List of works by Francesco Cecconi

A New Transgenic Mouse Model for Studying the Neurotoxicity of Spermine Oxidase Dosage in the Response to Excitotoxic Injury

scientific article

A brain-specific isoform of mitochondrial apoptosis-inducing factor: AIF2

scientific article

A dual role of p53 in the control of autophagy

scientific article

A new transgenic mouse model for studying the neurotoxicity of spermine oxidase dosage in the response to excitotoxic injury

A novel player in the p53-mediated autophagy: Sestrin2.

scientific article published on 15 May 2009

A novel role for autophagy in neurodevelopment

scientific article published on 21 June 2007

AMBRA1 Controls Regulatory T-Cell Differentiation and Homeostasis Upstream of the FOXO3-FOXP3 Axis

scientific article published on 01 December 2018

AMBRA1 and BECLIN 1 interplay in the crosstalk between autophagy and cell proliferation

scientific article

AMBRA1 interplay with cullin E3 ubiquitin ligases regulates autophagy dynamics

scientific article published on 11 December 2014

AMBRA1 is able to induce mitophagy via LC3 binding, regardless of PARKIN and p62/SQSTM1

scientific article

AMBRA1 links autophagy to cell proliferation and tumorigenesis by promoting c-Myc dephosphorylation and degradation

scientific article published on December 2014

AMBRA1 regulates cyclin D to guard S-phase entry and genomic integrity

scientific article published on 14 April 2021

AMBRA1-induced mitophagy: A new mechanism to cope with cancer?

scientific article published on 25 February 2015

AMBRA1: When autophagy meets cell proliferation

scientific article

APAF1 is a key transcriptional target for p53 in the regulation of neuronal cell death.

scientific article

Age-dependent roles of peroxisomes in the hippocampus of a transgenic mouse model of Alzheimer's disease

scientific article published on 2 February 2013

Altered mitochondria morphology and cell metabolism in Apaf1-deficient cells.

scientific article published on 9 January 2014

Ambra1 at a glance

scientific article published on June 2015

Ambra1 regulates autophagy and development of the nervous system

scientific article

Analysis of apoptosome dysregulation in pancreatic cancer and of its role in chemoresistance

scientific article published on 25 February 2007

Analysis of neuronal cell death in mammals

scientific article published in January 2008

Apaf-1 is a transcriptional target for E2F and p53

Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development

scientific article

Apaf1 in developmental apoptosis and cancer: how many ways to die?

scientific article

Apaf1 in embryonic development - shaping life by death, and more

scientific article

Apaf1 is no longer single

scientific article

Apaf1 mediates apoptosis and mitochondrial damage induced by mutant human SOD1s typical of familial amyotrophic lateral sclerosis

scientific article

Apaf1 plays a pro-survival role by regulating centrosome morphology and function

scientific article published on 07 October 2011

Apaf1 reduced expression levels generate a mutant phenotype in adult brain and skeleton

scientific article published in March 2002

Apaf1-dependent programmed cell death is required for inner ear morphogenesis and growth

scientific article published in May 2004

Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome

scientific article

Apoptosis is not required for mammalian neural tube closure.

scholarly article

Apoptosis-inducing factor (AIF): key to the conserved caspase-independent pathways of cell death?

scientific article

Apoptosis-inducing factor is involved in the regulation of caspase-independent neuronal cell death

scientific article

Apoptosome impairment during development results in activation of an autophagy program in cerebral cortex

scientific article published on September 2006

Apoptosome inactivation rescues proneural and neural cells from neurodegeneration.

scientific article published in November 2004

Apoptosome-deficient cells lose cytochrome c through proteasomal degradation but survive by autophagy-dependent glycolysis

scientific article published on 11 June 2008

Astrocyte-Dependent Vulnerability to Excitotoxicity in Spermine Oxidase-Overexpressing Mouse

scientific article published on 3 November 2015

Atg5 and Ambra1 differentially modulate neurogenesis in neural stem cells

scientific article

Autophagic and apoptotic response to stress signals in mammalian cells

scientific article published on March 2007

Autophagy and cancer stem cells: molecular mechanisms and therapeutic applications

scientific article published on 06 February 2019

Autophagy in malignant transformation and cancer progression

scientific article

Autophagy in stem and progenitor cells

scientific article

Autophagy in the CNS and Periphery Coordinate Lipophagy and Lipolysis in the Brown Adipose Tissue and Liver

scientific article

Autophagy induction impairs migration and invasion by reversing EMT in glioblastoma cells

scientific article published on 13 May 2015

Autophagy regulation by miRNAs: when cleaning goes out of service

scientific article published on 16 November 2011

Autophagy, Inflammation, and Metabolism (AIM) Center of Biomedical Research Excellence: supporting the next generation of autophagy researchers and fostering international collaborations

scientific article published on 01 January 2018

Autophagy, replication stress and DNA synthesis, an intricate relationship

scientific article published on 03 January 2020

Autophagy-dependent NFκB regulation

Aβ toxicity in Alzheimer's disease

scientific article published on 14 March 2012

CRL4<sup>AMBRA1</sup> is a master regulator of D-type cyclins

scientific article published on 14 April 2021

Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells

scientific article

Caspase regulation of genotoxin-induced neural precursor cell death

scientific article published in November 2003

Caspase-2 is not required for thymocyte or neuronal apoptosis even though cleavage of caspase-2 is dependent on both Apaf-1 and caspase-9

scientific article published on 01 August 2002

Caspase-3 in the central nervous system: beyond apoptosis

scientific article published on 14 July 2012

Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer's disease

scientific article published on 12 December 2010

Caspase-8 and Apaf-1-independent caspase-9 activation in Sendai virus-infected cells

scientific article published on 20 May 2002

Cloning and characterization of the European seabass, Dicentrarchus labrax, mitochondrial genome

scientific article published in August 1994

Cloud hunting: doryphagy, a form of selective autophagy that degrades centriolar satellites

scientific article published on 19 December 2019

Comparative structure analysis of vertebrate U17 small nucleolar RNA (snoRNA)

scientific article (publication date: February 2002)

Conditional activation of Pax6 in the developing cortex of transgenic mice causes progenitor apoptosis

scientific article

Connecting autophagy: AMBRA1 and its network of regulation

scientific article published on January 2015

Correction to: HUWE1 controls MCL1 stability to unleash AMBRA1-induced mitophagy

scientific article published on 30 October 2019

Different Role of Apaf-1 in Positive Selection, Negative Selection and Death by Neglect in Foetal Thymic Organ Culture

article

Doryphagy: when selective autophagy safeguards centrosome integrity

scientific article published on 07 February 2020

Early biochemical and morphological modifications in the brain of a transgenic mouse model of Alzheimer's disease: a role for peroxisomes

scientific article published in January 2009

Endoplasmic Reticulum Stress Induces Apoptosis by an Apoptosome-dependent but Caspase 12-independent Mechanism

scientific article published in Journal of Biological Chemistry

Erratum: Corrigendum: AMBRA1 links autophagy to cell proliferation and tumorigenesis by promoting c-Myc dephosphorylation and degradation

scholarly article published in Nature Cell Biology

Essential versus accessory aspects of cell death: recommendations of the NCCD 2015.

scientific article

Expanding roles of programmed cell death in mammalian neurodevelopment

scientific article

Expression of Ambra1 in mouse brain during physiological and Alzheimer type aging

scientific article published on 2 August 2013

Expression of Foxb1 Reveals Two Strategies for the Formation of Nuclei in the Developing Ventral Diencephalon

Expression of Meis2, a Knotted-related murine homeobox gene, indicates a role in the differentiation of the forebrain and the somitic mesoderm

scientific article published in October 1997

Faf1 is expressed during neurodevelopment and is involved in Apaf1-dependent caspase-3 activation in proneural cells

scientific article published on 01 June 2008

Fanconi Anemia Genes, of Menders and Sweepers

article

Fine-tuning of ULK1 mRNA and protein levels is required for autophagy oscillation.

scientific article

Foregut separation and tracheo-oesophageal malformations: the role of tracheal outgrowth, dorso-ventral patterning and programmed cell death

scientific article

Fugu intron oversize reveals the presence of U15 snoRNA coding sequences in some introns of the ribosomal protein S3 gene

scientific article published in December 1996

Glial cells generate neurons: the role of the transcription factor Pax6.

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

scientific article

HUWE1 controls MCL1 stability to unleash AMBRA1-induced mitophagy

scientific article published on 21 August 2019

Ho(a)xing autophagy to regulate development

scientific article published in January 2014

Inflammation triggers synaptic alteration and degeneration in experimental autoimmune encephalomyelitis

scientific article published on March 2009

Interdigital cell death can occur through a necrotic and caspase-independent pathway.

scientific article published in September 1999

Intracellular bacteriolysis triggers a massive apoptotic cell death in Shigella-infected epithelial cells.

scientific article

Involvement of peroxisome proliferator-activated receptor β/δ (PPAR β/δ) in BDNF signaling during aging and in Alzheimer disease: possible role of 4-hydroxynonenal (4-HNE).

scientific article

Iron-Starvation-Induced Mitophagy Mediates Lifespan Extension upon Mitochondrial Stress in C. elegans

scientific article published on 2 July 2015

Live or Die: Choice Mechanisms in Stressed Cells

scientific article published on 8 October 2015

Localization of Apaf1 gene expression in the early development of the mouse by means of in situ reverse transcriptase-polymerase chain reaction

scientific article published in September 2005

Loss of Ambra1 promotes melanoma growth and invasion

scientific article published on 05 May 2021

Macroautophagy inhibition maintains fragmented mitochondria to foster T cell receptor-dependent apoptosis.

scientific article published on 7 July 2016

Maize polyamine oxidase: primary structure from protein and cDNA sequencing

scientific article

Mitochondrial BCL-2 inhibits AMBRA1-induced autophagy

scientific article

Mitochondrial dismissal in mammals, from protein degradation to mitophagy

scientific article

Mitochondrial release of AIF and EndoG requires caspase activation downstream of Bax/Bak-mediated permeabilization

scientific article

Mitophagy in neurodegenerative diseases

scientific article published on 7 August 2017

Molecular clearance at the cell's antenna

scientific article published in Nature

Molecular definitions of autophagy and related processes.

scientific article published on 08 June 2017

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

scientific article

Multilingual Word Sense Disambiguation and Entity Linking for Everybody

scientific article published in proceedings of the iswc 2014 posters & demonstrations track

Neuronal caspase-3 signaling: not only cell death

scientific article published on 04 December 2009

New insights into the link between DNA damage and apoptosis

scientific article

Non-apoptotic roles for death-related molecules: when mitochondria chose cell fate

scientific article published on 08 February 2012

Nonapoptotic Role for Apaf-1 in the DNA Damage Checkpoint

Nonapoptotic role for Apaf-1 in the DNA damage checkpoint

scientific article published on November 2007

Novel inducers of BECN1-independent autophagy: cis-unsaturated fatty acids

scientific article

Oxidative DNA damage in neurons: implication of ku in neuronal homeostasis and survival

scientific article published on 12 June 2012

Oxidative Stress during the Progression of β-Amyloid Pathology in the Neocortex of the Tg2576 Mouse Model of Alzheimer's Disease

scientific article published on 20 April 2015

Oxidative stress and autophagy: the clash between damage and metabolic needs

scientific article

Physiological and pathological roles of Apaf1 and the apoptosome.

scientific article

Prolonged Pseudohypoxia Targets Ambra1 mRNA to P-Bodies for Translational Repression

scientific article published on 18 June 2015

Prosurvival AMBRA1 turns into a proapoptotic BH3-like protein during mitochondrial apoptosis

scientific article published on 28 April 2016

Proteolysis of Ambra1 during apoptosis has a role in the inhibition of the autophagic pro-survival response.

scientific article published on 23 March 2012

Rapamycin and fasting sustain autophagy response activated by ischemia/reperfusion injury and promote retinal ganglion cell survival

scientific article published on 24 September 2018

Reactivation of autophagy by spermidine ameliorates the myopathic defects of collagen VI-null mice

scientific article published on 13 November 2015

Reduced cathepsins B and D cause impaired autophagic degradation that can be almost completely restored by overexpression of these two proteases in Sap C-deficient fibroblasts

scientific journal article

Regulation of autophagy by cytoplasmic p53

scientific article

Reversible induction of mitophagy by an optogenetic bimodular system

scientific article published on 04 April 2019

S-Nitrosoglutathione Reductase Plays Opposite Roles in SH-SY5Y Models of Parkinson's Disease and Amyotrophic Lateral Sclerosis

scientific article

S-nitrosoglutathione reductase deficiency-induced S-nitrosylation results in neuromuscular dysfunction.

scientific article

Schwann cell autophagy counteracts the onset and chronification of neuropathic pain

scientific article published on 13 September 2013

Selective autophagy maintains centrosome integrity and accurate mitosis by turnover of centriolar satellites

scientific article published on 13 September 2019

Sequence of the gene coding for ribosomal protein S8 of Xenopus laevis

scientific article

Sequence of the mitochondrial tRNA(Thr) and tRNA(Pro) genes from European seabass, Dicentrarchus labrax.

scientific article published on May 1993

Sexual dimorphism of AMBRA1-related autistic features in human and mouse

scientific article

Spatial specification of mammalian eye territories by reciprocal transcriptional repression of Pax2 and Pax6.

scientific article published in October 2000

Stimulation of autophagy by rapamycin protects neurons from remote degeneration after acute focal brain damage

scientific article published on February 2012

Structural and sequence evolution of U17 small nucleolar RNA (snoRNA) and its phylogenetic congruence in chelonians

scientific article published in July 2003

Structure and expression of ribosomal protein genes in Xenopus laevis.

scientific article published on November 1995

TFG binds LC3C to regulate ULK1 localization and autophagosome formation

scientific article published on 01 May 2021

Targeting cancer stem cells in medulloblastoma by inhibiting AMBRA1 dual function in autophagy and STAT3 signalling

scientific article published on 24 July 2021

Targeting ions-induced autophagy in cancer.

scientific article published on 10 November 2014

The DNA repair complex Ku70/86 modulates Apaf1 expression upon DNA damage

scientific article

The Xenopus intron-encoded U17 snoRNA is produced by exonucleolytic processing of its precursor in oocytes

scientific article

The apoptosome: emerging insights and new potential targets for drug design

scientific article published on 3 August 2007

The autophagy regulators Ambra1 and Beclin 1 are required for adult neurogenesis in the brain subventricular zone.

scientific article

The dynamic interaction of AMBRA1 with the dynein motor complex regulates mammalian autophagy

scientific article

The epg5 knockout zebrafish line: a model to study Vici syndrome

scientific article published on 17 March 2019

The fork head transcription factor Fkh5/Mf3 is a developmental marker gene for superior colliculus layers and derivatives of the hindbrain somatic afferent zone

scientific article published in February 1999

The involvement of cell death and survival in neural tube defects: a distinct role for apoptosis and autophagy?

scientific article published on 02 May 2008

The multifaceted mitochondrion: An attractive candidate for therapeutic strategies

scientific article published on 24 March 2015

The pro-oxidant adaptor p66SHC promotes B cell mitophagy by disrupting mitochondrial integrity and recruiting LC3-II

scientific article published on 06 September 2018

The role of autophagy during development in higher eukaryotes

scientific article published on October 2010

The role of autophagy in mammalian development: cell makeover rather than cell death

scientific article published on September 2008

To eat, or NOt to eat: S-nitrosylation signaling in autophagy.

scientific article published on 15 April 2016

Type 2 transglutaminase is involved in the autophagy-dependent clearance of ubiquitinated proteins

scientific article published on 10 February 2012

U17XS8, a small nucleolar RNA with a 12 nt complementarity to 18S rRNA and coded by a sequence repeated in the six introns of Xenopus laevis ribosomal protein S8 gene.

scientific article

ULK1 ubiquitylation is regulated by phosphorylation on its carboxy terminus

scientific article published on 18 August 2017

Unique features in the mitochondrial D-loop region of the European seabass Dicentrarchus labrax

scientific article

Unleashing the Ambra1-Beclin 1 complex from dynein chains: Ulk1 sets Ambra1 free to induce autophagy

scientific article

Unsaturated fatty acids induce non-canonical autophagy

scientific article published on 13 January 2015

XIAP: inhibitor of two worlds

scientific article published on 21 June 2013

Zebrafish ambra1a and ambra1b knockdown impairs skeletal muscle development

scientific article

c-Cbl targets active Src for autophagy

mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6.

scientific article published on 24 March 2013

mTOR, AMBRA1, and autophagy: an intricate relationship

scientific article published on 30 July 2013

nNOS/GSNOR interaction contributes to skeletal muscle differentiation and homeostasis

scientific article published on 01 May 2019

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