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List of works by Richard Marais

(G12D) NRAS and kinase-dead BRAF cooperate to drive naevogenesis and melanomagenesis

scientific article published on 12 August 2014

14-3-3 antagonizes Ras-mediated Raf-1 recruitment to the plasma membrane to maintain signaling fidelity

scientific article

14-3-3 proteins: structure resolved, functions less clear

scientific article

A PAX3/BRN2 rheostat controls the dynamics of BRAF mediated MITF regulation in MITF /AXL melanoma

scientific article published on 19 October 2018

A cell surface tethered enzyme improves efficiency in gene-directed enzyme prodrug therapy

scientific article published on December 1997

A common alternative splicing signature is associated with SF3B1 mutations in malignancies from different cell lineages.

scientific article

A mouse model of melanoma driven by oncogenic KRAS.

scientific article published on June 2010

A novel vascular endothelial growth factor-directed therapy that selectively activates cytotoxic prodrugs

scientific article published on May 2003

A novel, selective, and efficacious nanomolar pyridopyrazinone inhibitor of V600EBRAF.

scientific article

A whole-genome massively parallel sequencing analysis of BRCA1 mutant oestrogen receptor-negative and -positive breast cancers

scientific article published on 23 February 2012

A-Raf and Raf-1 work together to influence transient ERK phosphorylation and Gl/S cell cycle progression

scientific article

ARAF acts as a scaffold to stabilize BRAF:CRAF heterodimers

scientific article published on 27 August 2012

Activated B-RAF is an Hsp90 client protein that is targeted by the anticancer drug 17-allylamino-17-demethoxygeldanamycin

scientific article published on December 2005

Activation of forkhead box O transcription factors by oncogenic BRAF promotes p21cip1-dependent senescence.

scientific article published on 19 October 2010

Activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway by conventional, novel, and atypical protein kinase C isotypes.

scientific article published on February 1998

Activity of sodium fusidate in vitro against anaerobic bacteria

scientific article published on 01 June 1987

All Roads Lead to the Ribosome

Analysis of the efficacy and toxicity of sorafenib in thyroid cancer: a phase II study in a UK based population

article

Appropriate subcellular localisation of prodrug-activating enzymes has important consequences for suicide gene therapy

scientific article

Attenuated Salmonella targets prodrug activating enzyme carboxypeptidase G2 to mouse melanoma and human breast and colon carcinomas for effective suicide gene therapy

scientific article

B-RAF is a therapeutic target in melanoma

scientific article published on August 2004

B-Raf acts via the ROCKII/LIMK/cofilin pathway to maintain actin stress fibers in fibroblasts

scientific journal article

BIM mediates synergistic killing of B-cell acute lymphoblastic leukemia cells by BCL-2 and MEK inhibitors

scientific article published on 7 April 2016

BRAF and NRAS mutations in melanoma: potential relationships to clinical response to HSP90 inhibitors

scientific article

BRAF as a therapeutic target: a patent review (2006 - 2012).

scientific article published on 07 January 2013

BRAF inactivation drives aneuploidy by deregulating CRAF

scientific article

BRAF inhibitors based on an imidazo[4,5]pyridin-2-one scaffold and a meta substituted middle ring

scientific article

BRAF inhibitors induce metastasis in RAS mutant or inhibitor-resistant melanoma cells by reactivating MEK and ERK signaling

scientific article published on 25 March 2014

BRAF signaling and targeted therapies in melanoma

scientific article published on June 2009

Braking BRAF: AMPK leaves ERK stranded in the desert

scientific article

C-end your drugs using peptide tags

article

COX-2 inhibition prevents the appearance of cutaneous squamous cell carcinomas accelerated by BRAF inhibitors

scientific article published on December 2013

CRAF autophosphorylation of serine 621 is required to prevent its proteasome-mediated degradation

scientific article published on September 2008

Calmodulin binds to K-Ras, but not to H- or N-Ras, and modulates its downstream signaling

scientific article (publication date: November 2001)

Calmodulin prevents activation of Ras by PKC in 3T3 fibroblasts

scientific article published on 31 July 2002

Cancer: Melanoma troops massed

scientific article

Casein kinase II phosphorylation increases the rate of serum response factor-binding site exchange.

scientific article published on January 1992

Cellular senescence in naevi and immortalisation in melanoma: a role for p16?

scientific article published on August 2006

Childhood papillary thyroid cancer as second malignancy after successful treatment of rhabdomyosarcoma

scientific article

Combined zebrafish-yeast chemical-genetic screens reveal gene-copper-nutrition interactions that modulate melanocyte pigmentation

scientific article

Control of the ERK MAP kinase cascade by Ras and Raf.

scientific article

Cyclic AMP blocks cell growth through Raf-1-dependent and Raf-1-independent mechanisms

scientific article published on June 2002

Deja Vu: EGF receptors drive resistance to BRAF inhibitors

scientific article published on May 2013

Dephosphorylation of the human T lymphocyte CD3 antigen

scientific article

Development of novel, highly potent inhibitors of V-RAF murine sarcoma viral oncogene homologue B1 (BRAF): increasing cellular potency through optimization of a distal heteroaromatic group

scientific article

Diabetes mellitus in black and coloured tuberculosis patients

scientific article published in March 1980

Differential regulation of Raf-1, A-Raf, and B-Raf by oncogenic ras and tyrosine kinases

scientific journal article

Diverse matrix metalloproteinase functions regulate cancer amoeboid migration

scientific article

ERK signalling and oncogene transformation are not impaired in cells lacking A-Raf

scientific article published on January 2002

ERK-MAPK signaling opposes Rho-kinase to promote endothelial cell survival and sprouting during angiogenesis

Effect of SMURF2 targeting on susceptibility to MEK inhibitors in melanoma

scientific article published on 17 December 2012

Elevated expression of MITF counteracts B-RAF-stimulated melanocyte and melanoma cell proliferation

scientific article published on August 2005

Elucidating distinct roles for NF1 in melanomagenesis

scientific article

Erythropoietin-stimulated Raf-1 tyrosine phosphorylation is associated with the tyrosine kinase Lyn in J2E erythroleukemic cells

scientific article

Expression of endogenous oncogenic V600EB-raf induces proliferation and developmental defects in mice and transformation of primary fibroblasts

scientific article published on December 2005

Expression of kinase suppressor of Ras in the normal adult and embryonic mouse.

scientific article published in July 2002

FGF-2 protects small cell lung cancer cells from apoptosis through a complex involving PKCepsilon, B-Raf and S6K2

scientific article published on 12 July 2006

Functional analysis of a growth factor-responsive transcription factor complex

scientific article

Future perspectives in melanoma research. Meeting report from the "Melanoma research: a bridge from Naples to the World. Napoli, December 5th-6th 2011".

scientific article published on 4 July 2012

Future perspectives in melanoma research: meeting report from the "Melanoma Bridge", Napoli, December 5th-8th 2013.

scientific article

Gatekeeper mutations mediate resistance to BRAF-targeted therapies.

scientific article published on June 2010

Gene regulation in cancer gene therapy strategies

scientific article

Gene-Directed Enzyme Prodrug Therapy

article

Gene-directed enzyme prodrug therapy with a mustard prodrug/carboxypeptidase G2 combination

article

Genetic and cellular mechanisms of oncogenesis

Genome sequencing of mucosal melanomas reveals that they are driven by distinct mechanisms from cutaneous melanoma

scientific article published in July 2013

Genomic characterisation of acral melanoma cell lines

scientific article published on July 2012

Guilty as charged: B-RAF is a human oncogene

scientific article

Heterogeneity of protein kinase C expression and regulation in T lymphocytes

scientific article published on January 1990

Identification of direct transcriptional targets of (V600E)BRAF/MEK signalling in melanoma

scientific article

Identification of inhibitors of the kinase activity of oncogenic V600E BRAF in an enzyme cascade high-throughput screen

scientific article published on 16 December 2005

Importance of low affinity Elf-1 sites in the regulation of lymphoid-specific inducible gene expression

scientific article

In melanoma, RAS mutations are accompanied by switching signaling from BRAF to CRAF and disrupted cyclic AMP signaling

scientific article published on October 2006

In suicide gene therapy, the site of subcellular localization of the activating enzyme is more important than the rate at which it activates prodrug

scientific article published in October 2000

In vitro Biological Characterization of a Novel, Synthetic Diaryl Pyrazole Resorcinol Class of Heat Shock Protein 90 Inhibitors

In vitro activity of vancomycin and teicoplanin against anaerobic bacteria

scientific article

Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma

scientific article published on 25 August 2016

Inducible expression of (V600E) Braf using tyrosinase-driven Cre recombinase results in embryonic lethality.

scientific article published on 11 December 2009

Inhibiting EGF receptor or SRC family kinase signaling overcomes BRAF inhibitor resistance in melanoma

scientific article published on 14 December 2012

Integrating signals between cAMP and the RAS/RAF/MEK/ERK signalling pathways. Based on the anniversary prize of the Gesellschaft für Biochemie und Molekularbiologie Lecture delivered on 5 July 2003 at the Special FEBS Meeting in Brussels

scientific article

Intravital imaging reveals transient changes in pigment production and Brn2 expression during metastatic melanoma dissemination

scientific article

Is BRAF the Achilles' Heel of Thyroid Cancer?

scientific article published on 01 March 2006

Isolation and characterization of SRF accessory proteins.

scientific article

KIT and BRAF mutational status in a patient with a synchronous lentigo maligna melanoma and a gastrointestinal stromal tumor.

scientific article

Kinase-activating and kinase-impaired cardio-facio-cutaneous syndrome alleles have activity during zebrafish development and are sensitive to small molecule inhibitors

scientific article

Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF

scientific article

Localization of O-GlcNAc modification on the serum response transcription factor ⬇️

scientific article published on August 25, 1992

Lysyl oxidase drives tumour progression by trapping EGF receptors at the cell surface.

scientific article

MEK1/2 inhibition decreases lactate in BRAF-driven human cancer cells

scientific article published on 2 May 2013

Malignancy without immortality? Cellular immortalization as a possible late event in melanoma progression

scientific article published on 20 April 2011

Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF

scientific article

Melanoma biology and new targeted therapy

scientific article published on February 2007

Metformin accelerates the growth of BRAF V600E-driven melanoma by upregulating VEGF-A.

scientific article

Metformin: a diabetes drug for cancer, or a cancer drug for diabetics?

scientific article

Methods to improve efficacy in suicide gene therapy approaches: targeting prodrug-activating enzymes carboxypeptidase G2 and nitroreductase to different subcellular compartments.

scientific article

Mind the IQGAP.

scientific article published in June 2013

Mixed lineage kinases activate MEK independently of RAF to mediate resistance to RAF inhibitors

scientific article

Monoclonal antibodies to protein kinase C gamma. Functional relationship between epitopes and cofactor binding sites.

scientific article published in June 1989

Mood states and health behaviours in paramedical first-year students.

scientific article published in December 1990

Murine cutaneous melanoma models. Importance of the genetic background

scientific article published on 5 October 2011

Mutations of C-RAF are rare in human cancer because C-RAF has a low basal kinase activity compared with B-RAF

scientific article

Mutations of the BRAF gene in human cancer

scientific article (publication date: 27 June 2002)

Neuron-specific protein F1/GAP-43 shows substrate specificity for the beta subtype of protein kinase C.

scientific article

New insight into BRAF mutations in cancer

scientific article published on February 2007

New insight puts CRAF in sight as a therapeutic target

scientific article published on July 2011

Nilotinib and MEK inhibitors induce synthetic lethality through paradoxical activation of RAF in drug-resistant chronic myeloid leukemia

scientific article

Novel hinge binder improves activity and pharmacokinetic properties of BRAF inhibitors

scientific article published in August 2010

Novel inhibitors of B-RAF based on a disubstituted pyrazine scaffold. Generation of a nanomolar lead

scientific article published in January 2006

Novel inhibitors of the v-raf murine sarcoma viral oncogene homologue B1 (BRAF) based on a 2,6-disubstituted pyrazine scaffold

scientific article

Novel potent BRAF inhibitors: toward 1 nM compounds through optimization of the central phenyl ring.

scientific article published in July 2009

Novel tricyclic pyrazole BRAF inhibitors with imidazole or furan central scaffolds.

scientific article

Oncogenic BRAF induces melanoma cell invasion by downregulating the cGMP-specific phosphodiesterase PDE5A.

scientific article published on 6 January 2011

Oncogenic BRAF regulates melanoma proliferation through the lineage specific factor MITF.

scientific article

Oncogenic Braf induces melanocyte senescence and melanoma in mice

scientific article

Phosphorylation and activation of B-Myb by cyclin A-Cdk2.

scientific article published on April 1997

Potent BRAF kinase inhibitors based on 2,4,5-trisubstituted imidazole with naphthyl and benzothiophene 4-substituents

scientific article published on 3 January 2013

Primary melanoma of the CNS in children is driven by congenital expression of oncogenic NRAS in melanocytes.

scientific article published on 09 January 2013

Protein kinase A blocks Raf-1 activity by stimulating 14-3-3 binding and blocking Raf-1 interaction with Ras.

scientific article published on 11 June 2003

Protein kinase C as a second messenger target

scientific article published on 01 April 1989

Protein kinase C--a family affair

scientific article

Protein kinase C--structural studies

scientific article published on 01 January 1988

Publisher Correction: Ultraviolet radiation–induced DNA damage is prognostic for outcome in melanoma

scientific article published on 01 February 2019

Purification and characterisation of bovine brain protein kinase C isotypes alpha, beta and gamma

scientific article published in June 1989

Purification of protein kinase C isotypes from bovine brain

scientific article published in January 1991

Pyridoimidazolones as novel potent inhibitors of v-Raf murine sarcoma viral oncogene homologue B1 (BRAF).

scientific article published on April 2009

RAS mutations in cutaneous squamous-cell carcinomas in patients treated with BRAF inhibitors

scientific article published on January 2012

ROCK and JAK1 Signaling Cooperate to Control Actomyosin Contractility in Tumor Cells and Stroma

scientific article published on 01 August 2011

Radioactive labeling of recombinant antibody fragments by phosphorylation using human casein kinase II and [gamma-32P]-ATP.

scientific article

Raf Phosphorylation

Raf inhibitors target ras spatiotemporal dynamics

scientific article published on 3 May 2012

Ras recruits Raf-1 to the plasma membrane for activation by tyrosine phosphorylation

scientific journal article

Ras subcellular localization defines extracellular signal-regulated kinase 1 and 2 substrate specificity through distinct utilization of scaffold proteins

scientific article

Regressions of established breast carcinoma xenografts by carboxypeptidase G2 suicide gene therapy and the prodrug CMDA are due to a bystander effect

scientific article published in January 2000

Regulation of GATA-2 phosphorylation by mitogen-activated protein kinase and interleukin-3.

scientific article

Regulation of Ras·GTP Loading and Ras-Raf Association in Neonatal Rat Ventricular Myocytes by G Protein-coupled Receptor Agonists and Phorbol Ester

scientific article published in Journal of Biological Chemistry

Regulation of mitogen-activated protein kinases in cardiac myocytes through the small G protein Rac1

scientific article

Requirement of Ras-GTP-Raf Complexes for Activation of Raf-1 by Protein Kinase C

scientific article published in Science

S338 phosphorylation of Raf-1 is independent of phosphatidylinositol 3-kinase and Pak3

scientific article

SF3B1 mutations are associated with alternative splicing in uveal melanoma

scientific article published on 16 July 2013

Self-immolative anthracycline prodrugs for suicide gene therapy

scientific article published on July 1999

Self-immolative nitrogen mustard prodrugs for suicide gene therapy.

scientific article published on December 1998

Self-immolative nitrogen mustards prodrugs cleavable by carboxypeptidase G2 (CPG2) showing large cytotoxicity differentials in GDEPT.

scientific article published on April 2003

Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation

scientific article

Significant differences in biological parameters between prodrugs cleavable by carboxypeptidase G2 that generate 3,5-difluoro-phenol and -aniline nitrogen mustards in gene-directed enzyme prodrug therapy systems

scientific article published on May 2004

Small molecule inhibitors of BRAF in clinical trials

scientific article published on 03 December 2011

Sorafenib and dacarbazine as first-line therapy for advanced melanoma: phase I and open-label phase II studies

scientific article

Sorafenib in advanced melanoma: a Phase II randomised discontinuation trial analysis

scientific article published on August 2006

Spatial flexibility in ternary complexes between SRF and its accessory proteins

scientific article

Stroma remodeling and reduced cell division define durable response to PD-1 blockade in melanoma

scientific article published on 12 February 2020

Studies on the primary sequence requirements for PKC-α, -β1 and -γ peptide substrates

scientific article published on 01 December 1990

Suicide gene therapy of human colon carcinoma xenografts using an armed oncolytic adenovirus expressing carboxypeptidase G2.

scientific article published on May 2007

Systemic gene-directed enzyme prodrug therapy of hepatocellular carcinoma using a targeted adenovirus armed with carboxypeptidase G2.

scientific article published on June 2005

Taking the stress out of melanoma

scientific article published on March 2009

The Brn-2 transcription factor links activated BRAF to melanoma proliferation

scientific article

The EGF Receptor Hokey-Cokey

article

The T cell receptor repertoire of tumor infiltrating T cells is predictive and prognostic for cancer survival

scientific article published on 02 July 2021

The effect of carbon dioxide on the in vitro activity of erythromycin and RU-28965 against anaerobic bacteria

scientific article published on January 1987

The endocytic protein intersectin is a major binding partner for the Ras exchange factor mSos1 in rat brain

scientific article

The in-vitro activity of doxycycline and minocycline against anaerobic bacteria

scientific article

The intermediate-activity (L597V)BRAF mutant acts as an epistatic modifier of oncogenic RAS by enhancing signaling through the RAF/MEK/ERK pathway

scientific journal article

The mutational burden of acral melanoma revealed by whole-genome sequencing and comparative analysis

scientific article published on 30 June 2014

The need for exercise rehabilitation in Botswana

scientific article published in April 2008

The phosphorylation of protein kinase C as a potential measure of activation

scientific article published on July 1989

The role of B-RAF in melanoma.

scientific article

The role of signaling pathways in the development and treatment of hepatocellular carcinoma

scientific article published on 19 July 2010

Three new prodrugs for suicide gene therapy using carboxypeptidase G2 elicit bystander efficacy in two xenograft models

scientific article published in March 2002

Thyrotrophin receptor signaling dependence of Braf-induced thyroid tumor initiation in mice

scientific article

Topical 5-fluorouracil elicits regressions of BRAF inhibitor-induced cutaneous squamous cell carcinoma

scientific article published on 16 August 2012

Transonic, thermodilution, or ionic dialysance to manage vascular access: Which method is best?

Tumor necrosis factor-alpha blocks apoptosis in melanoma cells when BRAF signaling is inhibited

scientific article published on January 2007

Twenty-fourth annual Pezcoller symposium: Molecular basis for resistance to targeted agents

scientific article published on 7 December 2012

Ultraviolet radiation accelerates BRAF-driven melanomagenesis by targeting TP53

scientific article

Ultraviolet radiation drives mutations in a subset of mucosal melanomas

scientific article published on 11 January 2021

Ultraviolet radiation–induced DNA damage is prognostic for outcome in melanoma

scientific article published on 03 December 2018

Unswitch-ABL Drugs Overcome Resistance in Chronic Myeloid Leukemia

Utility of ctDNA to support patient selection for early phase clinical trials: the TARGET study

scientific article published on 22 April 2019

V599EB-RAF is an oncogene in melanocytes

scientific article published on April 2004

V600EBraf induces gastrointestinal crypt senescence and promotes tumour progression through enhanced CpG methylation of p16INK4a

scientific article published on November 2010

V600EBraf::Tyr-CreERT2::K14-Kitl Mice Do Not Develop Superficial Spreading-Like Melanoma: Keratinocyte Kit Ligand Is Insufficient to “Translocate” V600EBraf-Driven Melanoma to the Epidermis

article

Whole genome sequencing of matched primary and metastatic acral melanomas

scientific article

Whole-genome sequencing reveals complex mechanisms of intrinsic resistance to BRAF inhibition

scientific article

Wild-type and mutant B-RAF activate C-RAF through distinct mechanisms involving heterodimerization

scientific article

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