List of works - Elisa Greggio

Analysis of IFT74 as a candidate gene for chromosome 9p-linked ALS-FTD

scientific article

Biochemical characterization of highly purified leucine-rich repeat kinases 1 and 2 demonstrates formation of homodimers

scientific article

Differential protein-protein interactions of LRRK1 and LRRK2 indicate roles in distinct cellular signaling pathways

scientific article

Formation of a Stabilized Cysteine Sulfinic Acid Is Critical for the Mitochondrial Function of the Parkinsonism Protein DJ-1

scientific article

GTP binding controls complex formation by the human ROCO protein MASL1

scientific article

GTPase activity regulates kinase activity and cellular phenotypes of Parkinson's disease-associated LRRK2

scientific article

Insight into the mode of action of the LRRK2 Y1699C pathogenic mutant

scientific article

Kinase activity of mutant LRRK2 manifests differently in hetero-dimeric vs. homo-dimeric complexes

scientific article published on 08 February 2019

Kinase signaling pathways as potential targets in the treatment of Parkinson's disease

scientific article published on December 2007

LRRK2 kinase activity regulates synaptic vesicle trafficking and neurotransmitter release through modulation of LRRK2 macro-molecular complex

scientific article

Leucine-rich repeat kinase 2 and lysosomal dyshomeostasis in Parkinson disease

scientific article published on 24 November 2019

Leucine-rich repeat kinase 2 interacts with p21-activated kinase 6 to control neurite complexity in mammalian brain

scientific article

MKK6 binds and regulates expression of Parkinson's disease-related protein LRRK2

scientific article

Parkinson's disease and immune system: is the culprit LRRKing in the periphery?

scientific article

Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase

scientific article

The Parkinson disease-associated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylation

scientific article

The Parkinson's disease kinase LRRK2 autophosphorylates its GTPase domain at multiple sites

scientific article

The R1441C mutation of LRRK2 disrupts GTP hydrolysis

scientific article

The chaperone-like protein 14-3-3η interacts with human α-synuclein aggregation intermediates rerouting the amyloidogenic pathway and reducing α-synuclein cellular toxicity

scientific article

The role of LRRK2 in cytoskeletal dynamics

scientific article published on 22 November 2018

Transcriptome analysis of LRRK2 knock-out microglia cells reveals alterations of inflammatory- and oxidative stress-related pathways upon treatment with α-synuclein fibrils

scientific article published on 15 May 2019

Tyrosinase exacerbates dopamine toxicity but is not genetically associated with Parkinson's disease

scientific article

Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease

scientific article

List of works by Elisa Greggio

Analysis of IFT74 as a candidate gene for chromosome 9p-linked ALS-FTD

Biochemical characterization of highly purified leucine-rich repeat kinases 1 and 2 demonstrates formation of homodimers

Differential protein-protein interactions of LRRK1 and LRRK2 indicate roles in distinct cellular signaling pathways

Formation of a Stabilized Cysteine Sulfinic Acid Is Critical for the Mitochondrial Function of the Parkinsonism Protein DJ-1

GTP binding controls complex formation by the human ROCO protein MASL1

GTPase activity regulates kinase activity and cellular phenotypes of Parkinson's disease-associated LRRK2

Insight into the mode of action of the LRRK2 Y1699C pathogenic mutant

Kinase activity of mutant LRRK2 manifests differently in hetero-dimeric vs. homo-dimeric complexes

Kinase signaling pathways as potential targets in the treatment of Parkinson's disease

LRRK2 kinase activity regulates synaptic vesicle trafficking and neurotransmitter release through modulation of LRRK2 macro-molecular complex

Leucine-rich repeat kinase 2 and lysosomal dyshomeostasis in Parkinson disease

Leucine-rich repeat kinase 2 interacts with p21-activated kinase 6 to control neurite complexity in mammalian brain

MKK6 binds and regulates expression of Parkinson's disease-related protein LRRK2

Parkinson's disease and immune system: is the culprit LRRKing in the periphery?

Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase

The Parkinson disease-associated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylation

The Parkinson's disease kinase LRRK2 autophosphorylates its GTPase domain at multiple sites

The R1441C mutation of LRRK2 disrupts GTP hydrolysis

The chaperone-like protein 14-3-3η interacts with human α-synuclein aggregation intermediates rerouting the amyloidogenic pathway and reducing α-synuclein cellular toxicity

The role of LRRK2 in cytoskeletal dynamics

Transcriptome analysis of LRRK2 knock-out microglia cells reveals alterations of inflammatory- and oxidative stress-related pathways upon treatment with α-synuclein fibrils

Tyrosinase exacerbates dopamine toxicity but is not genetically associated with Parkinson's disease

Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease