List of works - Gerold Schmitt-Ulms

A Proteome Resource of Ovarian Cancer Ascites: Integrated Proteomic and Bioinformatic Analyses To Identify Putative Biomarkers

A ZIP6-ZIP10 heteromer controls NCAM1 phosphorylation and integration into focal adhesion complexes during epithelial-to-mesenchymal transition

scientific article published on 18 January 2017

ALS/FTD Mutation-Induced Phase Transition of FUS Liquid Droplets and Reversible Hydrogels into Irreversible Hydrogels Impairs RNP Granule Function

scientific article

APH1 polar transmembrane residues regulate the assembly and activity of presenilin complexes

scientific article published on 15 April 2009

Alzheimer disease: advances in pathogenesis, diagnosis, and therapy

scientific article published on 10 February 2011

Alzheimer's disease: Selectively tuning gamma-secretase.

scientific article

An emerging role of the cellular prion protein as a modulator of a morphogenetic program underlying epithelial-to-mesenchymal transition

scientific article published on 18 September 2014

An endogenous PI3K interactome promoting astrocyte mediated neuroprotection identifies a novel association with RNA binding protein ZC3H14

scientific article published on 24 November 2020

An updated h-index measures both the primary and total scientific output of a researcher

scientific article

Application of CRISPR genetic screens to investigate neurological diseases.

scientific article published on 14 November 2019

Aβ43 aggregates exhibit enhanced prion-like seeding activity in mice

scientific article published on 10 May 2021

Bcl-2-associated athanogene 5 (BAG5) regulates Parkin-dependent mitophagy and cell death

scientific article published on 02 December 2019

Both the sequence and length of the C terminus of PEN-2 are critical for intermolecular interactions and function of presenilin complexes

scientific article published on 17 August 2004

CRISPR-Cas9 System: Opportunities and Concerns

scientific article published on 22 August 2016

CRISPR-Cas9-based knockout of the prion protein and its effect on the proteome

scientific article

Childhood Onset in Familial Prion Disease With a Novel Mutation in the PRNP Gene

article

Choice of biological source material supersedes oxidative stress in its influence on DJ-1 in vivo interactions with Hsp90.

scientific article published on 26 August 2011

Co-immunoprecipitations revisited: an update on experimental concepts and their implementation for sensitive interactome investigations of endogenous proteins

scientific article published on 22 June 2007

Combining molecular dynamics simulations and experimental analyses in protein misfolding

scientific article published on 01 January 2019

Correction: Interactome Analyses Identify Ties of PrPC and Its Mammalian Paralogs to Oligomannosidic N-Glycans and Endoplasmic Reticulum-Derived Chaperones.

scientific article published on 29 October 2009

Crosslinking Strategies for the Study of Membrane Protein Complexes and Protein Interaction Interfaces ⬇️

scientific article published on January 1, 2006

Does BDNF Val66Met contribute to preclinical Alzheimer's disease?

scientific article published in October 2016

Down-Regulation of Shadoo in Prion Infections Traces a Pre-Clinical Event Inversely Related to PrPSc Accumulation ⬇️

scientific article published on November 17, 2011

Drug Repositioning for Alzheimer's Disease Based on Systematic 'omics' Data Mining

scientific article

Endoproteolytic processing of the mammalian prion glycoprotein family

scientific article published on 23 December 2013

Engineering a murine cell line for the stable propagation of hamster prions

scientific article published on 31 January 2019

Evidence for retrogene origins of the prion gene family

scientific article (publication date: 2011)

Evolutionary descent of prion genes from the ZIP family of metal ion transporters

scientific article

FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-π Interactions.

scientific article published in April 2018

Family reunion--the ZIP/prion gene family

scientific article published on 14 December 2010

Functional Amyloids and their Possible Influence on Alzheimer Disease

scientific article published on 16 October 2017

Interactions of MAP/microtubule affinity regulating kinases with the adaptor complex AP-2 of clathrin-coated vesicles

scientific article published in August 2009

Interactome analyses identify ties of PrP and its mammalian paralogs to oligomannosidic N-glycans and endoplasmic reticulum-derived chaperones

scientific article

Interactome analyses of mature γ-secretase complexes reveal distinct molecular environments of presenilin (PS) paralogs and preferential binding of signal peptide peptidase to PS2.

scientific article published on 15 April 2013

Interactome and interface protocol (2IP): a novel strategy for high sensitivity topology mapping of protein complexes

scientific article

LIV-1 ZIP ectodomain shedding in prion-infected mice resembles cellular response to transition metal starvation

scientific article

Mass spectrometric analysis of protein mixtures at low levels using cleavable 13C-isotope-coded affinity tag and multidimensional chromatography

scientific article

Method for the affinity purification of covalently linked peptides following cyanogen bromide cleavage of proteins

scientific article

NCAM1 Polysialylation: The Prion Protein's Elusive Reason for Being?

scientific article

Octarepeat region flexibility impacts prion function, endoproteolysis and disease manifestation

scientific article

Overcoming barriers and thresholds – signaling of oligomeric Aβ through the prion protein to Fyn ⬇️

scientific article published on July 16, 2013

Peptide separations by on-line MudPIT compared to isoelectric focusing in an off-gel format: application to a membrane-enriched fraction from C2C12 mouse skeletal muscle cells.

scientific article published on October 2009

Prion Protein Deficiency Causes Diverse Proteome Shifts in Cell Models That Escape Detection in Brain Tissue

scientific article

Prion-like propagation of β-amyloid aggregates in the absence of APP overexpression

scientific article published on 3 April 2018

PrionHome: a database of prions and other sequences relevant to prion phenomena

scientific article

Proteome-wide identification of mycobacterial pupylation targets

scientific article

Somatostatin binds to the human amyloid β peptide and favors the formation of distinct oligomers

scientific article published on 26 June 2017

Somatostatin in Alzheimer'S disease: A new Role for an Old Player

scientific article published in December 2017

Structural biology of presenilin 1 complexes

scientific article

Structural interactions between inhibitor and substrate docking sites give insight into mechanisms of human PS1 complexes

scientific article

TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity

scientific article

TMP21 transmembrane domain regulates gamma-secretase cleavage

scientific article

Tau interactome analyses in CRISPR-Cas9 engineered neuronal cells reveal ATPase-dependent binding of wild-type but not P301L Tau to non-muscle myosins

scientific article published on 07 November 2019

The CNS glycoprotein Shadoo has PrP(C)-like protective properties and displays reduced levels in prion infections

scientific article published on 16 August 2007

The Evolutionary unZIPping of a Dimerization Motif—A Comparison of ZIP and PrP Architectures.

scientific article published on 29 December 2017

The Human Tau Interactome: Binding to the Ribonucleoproteome, and Impaired Binding of the Proline-to-Leucine Mutant at Position 301 (P301L) to Chaperones and the Proteasome

scientific article

The Prion Protein Controls Polysialylation of Neural Cell Adhesion Molecule 1 during Cellular Morphogenesis

scientific article

The ZIP-prion connection

scientific article published on 17 May 2012

The ZIP5 ectodomain co-localizes with PrP and may acquire a PrP-like fold that assembles into a dimer

scientific article

The human brain somatostatin interactome: SST binds selectively to P-type family ATPases

scientific article published on 28 May 2019

The in vivo brain interactome of the amyloid precursor protein

scientific journal article

The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease

scientific article

The presenilin proteins are components of multiple membrane-bound complexes that have different biological activities

scientific article published on 30 April 2004

The prion protein is embedded in a molecular environment that modulates transforming growth factor β and integrin signaling.

scientific article

The prion protein modulates A-type K+ currents mediated by Kv4.2 complexes through dipeptidyl aminopeptidase-like protein 6

scientific journal article

Time-Controlled Transcardiac Perfusion Crosslinking for In Vivo Interactome Studies ⬇️

scientific article published on 01 January 2012

Time-controlled transcardiac perfusion cross-linking for the study of protein interactions in complex tissues

scientific article

Time-course global proteome analyses reveal an inverse correlation between Aβ burden and immunoglobulin M levels in the APPNL-F mouse model of Alzheimer disease.

scientific article published on 23 August 2017

Vigilin interacts with signal peptide peptidase

scientific article

Wild-type Shadoo proteins convert to amyloid-like forms under native conditions.

scientific article published on 8 January 2010

Zinc transporter ZIP10 forms a heteromer with ZIP6 which regulates embryonic development and cell migration.

scientific article

List of works by Gerold Schmitt-Ulms

A Proteome Resource of Ovarian Cancer Ascites: Integrated Proteomic and Bioinformatic Analyses To Identify Putative Biomarkers

A ZIP6-ZIP10 heteromer controls NCAM1 phosphorylation and integration into focal adhesion complexes during epithelial-to-mesenchymal transition

ALS/FTD Mutation-Induced Phase Transition of FUS Liquid Droplets and Reversible Hydrogels into Irreversible Hydrogels Impairs RNP Granule Function

APH1 polar transmembrane residues regulate the assembly and activity of presenilin complexes

Alzheimer disease: advances in pathogenesis, diagnosis, and therapy

Alzheimer's disease: Selectively tuning gamma-secretase.

An emerging role of the cellular prion protein as a modulator of a morphogenetic program underlying epithelial-to-mesenchymal transition

An endogenous PI3K interactome promoting astrocyte mediated neuroprotection identifies a novel association with RNA binding protein ZC3H14

An updated h-index measures both the primary and total scientific output of a researcher

Application of CRISPR genetic screens to investigate neurological diseases.

Aβ43 aggregates exhibit enhanced prion-like seeding activity in mice

Bcl-2-associated athanogene 5 (BAG5) regulates Parkin-dependent mitophagy and cell death

Both the sequence and length of the C terminus of PEN-2 are critical for intermolecular interactions and function of presenilin complexes

CRISPR-Cas9 System: Opportunities and Concerns

CRISPR-Cas9-based knockout of the prion protein and its effect on the proteome

Childhood Onset in Familial Prion Disease With a Novel Mutation in the PRNP Gene

Choice of biological source material supersedes oxidative stress in its influence on DJ-1 in vivo interactions with Hsp90.

Co-immunoprecipitations revisited: an update on experimental concepts and their implementation for sensitive interactome investigations of endogenous proteins

Combining molecular dynamics simulations and experimental analyses in protein misfolding

Correction: Interactome Analyses Identify Ties of PrPC and Its Mammalian Paralogs to Oligomannosidic N-Glycans and Endoplasmic Reticulum-Derived Chaperones.

Crosslinking Strategies for the Study of Membrane Protein Complexes and Protein Interaction Interfaces ⬇️

Does BDNF Val66Met contribute to preclinical Alzheimer's disease?

Down-Regulation of Shadoo in Prion Infections Traces a Pre-Clinical Event Inversely Related to PrPSc Accumulation ⬇️

Drug Repositioning for Alzheimer's Disease Based on Systematic 'omics' Data Mining

Endoproteolytic processing of the mammalian prion glycoprotein family

Engineering a murine cell line for the stable propagation of hamster prions

Evidence for retrogene origins of the prion gene family

Evolutionary descent of prion genes from the ZIP family of metal ion transporters

FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-π Interactions.

Family reunion--the ZIP/prion gene family

Functional Amyloids and their Possible Influence on Alzheimer Disease

Interactions of MAP/microtubule affinity regulating kinases with the adaptor complex AP-2 of clathrin-coated vesicles

Interactome analyses identify ties of PrP and its mammalian paralogs to oligomannosidic N-glycans and endoplasmic reticulum-derived chaperones

Interactome analyses of mature γ-secretase complexes reveal distinct molecular environments of presenilin (PS) paralogs and preferential binding of signal peptide peptidase to PS2.

Interactome and interface protocol (2IP): a novel strategy for high sensitivity topology mapping of protein complexes

LIV-1 ZIP ectodomain shedding in prion-infected mice resembles cellular response to transition metal starvation

Mass spectrometric analysis of protein mixtures at low levels using cleavable 13C-isotope-coded affinity tag and multidimensional chromatography

Method for the affinity purification of covalently linked peptides following cyanogen bromide cleavage of proteins

NCAM1 Polysialylation: The Prion Protein's Elusive Reason for Being?

Octarepeat region flexibility impacts prion function, endoproteolysis and disease manifestation

Overcoming barriers and thresholds – signaling of oligomeric Aβ through the prion protein to Fyn ⬇️

Peptide separations by on-line MudPIT compared to isoelectric focusing in an off-gel format: application to a membrane-enriched fraction from C2C12 mouse skeletal muscle cells.

Prion Protein Deficiency Causes Diverse Proteome Shifts in Cell Models That Escape Detection in Brain Tissue

Prion-like propagation of β-amyloid aggregates in the absence of APP overexpression

PrionHome: a database of prions and other sequences relevant to prion phenomena

Proteome-wide identification of mycobacterial pupylation targets

Somatostatin binds to the human amyloid β peptide and favors the formation of distinct oligomers

Somatostatin in Alzheimer'S disease: A new Role for an Old Player

Structural biology of presenilin 1 complexes

Structural interactions between inhibitor and substrate docking sites give insight into mechanisms of human PS1 complexes

TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity

TMP21 transmembrane domain regulates gamma-secretase cleavage

Tau interactome analyses in CRISPR-Cas9 engineered neuronal cells reveal ATPase-dependent binding of wild-type but not P301L Tau to non-muscle myosins

The CNS glycoprotein Shadoo has PrP(C)-like protective properties and displays reduced levels in prion infections

The Evolutionary unZIPping of a Dimerization Motif—A Comparison of ZIP and PrP Architectures.

The Human Tau Interactome: Binding to the Ribonucleoproteome, and Impaired Binding of the Proline-to-Leucine Mutant at Position 301 (P301L) to Chaperones and the Proteasome

The Prion Protein Controls Polysialylation of Neural Cell Adhesion Molecule 1 during Cellular Morphogenesis

The ZIP-prion connection

The ZIP5 ectodomain co-localizes with PrP and may acquire a PrP-like fold that assembles into a dimer

The human brain somatostatin interactome: SST binds selectively to P-type family ATPases

The in vivo brain interactome of the amyloid precursor protein

The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease

The presenilin proteins are components of multiple membrane-bound complexes that have different biological activities

The prion protein is embedded in a molecular environment that modulates transforming growth factor β and integrin signaling.

The prion protein modulates A-type K+ currents mediated by Kv4.2 complexes through dipeptidyl aminopeptidase-like protein 6

Time-Controlled Transcardiac Perfusion Crosslinking for In Vivo Interactome Studies ⬇️

Time-controlled transcardiac perfusion cross-linking for the study of protein interactions in complex tissues

Time-course global proteome analyses reveal an inverse correlation between Aβ burden and immunoglobulin M levels in the APPNL-F mouse model of Alzheimer disease.

Vigilin interacts with signal peptide peptidase

Wild-type Shadoo proteins convert to amyloid-like forms under native conditions.

Zinc transporter ZIP10 forms a heteromer with ZIP6 which regulates embryonic development and cell migration.