List of works by Paul van Helden

'One Health' infectious diseases surveillance in Tanzania: are we all on board the same flight?

scientific article published on 19 July 2012

A Global Perspective on Pyrazinamide Resistance: Systematic Review and Meta-Analysis

scientific article

A Sex-Stratified Genome-Wide Association Study of Tuberculosis Using a Multi-Ethnic Genotyping Array

scientific article published on 01 January 2018

A Subgroup of Latently Mycobacterium tuberculosis Infected Individuals Is Characterized by Consistently Elevated IgA Responses to Several Mycobacterial Antigens.

scientific article

A commercial ELISA for detection of interferon gamma in white rhinoceros

scientific article published on 11 April 2019

A functional haplotype in the 3'untranslated region of TNFRSF1B is associated with tuberculosis in two African populations

scientific article

A new TB vaccine: fact or fiction?

scientific article

A novel inhibitor of gyrase B is a potent drug candidate for treatment of tuberculosis and nontuberculosis mycobacterial infections.

scientific article

A panel of ancestry informative markers for the complex five-way admixed South African coloured population

scientific article

A post-GWAS analysis of predicted regulatory variants and tuberculosis susceptibility

scientific article

A regulatory variant in the C1Q gene cluster is associated with tuberculosis susceptibility and C1qA plasma levels in a South African population

scientific article published on 19 June 2020

A sensitive urinary lipoarabinomannan test for tuberculosis

scientific article published on 23 April 2015

A threshold value for the time delay to TB diagnosis

scientific article

AN INTERFERON GAMMA RELEASE ASSAY FOR THE DETECTION OF IMMUNE SENSITIZATION TO MYCOBACTERIUM BOVIS IN AFRICAN WILD DOGS (LYCAON PICTUS)

scientific article published on 17 December 2018

Absence of an association between Mycobacterium tuberculosis genotype and clinical features in children with tuberculous meningitis

scientific article published in January 2007

African 1, an epidemiologically important clonal complex of Mycobacterium bovis dominant in Mali, Nigeria, Cameroon, and Chad

scientific article published on 09 January 2009

African 2, a Clonal Complex of Mycobacterium bovis Epidemiologically Important in East Africa

scientific article published in 2012

African 2, a clonal complex of Mycobacterium bovis epidemiologically important in East Africa

scientific article

Agreement between assays of cell-mediated immunity utilizing Mycobacterium bovis-specific antigens for the diagnosis of tuberculosis in African buffaloes (Syncerus caffer)

scientific article published on 04 April 2014

Alcohol, hospital discharge, and socioeconomic risk factors for default from multidrug resistant tuberculosis treatment in rural South Africa: a retrospective cohort study

scientific article (publication date: 2013)

Allele frequencies for glutathione S-transferase and N-acetyltransferase 2 differ in African population groups and may be associated with oesophageal cancer or tuberculosis incidence

scientific article published in April 2003

Allelic variation in BTNL2 and susceptibility to tuberculosis in a South African population

scientific article

An evaluation of commercial fluorescent bead-based luminex cytokine assays

scientific article

An interferon-gamma release assay for the diagnosis of the Mycobacterium bovis infection in white rhinoceros (Ceratotherium simum)

scientific article published on 15 August 2019

Anaerobe-enriched gut microbiota predicts pro-inflammatory responses in pulmonary tuberculosis

scientific article published on 08 May 2021

Analysis of eight genes modulating interferon gamma and human genetic susceptibility to tuberculosis: a case-control association study

scientific article

Animal-adapted members of the Mycobacterium tuberculosis complex endemic to the southern African subregion.

scientific article published on 26 April 2016

Antemortem diagnosis of Mycobacterium bovis infection in free-ranging African lions (Panthera leo) and implications for transmission

scientific article published on 3 February 2015

Anti-mycobacterium tuberculosis activity of polyherbal medicines used for the treatment of tuberculosis in Eastern Cape, South Africa

scientific article

Antigen-Specific IP-10 Release Is a Sensitive Biomarker of Mycobacterium bovis Infection in Cattle.

scientific article

Antimicrobial resistance in tuberculosis: an international perspective.

scientific article published on October 2006

Antitubercular 2-Pyrazolylpyrimidinones: Structure-Activity Relationship and Mode-of-Action Studies

scientific article published on 04 January 2021

Application of Rapid Serologic Tests for Detection of Mycobacterium bovis Infection in Free-Ranging Warthogs (Phacochoerus africanus)--Implications for Antemortem Disease Screening

scientific article published on 10 November 2015

Application of sensitive and specific molecular methods to uncover global dissemination of the major RDRio Sublineage of the Latin American-Mediterranean Mycobacterium tuberculosis spoligotype family

scientific article published on 30 January 2008

Association between tuberculosis and a polymorphic NFkappaB binding site in the interferon gamma gene

scientific article published in May 2003

Association of toll-like receptors with susceptibility to tuberculosis suggests sex-specific effects of TLR8 polymorphisms.

scientific article published on 6 July 2015

Associations between human leukocyte antigen class I variants and the Mycobacterium tuberculosis subtypes causing disease

scientific article published on 14 August 2013

Author Correction: Genome-wide analysis of multi- and extensively drug-resistant Mycobacterium tuberculosis.

scientific article published on 19 April 2018

Autosomal Dominant IFN-γR1 Deficiency Presenting with both Atypical Mycobacteriosis and Tuberculosis in a BCG-Vaccinated South African Patient.

scientific article published on 18 May 2018

Bacterial and host determinants of cough aerosol culture positivity in patients with drug-resistant versus drug-susceptible tuberculosis

scientific article published on 29 June 2020

Baseline Hematologic Results for Free-ranging White Rhinoceros (Ceratotherium simum) in Kruger National Park, South Africa

scientific article published on 12 August 2015

Beijing and Haarlem genotypes are overrepresented among children with drug-resistant tuberculosis in the Western Cape Province of South Africa

scientific article

Bovine TB in livestock and wildlife: what's in the genes?

scientific article

Bovine tuberculosis at the human-livestock-wildlife interface: is it a public health problem in Tanzania? A review

scientific article published on 20 June 2012

Bovine tuberculosis in African buffaloes: observations regarding Mycobacterium bovis shedding into water and exposure to environmental mycobacteria

scientific article

Changes in Host Immune-Endocrine Relationships during Tuberculosis Treatment in Patients with Cured and Failed Treatment Outcomes

scientific article

Changes in the kinetics of intracellular IFN-gamma production in TB patients during treatment

scientific article published on 5 July 2007

Characterization of Mycobacterium orygis

scientific article published on October 2012

Characterization of tuberculous lesions in naturally infected African buffalo (Syncerus caffer).

scientific article published in September 2011

Classification of drug resistant tuberculosis

scientific article published in The Lancet

Clinical Relevance of Nontuberculous Mycobacteria Isolated from Sputum in a Gold Mining Workforce in South Africa: An Observational, Clinical Study

scientific article published on 28 May 2015

Combining fine-needle aspiration biopsy (FNAB) and high-resolution melt analysis to reduce diagnostic delay in Mycobacterial lymphadenitis.

scientific article

Comparative analysis of Mycobacterium tuberculosis pe and ppe genes reveals high sequence variation and an apparent absence of selective constraints

scientific article published on 4 April 2012

Conservation of White Rhinoceroses Threatened by Bovine Tuberculosis, South Africa, 2016-2017

scientific article published on 01 December 2018

Correction: Drug-Associated Adverse Events and Their Relationship with Outcomes in Patients Receiving Treatment for Extensively Drug-Resistant Tuberculosis in South Africa

scientific article (publication date: 31 May 2013)

Correction: Potential of Host Markers Produced by Infection Phase-Dependent Antigen-Stimulated Cells for the Diagnosis of Tuberculosis in a Highly Endemic Area.

scientific article published on 31 August 2012

Correction: The Rationale for Using Rifabutin in the Treatment of MDR and XDR Tuberculosis Outbreaks

scientific article published on 21 July 2015

Corrigendum to “Detection of Mycobacterium bovis infection in African buffaloes ( Syncerus caffer ) using QuantiFERON ® -TB Gold (QFT) tubes and the Qiagen cattletype ® IFN-gamma ELISA” [J. Vet. Immunol. Immunopathol. 196 (2018) 48–52]

scientific article published on 07 March 2018

Creation and characterisation of a high-copy-number version of the pAL5000 mycobacterial replicon

scientific article

Criteria for Identification of Cross-Contamination of Cultures of Mycobacterium tuberculosis in Routine Microbiology Laboratories ⬇️

scientific article published on May 1, 2003

Cytokine biomarker discovery in the white rhinoceros (Ceratotherium simum)

scientific article published on 14 December 2020

Cytokine gene expression assay as a diagnostic tool for detection of Mycobacterium bovis infection in warthogs (Phacochoerus africanus)

scientific article published on 11 November 2019

DIAGNOSIS AND IMPLICATIONS OF MYCOBACTERIUM BOVIS INFECTION IN BANDED MONGOOSES (MUNGOS MUNGO) IN THE KRUGER NATIONAL PARK, SOUTH AFRICA.

scientific article

Design, synthesis, and In vitro antituberculosis activity of 2(5H)-Furanone derivatives

scientific article

Detecting drug-resistant tuberculosis: the importance of rapid testing.

scientific article published in August 2011

Detection and treatment of subclinical tuberculosis

article

Detection of Mycobacterium bovis infection in African buffaloes (Syncerus caffer) using QuantiFERON®-TB Gold (QFT) tubes and the Qiagen cattletype® IFN-gamma ELISA.

scientific article

Detection of Mycobacterium kansasii infection in a rhesus macaque (Macaca mulatta) using a modified QuantiFERON-TB Gold assay

scientific article published on 30 March 2010

Detection of antibodies to tuberculosis antigens in free-ranging lions (Panthera leo) infected with Mycobacterium bovis in Kruger National Park, South Africa

scientific article published in June 2012

Detection ofMycobacterium tuberculosisinfection in chacma baboons (Papio ursinus) using the QuantiFERON-TB Gold (In-Tube) assay

scientific article published on 14 July 2009

Determining ancestry proportions in complex admixture scenarios in South Africa using a novel proxy ancestry selection method

scientific article

Development of a Novel Lead that Targets M. tuberculosis Polyketide Synthase 13.

scientific article

Development of a diagnostic gene expression assay for tuberculosis and its use under field conditions in African buffaloes (Syncerus caffer)

scientific article published on 19 May 2012

Development of gene expression assays measuring immune responses in the spotted hyena (Crocuta crocuta)

journal article; published in African Zoology in 2017

Diagnostic Accuracy and Utility of FluoroType MTBDR, a New Molecular Assay for Multidrug-Resistant Tuberculosis

scholarly article by Margaretha de Vos et al published September 2018 in Journal of Clinical Microbiology

Diagnostic performance of a seven-marker serum protein biosignature for the diagnosis of active TB disease in African primary healthcare clinic attendees with signs and symptoms suggestive of TB.

scientific article published on 4 May 2016

Differences in primary sites of infection between zoonotic and human tuberculosis: results from a worldwide systematic review

scientific article

Differential cytokine/chemokines and KL-6 profiles in patients with different forms of tuberculosis

scientific article published on 30 June 2009

Differential expression of interleukin-4 (IL-4) and IL-4 delta 2 mRNA, but not transforming growth factor beta (TGF-beta), TGF-beta RII, Foxp3, gamma interferon, T-bet, or GATA-3 mRNA, in patients with fast and slow responses to antituberculosis tre

scientific article published on 25 June 2008

Differential expression of mycothiol pathway genes: are they affected by antituberculosis drugs?

scientific article

Distinct phases of blood gene expression pattern through tuberculosis treatment reflect modulation of the humoral immune response

scientific article published on 7 August 2012

Distinct serum biosignatures are associated with different tuberculosis treatment outcomes

scientific article published on 12 August 2019

Drug resistance in Mycobacterium tuberculosis

scientific article published on 01 July 2006

Drug susceptibility testing using molecular techniques can enhance tuberculosis diagnosis.

scientific article published in February 2008

Drug-Penetration Gradients Associated with Acquired Drug Resistance in Patients with Tuberculosis

scientific article published on 01 November 2018

Drug-associated adverse events and their relationship with outcomes in patients receiving treatment for extensively drug-resistant tuberculosis in South Africa

scientific article

ESAT-6 and CFP-10: what is the diagnosis?

scientific article published on November 2002

Early treatment outcomes and HIV status of patients with extensively drug-resistant tuberculosis in South Africa: a retrospective cohort study

scientific article published in May 2010

Efflux pump inhibitors: targeting mycobacterial efflux systems to enhance TB therapy

scientific article published on 15 October 2015

Emergence and treatment of multidrug resistant (MDR) and extensively drug-resistant (XDR) tuberculosis in South Africa

scientific article published on 04 August 2011

Emergence of increased resistance and extensively drug-resistant tuberculosis despite treatment adherence, South Africa

scientific article

Energy metabolism and drug efflux in Mycobacterium tuberculosis

scientific article published on 10 March 2014

Ergothioneine is a secreted antioxidant in Mycobacterium smegmatis

scientific article published on 29 April 2013

European 1: a globally important clonal complex of Mycobacterium bovis

scientific article published on 6 May 2011

Evaluation of the Capilia TB assay for culture confirmation of Mycobacterium tuberculosis infections in Zambia and South Africa

scientific article published on 4 August 2010

Evidence for a rapid rate of molecular evolution at the hypervariable and immunogenic Mycobacterium tuberculosis PPE38 gene region

scientific article

Evolution and expansion of the Mycobacterium tuberculosis PE and PPE multigene families and their association with the duplication of the ESAT-6 (esx) gene cluster regions

scientific article

Evolution of rifampicin treatment for tuberculosis

scientific article published on 24 June 2019

Excessive Cytolytic Responses Predict Tuberculosis Relapse After Apparently Successful Treatment

scientific article

Exome sequencing identifies a novel TTC37 mutation in the first reported case of Trichohepatoenteric syndrome (THE-S) in South Africa.

scientific article

Experimental Mycobacterium bovis infection in three white rhinoceroses (Ceratotherium simum): Susceptibility, clinical and anatomical pathology.

scientific article

Fatal Tuberculosis in a Free-Ranging African Elephant and One Health Implications of Human Pathogens in Wildlife

article

Fine mapping of a putative tuberculosis-susceptibility locus on chromosome 15q11-13 in African families

scientific article published in July 2002

Fine-Scale Human Population Structure in Southern Africa Reflects Ecogeographic Boundaries

scientific article published on 29 July 2016

Gene polymorphisms in African buffalo associated with susceptibility to bovine tuberculosis infection

scientific article

Gene-expression patterns in whole blood identify subjects at risk for recurrent tuberculosis.

scientific article

Gene-gene interaction between tuberculosis candidate genes in a South African population

scientific article

Genetic Resistance to Infection and Disease

scientific article published on 27 September 2018

Genetic diversity and potential routes of transmission of Mycobacterium bovis in Mozambique

scientific article published on 18 January 2018

Genetic diversity of Mycobacterium tuberculosis complex strains isolated from livestock workers and cattle in Nigeria

scientific article published on 20 February 2019

Genetic diversity of Mycobacterium tuberculosis isolated from tuberculosis patients in the Serengeti ecosystem in Tanzania

scientific article

Genome-wide analysis of multi- and extensively drug-resistant Mycobacterium tuberculosis

scientific article

Genome-wide analysis of the structure of the South African Coloured Population in the Western Cape

scientific article

Genome-wide association study of ancestry-specific TB risk in the South African Coloured population

scientific journal article

Genotype MTBDRsl line probe assay shortens time to diagnosis of extensively drug-resistant tuberculosis in a high-throughput diagnostic laboratory

scientific article published on 18 October 2012

Geospatial distribution of Mycobacterium tuberculosis genotypes in Africa

scientific article published in PLoS ONE

Glutamate Dehydrogenase Is Required by Mycobacterium bovis BCG for Resistance to Cellular Stress.

scientific article published on 29 January 2016

Glutamate dehydrogenase and glutamine synthetase are regulated in response to nitrogen availability in Myocbacterium smegmatis

scientific article

Glutamine synthetase sequence evolution in the mycobacteria and their use as molecular markers for Actinobacteria speciation

scientific article

HIV-1 and tuberculosis infection

scientific article published in May 2002

High diversity, inbreeding and a dynamic Pleistocene demographic history revealed by African buffalo genomes

scientific article published on 25 February 2021

High frequency of resistance, lack of clinical benefit, and poor outcomes in capreomycin treated South African patients with extensively drug-resistant tuberculosis

scientific article

High heritability of antimycobacterial immunity in an area of hyperendemicity for tuberculosis disease

scientific article published in January 2010

High levels of intracellular IL-4 are expressed in circulating apoptotic T cells in patients with tuberculosis and in community controls

scientific article

High prevalence of tuberculosis and insufficient case detection in two communities in the Western Cape, South Africa

scientific article

High yield of culture-based diagnosis in a TB-endemic setting

scientific article

Host markers in QuantiFERON supernatants differentiate active TB from latent TB infection: preliminary report

scientific article published on 16 May 2009

Host susceptibility to tuberculosis: CARD15 polymorphisms in a South African population

scientific article published on 18 October 2006

IP-10 Is a Sensitive Biomarker of Antigen Recognition in Whole-Blood Stimulation Assays Used for the Diagnosis of Mycobacterium bovis Infection in African Buffaloes (Syncerus caffer).

scientific article published on 24 June 2015

IP-10: A potential biomarker for detection of Mycobacterium bovis infection in warthogs ( Phacochoerus africanus )

scientific article published on 21 May 2018

Identification of a major locus, TNF1, that controls BCG-triggered tumor necrosis factor production by leukocytes in an area hyperendemic for tuberculosis

scientific article published on 25 June 2013

Identification of a novel WAS mutation in a South African patient presenting with atypical Wiskott-Aldrich syndrome: a case report

scientific article published on 05 June 2020

Immune parameters as markers of tuberculosis extent of disease and early prediction of anti-tuberculosis chemotherapy response

scientific article published on 21 March 2008

Immunophenotyping of macrophages in human pulmonary tuberculosis and sarcoidosis

scientific article published in December 2003

Impact of Mycobacterium bovis-induced pathology on interpretation of QuantiFERON®-TB Gold assay results in African buffaloes (Syncerus caffer)

scientific article published on 08 August 2019

Impact of nonlinear interactions of pharmacokinetics and MICs on sputum bacillary kill rates as a marker of sterilizing effect in tuberculosis

scientific article

Implementation of genotype MTBDRplus reduces time to multidrug-resistant tuberculosis therapy initiation in South Africa

scientific article published on 22 October 2012

Implications of Failure to Routinely Diagnose Resistance to Second-Line Drugs in Patients With Rifampicin-Resistant Tuberculosis on Xpert MTB/RIF: A Multisite Observational Study

scientific article published on 12 February 2017

Improved detection of <i>Mycobacterium tuberculosis</i> and <i>M. bovis</i> in African wildlife samples using cationic peptide decontamination and mycobacterial culture supplementation

scientific article published on 11 September 2021

Increased frequency of myeloid-derived suppressor cells during active tuberculosis and after recent mycobacterium tuberculosis infection suppresses T-cell function

scientific article published on September 2013

Independent large scale duplications in multiple M. tuberculosis lineages overlapping the same genomic region

scientific article

Infection of African buffalo (Syncerus caffer) by oryx bacillus, a rare member of the antelope clade of the Mycobacterium tuberculosis complex

scientific article published in October 2012

Insertion element IS6110-based restriction fragment length polymorphism genotyping of Mycobacterium tuberculosis

scientific article

Investigating the Role of Gene-Gene Interactions in TB Susceptibility

scientific article published on January 2014

Investigation of chromosome 17 candidate genes in susceptibility to TB in a South African population

scientific article published on 14 January 2009

Isoniazid Resistance and Dosage as Treatment for Patients with Tuberculosis

scientific article

Length Variation of DC-SIGN and L-SIGN Neck-Region has no Impact on Tuberculosis Susceptibility

scientific article published on 04 December 2006

Linkage disequilibrium between minisatellite loci supports clonal evolution of Mycobacterium tuberculosis in a high tuberculosis incidence area

scientific article published in January 2003

Localisation of mycobacterial DNA and mRNA in human tuberculous granulomas

scientific article published in October 2002

Long-term outcomes of patients with extensively drug-resistant tuberculosis in South Africa: a cohort study

scientific article published on 17 January 2014

MYCOBACTERIUM BOVIS IN FREE-RANGING LIONS (PANTHERA LEO) - EVALUATION OF SEROLOGICAL AND TUBERCULIN SKIN TESTS FOR DETECTION OF INFECTION AND DISEASE

scientific article published on 01 March 2019

Mapping of Mycobacterium tuberculosis Complex Genetic Diversity Profiles in Tanzania and Other African Countries

scientific article

Mapping of a novel susceptibility locus suggests a role for MC3R and CTSZ in human tuberculosis

scientific article published on 17 April 2008

Measuring antigen-specific responses in Mycobacterium bovis-infected warthogs (Phacochoerus africanus) using the intradermal tuberculin test

article

Measuring minimum inhibitory concentrations in mycobacteria

scientific article published on 01 January 2009

Medroxyprogesterone acetate alters Mycobacterium bovis BCG-induced cytokine production in peripheral blood mononuclear cells of contraceptive users

scientific article

Mixed infections of Corynebacterium pseudotuberculosis and non-tuberculous mycobacteria in South African antelopes presenting with tuberculosis-like lesions

scientific article published on 24 July 2010

Mixed-strain mycobacterium tuberculosis infections and the implications for tuberculosis treatment and control

scientific article

Modification of the QuantiFERON-TB Gold (In-Tube) assay for the diagnosis of Mycobacterium bovis infection in African buffaloes (Syncerus caffer)

scientific article published on 20 April 2011

Molecular Detection of Early Appearance of Drug Resistance during Mycobacterium tuberculosis Infection

scholarly article by Thomas C. Victor et al published 24 January 2002 in Clinical Chemistry and Laboratory Medicine

Molecular bacterial load assay, a culture-free biomarker for rapid and accurate quantification of sputum Mycobacterium tuberculosis bacillary load during treatment

scientific article published on 7 September 2011

Molecular characteristics and global spread of Mycobacterium tuberculosis with a western cape F11 genotype

scientific article

Moxifloxacin retains antimycobacterial activity in the presence of gyrA mutations

scientific article published on 10 February 2014

Multilaboratory Evaluation of a Novel Lateral Flow Immunochromatographic Assay for Confirming Isolation of Mycobacterium bovis from Veterinary Diagnostic Specimens

scientific article

Multiple Mycobacterium tuberculosis strains in early cultures from patients in a high-incidence community setting

scientific article

Multiple, independent, identical IS6110 insertions in Mycobacterium tuberculosis PPE genes

article

Mutations in the rrs A1401G Gene and Phenotypic Resistance to Amikacin and Capreomycin in Mycobacterium tuberculosis

article

Mycobacterial genomic DNA from used Xpert MTB/RIF cartridges can be utilised for accurate second-line genotypic drug susceptibility testing and spoligotyping

scientific article published in November 2017

Mycobacterial nucleoid associated proteins: An added dimension in gene regulation

article

Mycobacterium africanum is not a major cause of human tuberculosis in Cape Town, South Africa

article

Mycobacterium bovis BCG infection severely delays Trichuris muris expulsion and co-infection suppresses immune responsiveness to both pathogens.

scientific article

Mycobacterium bovis Infection in African Wild Dogs, Kruger National Park, South Africa.

scientific article published in July 2019

Mycobacterium bovis in a Free-Ranging Black Rhinoceros, Kruger National Park, South Africa, 2016.

scientific article published on March 2017

Mycobacterium bovis infection in the lion (Panthera leo): Current knowledge, conundrums and research challenges

scientific article published on 8 April 2015

Mycobacterium tuberculosis Beijing genotype is associated with HIV infection in Mozambique

scientific article (publication date: 2013)

Mycobacterium tuberculosis complex genetic diversity: mining the fourth international spoligotyping database (SpolDB4) for classification, population genetics and epidemiology

scientific article (publication date: 6 March 2006)

Mycobacterium tuberculosis pncA Polymorphisms That Do Not Confer Pyrazinamide Resistance at a Breakpoint Concentration of 100 Micrograms per Milliliter in MGIT.

scientific article

Mycobacterium tuberculosis: concentrate resources on recent infections

scientific article published on 15 November 2019

NAT2 polymorphisms and their influence on the pharmacology and toxicity of isoniazid in TB patients

article

Novel Antitubercular 6-Dialkylaminopyrimidine Carboxamides from Phenotypic Whole-Cell High Throughput Screening of a SoftFocus Library: Structure-Activity Relationship and Target Identification Studies.

scientific article published on 17 November 2017

Novel Mycobacterium tuberculosis complex pathogen, M. mungi

scientific article

Novel SNP Discovery in African Buffalo, Syncerus caffer, using high-throughput Sequencing

scientific article published on 7 November 2012

Novel cause of tuberculosis in meerkats, South Africa

scientific article published on December 2013

Novel thiolactone-isatin hybrids as potential antimalarial and antitubercular agents

scientific article published on 2 March 2011

One world, one health. Humans, animals and the environment are inextricably linked--a fact that needs to be remembered and exploited in our modern approach to health ⬇️

scientific article published on 17 May 2013

Outcomes, infectiousness, and transmission dynamics of patients with extensively drug-resistant tuberculosis and home-discharged patients with programmatically incurable tuberculosis: a prospective cohort study

scientific article

PERFORMANCE OF THE TUBERCULIN SKIN TEST IN MYCOBACTERIUM BOVIS-EXPOSED AND -UNEXPOSED AFRICAN LIONS (PANTHERA LEO)

scientific article published on 28 November 2018

Parallel measurement of IFN-γ and IP-10 in QuantiFERON®-TB Gold (QFT) plasma improves the detection of Mycobacterium bovis infection in African buffaloes (Syncerus caffer)

scientific article published on 23 May 2019

Parallel testing increases detection of Mycobacterium bovis-infected African buffaloes (Syncerus caffer)

scientific article published on 18 September 2018

Paratuberculosis in a domestic dog in South Africa.

scientific article published on 30 March 2017

Patients with active tuberculosis often have different strains in the same sputum specimen

scientific article published on 30 December 2003

Pentacyclo-undecane derived cyclic tetra-amines: synthesis and evaluation as potent anti-tuberculosis agents

scientific article

Phenotypically resembling myeloid derived suppressor cells are increased in children with HIV and exposed/infected with Mycobacterium tuberculosis

scientific article

Pleural tuberculosis in patients with early HIV infection is associated with increased TNF-alpha expression and necrosis in granulomas

scientific article

Polymorphisms and mutations found in the regions flanking exons 5 to 8 of the TP53 gene in a population at high risk for esophageal cancer in South Africa

scientific article published in January 2003

Polymorphisms in MC3R promoter and CTSZ 3'UTR are associated with tuberculosis susceptibility

scientific article

Polymorphisms in the Pattern Recognition Receptor Mincle Gene (CLEC4E) and Association with Tuberculosis.

scientific article published on 30 June 2016

Population structure and infectious disease risk in southern Africa

scientific article published on 22 February 2017

Population structure of mixed Mycobacterium tuberculosis infection is strain genotype and culture medium dependent

scientific article

Population structure of multi- and extensively drug-resistant Mycobacterium tuberculosis strains in South Africa

scientific article

Potential of host markers produced by infection phase-dependent antigen-stimulated cells for the diagnosis of tuberculosis in a highly endemic area

scientific article

Potential of rapid diagnosis for controlling drug-susceptible and drug-resistant tuberculosis in communities where Mycobacterium tuberculosis infections are highly prevalent

scientific article published on 18 March 2009

Predicting Reinfection in Tuberculosis

scientific article published on 01 January 2008

Prediction of drug resistance in M. tuberculosis: molecular mechanisms, tools, and applications

scientific article

Prevalence and Risk Factors for Mycobacterium bovis Infection in African Lions ( Panthera leo ) in the Kruger National Park.

scientific article published on 25 January 2017

Prevalence and risk factors for infection of bovine tuberculosis in indigenous cattle in the Serengeti ecosystem, Tanzania

scientific article

Prevalence of pyrazinamide resistance across the spectrum of drug resistant phenotypes of Mycobacterium tuberculosis

scientific article published on 30 May 2016

Profiling persistent tubercule bacilli from patient sputa during therapy predicts early drug efficacy

scientific article

Programmatically selected multidrug-resistant strains drive the emergence of extensively drug-resistant tuberculosis in South Africa

scientific article (publication date: 2013)

Promoter variation in the DC-SIGN-encoding gene CD209 is associated with tuberculosis

scientific article

Proportion of tuberculosis transmission that takes place in households in a high-incidence area

scientific article published in The Lancet

Proteogenomic Investigation of Strain Variation in Clinical Mycobacterium tuberculosis Isolates

scientific article published on 18 August 2017

Pulmonary infection due to Mycobacterium bovis in a black rhinoceros (Diceros bicornis minor) in South Africa

scientific article published in October 2009

Pulmonary infection due to Mycobacterium goodii in a spotted hyena (Crocuta crocuta) from South Africa

scientific article

Pulmonary infection due to the dassie bacillus (Mycobacterium tuberculosis complex sp.) in a free-living dassie (rock hyrax-Procavia capensis) from South Africa.

scientific article published on 22 October 2007

Pyrrolo[3,4-c]pyridine-1,3(2H)-diones: A Novel Antimycobacterial Class Targeting Mycobacterial Respiration

scientific article published on 9 November 2015

RNAseq reveals hypervirulence-specific host responses to M. tuberculosis infection

scientific article

Rapid diagnosis of pediatric mycobacterial lymphadenitis using fine needle aspiration biopsy

scientific article published on September 2014

Rapid sequencing of the Mycobacterium tuberculosis pncA gene for detection of pyrazinamide susceptibility

scientific article

Rate of reinfection tuberculosis after successful treatment is higher than rate of new tuberculosis

scientific article published on 14 April 2005

Recombination in pe/ppe genes contributes to genetic variation in Mycobacterium tuberculosis lineages

scientific article

Reduction of the rate of false-positive cultures of Mycobacterium tuberculosis in a laboratory with a high culture positivity rate

scientific article published in September 2002

Regulation of nitrogen metabolism in Mycobacterium tuberculosis: a comparison with mechanisms in Corynebacterium glutamicum and Streptomyces coelicolor

scientific article published on October 2008

Reinfection and mixed infection cause changing Mycobacterium tuberculosis drug-resistance patterns

scientific article published on 09 June 2005

Reply to Davies et al

scientific article published in 2007

Resistant Mycobacterium bovis Bacillus Calmette-Guérin disease: implications for management of Bacillus Calmette-Guérin Disease in human immunodeficiency virus-infected children

scientific article published in May 2004

Reverse zoonotic tuberculosis transmission from an emerging Uganda I strain between pastoralists and cattle in South-Eastern Nigeria

scientific article published on 04 December 2019

Rifampicin reduces susceptibility to ofloxacin in rifampicin-resistant Mycobacterium tuberculosis through efflux

scientific article published on 21 April 2011

Rv2629 191A/C nucleotide change is not associated with rifampicin resistance in Mycobacterium tuberculosis

scientific article

SNP/RD typing of Mycobacterium tuberculosis Beijing strains reveals local and worldwide disseminated clonal complexes

scientific article

Safe Mycobacterium tuberculosis DNA extraction method that does not compromise integrity

scientific article published in January 2006

Serodiagnostic markers for the prediction of the outcome of intensive phase tuberculosis therapy

scientific article published on 2 November 2012

Serologic diagnosis of tuberculosis by combining Ig classes against selected mycobacterial targets.

scientific article

Species diversity of non-tuberculous mycobacteria isolated from humans, livestock and wildlife in the Serengeti ecosystem, Tanzania

scientific article

Stability of polymorphic GC-rich repeat sequence-containing regions of Mycobacterium tuberculosis

scientific article published on March 2004

Stability of variable-number tandem repeats of mycobacterial interspersed repetitive units from 12 loci in serial isolates of Mycobacterium tuberculosis

scientific article

Strain families of Mycobacterium tuberculosis

scientific article published in April 2002

Strong Maternal Khoisan Contribution to the South African Coloured Population: A Case of Gender-Biased Admixture.

scientific article published in April 2010

Strong maternal Khoisan contribution to the South African coloured population: a case of gender-biased admixture

scientific article

Structural and functional effects of nucleotide variation on the human TB drug metabolizing enzyme arylamine N-acetyltransferase 1.

scientific article published on 10 June 2017

Sulfamethoxazole enhances the antimycobacterial activity of rifampicin

scientific article

Sulfatase-activated fluorophores for rapid discrimination of mycobacterial species and strains.

scientific article published on 22 July 2013

TB Control in Humans and Animals in South Africa: A Perspective on Problems and Successes

article

TB Epidemiology and Human Genetics

article

TB epidemiology and human genetics

scientific article published on January 2006

TB: a partnership for the benefit of research and community

scientific article published in October 2005

Test Characteristics of Assays to Detect Mycobacterium bovis Infection in High-Prevalence African Buffalo (Syncerus caffer) Herds

scientific article published on 21 November 2019

Test performance of three serological assays for the detection of Mycobacterium bovis infection in common warthogs (Phacochoerus africanus).

scientific article

The "Source" of Drug-Resistant TB Outbreaks

scientific article

The Host Response to a Clinical MDR Mycobacterial Strain Cultured in a Detergent-Free Environment: A Global Transcriptomics Approach

scientific article

The Kinetics of the Humoral and Interferon-Gamma Immune Responses to Experimental Mycobacterium bovis Infection in the White Rhinoceros (Ceratotherium simum).

scientific article published on 22 December 2017

The Risk of Tuberculosis Reinfection Soon after Cure of a First Disease Episode Is Extremely High in a Hyperendemic Community

scientific article published on 9 December 2015

The VetMAX™ M. tuberculosis complex PCR kit detects MTBC DNA in antemortem and postmortem samples from white rhinoceros (Ceratotherium simum), African elephants (Loxodonta africana) and African buffaloes (Syncerus caffer)

scientific article published on 29 June 2020

The Xpert MTB/RIF Ultra assay detects Mycobacterium tuberculosis complex DNA in white rhinoceros (Ceratotherium simum) and African elephants (Loxodonta africana)

scientific article published on 02 September 2020

The arms race between man and Mycobacterium tuberculosis: Time to regroup

scientific article published on 23 August 2017

The complete genome sequence of the African buffalo (Syncerus caffer).

scientific article

The contraceptive depot medroxyprogesterone acetate impairs mycobacterial control and inhibits cytokine secretion in mice infected with Mycobacterium tuberculosis

scientific article published on 4 February 2013

The diagnostic accuracy of the MTBDRplus and MTBDRsl assays for drug-resistant TB detection when performed on sputum and culture isolates

scientific article published on 10 February 2016

The effect of diagnostic delays on the drop-out rate and the total delay to diagnosis of tuberculosis

scientific article

The epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant, extensively drug-resistant, and incurable tuberculosis

scientific article

The evaluation of candidate biomarkers of cell-mediated immunity for the diagnosis of Mycobacterium bovis infection in African buffaloes (Syncerus caffer).

scientific article published on 26 October 2014

The human immune response to tuberculosis and its treatment: a view from the blood

scientific article

The non-clonality of drug resistance in Beijing-genotype isolates of Mycobacterium tuberculosis from the Western Cape of South Africa

scientific article

The prevalence of antibodies to Toxoplasma gondii in sheep in the Western Cape, South Africa

scientific article published on 3 November 2015

The pyrazinamide susceptibility breakpoint above which combination therapy fails

scientific article

The rationale for using rifabutin in the treatment of MDR and XDR tuberculosis outbreaks

scientific article

The role of IS6110 in the evolution of Mycobacterium tuberculosis

scientific article published on 12 July 2007

The role of ancestry in TB susceptibility of an admixed South African population

scientific article published on 13 April 2014

The role of glutamine oxoglutarate aminotransferase and glutamate dehydrogenase in nitrogen metabolism in Mycobacterium bovis BCG.

scientific article

The role of human host genetics in tuberculosis resistance

scientific article

The spectrum of mutations in TP53 in laryngeal cancer patients from a high-incidence population shows similarities to many of the known mutational hotspots

scientific article published in September 2003

The stability of plasma IP-10 enhances its utility for the diagnosis of Mycobacterium bovis infection in African buffaloes (Syncerus caffer).

scientific article published on 25 March 2016

The temporal dynamics of relapse and reinfection tuberculosis after successful treatment: a retrospective cohort study

scientific article published on 18 March 2014

Total Antioxidant Levels are Low During Active TB and Rise with Anti-tuberculosis Therapy

scientific article published on 01 February 2004

Towards eliminating bias in cluster analysis of TB genotyped data

scientific article

Translational Research for Tuberculosis Elimination: Priorities, Challenges, and Actions

scientific article

Transmission of tuberculosis in a high incidence urban community in South Africa

scientific article published on April 2004

Tuberculin Skin Test and In Vitro Assays Provide Complementary Measures of Antimycobacterial Immunity in Children and Adolescents

Tuberculosis cross-species transmission in Tanzania: towards a One-Health concept

scientific article published on 20 July 2012

Tuberculosis reinfection rate as a proportion of total infection rate correlates with the logarithm of the incidence rate: a mathematical model

scientific article published in January 2009

Two loci control tuberculin skin test reactivity in an area hyperendemic for tuberculosis

scientific article

Use of the MILLIPLEX® bovine cytokine/chemokine multiplex assay to identify Mycobacterium bovis-infection biomarkers in African buffaloes (Syncerus caffer)

scientific article published on 11 November 2020

Using a label-free proteomics method to identify differentially abundant proteins in closely related hypo- and hypervirulent clinical Mycobacterium tuberculosis Beijing isolates

scientific article

Using multi-way admixture mapping to elucidate TB susceptibility in the South African Coloured population

scientific article

Using routinely collected laboratory data to identify high rifampicin-resistant tuberculosis burden communities in the Western Cape Province, South Africa: A retrospective spatiotemporal analysis

article

Whole genome sequencing provides additional insights into recurrent tuberculosis classified as endogenous reactivation by IS6110 DNA fingerprinting

scientific article published on 02 July 2019

Whole-genome sequencing to establish relapse or re-infection with Mycobacterium tuberculosis: a retrospective observational study

scientific article

Xpert MTB/RIF Ultra and Xpert MTB/RIF for diagnosis of tuberculosis in an HIV-endemic setting with a high burden of previous tuberculosis: a two-cohort diagnostic accuracy study

scientific article published on 14 February 2020

Xpert MTB/RIF for rapid diagnosis of tuberculous lymphadenitis from fine-needle-aspiration biopsy specimens

scientific article published on 31 August 2011

Zoonotic Mycobacterium bovis-induced tuberculosis in humans

scientific article published on June 2013

embB306 mutations as molecular indicators to predict ethambutol susceptibility in Mycobacterium tuberculosis

scientific article published on 17 November 2012

gyrA mutations and phenotypic susceptibility levels to ofloxacin and moxifloxacin in clinical isolates of Mycobacterium tuberculosis

scientific article published on 22 February 2012

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