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Authors whose works are in public domain in at least one jurisdiction

List of works by Peter Vandenabeele

18th Euroconference on Apoptosis in Ghent, Belgium, 1-4 September 2010.

scientific article published on 3 June 2011

6E11, a highly selective inhibitor of Receptor-Interacting Protein Kinase 1, protects cells against cold hypoxia-reoxygenation injury

scientific article published on 10 October 2017

A Bcl-2 transgene expressed in hepatocytes does not protect mice from fulminant liver destruction induced by Fas ligand

scientific article published in May 2003

A T cell clone which responds to interkeukin 2 but not to interleukin 4

scholarly article by Werner Müller & Peter Vandenabeele published 1987 in European Journal of Immunology

A caspase-activated factor (CAF) induces mitochondrial membrane depolarization and cytochrome c release by a nonproteolytic mechanism.

scientific article published on December 1998

A novel RIPK4-IRF6 connection is required to prevent epithelial fusions characteristic for popliteal pterygium syndromes

scientific article published on 28 November 2014

A novel caspase-2 complex containing TRAF2 and RIP1.

scientific article

A novel pathway combining calreticulin exposure and ATP secretion in immunogenic cancer cell death

scientific article

A phylogenetic and functional overview of inflammatory caspases and caspase-1-related CARD-only proteins.

scientific article published on December 2007

A real-time fluorometric method for the simultaneous detection of cell death type and rate

scientific article published on 14 July 2016

A siRNA screen reveals the prosurvival effect of protein kinase A activation in conditions of unresolved endoplasmic reticulum stress.

scientific article published on 24 June 2016

A20 inhibits NF-kappaB activation independently of binding to 14-3-3 proteins

scientific article

A20 protects cells from TNF-induced apoptosis through linear ubiquitin-dependent and -independent mechanisms

scientific article published on 18 September 2019

ATP release from dying autophagic cells and their phagocytosis are crucial for inflammasome activation in macrophages

scientific article

Activated caspase-1 is not a central mediator of inflammation in the course of ischemia-reperfusion.

scientific article published in March 2001

Activation of p38 MAPK is required for Bax translocation to mitochondria, cytochrome c release and apoptosis induced by UVB irradiation in human keratinocytes

Acute modulations in permeability barrier function regulate epidermal cornification: role of caspase-14 and the protease-activated receptor type 2

scientific article

Alice in caspase land. A phylogenetic analysis of caspases from worm to man

scientific article published on 01 April 2002

Alternatively activated macrophages and impaired phagocytosis of S. aureus in chronic rhinosinusitis

scientific article published on 25 October 2010

An evolutionary perspective on the necroptotic pathway

scientific article published on 28 June 2016

An inactivating caspase-11 passenger mutation muddles sepsis research

scientific article published in July 2013

An outline of necrosome triggers

scientific article

Antioxidant and food additive BHA prevents TNF cytotoxicity by acting as a direct RIPK1 inhibitor

scientific article published on 14 July 2021

Antioxidant potential of CORM-A1 and resveratrol during TNF-α/cycloheximide-induced oxidative stress and apoptosis in murine intestinal epithelial MODE-K cells

scientific article published on 14 July 2015

Apoptosis and necrosis: detection, discrimination and phagocytosis

scientific article

Apoptosis of hematopoietic cells induced by growth factor withdrawal is associated with caspase-9 mediated cleavage of Raf-1.

scientific article published on February 2005

Apoptosis of intestinal epithelial cells restricts Clostridium difficile infection in a model of pseudomembranous colitis

scientific article published in Nature Communications

Apoptotic and necrotic cell death induced by death domain receptors.

scientific article

Are metacaspases caspases?

scientific article published on 29 October 2007

Atractyloside-induced release of cathepsin B, a protease with caspase-processing activity

scientific article published on November 1998

Author Correction: Hypericin-based photodynamic therapy induces surface exposure of damage-associated molecular patterns like HSP70 and calreticulin

scientific article published on 01 July 2018

Autophagy: for better or for worse

scientific article published on 13 September 2011

BNIP3 supports melanoma cell migration and vasculogenic mimicry by orchestrating the actin cytoskeleton

scientific article published on 13 March 2014

Bcl-2 family members as sentinels of cellular integrity and role of mitochondrial intermembrane space proteins in apoptotic cell death

scientific article published on January 2004

Beclin 1 functions as a negative modulator of MLKL oligomerisation by integrating into the necrosome complex

scientific article published on 26 May 2020

Beclin1: a role in membrane dynamics and beyond

scientific article published on January 2012

Blocking connexin43 hemichannels protects mice against tumour necrosis factor-induced inflammatory shock

scientific article published on 12 November 2019

Boosting Apoptotic Cell Clearance by Colonic Epithelial Cells Attenuates Inflammation In Vivo

scientific article

Butylated hydroxyanisole is more than a reactive oxygen species scavenger

scientific article published in January 2006

CHIP controls necroptosis through ubiquitylation- and lysosome-dependent degradation of RIPK3.

scientific article published on 22 February 2016

Calcium and connexin-based intercellular communication, a deadly catch?

scientific article published on 31 May 2011

Caspase deficiency alters the murine gut microbiome

scientific article published on 20 October 2011

Caspase inhibitors promote alternative cell death pathways

scientific article published on 24 October 2006

Caspase substrates: easily caught in deep waters?

scientific article published on 29 October 2009

Caspase-1 activates nuclear factor of the kappa-enhancer in B cells independently of its enzymatic activity

scientific article published on 23 March 2004

Caspase-1 and caspase-8 cleave and inactivate cellular parkin

scientific article published on 11 April 2003

Caspase-12: an overview

scientific article

Caspase-14 is expressed in the epidermis, the choroid plexus, the retinal pigment epithelium and thymic Hassall's bodies.

scientific article published in February 2003

Caspase-14 is required for filaggrin degradation to natural moisturizing factors in the skin

scientific article published on 9 June 2011

Caspase-14 overexpression in hairless mice is not involved in utricle formation

scientific article published in July 2013

Caspase-14 protects against epidermal UVB photodamage and water loss

scientific article

Caspase-14 reveals its secrets

scientific article

Caspase-14-deficient mice are more prone to the development of parakeratosis

scientific article published on 27 September 2012

Caspase-3 and RasGAP: a stress-sensing survival/demise switch.

scientific article published on 2 September 2013

Caspase-3 probes for PET imaging of apoptotic tumor response to anticancer therapy

scientific article published on 01 May 2019

Caspase-7 in molar tooth development.

scientific article published in August 2012

Caspase-7 participates in differentiation of cells forming dental hard tissues

scientific article published on 29 May 2013

Caspase-containing complexes in the regulation of cell death and inflammation

scientific article published on August 2006

Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria.

scientific article

Caspase-mediated cleavage of the U snRNP-associated Sm-F protein during apoptosis.

scientific article published on May 2003

Caspase-mediated cleavage of the exosome subunit PM/Scl-75 during apoptosis

scientific article published on January 2007

Caspases in cell survival, proliferation and differentiation.

scientific article

Caspases leave the beaten track: caspase-mediated activation of NF-kappaB.

scientific article

Cathepsin B-mediated activation of the proinflammatory caspase-11.

scientific article published in October 1998

Cell death in the skin

scientific article

Cell death induction by receptors of the TNF family: towards a molecular understanding.

scientific article published on June 1997

Cell surface-expressed phosphatidylserine as therapeutic target to enhance phagocytosis of apoptotic cells

scientific article published on 7 September 2012

Characteristic ERK1/2 signaling dynamics distinguishes necroptosis from apoptosis

scientific article published on 02 September 2021

Characterization of seven murine caspase family members

scientific article published in February 1997

Chemotherapy-induced ileal crypt apoptosis and the ileal microbiome shape immunosurveillance and prognosis of proximal colon cancer

scientific article published on 25 May 2020

Cigarette smoke and the terminal ileum: increased autophagy in murine follicle-associated epithelium and Peyer's patches

scientific article published on 24 December 2011

Cigarette smoke-induced necroptosis and DAMP release trigger neutrophilic airway inflammation in mice

scientific article published on 30 December 2015

Classification of cell death: recommendations of the Nomenclature Committee on Cell Death

scientific article

Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009

scientific article

Clearance of apoptotic and necrotic cells and its immunological consequences

scientific article published on October 2006

Clearance of dead cells: mechanisms, immune responses and implication in the development of diseases

scientific article

Cleavage of PITSLRE kinases by ICE/CASP-1 and CPP32/CASP-3 during apoptosis induced by tumor necrosis factor

scientific article (publication date: 2 May 1997)

Cleavage of transcription factor SP1 by caspases during anti-IgM-induced B-cell apoptosis

scientific article published on April 1999

Comparative study of the differential cell death protecting effect of various ROS scavengers

scientific article published on 01 January 2019

Connexin-related signaling in cell death: to live or let die?

scientific article published on 06 February 2009

Consensus guidelines for the definition, detection and interpretation of immunogenic cell death

scientific article published on 01 March 2020

Consensus guidelines for the detection of immunogenic cell death

scientific article published on October 2014

Correction: A20 protects cells from TNF-induced apoptosis through linear ubiquitin-dependent and -independent mechanisms

scientific article published on 23 January 2020

Correction: Resistance to anticancer vaccination effect is controlled by a cancer cell-autonomous phenotype that disrupts immunogenic phagocytic removal

scientific article published on 26 June 2018

Creation and X-ray structure analysis of the tumor necrosis factor receptor-1-selective mutant of a tumor necrosis factor-alpha antagonist

scientific article

Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophages

scientific journal article

Cytotoxicity in L929 murine fibrosarcoma cells after triggering of transfected human p75 tumour necrosis factor (TNF) receptor is mediated by endogenous murine TNF ⬇️

scientific article published on July 1, 1995

DAMPs activating innate and adaptive immune responses in COPD.

scientific article published on 23 October 2013

DAMPs and PDT-mediated photo-oxidative stress: exploring the unknown ⬇️

scientific article published on January 24, 2011

Death penalty for keratinocytes: apoptosis versus cornification.

scientific article

Death receptor-induced apoptotic and necrotic cell death: differential role of caspases and mitochondria.

scientific article published in August 2001

Deficiency in the mitochondrial apoptotic pathway reveals the toxic potential of autophagy under ER stress conditions

scientific article published in January 2014

Degradomics reveals that cleavage specificity profiles of caspase-2 and effector caspases are alike

scientific article

Depletion of Beclin-1 due to proteolytic cleavage by caspases in the Alzheimer's disease brain

scientific article

Depletion of RIPK3 or MLKL blocks TNF-driven necroptosis and switches towards a delayed RIPK1 kinase-dependent apoptosis

scientific article (publication date: 16 January 2014)

Determination of apoptotic and necrotic cell death in vitro and in vivo.

scientific article

Development of a dedicated peptide tandem mass spectral library for conservation science

scientific article

Development of a simple, sensitive and specific bioassay for interleukin-1 based on the proliferation of RPMI 1788 cells. Comparison with other bioassays for IL-1.

scientific article published on December 1990

Different pathways mediate cytochrome c release after photodynamic therapy with hypericin

scientific article

Differential activation of nuclear factor-kappaB by tumour necrosis factor receptor subtypes. TNFR1 predominates whereas TNFR2 activates transcription poorly

scientific article published on March 2002

Differential involvement of caspases in apoptosis of myeloid leukemic cells induced by chemotherapy versus growth factor withdrawal

scientific journal article

Differential role of calcium in tumour necrosis factor-mediated apoptosis and secretion of granulocyte-macrophage colony-stimulating factor in a T cell hybridoma.

scientific article

Differential signaling to apoptotic and necrotic cell death by Fas-associated death domain protein FADD.

scientific article published on 10 December 2003

Discovery of Novel, Drug-Like Ferroptosis Inhibitors with in Vivo Efficacy

article

Discrimination of zeolites and beryllium containing silicates using portable Raman spectroscometric equipment with near-infrared excitation.

scientific article

Disruption of HSP90 function reverts tumor necrosis factor-induced necrosis to apoptosis

scientific article published on 18 November 2002

Distinct EH domains of the endocytic TPLATE complex confer lipid and protein binding

scientific article published on 24 May 2021

Distinct mechanisms are involved in tumoristatic and tumoricidal activities of monocyte-derived dendritic cells

scientific article published in February 2004

Distinct regulation of cytosolic phospholipase A2 phosphorylation, translocation, proteolysis and activation by tumour necrosis factor-receptor subtypes

scientific article published on September 2003

Doxorubicin-induced activation of protein kinase D1 through caspase-mediated proteolytic cleavage: identification of two cleavage sites by microsequencing

scientific article

Dual face apoptotic machinery: from initiator of apoptosis to guardian of necroptosis

scientific article published in October 2011

Dying for a cause: NETosis, mechanisms behind an antimicrobial cell death modality

scientific article

ER stress-induced inflammation: does it aid or impede disease progression?

scientific article published on 08 August 2012

Elevated ΔNp63α Levels Facilitate Epidermal and Biliary Oncogenic Transformation

scientific article published on 7 October 2016

Emerging role of damage-associated molecular patterns derived from mitochondria in inflammation

scientific article published on 19 February 2011

Endonuclease G: a mitochondrial protein released in apoptosis and involved in caspase-independent DNA degradation.

scientific article published in December 2001

Endoplasmic reticulum stress induces ligand-independent TNFR1-mediated necroptosis in L929 cells

scientific article

Enzymatic degradation of tumor necrosis factor by activated human neutrophils: role of elastase

scientific article published on January 1991

Epidermal differentiation does not involve the pro-apoptotic executioner caspases, but is associated with caspase-14 induction and processing

scientific article (publication date: December 2000)

Erratum

scholarly article published in Autophagy

Erythropoietin-induced changes in brain gene expression reveal induction of synaptic plasticity genes in experimental stroke

scientific article

Escherichia coli induces bovine neutrophil cell death independent from caspase-3/-7/-1, but with phosphatidylserine exposure prior to membrane rupture

scientific article published on 27 February 2013

Essential versus accessory aspects of cell death: recommendations of the NCCD 2015.

scientific article

Evidence that pentoxifylline reduces anti-CD3 monoclonal antibody-induced cytokine release syndrome

scientific article published on 01 October 1991

Excessive phospholipid peroxidation distinguishes ferroptosis from other cell death modes including pyroptosis

scientific article published on 27 October 2020

Expression of calcium-sensing receptor in quail granulosa explants: a key to survival during folliculogenesis

scientific article published in May 2010

Extracellular ATP and P₂X₇ receptor exert context-specific immunogenic effects after immunogenic cancer cell death.

scientific article published on 18 February 2016

Filaggrin Degradation by Caspase-14 Is Required for UVB Photoprotection but Does Not Influence Allergic Sensitization in a Mouse Model of Atopic Dermatitis

scientific article published on 30 August 2012

Fine-tuning nucleophosmin in macrophage differentiation and activation.

scientific article

Functional characterization of the human tumor necrosis factor receptor p75 in a transfected rat/mouse T cell hybridoma ⬇️

scientific article published on October 1, 1992

Functional protection by acute phase proteins alpha(1)-acid glycoprotein and alpha(1)-antitrypsin against ischemia/reperfusion injury by preventing apoptosis and inflammation

scientific article published on 01 September 2000

Gene cloning and structure - function relationship of cytokines such as TNF and interleukins

article

Generation and Biological Characterization of Membrane-bound, Uncleavable Murine Tumor Necrosis Factor ⬇️

scientific article published on August 4, 1995

Generation of a new Gateway-compatible inducible lentiviral vector platform allowing easy derivation of co-transduced cells

scientific article published on May 2016

Generation of dendritic cells from bone marrow progenitors using GM-CSF, TNF-alpha, and additional cytokines: antagonistic effects of IL-4 and IFN-gamma and selective involvement of TNF-alpha receptor-1

scientific article published on 01 August 1997

Glucocorticoid receptor dimers control intestinal STAT1 and TNF-induced inflammation in mice

scientific article published on 25 June 2018

Glutathione peroxidase 4 prevents necroptosis in mouse erythroid precursors

scientific article published on 13 October 2015

Guidelines for the use and interpretation of assays for monitoring autophagy

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes.

scientific article published on 17 April 2009

Gut microbiota affects sensitivity to acute DSS-induced colitis independently of host genotype

scientific article

Head involution defective (Hid)-triggered apoptosis requires caspase-8 but not FADD (Fas-associated death domain) and is regulated by Erk in mammalian cells

scientific article published on 16 July 2002

Heme Oxygenase Activity and Heme Binding in a Neonatal Mouse Model

scientific article published on 20 September 2017

Heterogeneity of the gut microbiome in mice: guidelines for optimizing experimental design

scientific article

How do we fit ferroptosis in the family of regulated cell death?

scientific article published on 6 October 2017

Human TNF mutants with selective activity on the p55 receptor.

scientific article published on January 1993

Human tumor necrosis factor mutants with preferential binding to and activity on either the R55 or R75 receptor

scientific article published in March 1994

Hydroxylase inhibition abrogates TNF-alpha-induced intestinal epithelial damage by hypoxia-inducible factor-1-dependent repression of FADD.

scientific article published on 13 October 2010

Hypericin-based photodynamic therapy induces surface exposure of damage-associated molecular patterns like HSP70 and calreticulin ⬇️

scientific article published on December 23, 2011

Hypericin-induced photosensitization of HeLa cells leads to apoptosis or necrosis

scientific article published on 01 November 1998

IL-4 acts synergistically on the IL-2 response of an autoreactive T-cell clone; synergism correlates with increased intracellular IL-2, but not with a modified IL-2 receptor expression

scientific article published on October 1990

INCA, a novel human caspase recruitment domain protein that inhibits interleukin-1beta generation

scientific article

IP3, a small molecule with a powerful message

scientific article published on 02 January 2013

Identification of a new caspase homologue: caspase-14

scientific article

Identification of caspases that cleave presenilin-1 and presenilin-2

scientific article (publication date: 19 February 1999)

Identification of protein binders in works of art by high-performance liquid chromatography-diode array detector analysis of their tryptic digests.

scientific article

Identification of tumor necrosis factor (TNF) amino acids crucial for binding to the murine p75 TNF receptor and construction of receptor-selective mutants.

scientific article

Immunodominant AH1 Antigen-Deficient Necroptotic, but Not Apoptotic, Murine Cancer Cells Induce Antitumor Protection

scientific article published on 03 January 2020

Immunogenic Apoptotic Cell Death and Anticancer Immunity

scientific article

Immunogenic cell death and DAMPs in cancer therapy

scientific article

Immunogenic cell death, DAMPs and anticancer therapeutics: an emerging amalgamation

scientific article

Impact of caspase-1/11, -3, -7, or IL-1β/IL-18 deficiency on rabies virus-induced macrophage cell death and onset of disease.

scientific article published on 06 March 2017

Impairment of phagocytosis of apoptotic cells and its role in chronic airway diseases

scientific article published on September 2010

In vivo imaging of NF-kappaB activity during Escherichia coli-induced mammary gland infection

scientific article published on 30 January 2008

In vivo immunosuppression induced by a weakly mitogenic antibody to mouse CD3: evidence that induction of long-lasting in vivo unresponsiveness requires TcR signaling

scientific article published on 01 August 1994

Induction of apoptosis by TNF receptor 2 in a T-cell hybridoma is FADD dependent and blocked by caspase-8 inhibitors

scientific article published on 18 January 2005

Inflammation-associated enterotypes, host genotype, cage and inter-individual effects drive gut microbiota variation in common laboratory mice

scientific article

Inflammatory caspases: targets for novel therapies

scientific article published on January 2007

Inflammatory mediators in Escherichia coli-induced mastitis in mice

scientific article published on 19 February 2008

Inhibition of apoptosis induced by ischemia-reperfusion prevents inflammation

scientific article

Inhibition of caspases increases the sensitivity of L929 cells to necrosis mediated by tumor necrosis factor.

scientific article published on May 1998

Inhibition of nuclear factor-kappaB by a nitro-derivative of flurbiprofen: a possible mechanism for antiinflammatory and antiproliferative effect

scientific article published on April 2003

Inhibition of papain-like cysteine proteases and legumain by caspase-specific inhibitors: when reaction mechanism is more important than specificity

scientific article published in August 2003

Inhibition of spontaneous neutrophil apoptosis by parabutoporin acts independently of NADPH oxidase inhibition but by lipid raft-dependent stimulation of Akt.

scientific article published on 13 January 2009

Initiation and execution mechanisms of necroptosis: an overview

scientific article

Interaction of caspase-3 with the cyclic GMP binding cyclic GMP specific phosphodiesterase (PDE5a1).

scientific article published in March 2003

Interaction patches of procaspase-1 caspase recruitment domains (CARDs) are differently involved in procaspase-1 activation and receptor-interacting protein 2 (RIP2)-dependent nuclear factor κB signaling

scientific article

Interferon-β therapy against EAE is effective only when development of the disease depends on the NLRP3 inflammasome

scientific article

Interleukin-10 controls interferon-gamma and tumor necrosis factor production during experimental endotoxemia

scientific article published on 01 May 1994

Intermediate domain of receptor-interacting protein kinase 1 (RIPK1) determines switch between necroptosis and RIPK1 kinase-dependent apoptosis.

scientific article

Intersections between Regulated Cell Death and Autophagy

scientific article published on 18 January 2019

Ionizing radiation results in a mixture of cellular outcomes including mitotic catastrophe, senescence, methuosis, and iron-dependent cell death

scientific article published on 23 November 2020

Is SIRT2 required for necroptosis?

scientific article published on February 2014

Is amyloidogenesis during Alzheimer's disease due to an IL-1-/IL-6-mediated 'acute phase response' in the brain?

scientific article published on July 1991

Keratinocyte Expression of A20/TNFAIP3 Controls Skin Inflammation Associated with Atopic Dermatitis and Psoriasis

scientific article published on 14 August 2018

Keratinocyte-specific ablation of RIPK4 allows epidermal cornification but impairs skin barrier formation

scientific article published on 6 January 2018

Keratinocyte-specific ablation of the NF-κB regulatory protein A20 (TNFAIP3) reveals a role in the control of epidermal homeostasis

scientific article published on 13 May 2011

Life and death of female gametes during oogenesis and folliculogenesis

scientific article published on 14 July 2008

Loss of p63 and its microRNA-205 target results in enhanced cell migration and metastasis in prostate cancer

scientific article

MAGUKs, scaffolding proteins at cell junctions, are substrates of different proteases during apoptosis

scientific article published on 20 January 2011

MK2 phosphorylation of RIPK1 regulates TNF-mediated cell death

scientific article published on 18 September 2017

MLKL Reveals Its Friendly Face: A Role in Nerve Regeneration

scientific article published on 01 November 2018

MLKL compromises plasma membrane integrity by binding to phosphatidylinositol phosphates.

scientific article published on 9 May 2014

MLKL deficiency in Braf<sup>V600E</sup>Pten<sup>-/-</sup> melanoma model results in a modest delay of nevi development and reduced lymph node dissemination in male mice

scientific article published on 14 April 2022

Macrophages regulate the clearance of living cells by calreticulin

scientific article published in Nature Communications

Major cell death pathways at a glance

scientific article published on 04 September 2009

Many faces of DAMPs in cancer therapy

scientific article published on 16 May 2013

Many stimuli pull the necrotic trigger, an overview

scientific article

Mechanisms of internalization of apoptotic and necrotic L929 cells by a macrophage cell line studied by electron microscopy

scientific article published on December 2003

Methods for distinguishing apoptotic from necrotic cells and measuring their clearance

scientific article

Methylprednisolone differentially regulates IL-10 and tumour necrosis factor (TNF) production during murine endotoxaemia

scientific article published on 01 October 1996

Mitochondria and NADPH oxidases are the major sources of TNF-α/cycloheximide-induced oxidative stress in murine intestinal epithelial MODE-K cells

scientific article

Mitochondrial intermembrane proteins in cell death

scientific article

Mitotic catastrophe as a prestage to necrosis in mouse liver cells treated with Helicobacter pullorum sonicates

scientific article

Modulation by caspases of tumor necrosis factor-stimulated c-Jun N-terminal kinase activation but not nuclear factor-kappaB signaling

scientific article published on 01 January 2003

Molecular and Translational Classifications of DAMPs in Immunogenic Cell Death

scientific article

Molecular crosstalk between apoptosis, necroptosis, and survival signaling

scientific article

Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012

scientific article (publication date: 2012)

Molecular mechanisms and pathophysiology of necrotic cell death

scientific article published on May 2008

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

scientific article

Mouse mammary gland involution is associated with cytochrome c release and caspase activation

scientific article published on 01 June 2001

N-glycosylation of mouse TRAIL-R restrains TRAIL-induced apoptosis.

scientific article

NADPH oxidases: new players in TNF-induced necrotic cell death

scientific article

NF-κB-Independent Role of IKKα/IKKβ in Preventing RIPK1 Kinase-Dependent Apoptotic and Necroptotic Cell Death during TNF Signaling.

scientific article published on 2 September 2015

NIK promotes tissue destruction independently of the alternative NF-κB pathway through TNFR1/RIP1-induced apoptosis

scientific article published on 5 June 2015

NLRP3/caspase-1-independent IL-1beta production mediates diesel exhaust particle-induced pulmonary inflammation

scientific article published on 15 August 2011

NOD-like receptors and the innate immune system: coping with danger, damage and death.

scientific article published on 12 October 2011

Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma

scholarly article by Behrouz Hassannia et al published 1 August 2018 in Journal of Clinical Investigation

Nanoscopic X-ray fluorescence imaging and quantification of intracellular key-elements in cryofrozen Friedreich's ataxia fibroblasts

scientific article published on 17 January 2018

NecroX-7 reduces necrotic core formation in atherosclerotic plaques of Apoe knockout mice

scientific article published on 2 July 2016

Necroptosis and its role in inflammation

scientific article

Necroptosis, in vivo detection in experimental disease models

scientific article

Necroptosis, necrosis and secondary necrosis converge on similar cellular disintegration features.

scientific article

Necroptosis: (Last) Message in a Bubble

scientific article published in July 2017

Necroptosis: A Novel Cell Death Modality and Its Potential Relevance for Critical Care Medicine.

scientific article

Necroptosis: the release of damage-associated molecular patterns and its physiological relevance

scientific article

Necroptotic cell death in anti-cancer therapy

scientific article

Necrosis is associated with IL-6 production but apoptosis is not.

scientific article published on 14 July 2005

Necrosis, a well-orchestrated form of cell demise: signalling cascades, important mediators and concomitant immune response

scientific article published on 8 July 2006

Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models

scientific article published on 29 November 2012

Necrostatin-1 blocks both RIPK1 and IDO: consequences for the study of cell death in experimental disease models

scientific article published on 30 November 2012

Necrotic cell death and 'necrostatins': now we can control cellular explosion

scientific article published on 16 July 2008

Neutrophil extracellular trap cell death requires both autophagy and superoxide generation

scientific article

Non-apoptotic functions of caspase-7 during osteogenesis

scientific article published on 14 August 2014

Non-apoptotic role for caspase-7 in hair follicles and the surrounding tissue

scientific article published on 8 August 2015

Non-classical proIL-1beta activation during mammary gland infection is pathogen-dependent but caspase-1 independent

scientific article

Non-specific effects of methyl ketone peptide inhibitors of caspases

scientific article published on January 1999

Noninvasive whole-body imaging of phosphatidylethanolamine as a cell death marker using 99mTc-duramycin during TNF-induced SIRS.

scientific article published in February 2018

Novel Ferroptosis Inhibitors with Improved Potency and ADME Properties

scientific article published on 22 December 2015

Novel Reporter for Faithful Monitoring of ERK2 Dynamics in Living Cells and Model Organisms

scientific article

Nuclear RIPK3 and MLKL contribute to cytosolic necrosome formation and necroptosis

scientific article published on 22 January 2018

P2Z purinoreceptor ligation induces activation of caspases with distinct roles in apoptotic and necrotic alterations of cell death

scientific article published on March 1999

Pannexin-1-Mediated Recognition of Bacterial Molecules Activates the Cryopyrin Inflammasome Independent of Toll-like Receptor Signaling

article by Thirumala-Devi Kanneganti et al published April 2007 in Immunity

Passenger Mutations Confound Interpretation of All Genetically Modified Congenic Mice.

scientific article

Phagocytosis of necrotic cells by macrophages is phosphatidylserine dependent and does not induce inflammatory cytokine production

scientific article published on 10 December 2003

Phosphatidyl serine exposure during apoptosis precedes release of cytochrome c and decrease in mitochondrial transmembrane potential.

scientific article

Programmed necrosis from molecules to health and disease

scientific article published on January 2011

Protein synthesis persists during necrotic cell death

scientific article published on 7 February 2005

Proteolysis of Ambra1 during apoptosis has a role in the inhibition of the autophagic pro-survival response.

scientific article published on 23 March 2012

Proteolysis of enteric cell villin by Entamoeba histolytica cysteine proteinases

scientific article published on 10 April 2003

Proteolytic cleavage of beta-catenin by caspases: an in vitro analysis

scientific article published in September 1999

Proteome-wide Identification of HtrA2/Omi Substrates

scientific article

Proteome-wide substrate analysis indicates substrate exclusion as a mechanism to generate caspase-7 versus caspase-3 specificity

scientific journal article

RIP kinase-dependent necrosis drives lethal systemic inflammatory response syndrome

scientific article published in December 2011

RIP kinases at the crossroads of cell death and survival

scientific article published on July 2009

RIP1 is required for IAP inhibitor-mediated sensitization of childhood acute leukemia cells to chemotherapy-induced apoptosis

scientific article

RIP1's function in NF-kappaB activation: from master actor to onlooker.

scientific article published in March 2010

RIP1, a kinase on the crossroads of a cell's decision to live or die

scientific article

RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis.

scientific article published in September 2014

RIPK1 promotes death receptor-independent caspase-8-mediated apoptosis under unresolved ER stress conditions.

scientific article published on 4 December 2014

RIPK1 protects from TNF-α-mediated liver damage during hepatitis

scientific article

RIPK1 protects hepatocytes from Kupffer cells-mediated TNF-induced apoptosis in mouse models of PAMP-induced hepatitis.

scientific article published on 11 January 2017

RIPK1 protects hepatocytes from death in Fas-induced hepatitis

scientific article

RIPK1-dependent cell death: a novel target of the Aurora kinase inhibitor Tozasertib (VX-680).

scientific article published on 12 February 2018

RIPK3 contributes to TNFR1-mediated RIPK1 kinase-dependent apoptosis in conditions of cIAP1/2 depletion or TAK1 kinase inhibition

scientific article

RIPK4 activity in keratinocytes is controlled by the SCFβ-TrCP ubiquitin ligase to maintain cortical actin organization.

scientific article published on 12 February 2018

ROS-induced autophagy in cancer cells assists in evasion from determinants of immunogenic cell death

scientific article published on 19 June 2013

Recombinant interleukin 2 induces immunoglobulin secretion in Staphylococcus aureus Cowan strain I activated human B-cells

scientific article published on 01 January 1985

Reconstitution of protection against Aspergillus infection in chronic granulomatous disease (CGD)

scientific article published on 01 October 2009

Reduced protection of RIPK3-deficient mice against influenza by matrix protein 2 ectodomain targeted active and passive vaccination strategies

scientific article published on 29 March 2022

Regulated necrosis: disease relevance and therapeutic opportunities

scientific article published on 18 January 2016

Regulated necrosis: the expanding network of non-apoptotic cell death pathways.

scientific article

Regulation of RIPK1's cell death function by phosphorylation

scientific article published on 30 October 2015

Regulation of the expression and processing of caspase-12

scientific article

Requirement for tumor necrosis factor-receptor 2 in alveolar chemokine expression depends upon the form of the ligand

scientific article

Resistance to anticancer vaccination effect is controlled by a cancer cell-autonomous phenotype that disrupts immunogenic phagocytic removal

scientific article

Role of IL-1α and the Nlrp3/caspase-1/IL-1β axis in cigarette smoke-induced pulmonary inflammation and COPD.

scientific article

Selective stimulation of either tumor necrosis factor receptor differentially induces pain behavior in vivo and ectopic activity in sensory neurons in vitro

scientific article published on 11 September 2008

Serine 25 phosphorylation inhibits RIPK1 kinase-dependent cell death in models of infection and inflammation

scientific article published on 15 April 2019

Sesquiterpene lactones as drugs with multiple targets in cancer treatment: focus on parthenolide

scientific article published on October 2012

Severity of doxorubicin-induced small intestinal mucositis is regulated by the TLR-2 and TLR-9 pathways

scientific article

Shining light on cell death processes - a novel biosensor for necroptosis, a newly described cell death program

scientific article published on 03 January 2014

Sibiriline, a new small chemical inhibitor of receptor-interacting protein kinase 1, prevents immune-dependent hepatitis

scientific article published on 17 July 2017

Signaling to gene activation and cell death by tumor necrosis factor receptors and Fas.

scientific article published in January 2002

Simultaneous targeting of IL-1 and IL-18 is required for protection against inflammatory and septic shock

scientific article

Simultaneous targeting of interleukin-1 and interleukin-18 is required for protection against inflammatory and septic shock

SitePredicting the cleavage of proteinase substrates

scientific article published on 21 June 2009

Smac mimetic bypasses apoptosis resistance in FADD- or caspase-8-deficient cells by priming for tumor necrosis factor α-induced necroptosis

scientific article

Sorafenib tosylate inhibits directly necrosome complex formation and protects in mouse models of inflammation and tissue injury.

scientific article published on 29 June 2017

Stimulation of stress-activated but not mitogen-activated protein kinases by tumour necrosis factor receptor subtypes in airway smooth muscle

scientific article published on 01 March 2001

Structure/Function analysis of p55 tumor necrosis factor receptor and fas-associated death domain. Effect on necrosis in L929sA cells.

scientific article published on December 2000

Suppression of interleukin-33 bioactivity through proteolysis by apoptotic caspases.

scientific article

Survival of Single Positive Thymocytes Depends upon Developmental Control of RIPK1 Kinase Signaling by the IKK Complex Independent of NF-κB

scholarly article by Louise V Webb et al published 19 February 2019 in Immunity

Synchronized renal tubular cell death involves ferroptosis. ⬇️

scientific article

TLR-2 and TLR-9 are sensors of apoptosis in a mouse model of doxorubicin-induced acute inflammation

scientific article

TNF-alpha receptors simultaneously activate Ca2+ mobilisation and stress kinases in cultured sensory neurones.

scientific article published in January 2002

TNF-induced necroptosis in L929 cells is tightly regulated by multiple TNFR1 complex I and II members

scientific journal article

TNF/TNF-R1 pathway is involved in doxorubicin-induced acute sterile inflammation

scientific article published on 12 December 2013

TNFR1- and TNFR2-mediated signaling pathways in human kidney are cell type-specific and differentially contribute to renal injury

scientific article

TRAIL induces necroptosis involving RIPK1/RIPK3-dependent PARP-1 activation.

scientific article

TTRAP, a novel protein that associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor-associated factors (TRAFs), and that inhibits nuclear factor-kappa B activation

scientific article

Targeted peptidecentric proteomics reveals caspase-7 as a substrate of the caspase-1 inflammasomes

scientific article published on 30 July 2008

Targeting Ferroptosis to Iron Out Cancer

scientific article published on 16 May 2019

Targeting Rac1 by the Yersinia effector protein YopE inhibits caspase-1-mediated maturation and release of interleukin-1beta

scientific article published on April 2004

Tauroursodeoxycholic acid inhibits experimental colitis by preventing early intestinal epithelial cell death

scientific article published on 13 October 2014

Terminal differentiation of human keratinocytes and stratum corneum formation is associated with caspase-14 activation

scientific article (publication date: December 2000)

The Activation of the c-Jun N-terminal Kinase and p38 Mitogen-activated Protein Kinase Signaling Pathways Protects HeLa Cells from Apoptosis Following Photodynamic Therapy with Hypericin

scientific article published in Journal of Biological Chemistry

The EMAPII cytokine is released from the mammalian multisynthetase complex after cleavage of its p43/proEMAPII component

scientific article

The IL-33/ST2 axis is crucial in type 2 airway responses induced by Staphylococcus aureus-derived serine protease-like protein D.

scientific article published on 19 May 2017

The Nod-like receptor family member Naip5/Birc1e restricts Legionella pneumophila growth independently of caspase-1 activation

scientific article published on 01 June 2007

The Pseudomonas aeruginosa type III secretion system has an exotoxin S/T/Y independent pathogenic role during acute lung infection

scientific article

The Ripoptosome: death decision in the cytosol

scientific article published in August 2011

The Transcription Factor ZEB2 Is Required to Maintain the Tissue-Specific Identities of Macrophages

scientific article published on 31 July 2018

The Tumor Suppressor Hace1 Is a Critical Regulator of TNFR1-Mediated Cell Fate

scientific article published on 04 May 2016

The Tumor Suppressor Hace1 Is a Critical Regulator of TNFR1-Mediated Cell Fate

scientific article published on September 2016

The adjuvant-like activity of staphylococcal enterotoxin B in a murine asthma model is independent of IL-1R signaling

scientific article published on 25 January 2013

The death-fold superfamily of homotypic interaction motifs

scientific article published on 26 July 2011

The emergence of phox-ER stress induced immunogenic apoptosis ⬇️

scientific article published on August 1, 2012

The emerging roles of serine protease cascades in the epidermis

scientific article

The endothelial monocyte-activating polypeptide II (EMAP II) is a substrate for caspase-7.

scientific article published on January 2000

The flick of a switch: which death program to choose?

scientific article published in July 2012

The gamma subunit of the rod photoreceptor cGMP phosphodiesterase can modulate the proteolysis of two cGMP binding cGMP-specific phosphodiesterases (PDE6 and PDE5) by caspase-3.

scientific article

The intrinsic immunogenic properties of cancer cell lines, immunogenic cell death, and how these influence host antitumor immune responses

scientific article published on 19 November 2020

The mitochondrial serine protease HtrA2/Omi cleaves RIP1 during apoptosis of Ba/F3 cells induced by growth factor withdrawal

scientific article

The mitochondrial serine protease HtrA2/Omi: an overview

scientific article

The molecular machinery of regulated cell death

scientific article published on 04 April 2019

The p55 tumour necrosis factor receptor TNFR1 contains a trans-Golgi network localization signal in the C-terminal region of its cytoplasmic tail.

scientific article

The pseudokinase MLKL mediates programmed hepatocellular necrosis independently of RIPK3 during hepatitis

scientific article published on 18 October 2016

The role of mitochondrial factors in apoptosis: a Russian roulette with more than one bullet.

scientific article

The role of the IAP E3 ubiquitin ligases in regulating pattern-recognition receptor signalling

scientific article

The role of the kinases RIP1 and RIP3 in TNF-induced necrosis

scientific article published on 30 March 2010

The serine protease Omi/HtrA2 is released from mitochondria during apoptosis. Omi interacts with caspase-inhibitor XIAP and induces enhanced caspase activity

scientific article (publication date: 2002)

The skin microbiome of caspase-14-deficient mice shows mild dysbiosis.

scientific article

The soluble guanylate cyclase activator BAY 58-2667 protects against morbidity and mortality in endotoxic shock by recoupling organ systems

scientific article

The somatostatin analogue TT-232 induces apoptosis in A431 cells: sustained activation of stress-activated kinases and inhibition of signalling to extracellular signal-regulated kinases.

scientific article

The ubiquitin-editing enzyme A20 controls NK cell homeostasis through regulation of mTOR activity and TNF

scientific article published on 11 July 2019

Therapeutic Targeting of Connexin Channels: New Views and Challenges

scientific article published on 10 November 2018

Tipping the balance between necrosis and apoptosis in human and murine cells treated with interferon and dsRNA.

scientific article published in September 2002

To NET or not to NET:current opinions and state of the science regarding the formation of neutrophil extracellular traps

scientific article published on 08 January 2019

Tortoiseshell or Polymer? Spectroscopic Analysis to Redefine a Purported Tortoiseshell Box with Gold Decorations as a Plastic Box with Brass

scientific article published in January 2016

Towards the differentiation of non-treated and treated corundum minerals by ion-beam-induced luminescence and other complementary techniques

scientific article published on 26 February 2009

Toxic proteins released from mitochondria in cell death

scientific article published on April 2004

Tozasertib Analogues as Inhibitors of Necroptotic Cell Death

scientific article published on 13 February 2018

Transfer of IP₃ through gap junctions is critical, but not sufficient, for the spread of apoptosis

scientific article published on 25 November 2011

Translation inhibition in apoptosis: caspase-dependent PKR activation and eIF2-alpha phosphorylation

scientific article (publication date: 9 November 2001)

Treatment of PC-3 and DU145 prostate cancer cells by prenylflavonoids from hop (Humulus lupulus L.) induces a caspase-independent form of cell death ⬇️

scientific article published on February 2008

Treatment with mRNA coding for the necroptosis mediator MLKL induces antitumor immunity directed against neo-epitopes

scientific article published in Nature Communications

Tryptic peptide analysis of protein binders in works of art by liquid chromatography-tandem mass spectrometry

scientific article

Tumor necrosis factor induces distinct patterns of caspase activation in WEHI-164 cells associated with apoptosis or necrosis depending on cell cycle stage.

scientific article published on August 1999

Tumor necrosis factor receptor 2-signaling in CD133-expressing cells in renal clear cell carcinoma

scientific article published on 16 March 2016

Tumor necrosis factor-alpha-induced activation of RhoA in airway smooth muscle cells: role in the Ca2+ sensitization of myosin light chain20 phosphorylation

scientific article

Tumor necrosis factor-induced cytotoxicity is not related to rates of mitochondrial morphological abnormalities or autophagy-changes that can be mediated by TNFR-I or TNFR-II.

scientific article published on December 1998

Tumor necrosis factor-mediated cell death: to break or to burst, that's the question

scientific article published on 04 March 2010

Tumoricidal activity of monocyte-derived dendritic cells: evidence for a caspase-8-dependent, Fas-associated death domain-independent mechanism.

scientific article

Tumour necrosis factor-induced activation of c-Jun N-terminal kinase is sensitive to caspase-dependent modulation while activation of mitogen-activated protein kinase (MAPK) or p38 MAPK is not.

scientific article published on August 2002

Tumour necrosis factor-induced necrosis versus anti-Fas-induced apoptosis in L929 cells.

scientific article

Two tumour necrosis factor receptors: structure and function.

scientific article published in October 1995

Type II tumour necrosis factor-alpha receptor (TNFR2) activates c-Jun N-terminal kinase (JNK) but not mitogen-activated protein kinase (MAPK) or p38 MAPK pathways.

scientific article published in November 2001

USP8 suppresses death receptor-mediated apoptosis by enhancing FLIPL stability

scientific article published on 20 June 2016

Ubiquitin-Mediated Regulation of RIPK1 Kinase Activity Independent of IKK and MK2.

scientific article published in February 2018

Ultraviolet B radiation-induced apoptosis in human keratinocytes: cytosolic activation of procaspase-8 and the role of Bcl-2.

scientific article published on April 2003

Use of dendrograms of slice spectra as a new graphical tool for the interpretation of two-dimensional correlation spectra

scientific article published in January 2009

Vaccination with Necroptotic Cancer Cells Induces Efficient Anti-tumor Immunity

scientific article published on 30 March 2016

Vitamin D3 induces caspase-14 expression in psoriatic lesions and enhances caspase-14 processing in organotypic skin cultures

scientific article

When PERK inhibitors turn out to be new potent RIPK1 inhibitors: critical issues on the specificity and use of GSK2606414 and GSK2656157.

scientific article

Workshop summary: cell death mechanisms controlled by the TNF family

scientific article published on 01 January 2011

Yersinia enterocolitica YopP-induced apoptosis of macrophages involves the apoptotic signaling cascade upstream of bid.

scientific article published on 14 March 2001

cIAP1 and TAK1 protect cells from TNF-induced necrosis by preventing RIP1/RIP3-dependent reactive oxygen species production

scientific journal article

cIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4)

scientific article

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