List of works - Alexandra Beilina

A direct interaction between leucine-rich repeat kinase 2 and specific β-tubulin isoforms regulates tubulin acetylation

scientific article

Age-associated changes in gene expression in human brain and isolated neurons

scientific article

Arsenite stress down-regulates phosphorylation and 14-3-3 binding of leucine-rich repeat kinase 2 (LRRK2), promoting self-association and cellular redistribution

scientific article

Biochemical characterization of highly purified leucine-rich repeat kinases 1 and 2 demonstrates formation of homodimers

scientific article

Cell population-specific expression analysis of human cerebellum ⬇️

scientific article published on November 12, 2012

Comparative Protein Interaction Network Analysis Identifies Shared and Distinct Functions for the Human ROCO Proteins

scientific article published on 7 March 2018

Correction to: Molecular mechanism of olesoxime-mediated neuroprotection through targeting α-synuclein interaction with mitochondrial VDAC

scientific article published on 09 January 2020

DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy

scientific article

Detection of endogenous S1292 LRRK2 autophosphorylation in mouse tissue as a readout for kinase activity.

scientific article

Differences in Stability, Activity and Mutation Effects Between Human and Mouse Leucine-Rich Repeat Kinase 2

scientific article published on 05 October 2018

Differential protein-protein interactions of LRRK1 and LRRK2 indicate roles in distinct cellular signaling pathways

scientific article

Elevated FMR1 mRNA in premutation carriers is due to increased transcription.

scientific article published on 5 February 2007

Expression of PINK1 mRNA in human and rodent brain and in Parkinson's disease

scholarly article by Jeff G. Blackinton et al published December 2007 in Brain Research

Genes associated with Parkinson's disease: regulation of autophagy and beyond

scientific article published on 30 July 2015

Hexokinases link DJ-1 to the PINK1/parkin pathway

scientific article published on 29 September 2017

Induction of inclusion formation and disruption of lamin A/C structure by premutation CGG-repeat RNA in human cultured neural cells

scientific article

LRRK2 kinase activity is dependent on LRRK2 GTP binding capacity but independent of LRRK2 GTP binding

scientific article

LRRK2 mediates microglial neurotoxicity via NFATc2 in rodent models of synucleinopathies

scientific article published on 01 October 2020

LRRK2 mediates tubulation and vesicle sorting from lysosomes

scientific article published on 11 November 2020

LRRK2 phosphorylates membrane-bound Rabs and is activated by GTP-bound Rab7L1 to promote recruitment to the trans-Golgi network

scientific article published on 21 November 2017

Leucine-rich repeat kinase 2 interacts with p21-activated kinase 6 to control neurite complexity in mammalian brain

scientific article

Mitochondrial alterations in PINK1 deficient cells are influenced by calcineurin-dependent dephosphorylation of dynamin-related protein 1.

scientific article

Molecular mechanism of olesoxime-mediated neuroprotection through targeting α-synuclein interaction with mitochondrial VDAC

scientific article published on 23 November 2019

Mutations in LRRK2/dardarin associated with Parkinson disease are more toxic than equivalent mutations in the homologous kinase LRRK1.

scientific article

Mutations in PTEN-induced putative kinase 1 associated with recessive parkinsonism have differential effects on protein stability

scientific article

Phosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7

scientific article

Proteomic analysis reveals co-ordinated alterations in protein synthesis and degradation pathways in LRRK2 knockout mice

RNA binding activity of the recessive parkinsonism protein DJ-1 supports involvement in multiple cellular pathways

scientific article

Redistribution of transcription start sites within the FMR1 promoter region with expansion of the downstream CGG-repeat element

scientific article published on 13 January 2004

Sequential screening nominates the Parkinson's disease associated kinase LRRK2 as a regulator of Clathrin-mediated endocytosis

scientific article published on 17 May 2020

Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase

scientific article

The G2385R risk factor for Parkinson's disease enhances CHIP-dependent intracellular degradation of LRRK2.

scientific article published on 20 March 2017

The Parkinson disease-associated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylation

scientific article

The Parkinson's Disease Protein LRRK2 Interacts with the GARP Complex to Promote Retrograde Transport to the trans-Golgi Network

scientific article published on 01 May 2020

The Parkinson's disease associated LRRK2 exhibits weaker in vitro phosphorylation of 4E-BP compared to autophosphorylation

scientific article

The Parkinson's disease kinase LRRK2 autophosphorylates its GTPase domain at multiple sites

scientific article

The R1441C mutation of LRRK2 disrupts GTP hydrolysis

scientific article

Tyrosinase exacerbates dopamine toxicity but is not genetically associated with Parkinson's disease

scientific article

Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease

scientific article

List of works by Alexandra Beilina

A direct interaction between leucine-rich repeat kinase 2 and specific β-tubulin isoforms regulates tubulin acetylation

Age-associated changes in gene expression in human brain and isolated neurons

Arsenite stress down-regulates phosphorylation and 14-3-3 binding of leucine-rich repeat kinase 2 (LRRK2), promoting self-association and cellular redistribution

Biochemical characterization of highly purified leucine-rich repeat kinases 1 and 2 demonstrates formation of homodimers

Cell population-specific expression analysis of human cerebellum ⬇️

Comparative Protein Interaction Network Analysis Identifies Shared and Distinct Functions for the Human ROCO Proteins

Correction to: Molecular mechanism of olesoxime-mediated neuroprotection through targeting α-synuclein interaction with mitochondrial VDAC

DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy

Detection of endogenous S1292 LRRK2 autophosphorylation in mouse tissue as a readout for kinase activity.

Differences in Stability, Activity and Mutation Effects Between Human and Mouse Leucine-Rich Repeat Kinase 2

Differential protein-protein interactions of LRRK1 and LRRK2 indicate roles in distinct cellular signaling pathways

Elevated FMR1 mRNA in premutation carriers is due to increased transcription.

Expression of PINK1 mRNA in human and rodent brain and in Parkinson's disease

Genes associated with Parkinson's disease: regulation of autophagy and beyond

Hexokinases link DJ-1 to the PINK1/parkin pathway

Induction of inclusion formation and disruption of lamin A/C structure by premutation CGG-repeat RNA in human cultured neural cells

LRRK2 kinase activity is dependent on LRRK2 GTP binding capacity but independent of LRRK2 GTP binding

LRRK2 mediates microglial neurotoxicity via NFATc2 in rodent models of synucleinopathies

LRRK2 mediates tubulation and vesicle sorting from lysosomes

LRRK2 phosphorylates membrane-bound Rabs and is activated by GTP-bound Rab7L1 to promote recruitment to the trans-Golgi network

Leucine-rich repeat kinase 2 interacts with p21-activated kinase 6 to control neurite complexity in mammalian brain

Mitochondrial alterations in PINK1 deficient cells are influenced by calcineurin-dependent dephosphorylation of dynamin-related protein 1.

Molecular mechanism of olesoxime-mediated neuroprotection through targeting α-synuclein interaction with mitochondrial VDAC

Mutations in LRRK2/dardarin associated with Parkinson disease are more toxic than equivalent mutations in the homologous kinase LRRK1.

Mutations in PTEN-induced putative kinase 1 associated with recessive parkinsonism have differential effects on protein stability

Phosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7

Proteomic analysis reveals co-ordinated alterations in protein synthesis and degradation pathways in LRRK2 knockout mice

RNA binding activity of the recessive parkinsonism protein DJ-1 supports involvement in multiple cellular pathways

Redistribution of transcription start sites within the FMR1 promoter region with expansion of the downstream CGG-repeat element

Sequential screening nominates the Parkinson's disease associated kinase LRRK2 as a regulator of Clathrin-mediated endocytosis

Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase

The G2385R risk factor for Parkinson's disease enhances CHIP-dependent intracellular degradation of LRRK2.

The Parkinson disease-associated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylation

The Parkinson's Disease Protein LRRK2 Interacts with the GARP Complex to Promote Retrograde Transport to the trans-Golgi Network

The Parkinson's disease associated LRRK2 exhibits weaker in vitro phosphorylation of 4E-BP compared to autophosphorylation

The Parkinson's disease kinase LRRK2 autophosphorylates its GTPase domain at multiple sites

The R1441C mutation of LRRK2 disrupts GTP hydrolysis

Tyrosinase exacerbates dopamine toxicity but is not genetically associated with Parkinson's disease

Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease