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List of works by Margarita Villar

A Novel Combined Scientific and Artistic Approach for the Advanced Characterization of Interactomes: The Akirin/Subolesin Model

scientific article published on 08 February 2020

A Vaccinomics Approach for the Identification of Tick Protective Antigens for the Control of Ixodes ricinus and Dermacentor reticulatus Infestations in Companion Animals

scientific article published on 26 July 2019

A metaproteomics approach reveals changes in mandibular lymph node microbiota of wild boar naturally exposed to an increasing trend of Mycobacterium tuberculosis complex infection

scientific article published on 20 December 2018

A reverse vaccinology approach to the identification and characterization of Ctenocephalides felis candidate protective antigens for the control of cat flea infestations.

scientific article published on 18 January 2018

A systems biology approach to the characterization of stress response in Dermacentor reticulatus tick unfed larvae

scientific article

A vaccinology Approach to the Identification and Characterization of Dermanyssus Gallinae Candidate Protective Antigens for the Control of Poultry Red Mite Infestations

scientific article published on 20 November 2019

Allergic Reactions and Immunity in Response to Tick Salivary Biogenic Substances and Red Meat Consumption in the Zebrafish Model

scientific article published on 10 March 2020

Altered subcellular distribution of IRS-1 and IRS-3 is associated with defective Akt activation and GLUT4 translocation in insulin-resistant old rat adipocytes

scientific journal article

Anaplasma phagocytophilum Infection Subverts Carbohydrate Metabolic Pathways in the Tick Vector, Ixodes scapularis

scientific article published on 07 February 2017

Anaplasma phagocytophilum MSP4 and HSP70 Proteins Are Involved in Interactions with Host Cells during Pathogen Infection

scientific article

Anaplasma phagocytophilum increases the levels of histone modifying enzymes to inhibit cell apoptosis and facilitate pathogen infection in the tick vector Ixodes scapularis.

scientific article published on 28 March 2016

Anaplasma phagocytophilum inhibits apoptosis and promotes cytoskeleton rearrangement for infection of tick cells

scientific article published on 29 April 2013

Anaplasma phagocytophilum modifies tick cell microRNA expression and upregulates isc-mir-79 to facilitate infection by targeting the Roundabout protein 2 pathway

scientific article published on 24 June 2019

Application of highly sensitive saturation labeling to the analysis of differential protein expression in infected ticks from limited samples

scientific article

Applying proteomics to tick vaccine development: where are we?

scientific article published on 18 January 2017

Bacterial membranes enhance the immunogenicity and protective capacity of the surface exposed tick Subolesin-Anaplasma marginale MSP1a chimeric antigen.

scientific article published on 20 July 2015

Biotic and abiotic factors shape the microbiota of wild-caught populations of the arbovirus vector Culicoides imicola

scientific article published on 17 September 2018

Changes in Serum Biomarkers of Oxidative Stress in Cattle Vaccinated with Tick Recombinant Antigens: A Pilot Study

scientific article published on 24 December 2020

Characterization of Aedes albopictus akirin for the control of mosquito and sand fly infestations

scientific article published on 20 October 2010

Characterization of ferritin 2 for the control of tick infestations

scientific article published on 18 February 2010

Characterization of the tick-pathogen interface by quantitative proteomics.

scientific article published on 11 April 2012

Clinical gamasoidosis and antibody response in two patients infested with Ornithonyssus bursa (Acari: Gamasida: Macronyssidae)

scientific article published on 31 July 2019

Combination of RT-PCR and proteomics for the identification of Crimean-Congo hemorrhagic fever virus in ticks

scientific article published on 12 July 2017

Comparative Proteomics Identifies Host Immune System Proteins Affected by Infection with Mycobacterium bovis

scientific article (publication date: March 2016)

Comparative Proteomics Reveals Differences in Host-Pathogen Interaction between Infectious and Commensal Relationship with Campylobacter jejuni.

scientific article published on 26 April 2017

Comparative genomics and proteomics to study tissue-specific response and function in natural Mycobacterium bovis infections

scientific article published on June 2007

Comparative proteomics for the characterization of the most relevant Amblyomma tick species as vectors of zoonotic pathogens worldwide

scientific article

Comparative proteomics identified immune response proteins involved in response to vaccination with heat-inactivated Mycobacterium bovis and mycobacterial challenge in cattle

scientific article published on 29 October 2018

Conservation and immunogenicity of the mosquito ortholog of the tick-protective antigen, subolesin.

scientific article published on 21 February 2009

Control of Rhipicephalus (Boophilus) microplus infestations by the combination of subolesin vaccination and tick autocidal control after subolesin gene knockdown in ticks fed on cattle

article

Control of multiple arthropod vector infestations with subolesin/akirin vaccines.

scientific article published on 3 January 2013

Control of tick infestations in cattle vaccinated with bacterial membranes containing surface-exposed tick protective antigens

scientific article published on 12 November 2011

Coronavirus in cat flea: findings and questions regarding COVID-19

scientific article published on 10 August 2020

Cryopreservation of ram sperm alters the dynamic changes associated with in vitro capacitation

scientific article published on 24 January 2020

Effect of blood type on anti-α-Gal immunity and the incidence of infectious diseases

scientific article published on 10 March 2017

Erratum

scholarly article published in Autophagy

Expression of Early Growth Response Gene-2 and Regulated Cytokines Correlates with Recovery from Guillain-Barré Syndrome

scientific article published on 30 December 2015

Expression of Heat Shock and Other Stress Response Proteins in Ticks and Cultured Tick Cells in Response to Anaplasma spp. Infection and Heat Shock

scientific article

Expression of heat shock proteins and subolesin affects stress responses,Anaplasma phagocytophiluminfection and questing behaviour in the tick,Ixodes scapularis ⬇️

scientific article published on July 22, 2011

First data on Eurasian wild boar response to oral immunization with BCG and challenge with a Mycobacterium bovis field strain.

scientific article published on 9 September 2009

Freezing-Thawing Procedures Remodel the Proteome of Ram Sperm before and after In Vitro Capacitation

scientific article published on 17 September 2019

Functional Evolution of Subolesin/Akirin

scientific article published on 13 November 2018

Functional genomics of tick vectors challenged with the cattle parasite Babesia bigemina

scientific article

Genomic insights into the Ixodes scapularis tick vector of Lyme disease

scientific article published on 9 February 2016

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

High throughput discovery and characterization of tick and pathogen vaccine protective antigens using vaccinomics with intelligent Big Data analytic techniques

scientific article published on 12 July 2018

High-sensitivity analysis of specific peptides in complex samples by selected MS/MS ion monitoring and linear ion trap mass spectrometry: application to biological studies

scientific article published in November 2007

Host expression of methylmalonyl-CoA mutase and tuberculosis: a missing link?

scientific article

Human amyloid-β enriched extracts: evaluation of in vitro and in vivo internalization and molecular characterization

scientific article published on 29 June 2019

Identification and Characterization of Anaplasma phagocytophilum Proteins Involved in Infection of the Tick Vector, Ixodes scapularis

scientific article (publication date: 2015)

Identification and characterization of Rhipicephalus (Boophilus) microplus candidate protective antigens for the control of cattle tick infestations

scientific article

Identification of protective antigens by RNA interference for control of the lone star tick, Amblyomma americanum

scientific article

Infection-derived lipids elicit an immune deficiency circuit in arthropods

scientific article published on 14 February 2017

Integrated Metabolomics, Transcriptomics and Proteomics Identifies Metabolic Pathways Affected by Anaplasma phagocytophilum Infection in Tick Cells.

scientific article published on 30 September 2015

Integrated metatranscriptomics and metaproteomics for the characterization of bacterial microbiota in unfed Ixodes ricinus

scientific article published on 05 May 2018

Interactomics and tick vaccine development: new directions for the control of tick-borne diseases

article

Ixodes scapularis and Ixodes ricinus tick cell lines respond to infection with tick-borne encephalitis virus: transcriptomic and proteomic analysis

scientific article

Lesser protein degradation machinery correlates with higher BM86 tick vaccine efficacy in Rhipicephalus annulatus when compared to Rhipicephalus microplus

scientific article

Mapping protective epitopes in the tick and mosquito subolesin ortholog proteins

scientific article

Metaproteomics characterization of the alphaproteobacteria microbiome in different developmental and feeding stages of the poultry red mite Dermanyssus gallinae (De Geer, 1778)

scientific article published on 02 August 2019

Modeling Modulation of the Tick Regulome in Response to for the Identification of New Control Targets

scientific article published on 18 April 2019

Molecular and immunological characterization of three strains of Anaplasma marginale grown in cultured tick cells

scientific article published on 24 April 2015

Mosquito Akirin as a potential antigen for malaria control

scientific article

Myosin 1b and F-actin are involved in the control of secretory granule biogenesis

scientific article

Nuclease Tudor-SN Is Involved in Tick dsRNA-Mediated RNA Interference and Feeding but Not in Defense against Flaviviral or Anaplasma phagocytophilum Rickettsial Infection

scientific article published on 17 July 2015

ObRa and ObRe are differentially expressed in adipose tissue in aged food-restricted rats: effects on circulating soluble leptin receptor levels

scientific journal article

Oral vaccination with heat inactivated Mycobacterium bovis activates the complement system to protect against tuberculosis

scientific article (publication date: 2014)

Properties of average score distributions of SEQUEST: the probability ratio method.

scientific article published on 25 February 2008

Prospects for vaccination against the ticks of pets and the potential impact on pathogen transmission

scientific article published on 23 December 2014

Proteomic and transcriptomic analyses of differential stress/inflammatory responses in mandibular lymph nodes and oropharyngeal tonsils of European wild boars naturally infected with Mycobacterium bovis

scientific article published on January 2007

Proteomic characterisation of bovine and avian purified protein derivatives and identification of specific antigens for serodiagnosis of bovine tuberculosis

scientific article published on 2 November 2017

Proteomics Characterization of Tick-Host-Pathogen Interactions

Proteomics approach to the study of cattle tick adaptation to white tailed deer

scientific article published on 2 December 2013

Quantitative Proteomics Identifies Metabolic Pathways Affected by Babesia Infection and Blood Feeding in the Sialoproteome of the Vector Rhipicephalus bursa

scientific article published on 19 February 2020

Quantitative proteomics reveals Piccolo as a candidate serological correlate of recovery from Guillain-Barré syndrome.

scientific article published on 20 October 2016

Reciprocal regulation of NF-kB (Relish) and Subolesin in the tick vector, Ixodes scapularis

scientific article

Reduction in Oviposition of Poultry Red Mite (Dermanyssus gallinae) in Hens Vaccinated with Recombinant Akirin

scientific article published on 19 September 2019

Regulation of the Immune Response to α-Gal and Vector-borne Diseases

scientific article published on October 2015

Remodeling of tick cytoskeleton in response to infection with Anaplasma phagocytophilum.

scientific article

Salivary Prostaglandin E2: Role in Tick-Induced Allergy to Red Meat

scientific article published on 29 March 2017

Serum proteome of dogs at subclinical and clinical onset of canine leishmaniosis

scientific article published on 26 September 2019

Statistical model for large-scale peptide identification in databases from tandem mass spectra using SEQUEST.

scientific article

Subolesin expression in response to pathogen infection in ticks.

scientific article

Systematic characterization of phosphorylation sites in NFATc2 by linear ion trap mass spectrometry.

scientific article published on April 2006

Systems biology of tissue-specific response to Anaplasma phagocytophilum reveals differentiated apoptosis in the tick vector Ixodes scapularis.

scientific article

Targeting arthropod subolesin/akirin for the development of a universal vaccine for control of vector infestations and pathogen transmission

scientific article published on 19 April 2011

Targeting the tick protective antigen subolesin reduces vector infestations and pathogen infection by Anaplasma marginale and Babesia bigemina

scientific article

The alpha-Gal syndrome: new insights into the tick-host conflict and cooperation

scientific article published on 03 April 2019

The antibody response to the glycan α-Gal correlates with COVID-19 disease symptoms

scientific article published on 03 October 2020

The effect of aging on insulin signalling pathway is tissue dependent: central role of adipose tissue in the insulin resistance of aging.

scientific article

The impact of post-genomics approaches in neurodegenerative demyelinating diseases: the case of Guillain-Barré syndrome.

scientific article published on 14 March 2018

The intracellular bacterium Anaplasma phagocytophilum selectively manipulates the levels of vertebrate host proteins in the tick vector Ixodes scapularis

scientific article published on 25 August 2016

The redox metabolic pathways function to limit Anaplasma phagocytophilum infection and multiplication while preserving fitness in tick vector cells

scientific article published on 13 September 2019

Tick Bites Induce Anti-α-Gal Antibodies in Dogs

scientific article published on 15 September 2019

Tick and Host Derived Compounds Detected in the Cement Complex Substance

scientific article published on 05 April 2020

Tick galactosyltransferases are involved in α-Gal synthesis and play a role during Anaplasma phagocytophilum infection and Ixodes scapularis tick vector development

scientific article published in Scientific Reports

Tick-Host-Pathogen Interactions: Conflict and Cooperation

scientific article

Tick-Pathogen Interactions and Vector Competence: Identification of Molecular Drivers for Tick-Borne Diseases

scientific article published on 07 April 2017

Tick-host conflict: immunoglobulin E antibodies to tick proteins in patients with anaphylaxis to tick bite

scientific article

Tissue-Specific Signatures in the Transcriptional Response to Anaplasma phagocytophilum Infection of Ixodes scapularis and Ixodes ricinus Tick Cell Lines

scientific article published on 10 February 2016

Tonsils of the soft palate do not mediate the response of pigs to oral vaccination with heat-inactivated Mycobacterium bovis

scientific article

Transcriptome and Proteome Response of Tick Vector to Infection

scientific article published on 02 April 2019

Unraveling how in vitro capacitation alters ram sperm chromatin before and after cryopreservation

scientific article published on 04 September 2020

Use of Graph Theory to Characterize Human and Arthropod Vector Cell Protein Response to Infection With

scientific article published on 03 August 2018

Vaccination with Alpha-Gal Protects Against Mycobacterial Infection in the Zebrafish Model of Tuberculosis

scientific article published on 24 April 2020

Vaccination with BM86, subolesin and akirin protective antigens for the control of tick infestations in white tailed deer and red deer.

scientific article published on 8 November 2011

Vaccination with Ectoparasite Proteins Involved in Midgut Function and Blood Digestion Reduces Salmon Louse Infestations

scientific article published on 19 January 2020

Vaccinomics Approach to Tick Vaccine Development

scientific article published on January 2016

Vaccinomics Approach to the Identification of Candidate Protective Antigens for the Control of Tick Vector Infestations and Anaplasma phagocytophilum Infection

scientific article published on 09 August 2017

c-Jun N-terminal kinase (JNK) positively regulates NFATc2 transactivation through phosphorylation within the N-terminal regulatory domain.

scientific article published on 2 March 2005

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