Search filters

List of works by Jean-Marc Taymans

A Phosphosite Mutant Approach on LRRK2 Links Phosphorylation and Dephosphorylation to Protective and Deleterious Markers, Respectively

scientific article published on 17 March 2022

A direct interaction between leucine-rich repeat kinase 2 and specific β-tubulin isoforms regulates tubulin acetylation

scientific article

A potential patient stratification biomarker for Parkinson´s disease based on LRRK2 kinase-mediated centrosomal alterations in peripheral blood-derived cells

scientific article published in 2024

Activator of G protein signaling type 3 mRNA is widely distributed in the rat brain and is particularly abundant in the subventricular zone-olfactory bulb system of neural precursor cell proliferation, migration and differentiation

scientific article

Automated quantitative gait analysis in animal models of movement disorders

scientific article

Bilateral control of brain activity by dopamine D1 receptors: evidence from induction patterns of regulator of G protein signaling 2 and c-fos mRNA in D1-challenged hemiparkinsonian rats

scientific article published in January 2005

Biochemical characterization of highly purified leucine-rich repeat kinases 1 and 2 demonstrates formation of homodimers

scientific article

Can the increasing number of newly developed leucine-rich repeat kinase 2 inhibitors validate or invalidate a potential disease-modifying therapeutic approach for Parkinson's disease?

scientific article published on 30 May 2014

Centrosomal cohesion deficits as cellular biomarker in lymphoblastoid cell lines from LRRK2 Parkinson's disease patients

scientific article published on 01 October 2019

Chemical genetic approach identifies microtubule affinity-regulating kinase 1 as a leucine-rich repeat kinase 2 substrate.

scientific article published on 8 April 2015

Comparative analysis of adeno-associated viral vector serotypes 1, 2, 5, 7, and 8 in mouse brain

scientific article published in March 2007

Cryo-EM analysis of homodimeric full-length LRRK2 and LRRK1 protein complexes

scientific article

Deregulation of protein translation control, a potential game-changing hypothesis for Parkinson's disease pathogenesis.

scientific article published on 17 June 2015

Detailed localization of regulator of G protein signaling 2 messenger ribonucleic acid and protein in the rat brain.

scientific article

Differential protein-protein interactions of LRRK1 and LRRK2 indicate roles in distinct cellular signaling pathways

scientific article

Distribution of PINK1 and LRRK2 in rat and mouse brain

scientific article published on 12 June 2006

Dopamine receptor-mediated regulation of RGS2 and RGS4 mRNA differentially depends on ascending dopamine projections and time

scientific article published in April 2004

Evidence for the Involvement of the Small Subunit of HIV-1 Reverse Transcriptase (RT) in the TSAO-Resistance

article

Expression, purification and preliminary biochemical and structural characterization of the leucine rich repeat namesake domain of leucine rich repeat kinase 2.

scientific article

GTP binding regulates cellular localization of Parkinson's disease-associated LRRK2.

scientific article published on 26 April 2017

Identification of protein phosphatase 1 as a regulator of the LRRK2 phosphorylation cycle

scientific article

Immunohistochemical detection of transgene expression in the brain using small epitope tags

scientific article

In silico and Wet Bench Interactomics Sheds Light on the Similitudes and Differences between Human ROCO Proteins

scientific article published on 13 June 2018

In silico, in vitro and cellular analysis with a kinome-wide inhibitor panel correlates cellular LRRK2 dephosphorylation to inhibitor activity on LRRK2.

scientific article published on 3 June 2014

Indolinone based LRRK2 kinase inhibitors with a key hydrogen bond

scientific article published on 29 August 2014

Inhibition of FK506 binding proteins reduces alpha-synuclein aggregation and Parkinson's disease-like pathology.

scientific article published in February 2010

Insight into the mode of action of the LRRK2 Y1699C pathogenic mutant

scientific article

Kinases as targets for Parkinson's disease: from genetics to therapy

scientific article published on September 2011

LRRK2 Kinase Inhibition as a Therapeutic Strategy for Parkinson's Disease, Where Do We Stand?

scientific article

LRRK2 detection in human biofluids: potential use as a Parkinson's disease biomarker?

scientific article published on February 2017

LRRK2 kinase activity is dependent on LRRK2 GTP binding capacity but independent of LRRK2 GTP binding

scientific article

Leucine-rich repeat kinase 2 interacts with p21-activated kinase 6 to control neurite complexity in mammalian brain

scientific article

MK-801 alters RGS2 levels and adenylyl cyclase sensitivity in the rat striatum

scientific article published in February 2005

Metabolic labeling of leucine rich repeat kinases 1 and 2 with radioactive phosphate

scientific article published on 18 September 2013

MicroRNA-205 regulates the expression of Parkinson's disease-related leucine-rich repeat kinase 2 protein.

scientific article published on 2 November 2012

On the road to leucine-rich repeat kinase 2 signalling: evidence from cellular and in vivo studies

scientific article published on 23 March 2011

PAK6 Phosphorylates 14-3-3γ to Regulate Steady State Phosphorylation of LRRK2.

scientific article published on 14 December 2017

Parkinson disease-associated mutations in LRRK2 cause centrosomal defects via Rab8a phosphorylation

scientific article

Pharmacological LRRK2 kinase inhibition induces LRRK2 protein destabilization and proteasomal degradation

scientific article published on 23 September 2016

Phosphatases of α-synuclein, LRRK2, and tau: important players in the phosphorylation-dependent pathology of Parkinsonism

scientific article published in 2014

Phosphorylation of LRRK2: from kinase to substrate

scientific article published on October 2012

Phosphorylation of ezrin/radixin/moesin proteins by LRRK2 promotes the rearrangement of actin cytoskeleton in neuronal morphogenesis

scientific article

Regulation of LRRK2 by Phosphatases

scientific article published in January 2017

Resistance of HIV-1 reverse transcriptase against [2',5'-bis-O-(tert-butyldimethylsilyl)-3'-spiro-5''-(4''-amino-1'',2''- oxathiole-2'',2''-dioxide)] (TSAO) derivatives is determined by the mutation Glu138-->Lys on the p51 subunit.

scientific article published on October 1994

Role of LRRK2 in the regulation of dopamine receptor trafficking

scientific article

Striatal gene expression of RGS2 and RGS4 is specifically mediated by dopamine D1 and D2 receptors: clues for RGS2 and RGS4 functions

scientific article published in March 2003

The GTPase function of LRRK2 ⬇️

scientific article published on October 1, 2012

The Parkinson disease-associated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylation

scientific article

The Parkinson's disease associated LRRK2 exhibits weaker in vitro phosphorylation of 4E-BP compared to autophosphorylation

scientific article

The Parkinson's disease kinase LRRK2 autophosphorylates its GTPase domain at multiple sites

scientific article

Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease

scientific article

Paulina is supported by:

About Paulina

Help