List of works - David Westaway

A novel Gerstmann-Sträussler-Scheinker disease mutation defines a precursor for amyloidogenic 8 kDa PrP fragments and reveals N-terminal structural changes shared by other GSS alleles.

scientific article published on 16 January 2018

Abeta-degrading endopeptidase, neprilysin, in mouse brain: synaptic and axonal localization inversely correlating with Abeta pathology

scientific journal article

Application of high-throughput, capillary-based Western analysis to modulated cleavage of the cellular prion protein

scientific article published on 21 December 2018

Evolutionary descent of prion genes from the ZIP family of metal ion transporters

scientific article

Interactome analyses identify ties of PrP and its mammalian paralogs to oligomannosidic N-glycans and endoplasmic reticulum-derived chaperones

scientific article

Knockout of the prion protein (PrP)-like Sprn gene does not produce embryonic lethality in combination with PrP C -deficiency ⬇️

scientific article published on May 22, 2012

Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations

scientific journal article

Pathologic tau conformer ensembles induce dynamic, liquid-liquid phase separation events at the nuclear envelope

scientific article published on 09 September 2021

Presenilin 1 and presenilin 2 have differential effects on the stability and maturation of nicastrin in Mammalian brain

scientific journal article

Proteasomal Inhibition Redirects the PrP-Like Shadoo Protein to the Nucleus

scientific article published on 25 May 2019

Quaternary Structure Changes for PrPSc Predate PrPC Downregulation and Neuronal Death During Progression of Experimental Scrapie Disease

scientific article published on 21 September 2020

Shadoo/PrP (Sprn(0/0) /Prnp(0/0) ) double knockout mice: more than zeroes

scientific article

Short amylin receptor antagonist peptides improve memory deficits in Alzheimer's disease mouse model

scientific article published on 29 July 2019

Substitutions of PrP N-terminal histidine residues modulate scrapie disease pathogenesis and incubation time in transgenic mice.

scientific article published on 8 December 2017

TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity

scientific article

The PrP-like protein Doppel binds copper

scientific journal article

The in vivo brain interactome of the amyloid precursor protein

scientific journal article

The prion protein modulates A-type K+ currents mediated by Kv4.2 complexes through dipeptidyl aminopeptidase-like protein 6

scientific journal article

List of works by David Westaway

A novel Gerstmann-Sträussler-Scheinker disease mutation defines a precursor for amyloidogenic 8 kDa PrP fragments and reveals N-terminal structural changes shared by other GSS alleles.

Abeta-degrading endopeptidase, neprilysin, in mouse brain: synaptic and axonal localization inversely correlating with Abeta pathology

Application of high-throughput, capillary-based Western analysis to modulated cleavage of the cellular prion protein

Evolutionary descent of prion genes from the ZIP family of metal ion transporters

Interactome analyses identify ties of PrP and its mammalian paralogs to oligomannosidic N-glycans and endoplasmic reticulum-derived chaperones

Knockout of the prion protein (PrP)-like Sprn gene does not produce embryonic lethality in combination with PrP C -deficiency ⬇️

Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations

Pathologic tau conformer ensembles induce dynamic, liquid-liquid phase separation events at the nuclear envelope

Presenilin 1 and presenilin 2 have differential effects on the stability and maturation of nicastrin in Mammalian brain

Proteasomal Inhibition Redirects the PrP-Like Shadoo Protein to the Nucleus

Quaternary Structure Changes for PrPSc Predate PrPC Downregulation and Neuronal Death During Progression of Experimental Scrapie Disease

Shadoo/PrP (Sprn(0/0) /Prnp(0/0) ) double knockout mice: more than zeroes

Short amylin receptor antagonist peptides improve memory deficits in Alzheimer's disease mouse model

Substitutions of PrP N-terminal histidine residues modulate scrapie disease pathogenesis and incubation time in transgenic mice.

TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity

The PrP-like protein Doppel binds copper

The in vivo brain interactome of the amyloid precursor protein

The prion protein modulates A-type K+ currents mediated by Kv4.2 complexes through dipeptidyl aminopeptidase-like protein 6