metastatic cutaneous melanoma

scientific article

Proapoptotic Bid binds to monolysocardiolipin, a new molecular connection between mitochondrial membranes and cell death

scientific article published in December 2003

Prognostic and predictive biomarkers in early stage NSCLC: CTCs and serum/plasma markers

scientific article

Progress and prospects of early detection in lung cancer

scientific article published on September 2017

Protein Z: A putative novel biomarker for early detection of ovarian cancer

scientific article published on 27 January 2016

Protein kinase C delta is phosphorylated on five novel Ser/Thr sites following inducible overexpression in human colorectal cancer cells

scientific article

Publisher Correction: Pulmonary venous circulating tumor cell dissemination before tumor resection and disease relapse

scientific article published on 03 June 2020

Pulmonary venous circulating tumor cell dissemination before tumor resection and disease relapse

scientific article published on 07 October 2019

Qualification of M30 and M65 ELISAs as surrogate biomarkers of cell death: long term antigen stability in cancer patient plasma

article by J. Cummings et al published 27 February 2007 in Cancer Chemotherapy and Pharmacology

Quantification of skeletal metastases in castrate-resistant prostate cancer predicts progression-free and overall survival

scientific article published on 27 July 2014

Quantitative mass spectrometry-based techniques for clinical use: biomarker identification and quantification

scientific article

Quantitative multiplexed quantum dot immunohistochemistry.

scientific article published on 11 July 2008

Reactivating HIF prolyl hydroxylases under hypoxia results in metabolic catastrophe and cell death.

scientific article published on 31 August 2009

Recent advances in targeting regulators of apoptosis in cancer cells for therapeutic gain

scientific article

Recent advances in understanding apoptosis: new therapeutic opportunities in cancer chemotherapy

scientific article published on 01 June 2003

Reciprocal relationship between expression of hypoxia inducible factor 1alpha (HIF-1alpha) and the pro-apoptotic protein bid in ex vivo colorectal cancer

scientific article published on 22 July 2008

Requirement of basement membrane for the suppression of programmed cell death in mammary epithelium

scientific article published on 01 March 1996

Role of mitochondrial membrane permeabilization in apoptosis and cancer

scientific article published on April 2004

Short duration immunochemotherapy followed by radioimmunotherapy consolidation is effective and well tolerated in relapsed follicular lymphoma: 5-year results from a UK National Cancer Research Institute Lymphoma Group study.

scientific article published on 05 February 2016

Small Cell Lung Cancer: Can Recent Advances in Biology and Molecular Biology Be Translated into Improved Outcomes?

scientific article published on 29 January 2016

SnapShot: Circulating Tumor Cells

SnapShot: Circulating Tumor Cells

Somatically mutated ABL1 is an actionable and essential NSCLC survival gene

scientific article published on 12 January 2016

Specific demonstration of drug-induced tumour cell apoptosis in human xenografts models using a plasma biomarker

scientific article published on January 2009

Spotlight on circulating tumour cells

scientific article published on August 2017

Src family kinase inhibitor Saracatinib (AZD0530) impairs oxaliplatin uptake in colorectal cancer cells and blocks organic cation transporters

scientific article published on 15 June 2010

Statistical considerations of optimal study design for human plasma proteomics and biomarker discovery

scientific article published on 12 March 2012

Suppression of apoptosis by v-ABL protein tyrosine kinase is associated with nuclear translocation and activation of protein kinase C in an interleukin-3-dependent haemopoietic cell line ⬇️

scientific article published on July 1, 1995

Suppression of liver cell apoptosis in vitro by the non-genotoxic hepatocarcinogen and peroxisome proliferator nafenopin

scientific article published on April 1994

Sustained tumour eradication after induced caspase-3 activation and synchronous tumour apoptosis requires an intact host immune response

scientific article published on 15 February 2013

Synchronous apoptosis in established tumors leads to the induction of adaptive immunity

scientific article published on 16 April 2013

Systematic analysis of circulating soluble angiogenesis-associated proteins in ICON7 identifies Tie2 as a biomarker of vascular progression on bevacizumab ⬇️

scientific article published on 28 June 2016

Targeting DNA damage in SCLC.

scientific article published on 16 October 2017

Tetracycline regulated systems in functional oncogenomics ⬇️

scientific article published on March 28, 2007

The clinical utility of circulating tumour cells in patients with small cell lung cancer

scientific article published on August 2017

The combination of circulating Ang1 and Tie2 levels predicts progression-free survival advantage in bevacizumab-treated patients with ovarian cancer

scientific article

The development of composite circulating biomarker models for use in anticancer drug clinical development

scientific article published on April 2011

The interaction between prognostic and pharmacodynamic biomarkers.

scientific article published on 03 September 2013

The non-genotoxic hepatocarcinogen nafenopin suppresses rodent hepatocyte apoptosis induced by TGFbeta1, DNA damage and Fas.

scientific article published in February 1998

The novel Bcl-2 inhibitor ABT-737 is more effective in hypoxia and is able to reverse hypoxia-induced drug resistance in neuroblastoma cells

scientific article published on 17 October 2011

The rodent non-genotoxic hepatocarcinogen nafenopin suppresses apoptosis preferentially in non-cycling hepatocytes but also elevates CDK4, a cell cycle progression factor

scientific article published in October 1998

The suppression of drug-induced apoptosis by activation of v-ABL protein tyrosine kinase

scientific article published on October 1994

Tracking genomic cancer evolution for precision medicine: the lung TRACERx study

scientific article

Tracking the Evolution of Non-Small-Cell Lung Cancer

scientific article published on 26 April 2017

Tumorigenicity and genetic profiling of circulating tumor cells in small-cell lung cancer.

scientific article published in June 2014

Tumourigenic non-small-cell lung cancer mesenchymal circulating tumour cells: a clinical case study.

scientific article published on 24 March 2016

Utility of ctDNA to support patient selection for early phase clinical trials: the TARGET study

scientific article published on 22 April 2019

Validation of an ELISA for the determination of rituximab pharmacokinetics in clinical trials subjects

scientific article published on 11 June 2010

Validation of pharmacodynamic assays to evaluate the clinical efficacy of an antisense compound (AEG 35156) targeted to the X-linked inhibitor of apoptosis protein XIAP.

scientific article published on February 2005

Vasculogenic mimicry in small cell lung cancer

scientific article

X-linked inhibitor of apoptosis protein as a therapeutic target

scientific article

[18F]-FLT positron emission tomography can be used to image the response of sensitive tumors to PI3-kinase inhibition with the novel agent GDC-0941.

scientific article published on 20 February 2013

bcl-2 modulation of apoptosis induced by anticancer drugs: resistance to thymidylate stress is independent of classical resistance pathways.

scientific article

twoddpcr: An R/Bioconductor package and Shiny app for Droplet Digital PCR analysis.

scientific article published on 5 May 2017

v-Abl protein tyrosine kinase (PTK) mediated suppression of apoptosis is associated with the up-regulation of Bcl-XL.

scientific article

‘Fit-for-purpose’ validation of SearchLight multiplex ELISAs of angiogenesis for clinical trial use

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